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Protein

Poliovirus receptor

Gene

PVR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.2 Publications
(Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.1 Publication
(Microbial infection) Acts as a receptor for Pseudorabies virus.1 Publication
(Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells.1 Publication

Miscellaneous

The V-type domain is necessary and sufficient for virus binding and uptake.

Kineticsi

  1. KM=72 nM for VTN

    GO - Molecular functioni

    • cell adhesion molecule binding Source: BHF-UCL
    • protein homodimerization activity Source: GO_Central
    • signaling receptor activity Source: ProtInc
    • signaling receptor binding Source: GO_Central
    • virus receptor activity Source: UniProtKB-KW

    GO - Biological processi

    Keywordsi

    Molecular functionHost cell receptor for virus entry, Receptor
    Biological processCell adhesion, Host-virus interaction

    Enzyme and pathway databases

    ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    R-HSA-420597 Nectin/Necl trans heterodimerization
    SIGNORiP15151

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poliovirus receptor
    Alternative name(s):
    Nectin-like protein 5
    Short name:
    NECL-5
    CD_antigen: CD155
    Gene namesi
    Name:PVR
    Synonyms:PVS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 19

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000073008.14
    HGNCiHGNC:9705 PVR
    MIMi173850 gene+phenotype
    neXtProtiNX_P15151

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini21 – 343ExtracellularSequence analysisAdd BLAST323
    Transmembranei344 – 367HelicalSequence analysisAdd BLAST24
    Topological domaini368 – 417CytoplasmicSequence analysisAdd BLAST50

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi369 – 372KCSR → ACSA: Partial loss of DYNLT1 binding. 1 Publication4

    Organism-specific databases

    DisGeNETi5817
    MIMi173850 gene+phenotype
    OpenTargetsiENSG00000073008
    PharmGKBiPA34050

    Chemistry databases

    DrugBankiDB08231 MYRISTIC ACID
    DB03203 Sphingosine

    Polymorphism and mutation databases

    BioMutaiPVR
    DMDMi1346922

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Signal peptidei1 – 20Sequence analysisAdd BLAST20
    ChainiPRO_000001513121 – 417Poliovirus receptorAdd BLAST397

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Disulfide bondi49 ↔ 123PROSITE-ProRule annotation1 Publication
    Glycosylationi105N-linked (GlcNAc...) asparagine1
    Glycosylationi120N-linked (GlcNAc...) (complex) asparagine1 Publication1
    Disulfide bondi166 ↔ 221PROSITE-ProRule annotation
    Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi218N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi237N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi266 ↔ 312PROSITE-ProRule annotation
    Glycosylationi278N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi307N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi313N-linked (GlcNAc...) asparagineSequence analysis1
    Modified residuei398Phosphotyrosine2 Publications1
    Isoform Gamma (identifier: P15151-3)
    Glycosylationi352N-linked (GlcNAc...) asparagine1 Publication1
    Isoform Beta (identifier: P15151-2)
    Glycosylationi360N-linked (GlcNAc...) asparagine1 Publication1

    Post-translational modificationi

    N-glycosylated. N-glycan at Asn-120: Hex5HexNAc4.3 Publications
    Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation. Interaction with TIGIT is required for Phosphorylation.2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    EPDiP15151
    MaxQBiP15151
    PaxDbiP15151
    PeptideAtlasiP15151
    PRIDEiP15151
    ProteomicsDBi53110
    53111 [P15151-2]
    53112 [P15151-3]
    53113 [P15151-4]

    PTM databases

    GlyConnecti782
    iPTMnetiP15151
    PhosphoSitePlusiP15151
    SwissPalmiP15151
    UniCarbKBiP15151

    Expressioni

    Inductioni

    Transcriptionally regulated by SHH.1 Publication

    Gene expression databases

    BgeeiENSG00000073008 Expressed in 183 organ(s), highest expression level in left coronary artery
    CleanExiHS_PVR
    ExpressionAtlasiP15151 baseline and differential
    GenevisibleiP15151 HS

    Organism-specific databases

    HPAiHPA012568

    Interactioni

    Subunit structurei

    Can form trans-heterodimers with NECTIN3. The extracellular domain interacts with VTN, CD226 and CD96. The cytoplasmic domain interacts with DYNLT1. Binds with high affinity to TIGIT.9 Publications
    (Microbial infection) Interacts with poliovirus capsid proteins.1 Publication
    (Microbial infection) Interacts with human cytomegalovirus /HHV-5 UL141 protein.1 Publication
    (Microbial infection) Interacts with pseudorabies virus gD protein.1 Publication

    Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    BioGridi111775, 59 interactors
    DIPiDIP-43987N
    IntActiP15151, 54 interactors
    MINTiP15151
    STRINGi9606.ENSP00000402060

    Structurei

    Secondary structure

    1417
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    ProteinModelPortaliP15151
    SMRiP15151
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP15151

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini24 – 139Ig-like V-typeAdd BLAST116
    Domaini145 – 237Ig-like C2-type 1Add BLAST93
    Domaini244 – 328Ig-like C2-type 2Add BLAST85

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni368 – 372DYNLT1 binding5

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Motifi396 – 401ITIM motif6

    Domaini

    Sequence similaritiesi

    Belongs to the nectin family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiENOG410IY4J Eukaryota
    ENOG4111K6M LUCA
    GeneTreeiENSGT00900000140811
    HOGENOMiHOG000237277
    HOVERGENiHBG019169
    InParanoidiP15151
    KOiK06539
    PhylomeDBiP15151
    TreeFamiTF331051

    Family and domain databases

    Gene3Di2.60.40.10, 3 hits
    InterProiView protein in InterPro
    IPR013162 CD80_C2-set
    IPR007110 Ig-like_dom
    IPR036179 Ig-like_dom_sf
    IPR013783 Ig-like_fold
    IPR003599 Ig_sub
    IPR013106 Ig_V-set
    PfamiView protein in Pfam
    PF08205 C2-set_2, 1 hit
    PF07686 V-set, 1 hit
    SMARTiView protein in SMART
    SM00409 IG, 2 hits
    SM00406 IGv, 1 hit
    SUPFAMiSSF48726 SSF48726, 3 hits
    PROSITEiView protein in PROSITE
    PS50835 IG_LIKE, 3 hits

    Sequences (4+)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform Alpha (identifier: P15151-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MARAMAAAWP LLLVALLVLS WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY
    60 70 80 90 100
    LQVPNMEVTH VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG
    110 120 130 140 150
    AELRNASLRM FGLRVEDEGN YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE
    160 170 180 190 200
    VQKVQLTGEP VPMARCVSTG GRPPAQITWH SDLGGMPNTS QVPGFLSGTV
    210 220 230 240 250
    TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV YYPPEVSISG
    260 270 280 290 300
    YDNNWYLGQN EATLTCDARS NPEPTGYNWS TTMGPLPPFA VAQGAQLLIR
    310 320 330 340 350
    PVDKPINTTL ICNVTNALGA RQAELTVQVK EGPPSEHSGI SRNAIIFLVL
    360 370 380 390 400
    GILVFLILLG IGIYFYWSKC SREVLWHCHL CPSSTEHASA SANGHVSYSA
    410
    VSRENSSSQD PQTEGTR
    Length:417
    Mass (Da):45,303
    Last modified:February 1, 1996 - v2
    Checksum:iD15C012CE853169B
    GO
    Isoform Beta (identifier: P15151-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         340-384: Missing.

    Show »
    Length:372
    Mass (Da):40,125
    Checksum:i7B56B38F949996BE
    GO
    Isoform Gamma (identifier: P15151-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         331-331: E → G
         332-384: Missing.

    Show »
    Length:364
    Mass (Da):39,304
    Checksum:iF63D1B6CF19F2A6F
    GO
    Isoform Delta (identifier: P15151-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         385-392: TEHASASA → EHHQSCRN
         393-417: Missing.

    Show »
    Length:392
    Mass (Da):42,864
    Checksum:i528DFC93B73C7FD8
    GO

    Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A0A0MSA9A0A0A0MSA9_HUMAN
    Poliovirus receptor
    PVR
    392Annotation score:
    A0A0C4DG49A0A0C4DG49_HUMAN
    Poliovirus receptor
    PVR hCG_1996181
    417Annotation score:
    F8W7D4F8W7D4_HUMAN
    Poliovirus receptor
    PVR
    44Annotation score:
    K7EMC6K7EMC6_HUMAN
    Poliovirus receptor
    PVR
    70Annotation score:

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_00395267A → T. Corresponds to variant dbSNP:rs1058402Ensembl.1
    Natural variantiVAR_049994295A → T. Corresponds to variant dbSNP:rs35365841Ensembl.1
    Natural variantiVAR_011736340I → M1 PublicationCorresponds to variant dbSNP:rs203710Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_002618331E → G in isoform Gamma. Curated1
    Alternative sequenceiVSP_002619332 – 384Missing in isoform Gamma. CuratedAdd BLAST53
    Alternative sequenceiVSP_002617340 – 384Missing in isoform Beta. 1 PublicationAdd BLAST45
    Alternative sequenceiVSP_002620385 – 392TEHASASA → EHHQSCRN in isoform Delta. Curated8
    Alternative sequenceiVSP_002621393 – 417Missing in isoform Delta. CuratedAdd BLAST25

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M24407 mRNA Translation: AAA36461.1
    M24406 mRNA Translation: AAA36462.1
    X64116
    , X64117, X64118, X64119, X64120, X64121, X64122, X64123 Genomic DNA Translation: CAA45478.1
    X64116
    , X64117, X64118, X64119, X64120, X64121, X64122, X64123 Genomic DNA Translation: CAA45479.1
    X64116
    , X64117, X64118, X64119, X64120, X64122, X64123 Genomic DNA Translation: CAA45480.1
    AK300349 mRNA Translation: BAG62091.1
    AC068948 Genomic DNA Translation: AAF69803.1
    BC015542 mRNA Translation: AAH15542.1
    CCDSiCCDS12640.1 [P15151-1]
    CCDS46105.1 [P15151-2]
    CCDS46106.1 [P15151-3]
    CCDS46107.1 [P15151-4]
    PIRiA43024 RWHUPD
    S12048 RWHUPA
    RefSeqiNP_001129240.1, NM_001135768.2 [P15151-2]
    NP_001129241.1, NM_001135769.2 [P15151-3]
    NP_001129242.2, NM_001135770.3
    NP_006496.4, NM_006505.4
    UniGeneiHs.171844

    Genome annotation databases

    EnsembliENST00000344956; ENSP00000340870; ENSG00000073008 [P15151-3]
    ENST00000403059; ENSP00000385344; ENSG00000073008 [P15151-2]
    GeneIDi5817
    KEGGihsa:5817
    UCSCiuc032hzv.2 human [P15151-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Similar proteinsi

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    The accidental crippler - Issue 75 of October 2006

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M24407 mRNA Translation: AAA36461.1
    M24406 mRNA Translation: AAA36462.1
    X64116
    , X64117, X64118, X64119, X64120, X64121, X64122, X64123 Genomic DNA Translation: CAA45478.1
    X64116
    , X64117, X64118, X64119, X64120, X64121, X64122, X64123 Genomic DNA Translation: CAA45479.1
    X64116
    , X64117, X64118, X64119, X64120, X64122, X64123 Genomic DNA Translation: CAA45480.1
    AK300349 mRNA Translation: BAG62091.1
    AC068948 Genomic DNA Translation: AAF69803.1
    BC015542 mRNA Translation: AAH15542.1
    CCDSiCCDS12640.1 [P15151-1]
    CCDS46105.1 [P15151-2]
    CCDS46106.1 [P15151-3]
    CCDS46107.1 [P15151-4]
    PIRiA43024 RWHUPD
    S12048 RWHUPA
    RefSeqiNP_001129240.1, NM_001135768.2 [P15151-2]
    NP_001129241.1, NM_001135769.2 [P15151-3]
    NP_001129242.2, NM_001135770.3
    NP_006496.4, NM_006505.4
    UniGeneiHs.171844

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1DGIelectron microscopy22.00R28-329[»]
    1NN8electron microscopy15.00R/S/T28-329[»]
    3EPCelectron microscopy8.00R30-242[»]
    3EPDelectron microscopy9.00R30-242[»]
    3EPFelectron microscopy9.00R30-242[»]
    3J8Felectron microscopy3.7071-417[»]
    3J9Felectron microscopy9.00728-143[»]
    8142-243[»]
    9242-333[»]
    3UDWX-ray2.90C/D28-145[»]
    3UROX-ray3.50R29-243[»]
    4FQPX-ray3.60A28-334[»]
    ProteinModelPortaliP15151
    SMRiP15151
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi111775, 59 interactors
    DIPiDIP-43987N
    IntActiP15151, 54 interactors
    MINTiP15151
    STRINGi9606.ENSP00000402060

    Chemistry databases

    DrugBankiDB08231 MYRISTIC ACID
    DB03203 Sphingosine

    PTM databases

    GlyConnecti782
    iPTMnetiP15151
    PhosphoSitePlusiP15151
    SwissPalmiP15151
    UniCarbKBiP15151

    Polymorphism and mutation databases

    BioMutaiPVR
    DMDMi1346922

    Proteomic databases

    EPDiP15151
    MaxQBiP15151
    PaxDbiP15151
    PeptideAtlasiP15151
    PRIDEiP15151
    ProteomicsDBi53110
    53111 [P15151-2]
    53112 [P15151-3]
    53113 [P15151-4]

    Protocols and materials databases

    DNASUi5817
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000344956; ENSP00000340870; ENSG00000073008 [P15151-3]
    ENST00000403059; ENSP00000385344; ENSG00000073008 [P15151-2]
    GeneIDi5817
    KEGGihsa:5817
    UCSCiuc032hzv.2 human [P15151-1]

    Organism-specific databases

    CTDi5817
    DisGeNETi5817
    EuPathDBiHostDB:ENSG00000073008.14
    GeneCardsiPVR
    HGNCiHGNC:9705 PVR
    HPAiHPA012568
    MIMi173850 gene+phenotype
    neXtProtiNX_P15151
    OpenTargetsiENSG00000073008
    PharmGKBiPA34050
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiENOG410IY4J Eukaryota
    ENOG4111K6M LUCA
    GeneTreeiENSGT00900000140811
    HOGENOMiHOG000237277
    HOVERGENiHBG019169
    InParanoidiP15151
    KOiK06539
    PhylomeDBiP15151
    TreeFamiTF331051

    Enzyme and pathway databases

    ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    R-HSA-420597 Nectin/Necl trans heterodimerization
    SIGNORiP15151

    Miscellaneous databases

    ChiTaRSiPVR human
    EvolutionaryTraceiP15151
    GeneWikiiCD155
    GenomeRNAii5817
    PROiPR:P15151
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000073008 Expressed in 183 organ(s), highest expression level in left coronary artery
    CleanExiHS_PVR
    ExpressionAtlasiP15151 baseline and differential
    GenevisibleiP15151 HS

    Family and domain databases

    Gene3Di2.60.40.10, 3 hits
    InterProiView protein in InterPro
    IPR013162 CD80_C2-set
    IPR007110 Ig-like_dom
    IPR036179 Ig-like_dom_sf
    IPR013783 Ig-like_fold
    IPR003599 Ig_sub
    IPR013106 Ig_V-set
    PfamiView protein in Pfam
    PF08205 C2-set_2, 1 hit
    PF07686 V-set, 1 hit
    SMARTiView protein in SMART
    SM00409 IG, 2 hits
    SM00406 IGv, 1 hit
    SUPFAMiSSF48726 SSF48726, 3 hits
    PROSITEiView protein in PROSITE
    PS50835 IG_LIKE, 3 hits
    ProtoNetiSearch...

    Entry informationi

    Entry nameiPVR_HUMAN
    AccessioniPrimary (citable) accession number: P15151
    Secondary accession number(s): B4DTS9
    , P15152, Q15267, Q15268, Q96BJ1
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: February 1, 1996
    Last modified: September 12, 2018
    This is version 201 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    7. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    8. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    UniProt is an ELIXIR core data resource
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