UniProtKB - P15151 (PVR_HUMAN)
Poliovirus receptor
PVR
Functioni
Miscellaneous
Kineticsi
- KM=72 nM for VTN
GO - Molecular functioni
- cell adhesion molecule binding Source: BHF-UCL
- signaling receptor activity Source: ProtInc
- virus receptor activity Source: UniProtKB-KW
GO - Biological processi
- adherens junction organization Source: Reactome
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central
- positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL
- positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: BHF-UCL
- regulation of immune response Source: Reactome
- susceptibility to natural killer cell mediated cytotoxicity Source: BHF-UCL
- susceptibility to T cell mediated cytotoxicity Source: BHF-UCL
Keywordsi
Molecular function | Host cell receptor for virus entry, Receptor |
Biological process | Cell adhesion, Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | P15151 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-420597, Nectin/Necl trans heterodimerization |
SIGNORi | P15151 |
Names & Taxonomyi
Protein namesi | Recommended name: Poliovirus receptorAlternative name(s): Nectin-like protein 5 Short name: NECL-5 CD_antigen: CD155 |
Gene namesi | Name:PVR Synonyms:PVS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9705, PVR |
MIMi | 173850, gene+phenotype |
neXtProti | NX_P15151 |
VEuPathDBi | HostDB:ENSG00000073008.14 |
Subcellular locationi
Plasma membrane
Plasma membrane
Extracellular region or secreted
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: ProtInc
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- adherens junction Source: GO_Central
- cell surface Source: BHF-UCL
- cytoplasm Source: ProtInc
- focal adhesion Source: UniProtKB
- integral component of membrane Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 343 | ExtracellularSequence analysisAdd BLAST | 323 | |
Transmembranei | 344 – 367 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 368 – 417 | CytoplasmicSequence analysisAdd BLAST | 50 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 369 – 372 | KCSR → ACSA: Partial loss of DYNLT1 binding. 1 Publication | 4 |
Organism-specific databases
DisGeNETi | 5817 |
MIMi | 173850, gene+phenotype |
OpenTargetsi | ENSG00000073008 |
PharmGKBi | PA34050 |
Miscellaneous databases
Pharosi | P15151, Tbio |
Chemistry databases
DrugBanki | DB08231, Myristic acid DB03203, Sphingosine |
Genetic variation databases
BioMutai | PVR |
DMDMi | 1346922 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000015131 | 21 – 417 | Poliovirus receptorAdd BLAST | 397 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Disulfide bondi | 49 ↔ 123 | PROSITE-ProRule annotation1 Publication | |||
Glycosylationi | 105 | N-linked (GlcNAc...) asparagine | 1 | ||
Glycosylationi | 120 | N-linked (GlcNAc...) (complex) asparagine1 Publication | 1 | ||
Disulfide bondi | 166 ↔ 221 | PROSITE-ProRule annotation | |||
Glycosylationi | 188 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Glycosylationi | 218 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Glycosylationi | 237 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Disulfide bondi | 266 ↔ 312 | PROSITE-ProRule annotation | |||
Glycosylationi | 278 | N-linked (GlcNAc...) asparagine1 Publication | 1 | ||
Glycosylationi | 307 | N-linked (GlcNAc...) asparagine1 Publication | 1 | ||
Glycosylationi | 313 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Modified residuei | 398 | Phosphotyrosine2 Publications | 1 | ||
Isoform Gamma (identifier: P15151-3) | |||||
Glycosylationi | 352 | N-linked (GlcNAc...) asparagine1 Publication | 1 | ||
Isoform Beta (identifier: P15151-2) | |||||
Glycosylationi | 360 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P15151 |
jPOSTi | P15151 |
MassIVEi | P15151 |
MaxQBi | P15151 |
PaxDbi | P15151 |
PeptideAtlasi | P15151 |
PRIDEi | P15151 |
ProteomicsDBi | 53110 [P15151-1] 53111 [P15151-2] 53112 [P15151-3] 53113 [P15151-4] |
PTM databases
GlyConnecti | 782, 1 N-Linked glycan (1 site) |
GlyGeni | P15151, 10 sites, 1 N-linked glycan (1 site) |
iPTMneti | P15151 |
PhosphoSitePlusi | P15151 |
SwissPalmi | P15151 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000073008, Expressed in left coronary artery and 196 other tissues |
ExpressionAtlasi | P15151, baseline and differential |
Genevisiblei | P15151, HS |
Organism-specific databases
HPAi | ENSG00000073008, Tissue enhanced (liver) |
Interactioni
Subunit structurei
Can form trans-heterodimers with NECTIN3. The extracellular domain interacts with VTN, CD226 and CD96. The cytoplasmic domain interacts with DYNLT1. Binds with high affinity to TIGIT.
9 Publications(Microbial infection) Interacts with poliovirus capsid proteins.
1 Publication(Microbial infection) Interacts with human cytomegalovirus /HHV-5 UL141 protein.
1 Publication(Microbial infection) Interacts with pseudorabies virus gD protein.
1 PublicationBinary interactionsi
P15151
GO - Molecular functioni
- cell adhesion molecule binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 111775, 121 interactors |
DIPi | DIP-43987N |
IntActi | P15151, 104 interactors |
MINTi | P15151 |
STRINGi | 9606.ENSP00000402060 |
Miscellaneous databases
RNActi | P15151, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P15151 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P15151 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 139 | Ig-like V-typeAdd BLAST | 116 | |
Domaini | 145 – 237 | Ig-like C2-type 1Add BLAST | 93 | |
Domaini | 244 – 328 | Ig-like C2-type 2Add BLAST | 85 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 368 – 372 | DYNLT1 binding | 5 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 396 – 401 | ITIM motif | 6 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QWSY, Eukaryota |
GeneTreei | ENSGT00940000162848 |
HOGENOMi | CLU_029618_0_0_1 |
InParanoidi | P15151 |
OrthoDBi | 1087343at2759 |
PhylomeDBi | P15151 |
TreeFami | TF331051 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MARAMAAAWP LLLVALLVLS WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY
60 70 80 90 100
LQVPNMEVTH VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG
110 120 130 140 150
AELRNASLRM FGLRVEDEGN YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE
160 170 180 190 200
VQKVQLTGEP VPMARCVSTG GRPPAQITWH SDLGGMPNTS QVPGFLSGTV
210 220 230 240 250
TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV YYPPEVSISG
260 270 280 290 300
YDNNWYLGQN EATLTCDARS NPEPTGYNWS TTMGPLPPFA VAQGAQLLIR
310 320 330 340 350
PVDKPINTTL ICNVTNALGA RQAELTVQVK EGPPSEHSGI SRNAIIFLVL
360 370 380 390 400
GILVFLILLG IGIYFYWSKC SREVLWHCHL CPSSTEHASA SANGHVSYSA
410
VSRENSSSQD PQTEGTR
The sequence of this isoform differs from the canonical sequence as follows:
340-384: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
331-331: E → G
332-384: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
385-392: TEHASASA → EHHQSCRN
393-417: Missing.
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DG49 | A0A0C4DG49_HUMAN | Poliovirus receptor | PVR hCG_1996181 | 417 | Annotation score: | ||
A0A0A0MSA9 | A0A0A0MSA9_HUMAN | Poliovirus receptor | PVR | 392 | Annotation score: | ||
F8W7D4 | F8W7D4_HUMAN | Poliovirus receptor | PVR | 44 | Annotation score: | ||
K7EMC6 | K7EMC6_HUMAN | Poliovirus receptor | PVR | 70 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_003952 | 67 | A → T. Corresponds to variant dbSNP:rs1058402Ensembl. | 1 | |
Natural variantiVAR_049994 | 295 | A → T. Corresponds to variant dbSNP:rs35365841Ensembl. | 1 | |
Natural variantiVAR_011736 | 340 | I → M1 PublicationCorresponds to variant dbSNP:rs203710Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002618 | 331 | E → G in isoform Gamma. Curated | 1 | |
Alternative sequenceiVSP_002619 | 332 – 384 | Missing in isoform Gamma. CuratedAdd BLAST | 53 | |
Alternative sequenceiVSP_002617 | 340 – 384 | Missing in isoform Beta. 1 PublicationAdd BLAST | 45 | |
Alternative sequenceiVSP_002620 | 385 – 392 | TEHASASA → EHHQSCRN in isoform Delta. Curated | 8 | |
Alternative sequenceiVSP_002621 | 393 – 417 | Missing in isoform Delta. CuratedAdd BLAST | 25 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M24407 mRNA Translation: AAA36461.1 M24406 mRNA Translation: AAA36462.1 X64116 , X64117, X64118, X64119, X64120, X64121, X64122, X64123 Genomic DNA Translation: CAA45478.1 X64116 , X64117, X64118, X64119, X64120, X64121, X64122, X64123 Genomic DNA Translation: CAA45479.1 X64116 , X64117, X64118, X64119, X64120, X64122, X64123 Genomic DNA Translation: CAA45480.1 AK300349 mRNA Translation: BAG62091.1 AC068948 Genomic DNA Translation: AAF69803.1 BC015542 mRNA Translation: AAH15542.1 |
CCDSi | CCDS12640.1 [P15151-1] CCDS46105.1 [P15151-2] CCDS46106.1 [P15151-3] CCDS46107.1 [P15151-4] |
PIRi | A43024, RWHUPD S12048, RWHUPA |
RefSeqi | NP_001129240.1, NM_001135768.2 [P15151-2] NP_001129241.1, NM_001135769.2 [P15151-3] NP_001129242.2, NM_001135770.3 NP_006496.4, NM_006505.4 |
Genome annotation databases
Ensembli | ENST00000344956; ENSP00000340870; ENSG00000073008 [P15151-3] ENST00000403059; ENSP00000385344; ENSG00000073008 [P15151-2] |
GeneIDi | 5817 |
KEGGi | hsa:5817 |
UCSCi | uc032hzv.2, human [P15151-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight The accidental crippler - Issue 75 of October 2006 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M24407 mRNA Translation: AAA36461.1 M24406 mRNA Translation: AAA36462.1 X64116 , X64117, X64118, X64119, X64120, X64121, X64122, X64123 Genomic DNA Translation: CAA45478.1 X64116 , X64117, X64118, X64119, X64120, X64121, X64122, X64123 Genomic DNA Translation: CAA45479.1 X64116 , X64117, X64118, X64119, X64120, X64122, X64123 Genomic DNA Translation: CAA45480.1 AK300349 mRNA Translation: BAG62091.1 AC068948 Genomic DNA Translation: AAF69803.1 BC015542 mRNA Translation: AAH15542.1 |
CCDSi | CCDS12640.1 [P15151-1] CCDS46105.1 [P15151-2] CCDS46106.1 [P15151-3] CCDS46107.1 [P15151-4] |
PIRi | A43024, RWHUPD S12048, RWHUPA |
RefSeqi | NP_001129240.1, NM_001135768.2 [P15151-2] NP_001129241.1, NM_001135769.2 [P15151-3] NP_001129242.2, NM_001135770.3 NP_006496.4, NM_006505.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1DGI | electron microscopy | 22.00 | R | 28-329 | [»] | |
1NN8 | electron microscopy | 15.00 | R/S/T | 28-329 | [»] | |
3EPC | electron microscopy | 8.00 | R | 30-242 | [»] | |
3EPD | electron microscopy | 9.00 | R | 30-242 | [»] | |
3EPF | electron microscopy | 9.00 | R | 30-242 | [»] | |
3J8F | electron microscopy | 3.70 | 7 | 1-417 | [»] | |
3J9F | electron microscopy | 9.00 | 7 | 28-143 | [»] | |
8 | 142-243 | [»] | ||||
9 | 242-333 | [»] | ||||
3UDW | X-ray | 2.90 | C/D | 28-145 | [»] | |
3URO | X-ray | 3.50 | R | 29-243 | [»] | |
4FQP | X-ray | 3.60 | A | 28-334 | [»] | |
6ARQ | X-ray | 2.88 | D | 28-334 | [»] | |
6ISC | X-ray | 2.20 | B | 28-145 | [»] | |
6O3O | X-ray | 2.80 | C/D | 28-334 | [»] | |
SMRi | P15151 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111775, 121 interactors |
DIPi | DIP-43987N |
IntActi | P15151, 104 interactors |
MINTi | P15151 |
STRINGi | 9606.ENSP00000402060 |
Chemistry databases
DrugBanki | DB08231, Myristic acid DB03203, Sphingosine |
PTM databases
GlyConnecti | 782, 1 N-Linked glycan (1 site) |
GlyGeni | P15151, 10 sites, 1 N-linked glycan (1 site) |
iPTMneti | P15151 |
PhosphoSitePlusi | P15151 |
SwissPalmi | P15151 |
Genetic variation databases
BioMutai | PVR |
DMDMi | 1346922 |
Proteomic databases
EPDi | P15151 |
jPOSTi | P15151 |
MassIVEi | P15151 |
MaxQBi | P15151 |
PaxDbi | P15151 |
PeptideAtlasi | P15151 |
PRIDEi | P15151 |
ProteomicsDBi | 53110 [P15151-1] 53111 [P15151-2] 53112 [P15151-3] 53113 [P15151-4] |
Protocols and materials databases
Antibodypediai | 2235, 681 antibodies |
CPTCi | P15151, 1 antibody |
DNASUi | 5817 |
Genome annotation databases
Ensembli | ENST00000344956; ENSP00000340870; ENSG00000073008 [P15151-3] ENST00000403059; ENSP00000385344; ENSG00000073008 [P15151-2] |
GeneIDi | 5817 |
KEGGi | hsa:5817 |
UCSCi | uc032hzv.2, human [P15151-1] |
Organism-specific databases
CTDi | 5817 |
DisGeNETi | 5817 |
GeneCardsi | PVR |
HGNCi | HGNC:9705, PVR |
HPAi | ENSG00000073008, Tissue enhanced (liver) |
MIMi | 173850, gene+phenotype |
neXtProti | NX_P15151 |
OpenTargetsi | ENSG00000073008 |
PharmGKBi | PA34050 |
VEuPathDBi | HostDB:ENSG00000073008.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWSY, Eukaryota |
GeneTreei | ENSGT00940000162848 |
HOGENOMi | CLU_029618_0_0_1 |
InParanoidi | P15151 |
OrthoDBi | 1087343at2759 |
PhylomeDBi | P15151 |
TreeFami | TF331051 |
Enzyme and pathway databases
PathwayCommonsi | P15151 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-420597, Nectin/Necl trans heterodimerization |
SIGNORi | P15151 |
Miscellaneous databases
BioGRID-ORCSi | 5817, 3 hits in 877 CRISPR screens |
ChiTaRSi | PVR, human |
EvolutionaryTracei | P15151 |
GeneWikii | CD155 |
GenomeRNAii | 5817 |
Pharosi | P15151, Tbio |
PROi | PR:P15151 |
RNActi | P15151, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000073008, Expressed in left coronary artery and 196 other tissues |
ExpressionAtlasi | P15151, baseline and differential |
Genevisiblei | P15151, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PVR_HUMAN | |
Accessioni | P15151Primary (citable) accession number: P15151 Secondary accession number(s): B4DTS9 Q96BJ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | February 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 219 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries