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UniProtKB - P15151 (PVR_HUMAN)

Entry version 205 (13 Feb 2019)
Sequence version 2 (01 Feb 1996)
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Protein

Poliovirus receptor

Gene

PVR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.2 Publications
(Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.1 Publication
(Microbial infection) Acts as a receptor for Pseudorabies virus.1 Publication
(Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells.1 Publication

Miscellaneous

The V-type domain is necessary and sufficient for virus binding and uptake.

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=72 nM for VTN

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • cell adhesion molecule binding Source: BHF-UCL
    • protein homodimerization activity Source: GO_Central
    • signaling receptor activity Source: GO_Central
    • virus receptor activity Source: UniProtKB-KW
    View the complete GO annotation on QuickGO ...

    GO - Biological processi

    View the complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHost cell receptor for virus entry, Receptor
    Biological processCell adhesion, Host-virus interaction

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    R-HSA-420597 Nectin/Necl trans heterodimerization

    SIGNOR Signaling Network Open Resource

    More...    SIGNORi    		P15151

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Poliovirus receptor
    Alternative name(s):
    Nectin-like protein 5
    Short name:
    NECL-5
    CD_antigen: CD155
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PVR
    Synonyms:PVS
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000073008.14

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:9705 PVR

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		173850 gene+phenotype

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P15151

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 343ExtracellularSequence analysisAdd BLAST323
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei344 – 367HelicalSequence analysisAdd BLAST24
    Topological domaini368 – 417CytoplasmicSequence analysisAdd BLAST50

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi369 – 372KCSR → ACSA: Partial loss of DYNLT1 binding. 1 Publication4

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		5817
    MIMi173850 gene+phenotype

    Open Targets

    More...    OpenTargetsi    		ENSG00000073008

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA34050

    Chemistry databases

    Drug and drug target database

    More...    DrugBanki    		DB08231 MYRISTIC ACID
    DB03203 Sphingosine

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		PVR

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		1346922

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001513121 – 417Poliovirus receptorAdd BLAST397

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi49 ↔ 123PROSITE-ProRule annotation1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi105N-linked (GlcNAc...) asparagine1
    Glycosylationi120N-linked (GlcNAc...) (complex) asparagine1 Publication1
    Disulfide bondi166 ↔ 221PROSITE-ProRule annotation
    Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi218N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi237N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi266 ↔ 312PROSITE-ProRule annotation
    Glycosylationi278N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi307N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi313N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei398Phosphotyrosine2 Publications1
    Isoform Gamma (identifier: P15151-3)
    Glycosylationi352N-linked (GlcNAc...) asparagine1 Publication1
    Isoform Beta (identifier: P15151-2)
    Glycosylationi360N-linked (GlcNAc...) asparagine1 Publication1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    N-glycosylated. N-glycan at Asn-120: Hex5HexNAc4.3 Publications
    Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation. Interaction with TIGIT is required for Phosphorylation.2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		P15151

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P15151

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		P15151

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P15151

    PeptideAtlas

    More...    PeptideAtlasi    		P15151

    PRoteomics IDEntifications database

    More...    PRIDEi    		P15151

    ProteomicsDB human proteome resource

    More...    ProteomicsDBi    		53110
    53111 [P15151-2]
    53112 [P15151-3]
    53113 [P15151-4]

    PTM databases

    GlyConnect protein glycosylation platform

    More...    GlyConnecti    		782

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P15151

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P15151

    SwissPalm database of S-palmitoylation events

    More...    SwissPalmi    		P15151

    UniCarbKB; an annotated and curated database of glycan structures

    More...    UniCarbKBi    		P15151

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Transcriptionally regulated by SHH.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000073008 Expressed in 183 organ(s), highest expression level in left coronary artery

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P15151 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P15151 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		HPA012568

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Can form trans-heterodimers with NECTIN3. The extracellular domain interacts with VTN, CD226 and CD96. The cytoplasmic domain interacts with DYNLT1. Binds with high affinity to TIGIT.9 Publications
    (Microbial infection) Interacts with poliovirus capsid proteins.1 Publication
    (Microbial infection) Interacts with human cytomegalovirus /HHV-5 UL141 protein.1 Publication
    (Microbial infection) Interacts with pseudorabies virus gD protein.1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    View the complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...    BioGridi    		111775, 60 interactors

    Database of interacting proteins

    More...    DIPi    		DIP-43987N

    Protein interaction database and analysis system

    More...    IntActi    		P15151, 54 interactors

    Molecular INTeraction database

    More...    MINTi    		P15151

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000402060

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1417
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1DGIelectron microscopy22.00R28-329[»]
    1NN8electron microscopy15.00R/S/T28-329[»]
    3EPCelectron microscopy8.00R30-242[»]
    3EPDelectron microscopy9.00R30-242[»]
    3EPFelectron microscopy9.00R30-242[»]
    3J8Felectron microscopy3.7071-417[»]
    3J9Felectron microscopy9.00728-143[»]
    8142-243[»]
    9242-333[»]
    3UDWX-ray2.90C/D28-145[»]
    3UROX-ray3.50R29-243[»]
    4FQPX-ray3.60A28-334[»]
    6ARQX-ray2.88D28-334[»]
    6ISCX-ray2.20B28-145[»]

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...    ProteinModelPortali    		P15151

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P15151

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		P15151

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 139Ig-like V-typeAdd BLAST116
    Domaini145 – 237Ig-like C2-type 1Add BLAST93
    Domaini244 – 328Ig-like C2-type 2Add BLAST85

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni368 – 372DYNLT1 binding5

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi396 – 401ITIM motif6

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.1 Publication

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the nectin family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		ENOG410IY4J Eukaryota
    ENOG4111K6M LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000162848

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		HOG000237277

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...    HOVERGENi    		HBG019169

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P15151

    KEGG Orthology (KO)

    More...    KOi    		K06539

    Database of Orthologous Groups

    More...    OrthoDBi    		1087343at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P15151

    TreeFam database of animal gene trees

    More...    TreeFami    		TF331051

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		2.60.40.10, 3 hits

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR013162 CD80_C2-set
    IPR007110 Ig-like_dom
    IPR036179 Ig-like_dom_sf
    IPR013783 Ig-like_fold
    IPR003599 Ig_sub
    IPR013106 Ig_V-set

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF08205 C2-set_2, 1 hit
    PF07686 V-set, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...    SMARTi    		View protein in SMART
    SM00409 IG, 2 hits
    SM00406 IGv, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF48726 SSF48726, 3 hits

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS50835 IG_LIKE, 3 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform Alpha (identifier: P15151-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MARAMAAAWP LLLVALLVLS WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY 
            60         70         80         90        100
    LQVPNMEVTH VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG 
           110        120        130        140        150
    AELRNASLRM FGLRVEDEGN YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE 
           160        170        180        190        200
    VQKVQLTGEP VPMARCVSTG GRPPAQITWH SDLGGMPNTS QVPGFLSGTV 
           210        220        230        240        250
    TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV YYPPEVSISG 
           260        270        280        290        300
    YDNNWYLGQN EATLTCDARS NPEPTGYNWS TTMGPLPPFA VAQGAQLLIR 
           310        320        330        340        350
    PVDKPINTTL ICNVTNALGA RQAELTVQVK EGPPSEHSGI SRNAIIFLVL 
           360        370        380        390        400
    GILVFLILLG IGIYFYWSKC SREVLWHCHL CPSSTEHASA SANGHVSYSA 
           410 
    VSRENSSSQD PQTEGTR
    Length:417
    Mass (Da):45,303
    Last modified:February 1, 1996 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD15C012CE853169B
    GO
    Isoform Beta (identifier: P15151-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         340-384: Missing.

    Show »
    Length:372
    Mass (Da):40,125
    Checksum:i7B56B38F949996BE
    GO
    Isoform Gamma (identifier: P15151-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         331-331: E → G
         332-384: Missing.

    Show »
    Length:364
    Mass (Da):39,304
    Checksum:iF63D1B6CF19F2A6F
    GO
    Isoform Delta (identifier: P15151-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         385-392: TEHASASA → EHHQSCRN
         393-417: Missing.

    Show »
    Length:392
    Mass (Da):42,864
    Checksum:i528DFC93B73C7FD8
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    A0A0A0MSA9A0A0A0MSA9_HUMAN
    Poliovirus receptor
    PVR
    		392Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0C4DG49A0A0C4DG49_HUMAN
    Poliovirus receptor
    PVR hCG_1996181
    		417Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8W7D4F8W7D4_HUMAN
    Poliovirus receptor
    PVR
    		44Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EMC6K7EMC6_HUMAN
    Poliovirus receptor
    PVR
    		70Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00395267A → T. Corresponds to variant dbSNP:rs1058402Ensembl.1
    Natural variantiVAR_049994295A → T. Corresponds to variant dbSNP:rs35365841Ensembl.1
    Natural variantiVAR_011736340I → M1 PublicationCorresponds to variant dbSNP:rs203710Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002618331E → G in isoform Gamma. Curated1
    Alternative sequenceiVSP_002619332 – 384Missing in isoform Gamma. CuratedAdd BLAST53
    Alternative sequenceiVSP_002617340 – 384Missing in isoform Beta. 1 PublicationAdd BLAST45
    Alternative sequenceiVSP_002620385 – 392TEHASASA → EHHQSCRN in isoform Delta. Curated8
    Alternative sequenceiVSP_002621393 – 417Missing in isoform Delta. CuratedAdd BLAST25

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		M24407 mRNA Translation: AAA36461.1
    M24406 mRNA Translation: AAA36462.1
    X64116
    , X64117, X64118, X64119, X64120, X64121, X64122, X64123 Genomic DNA Translation: CAA45478.1
    X64116
    , X64117, X64118, X64119, X64120, X64121, X64122, X64123 Genomic DNA Translation: CAA45479.1
    X64116
    , X64117, X64118, X64119, X64120, X64122, X64123 Genomic DNA Translation: CAA45480.1
    AK300349 mRNA Translation: BAG62091.1
    AC068948 Genomic DNA Translation: AAF69803.1
    BC015542 mRNA Translation: AAH15542.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS12640.1 [P15151-1]
    CCDS46105.1 [P15151-2]
    CCDS46106.1 [P15151-3]
    CCDS46107.1 [P15151-4]

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		A43024 RWHUPD
    S12048 RWHUPA

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001129240.1, NM_001135768.2 [P15151-2]
    NP_001129241.1, NM_001135769.2 [P15151-3]
    NP_001129242.2, NM_001135770.3
    NP_006496.4, NM_006505.4

    UniGene gene-oriented nucleotide sequence clusters

    More...    UniGenei    		Hs.171844

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000344956; ENSP00000340870; ENSG00000073008 [P15151-3]
    ENST00000403059; ENSP00000385344; ENSG00000073008 [P15151-2]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		5817

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:5817

    UCSC genome browser

    More...    UCSCi    		uc032hzv.2 human [P15151-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Protein Spotlight

    The accidental crippler - Issue 75 of October 2006

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		M24407 mRNA Translation: AAA36461.1
    M24406 mRNA Translation: AAA36462.1
    X64116
    , X64117, X64118, X64119, X64120, X64121, X64122, X64123 Genomic DNA Translation: CAA45478.1
    X64116
    , X64117, X64118, X64119, X64120, X64121, X64122, X64123 Genomic DNA Translation: CAA45479.1
    X64116
    , X64117, X64118, X64119, X64120, X64122, X64123 Genomic DNA Translation: CAA45480.1
    AK300349 mRNA Translation: BAG62091.1
    AC068948 Genomic DNA Translation: AAF69803.1
    BC015542 mRNA Translation: AAH15542.1
    CCDSiCCDS12640.1 [P15151-1]
    CCDS46105.1 [P15151-2]
    CCDS46106.1 [P15151-3]
    CCDS46107.1 [P15151-4]
    PIRiA43024 RWHUPD
    S12048 RWHUPA
    RefSeqiNP_001129240.1, NM_001135768.2 [P15151-2]
    NP_001129241.1, NM_001135769.2 [P15151-3]
    NP_001129242.2, NM_001135770.3
    NP_006496.4, NM_006505.4
    UniGeneiHs.171844

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1DGIelectron microscopy22.00R28-329[»]
    1NN8electron microscopy15.00R/S/T28-329[»]
    3EPCelectron microscopy8.00R30-242[»]
    3EPDelectron microscopy9.00R30-242[»]
    3EPFelectron microscopy9.00R30-242[»]
    3J8Felectron microscopy3.7071-417[»]
    3J9Felectron microscopy9.00728-143[»]
    8142-243[»]
    9242-333[»]
    3UDWX-ray2.90C/D28-145[»]
    3UROX-ray3.50R29-243[»]
    4FQPX-ray3.60A28-334[»]
    6ARQX-ray2.88D28-334[»]
    6ISCX-ray2.20B28-145[»]
    ProteinModelPortaliP15151
    SMRiP15151
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi111775, 60 interactors
    DIPiDIP-43987N
    IntActiP15151, 54 interactors
    MINTiP15151
    STRINGi9606.ENSP00000402060

    Chemistry databases

    DrugBankiDB08231 MYRISTIC ACID
    DB03203 Sphingosine

    PTM databases

    GlyConnecti782
    iPTMnetiP15151
    PhosphoSitePlusiP15151
    SwissPalmiP15151
    UniCarbKBiP15151

    Polymorphism and mutation databases

    BioMutaiPVR
    DMDMi1346922

    Proteomic databases

    EPDiP15151
    jPOSTiP15151
    MaxQBiP15151
    PaxDbiP15151
    PeptideAtlasiP15151
    PRIDEiP15151
    ProteomicsDBi53110
    53111 [P15151-2]
    53112 [P15151-3]
    53113 [P15151-4]

    Protocols and materials databases

    The DNASU plasmid repository

    More...    DNASUi    		5817
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000344956; ENSP00000340870; ENSG00000073008 [P15151-3]
    ENST00000403059; ENSP00000385344; ENSG00000073008 [P15151-2]
    GeneIDi5817
    KEGGihsa:5817
    UCSCiuc032hzv.2 human [P15151-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		5817
    DisGeNETi5817
    EuPathDBiHostDB:ENSG00000073008.14

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		PVR
    HGNCiHGNC:9705 PVR
    HPAiHPA012568
    MIMi173850 gene+phenotype
    neXtProtiNX_P15151
    OpenTargetsiENSG00000073008
    PharmGKBiPA34050

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiENOG410IY4J Eukaryota
    ENOG4111K6M LUCA
    GeneTreeiENSGT00940000162848
    HOGENOMiHOG000237277
    HOVERGENiHBG019169
    InParanoidiP15151
    KOiK06539
    OrthoDBi1087343at2759
    PhylomeDBiP15151
    TreeFamiTF331051

    Enzyme and pathway databases

    ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    R-HSA-420597 Nectin/Necl trans heterodimerization
    SIGNORiP15151

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		PVR human
    EvolutionaryTraceiP15151

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		CD155

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		5817

    Protein Ontology

    More...    PROi    		PR:P15151

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000073008 Expressed in 183 organ(s), highest expression level in left coronary artery
    ExpressionAtlasiP15151 baseline and differential
    GenevisibleiP15151 HS

    Family and domain databases

    Gene3Di2.60.40.10, 3 hits
    InterProiView protein in InterPro
    IPR013162 CD80_C2-set
    IPR007110 Ig-like_dom
    IPR036179 Ig-like_dom_sf
    IPR013783 Ig-like_fold
    IPR003599 Ig_sub
    IPR013106 Ig_V-set
    PfamiView protein in Pfam
    PF08205 C2-set_2, 1 hit
    PF07686 V-set, 1 hit
    SMARTiView protein in SMART
    SM00409 IG, 2 hits
    SM00406 IGv, 1 hit
    SUPFAMiSSF48726 SSF48726, 3 hits
    PROSITEiView protein in PROSITE
    PS50835 IG_LIKE, 3 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPVR_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15151
    Secondary accession number(s): B4DTS9
    , P15152, Q15267, Q15268, Q96BJ1
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: February 1, 1996
    Last modified: February 13, 2019
    This is version 205 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    7. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    8. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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