PVR

Functionⁱ

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.2 Publications

(Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.1 Publication

(Microbial infection) Acts as a receptor for Pseudorabies virus.1 Publication

(Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells.1 Publication

Miscellaneous

The V-type domain is necessary and sufficient for virus binding and uptake.

Kineticsⁱ

K_M=72 nM for VTN

GO - Molecular functionⁱ

cell adhesion molecule binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12913096
protein homodimerization activity Source: GO_Central
signaling receptor activity
Source: ProtInc
Traceable author statementⁱ
- 2538245
signaling receptor binding Source: GO_Central
virus receptor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adherens junction organization Source: Reactome
cell recognition Source: GO_Central
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central
positive regulation of natural killer cell mediated cytotoxicity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16304049
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12913096
regulation of immune response Source: Reactome
susceptibility to natural killer cell mediated cytotoxicity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12913096
susceptibility to T cell mediated cytotoxicity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15039383

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Host cell receptor for virus entry, Receptor
Biological process	Cell adhesion, Host-virus interaction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-420597 Nectin/Necl trans heterodimerization
SIGNORⁱ	P15151

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Poliovirus receptor Alternative name(s): Nectin-like protein 5 Short name: NECL-5 CD_antigen: CD155
Gene namesⁱ	Name:PVR Synonyms:PVS
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000073008.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9705 PVR
MIMⁱ	173850 gene+phenotype
neXtProtⁱ	NX_P15151

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	21 – 343	ExtracellularSequence analysisAdd BLAST	323
Transmembraneⁱ	344 – 367	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	368 – 417	CytoplasmicSequence analysisAdd BLAST	50

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	369 – 372	KCSR → ACSA: Partial loss of DYNLT1 binding. 1 Publication		4

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5817
MIMⁱ	173850 gene+phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000073008
PharmGKBⁱ	PA34050

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB08231 MYRISTIC ACID DB03203 Sphingosine

DrugBankⁱ

DB08231 MYRISTIC ACID
DB03203 Sphingosine

Polymorphism and mutation databases

BioMutaⁱ	PVR
DMDMⁱ	1346922

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_0000015131	21 – 417	Poliovirus receptorAdd BLAST		397

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	49 ↔ 123	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	105	N-linked (GlcNAc...) asparagine	1
Glycosylationⁱ	120	N-linked (GlcNAc...) (complex) asparagine1 Publication	1
Disulfide bondⁱ	166 ↔ 221	PROSITE-ProRule annotation
Glycosylationⁱ	188	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	218	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	237	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	266 ↔ 312	PROSITE-ProRule annotation
Glycosylationⁱ	278	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	307	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	313	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	398	Phosphotyrosine2 Publications	1
Isoform Gamma (identifier: P15151-3)
Glycosylationⁱ	352	N-linked (GlcNAc...) asparagine1 Publication	1
Isoform Beta (identifier: P15151-2)
Glycosylationⁱ	360	N-linked (GlcNAc...) asparagine1 Publication	1

Post-translational modificationⁱ

N-glycosylated. N-glycan at Asn-120: Hex5HexNAc4.3 Publications

Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation. Interaction with TIGIT is required for Phosphorylation.2 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P15151
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P15151
PaxDbⁱ	P15151
PeptideAtlas More...PeptideAtlasⁱ	P15151
PRIDEⁱ	P15151
ProteomicsDBⁱ	53110 53111 [P15151-2] 53112 [P15151-3] 53113 [P15151-4]

PTM databases

GlyConnectⁱ	782
iPTMnetⁱ	P15151
PhosphoSitePlusⁱ	P15151
SwissPalmⁱ	P15151
UniCarbKBⁱ	P15151

Expressionⁱ

Inductionⁱ

Transcriptionally regulated by SHH.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000073008 Expressed in 183 organ(s), highest expression level in left coronary artery
CleanExⁱ	HS_PVR
ExpressionAtlasⁱ	P15151 baseline and differential
Genevisibleⁱ	P15151 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA012568

HPAⁱ

HPA012568

Interactionⁱ

Subunit structureⁱ

Can form trans-heterodimers with NECTIN3. The extracellular domain interacts with VTN, CD226 and CD96. The cytoplasmic domain interacts with DYNLT1. Binds with high affinity to TIGIT.9 Publications

(Microbial infection) Interacts with poliovirus capsid proteins.1 Publication

(Microbial infection) Interacts with human cytomegalovirus /HHV-5 UL141 protein.1 Publication

(Microbial infection) Interacts with pseudorabies virus gD protein.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
KRTAP10-7	P60409	3	EBI-3919694,EBI-10172290
KRTAP10-8	P60410	5	EBI-3919694,EBI-10171774
KRTAP10-9	P60411	3	EBI-3919694,EBI-10172052
NOTCH2NL	Q7Z3S9	5	EBI-3919694,EBI-945833
SLC30A2	Q9BRI3	7	EBI-3919694,EBI-8644112
TIGIT	Q495A1	2	EBI-3919694,EBI-4314807

GO - Molecular functionⁱ

cell adhesion molecule binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12913096
protein homodimerization activity Source: GO_Central
signaling receptor binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111775, 59 interactors
Database of interacting proteins More...DIPⁱ	DIP-43987N
IntActⁱ	P15151, 54 interactors
Molecular INTeraction database More...MINTⁱ	P15151
STRINGⁱ	9606.ENSP00000402060

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	30 – 32	Combined sources	3
Beta strandⁱ	35 – 40	Combined sources	6
Beta strandⁱ	45 – 47	Combined sources	3
Beta strandⁱ	50 – 52	Combined sources	3
Beta strandⁱ	60 – 68	Combined sources	9
Beta strandⁱ	75 – 79	Combined sources	5
Turnⁱ	80 – 82	Combined sources	3
Beta strandⁱ	83 – 86	Combined sources	4
Beta strandⁱ	90 – 94	Combined sources	5
Beta strandⁱ	108 – 110	Combined sources	3
Helixⁱ	115 – 117	Combined sources	3
Beta strandⁱ	119 – 128	Combined sources	10
Beta strandⁱ	131 – 142	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	P15151
SMRⁱ	P15151
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P15151

EvolutionaryTraceⁱ

P15151

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	24 – 139	Ig-like V-typeAdd BLAST	116
Domainⁱ	145 – 237	Ig-like C2-type 1Add BLAST	93
Domainⁱ	244 – 328	Ig-like C2-type 2Add BLAST	85

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	368 – 372	DYNLT1 binding		5

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	396 – 401	ITIM motif		6

Domainⁱ

Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.1 Publication

Sequence similaritiesⁱ

Belongs to the nectin family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IY4J Eukaryota ENOG4111K6M LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140811
HOGENOMⁱ	HOG000237277
HOVERGENⁱ	HBG019169
InParanoidⁱ	P15151
KEGG Orthology (KO) More...KOⁱ	K06539
PhylomeDBⁱ	P15151
TreeFamⁱ	TF331051

Family and domain databases

Gene3Dⁱ	2.60.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR013162 CD80_C2-set IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08205 C2-set_2, 1 hit PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 3 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 3 hits

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform Alpha (identifier: P15151-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARAMAAAWP LLLVALLVLS WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY 
        60         70         80         90        100
LQVPNMEVTH VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG 
       110        120        130        140        150
AELRNASLRM FGLRVEDEGN YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE 
       160        170        180        190        200
VQKVQLTGEP VPMARCVSTG GRPPAQITWH SDLGGMPNTS QVPGFLSGTV 
       210        220        230        240        250
TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV YYPPEVSISG 
       260        270        280        290        300
YDNNWYLGQN EATLTCDARS NPEPTGYNWS TTMGPLPPFA VAQGAQLLIR 
       310        320        330        340        350
PVDKPINTTL ICNVTNALGA RQAELTVQVK EGPPSEHSGI SRNAIIFLVL 
       360        370        380        390        400
GILVFLILLG IGIYFYWSKC SREVLWHCHL CPSSTEHASA SANGHVSYSA 
       410 
VSRENSSSQD PQTEGTR

Length:417

Mass (Da):45,303

Last modified:February 1, 1996 - v2

Checksum:ⁱD15C012CE853169B

GO

Isoform Beta (identifier: P15151-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
340-384: Missing.

« Hide

        10         20         30         40         50
MARAMAAAWP LLLVALLVLS WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY 
        60         70         80         90        100
LQVPNMEVTH VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG 
       110        120        130        140        150
AELRNASLRM FGLRVEDEGN YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE 
       160        170        180        190        200
VQKVQLTGEP VPMARCVSTG GRPPAQITWH SDLGGMPNTS QVPGFLSGTV 
       210        220        230        240        250
TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV YYPPEVSISG 
       260        270        280        290        300
YDNNWYLGQN EATLTCDARS NPEPTGYNWS TTMGPLPPFA VAQGAQLLIR 
       310        320        330        340        350
PVDKPINTTL ICNVTNALGA RQAELTVQVK EGPPSEHSGT EHASASANGH 
       360        370 
VSYSAVSREN SSSQDPQTEG TR

Show »

Length:372

Mass (Da):40,125

Checksum:ⁱ7B56B38F949996BE

GO

Isoform Gamma (identifier: P15151-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
331-331: E → G
332-384: Missing.

« Hide

        10         20         30         40         50
MARAMAAAWP LLLVALLVLS WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY 
        60         70         80         90        100
LQVPNMEVTH VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG 
       110        120        130        140        150
AELRNASLRM FGLRVEDEGN YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE 
       160        170        180        190        200
VQKVQLTGEP VPMARCVSTG GRPPAQITWH SDLGGMPNTS QVPGFLSGTV 
       210        220        230        240        250
TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV YYPPEVSISG 
       260        270        280        290        300
YDNNWYLGQN EATLTCDARS NPEPTGYNWS TTMGPLPPFA VAQGAQLLIR 
       310        320        330        340        350
PVDKPINTTL ICNVTNALGA RQAELTVQVK GTEHASASAN GHVSYSAVSR 
       360 
ENSSSQDPQT EGTR

Show »

Length:364

Mass (Da):39,304

Checksum:ⁱF63D1B6CF19F2A6F

GO

Isoform Delta (identifier: P15151-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
385-392: TEHASASA → EHHQSCRN
393-417: Missing.

« Hide

        10         20         30         40         50
MARAMAAAWP LLLVALLVLS WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY 
        60         70         80         90        100
LQVPNMEVTH VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG 
       110        120        130        140        150
AELRNASLRM FGLRVEDEGN YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE 
       160        170        180        190        200
VQKVQLTGEP VPMARCVSTG GRPPAQITWH SDLGGMPNTS QVPGFLSGTV 
       210        220        230        240        250
TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV YYPPEVSISG 
       260        270        280        290        300
YDNNWYLGQN EATLTCDARS NPEPTGYNWS TTMGPLPPFA VAQGAQLLIR 
       310        320        330        340        350
PVDKPINTTL ICNVTNALGA RQAELTVQVK EGPPSEHSGI SRNAIIFLVL 
       360        370        380        390 
GILVFLILLG IGIYFYWSKC SREVLWHCHL CPSSEHHQSC RN

Show »

Length:392

Mass (Da):42,864

Checksum:ⁱ528DFC93B73C7FD8

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0A0MSA9	A0A0A0MSA9_HUMAN	Poliovirus receptor Poliovirus receptor	PVR	392	Annotation score:
A0A0C4DG49	A0A0C4DG49_HUMAN	Poliovirus receptor Poliovirus receptor (Poliovirus receptor, isoform CRA_c)	PVR hCG_1996181	417	Annotation score:
F8W7D4	F8W7D4_HUMAN	Poliovirus receptor Poliovirus receptor	PVR	44	Annotation score:
K7EMC6	K7EMC6_HUMAN	Poliovirus receptor Poliovirus receptor	PVR	70	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_003952	67	A → T. Corresponds to variant dbSNP:rs1058402Ensembl.	1
Natural variantⁱVAR_049994	295	A → T. Corresponds to variant dbSNP:rs35365841Ensembl.	1
Natural variantⁱVAR_011736	340	I → M1 PublicationCorresponds to variant dbSNP:rs203710Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_002618	331	E → G in isoform Gamma. Curated	1
Alternative sequenceⁱVSP_002619	332 – 384	Missing in isoform Gamma. CuratedAdd BLAST	53
Alternative sequenceⁱVSP_002617	340 – 384	Missing in isoform Beta. 1 PublicationAdd BLAST	45
Alternative sequenceⁱVSP_002620	385 – 392	TEHASASA → EHHQSCRN in isoform Delta. Curated	8
Alternative sequenceⁱVSP_002621	393 – 417	Missing in isoform Delta. CuratedAdd BLAST	25

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M24407 mRNA Translation: AAA36461.1 M24406 mRNA Translation: AAA36462.1 X64116 X64123 Genomic DNA Translation: CAA45478.1 X64116 X64123 Genomic DNA Translation: CAA45479.1 X64116 X64123 Genomic DNA Translation: CAA45480.1 AK300349 mRNA Translation: BAG62091.1 AC068948 Genomic DNA Translation: AAF69803.1 BC015542 mRNA Translation: AAH15542.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12640.1 [P15151-1] CCDS46105.1 [P15151-2] CCDS46106.1 [P15151-3] CCDS46107.1 [P15151-4]
PIRⁱ	A43024 RWHUPD S12048 RWHUPA
NCBI Reference Sequences More...RefSeqⁱ	NP_001129240.1, NM_001135768.2 [P15151-2] NP_001129241.1, NM_001135769.2 [P15151-3] NP_001129242.2, NM_001135770.3 NP_006496.4, NM_006505.4
UniGeneⁱ	Hs.171844

Genome annotation databases

Ensemblⁱ	ENST00000344956; ENSP00000340870; ENSG00000073008 [P15151-3] ENST00000403059; ENSP00000385344; ENSG00000073008 [P15151-2]
GeneIDⁱ	5817
KEGGⁱ	hsa:5817
UCSC genome browser More...UCSCⁱ	uc032hzv.2 human [P15151-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P15151	Poliovirus receptor (Fragment)		PANTR		97	UniRef100_P15151
UPI0005AECED0		HUMAN		423
UPI0000110FBE		HUMAN		302
UPI000252CB00		HUMAN		118
UPI0005AECF43		HUMAN		92
+2

Protein	Similar proteins		Species	Score	Length	Source
P15151	Poliovirus receptor (Fragment)		PANTR		97	UniRef90_P15151
Poliovirus receptor		HUMAN		417
PVR isoform 2		PONAB		417
Uncharacterized protein		PAPAN		417
Uncharacterized protein		PANPA		413
+33

Protein	Similar proteins		Species	Score	Length	Source
P15151	Poliovirus receptor homolog		CHLAE		417	UniRef50_P15151
Poliovirus receptor (Fragment)		PANTR		97
Poliovirus receptor		HUMAN		417
Uncharacterized protein		PAPAN		417
PVR isoform 2		PONAB		417
+152

Cross-referencesⁱ

Web resourcesⁱ

Protein Spotlight

The accidental crippler - Issue 75 of October 2006

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M24407 mRNA Translation: AAA36461.1 M24406 mRNA Translation: AAA36462.1 X64116 X64123 Genomic DNA Translation: CAA45478.1 X64116 X64123 Genomic DNA Translation: CAA45479.1 X64116 X64123 Genomic DNA Translation: CAA45480.1 AK300349 mRNA Translation: BAG62091.1 AC068948 Genomic DNA Translation: AAF69803.1 BC015542 mRNA Translation: AAH15542.1
CCDSⁱ	CCDS12640.1 [P15151-1] CCDS46105.1 [P15151-2] CCDS46106.1 [P15151-3] CCDS46107.1 [P15151-4]
PIRⁱ	A43024 RWHUPD S12048 RWHUPA
RefSeqⁱ	NP_001129240.1, NM_001135768.2 [P15151-2] NP_001129241.1, NM_001135769.2 [P15151-3] NP_001129242.2, NM_001135770.3 NP_006496.4, NM_006505.4
UniGeneⁱ	Hs.171844

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1DGI	electron microscopy	22.00	R	28-329	[»]
	1NN8	electron microscopy	15.00	R/S/T	28-329	[»]
	3EPC	electron microscopy	8.00	R	30-242	[»]
	3EPD	electron microscopy	9.00	R	30-242	[»]
	3EPF	electron microscopy	9.00	R	30-242	[»]
	3J8F	electron microscopy	3.70	7	1-417	[»]
	3J9F	electron microscopy	9.00	7	28-143	[»]
				8	142-243	[»]
				9	242-333	[»]
	3UDW	X-ray	2.90	C/D	28-145	[»]
	3URO	X-ray	3.50	R	29-243	[»]
	4FQP	X-ray	3.60	A	28-334	[»]
ProteinModelPortalⁱ	P15151
SMRⁱ	P15151
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111775, 59 interactors
DIPⁱ	DIP-43987N
IntActⁱ	P15151, 54 interactors
MINTⁱ	P15151
STRINGⁱ	9606.ENSP00000402060

Chemistry databases

DrugBankⁱ	DB08231 MYRISTIC ACID DB03203 Sphingosine

DrugBankⁱ

DB08231 MYRISTIC ACID
DB03203 Sphingosine

PTM databases

GlyConnectⁱ	782
iPTMnetⁱ	P15151
PhosphoSitePlusⁱ	P15151
SwissPalmⁱ	P15151
UniCarbKBⁱ	P15151

Polymorphism and mutation databases

BioMutaⁱ	PVR
DMDMⁱ	1346922

Proteomic databases

EPDⁱ	P15151
MaxQBⁱ	P15151
PaxDbⁱ	P15151
PeptideAtlasⁱ	P15151
PRIDEⁱ	P15151
ProteomicsDBⁱ	53110 53111 [P15151-2] 53112 [P15151-3] 53113 [P15151-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5817
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000344956; ENSP00000340870; ENSG00000073008 [P15151-3] ENST00000403059; ENSP00000385344; ENSG00000073008 [P15151-2]
GeneIDⁱ	5817
KEGGⁱ	hsa:5817
UCSCⁱ	uc032hzv.2 human [P15151-1]

Organism-specific databases

CTDⁱ	5817
DisGeNETⁱ	5817
EuPathDBⁱ	HostDB:ENSG00000073008.14
GeneCardsⁱ	PVR
HGNCⁱ	HGNC:9705 PVR
HPAⁱ	HPA012568
MIMⁱ	173850 gene+phenotype
neXtProtⁱ	NX_P15151
OpenTargetsⁱ	ENSG00000073008
PharmGKBⁱ	PA34050
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IY4J Eukaryota ENOG4111K6M LUCA
GeneTreeⁱ	ENSGT00900000140811
HOGENOMⁱ	HOG000237277
HOVERGENⁱ	HBG019169
InParanoidⁱ	P15151
KOⁱ	K06539
PhylomeDBⁱ	P15151
TreeFamⁱ	TF331051

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-420597 Nectin/Necl trans heterodimerization
SIGNORⁱ	P15151

Miscellaneous databases

ChiTaRSⁱ	PVR human
EvolutionaryTraceⁱ	P15151
GeneWikiⁱ	CD155
GenomeRNAiⁱ	5817
Protein Ontology More...PROⁱ	PR:P15151
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000073008 Expressed in 183 organ(s), highest expression level in left coronary artery
CleanExⁱ	HS_PVR
ExpressionAtlasⁱ	P15151 baseline and differential
Genevisibleⁱ	P15151 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR013162 CD80_C2-set IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set
Pfamⁱ	View protein in Pfam PF08205 C2-set_2, 1 hit PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 3 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PVR_HUMAN
Accessionⁱ	P15151Primary (citable) accession number: P15151 Secondary accession number(s): B4DTS9 , P15152, Q15267, Q15268, Q96BJ1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	February 1, 1996
	Last modified:	September 12, 2018
	This is version 201 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

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UniProtKB - P15151 (PVR_HUMAN)

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Poliovirus receptor

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GO - Molecular functionⁱ

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Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

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Keywords - PTMⁱ

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Keywords - Technical termⁱ