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UniProtKB - P15146 (MTAP2_RAT)

Protein

Microtubule-associated protein 2

Gene

Map2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

GO - Molecular functioni

  • actin binding Source: CAFA
  • calmodulin binding Source: UniProtKB-KW
  • microtubule binding Source: CAFA
  • protein kinase binding Source: ARUK-UCL
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionCalmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 2
Short name:
MAP-2
Gene namesi
Name:Map2
Synonyms:Mtap2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3044 Map2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000727491 – 1861Microtubule-associated protein 2Add BLAST1861

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineBy similarity1
Modified residuei37PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei143PhosphoserineBy similarity1
Modified residuei221PhosphoserineCombined sources1
Modified residuei224PhosphoserineCombined sources1
Modified residuei285PhosphoserineBy similarity1
Modified residuei348PhosphoserineCombined sources1
Modified residuei478PhosphoserineBy similarity1
Modified residuei498PhosphoserineCombined sources1
Modified residuei522PhosphoserineCombined sources1
Modified residuei552PhosphoserineBy similarity1
Modified residuei598PhosphoserineBy similarity1
Modified residuei605PhosphoserineBy similarity1
Modified residuei610PhosphoserineCombined sources1
Modified residuei628PhosphoserineCombined sources1
Modified residuei728PhosphoserineBy similarity1
Modified residuei732PhosphoserineBy similarity1
Modified residuei736PhosphothreonineBy similarity1
Modified residuei739PhosphoserineBy similarity1
Modified residuei741PhosphoserineCombined sources1
Modified residuei748PhosphotyrosineBy similarity1
Modified residuei825PhosphoserineBy similarity1
Modified residuei884PhosphoserineCombined sources1
Modified residuei893PhosphoserineCombined sources1
Modified residuei939PhosphoserineCombined sources1
Modified residuei1051PhosphoserineCombined sources1
Modified residuei1140PhosphoserineCombined sources1
Modified residuei1141PhosphoserineCombined sources1
Modified residuei1146PhosphoserineBy similarity1
Modified residuei1161PhosphothreonineCombined sources1
Modified residuei1162PhosphoserineCombined sources1
Modified residuei1166PhosphoserineBy similarity1
Modified residuei1353PhosphoserineCombined sources1
Modified residuei1359PhosphothreonineCombined sources1
Modified residuei1541PhosphoserineCombined sources1
Modified residuei1562PhosphoserineBy similarity1
Modified residuei1594PhosphoserineBy similarity1
Modified residuei1608PhosphothreonineBy similarity1
Modified residuei1611PhosphothreonineCombined sources1
Modified residuei1622PhosphothreonineCombined sources1
Modified residuei1625PhosphothreonineCombined sources1
Modified residuei1652PhosphothreonineCombined sources1
Modified residuei1656PhosphoserineCombined sources1
Modified residuei1682Phosphoserine; by MARK11 Publication1
Modified residuei1816PhosphoserineCombined sources1
Modified residuei1821PhosphoserineBy similarity1
Modified residuei1824PhosphoserineCombined sources1
Modified residuei1829PhosphoserineCombined sources1
Modified residuei1842PhosphoserineCombined sources1
Isoform 3 (identifier: P15146-3)
Modified residuei319Phosphoserine1 Publication1
Modified residuei350Phosphoserine1 Publication1
Modified residuei382Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Isoform 3/MAP2c is probably phosphorylated by PKA at Ser-319, Ser-350 and Ser-382 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).By similarity2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP15146
PRIDEiP15146

PTM databases

iPTMnetiP15146
PhosphoSitePlusiP15146
SwissPalmiP15146

Expressioni

Developmental stagei

Isoform 3/MAP2c is expressed during embryonic brain development and until postanatal day 10. Isoform 2 is expressed throughout brain development.

Interactioni

Subunit structurei

Interacts with KNDC1 (via KIND2); the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites.By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi247625, 5 interactors
IntActiP15146, 4 interactors
MINTiP15146
STRINGi10116.ENSRNOP00000050877

Structurei

3D structure databases

DisProtiDP00122
SMRiP15146
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1664 – 1694Tau/MAP 1Add BLAST31
Repeati1695 – 1725Tau/MAP 2Add BLAST31
Repeati1726 – 1756Tau/MAP 3Add BLAST31
Repeati1757 – 1788Tau/MAP 4Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni704 – 747Interaction with KNDC1By similarityAdd BLAST44
Regioni1454 – 1474Calmodulin-bindingSequence analysisAdd BLAST21

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2418 Eukaryota
ENOG4111J07 LUCA
HOGENOMiHOG000113477
HOVERGENiHBG006322
InParanoidiP15146
PhylomeDBiP15146

Family and domain databases

InterProiView protein in InterPro
IPR030797 MAP2
IPR013588 MAP2_projctn
IPR001084 MAP_tubulin-bd_rpt
PANTHERiPTHR11501:SF15 PTHR11501:SF15, 2 hits
PfamiView protein in Pfam
PF08377 MAP2_projctn, 1 hit
PF00418 Tubulin-binding, 4 hits
PROSITEiView protein in PROSITE
PS00229 TAU_MAP_1, 3 hits
PS51491 TAU_MAP_2, 4 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P15146-1) [UniParc]FASTAAdd to basket
Also known as: MAP2x

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADERKDEGK APHWTSASLT EAAAHPHSPE MKDQGGSGEG LSRSANGFPY 
        60         70         80         90        100
REEEEGAFGE HGSQGTYSDT KENGINGELT SADRETAEEV SARIVQVVTA 
       110        120        130        140        150
EAVAVLKGEQ EKEAQHKDQP AALPLAAEET VNLPPSPPPS PASEQTAALE 
       160        170        180        190        200
EDLLTASKME FPEQQKLPSS FAEPLDKEET EFKMQSKPGE DFEHAALVPQ 
       210        220        230        240        250
PDTSKTPQDK KDPQDMEGEK SPASPFAQTF GTNLEDIKQI TEPSITVPSI 
       260        270        280        290        300
GLSAEPLAPK DQKDWFIEMP VESKKDEWGL AAPISPGPLT PMREKDVLED 
       310        320        330        340        350
IPRWEGKQFD SPMPSPFHGG SFTLPLDTVK DERVTEGSQP FAPVFFQSDD 
       360        370        380        390        400
KMSLQDTSGS ATSKESSKDE EPQKDKADKV ADVPVSEATT VLGDVHSPAV 
       410        420        430        440        450
EGFVGENISG EEKGTTDQEK KETSTPSVQE PTLTETEPQT KLEETSKVSI 
       460        470        480        490        500
EETVAKEEES LKLKDDKAGV IQTSTEQSFS KEDQKGQEQT IEALKQDSFP 
       510        520        530        540        550
ISLEQAVTDA AMATKTLEKV TSEPEAVSEK REIQGLFEED IADKSKLEGA 
       560        570        580        590        600
GSATVAEVEM PFYEDKSGMS KYFETSALKE DVTRSTGLGS DYYELSDSRG 
       610        620        630        640        650
NAQESLDTVS PKNQQDEKEL LAKASQPSPP AHEAGYSTLA QSYTSDHPSE 
       660        670        680        690        700
LPEEPSSPQE RMFTIDPKVY GEKRDLHSKN KDDLTLSRSL GLGGRSAIEQ 
       710        720        730        740        750
RSMSINLPMS CLDSIALGFN FGRGHDLSPL ASDILTNTSG SMDEGDDYLP 
       760        770        780        790        800
PTTPAVEKIP CFPIESKEEE DKTEQAKVTG GQTTQVETSS ESPFPAKEYY 
       810        820        830        840        850
KNGTVMAPDL PEMLDLAGTR SRLASVSADA EVARRKSVPS EAVVAESSTG 
       860        870        880        890        900
LPPVADDSQP VKPDSQLEDM GYCVFNKYTV PLPSPVQDSE NLSGESGSFY 
       910        920        930        940        950
EGTDDKVRRD LATDLSLIEV KLAAAGRVKD EFTAEKEASP PSSADKSGLS 
       960        970        980        990       1000
REFDQDRKAN DKLDTVLEKS EEHVDSKEHA KESEEVGDKV ELFGLGVTYE 
      1010       1020       1030       1040       1050
QTSAKELITT KETAPERAEK GLSSVPEVAE VETTTKADQG LDVAAKKDDQ 
      1060       1070       1080       1090       1100
SPLDIKVSDF GQMASGMSVD AGKTIELKFE VDQQLTLSSE APQETDSFMG 
      1110       1120       1130       1140       1150
IESSHVKDGA KVSETEVKEK VAKPDLVHQE AVDKEESYES SGEHESLTME 
      1160       1170       1180       1190       1200
SLKPDEGKKE TSPETSLIQD EVALKLSVEI PCPPPVSEAD SSIDEKAEVQ 
      1210       1220       1230       1240       1250
MEFIQLPKEE STETPDIPAI PSDVTQPQPE AVVSEPAEVR GEEEEIEAEG 
      1260       1270       1280       1290       1300
EYDKLLFRSD TLQITDLLVP GSREEFVETC PGEHKGVVES VVTIEDDFIT 
      1310       1320       1330       1340       1350
VVQTTTDEGE LGSHSVRFAA PVQPEEERRP YPHDEELEVL MAAEAQAEPK 
      1360       1370       1380       1390       1400
DGSPDAPATP EKEEVPFSEY KTETYDDYKD ETTIDDSIMD ADSLWVDTQD 
      1410       1420       1430       1440       1450
DDRSILTEQL ETIPKEERAE KEARRPSLEK HRKEKPFKTG RGRISTPERR 
      1460       1470       1480       1490       1500
EVAKKEPSTV SRDEVRRKKA VYKKAELAKE SEVQAHSPSR KLILKPAIKY 
      1510       1520       1530       1540       1550
TRPTHLSCVK RKTTATSGES AQAPSAFKQA KDKVTDGITK SPEKRSSLPR 
      1560       1570       1580       1590       1600
PSSILPPRRG VSGDREENSF SLNSSISSAR RTTRSEPIRR AGKSGTSTPT 
      1610       1620       1630       1640       1650
TPGSTAITPG TPPSYSSRTP GTPGTPSYPR TPGTPKSGIL VPSEKKVAII 
      1660       1670       1680       1690       1700
RTPPKSPATP KQLRLINQPL PDLKNVKSKI GSTDNIKYQP KGGQVRILNK 
      1710       1720       1730       1740       1750
KMDFSKVQSR CGSKDNIKHS AGGGNVQIVT KKIDLSHVTS KCGSLKNIRH 
      1760       1770       1780       1790       1800
RPGGGRVKIE SVKLDFKEKA QAKVGSLDNA HHVPGGGNVK IDSQKLNFRE 
      1810       1820       1830       1840       1850
HAKARVDHGA EIITQSPSRS SVASPRRLSN VSSSGSINLL ESPQLATLAE 
      1860 
DVTAALAKQG L
Length:1,861
Mass (Da):202,411
Last modified:June 1, 1994 - v3
Checksum:i42DCF116D21EF54E
GO
Isoform 2 (identifier: P15146-2) [UniParc]FASTAAdd to basket
Also known as: MAP2b

The sequence of this isoform differs from the canonical sequence as follows:
     1695-1725: Missing.

Show »
Length:1,830
Mass (Da):199,053
Checksum:i2A52B720268B0551
GO
Isoform 3 (identifier: P15146-3) [UniParc]FASTAAdd to basket
Also known as: MAP2c

The sequence of this isoform differs from the canonical sequence as follows:
     152-1514: Missing.
     1695-1725: Missing.

Show »
Length:467
Mass (Da):49,300
Checksum:i35ACB5CA6E542606
GO
Isoform 4 (identifier: P15146-4) [UniParc]FASTAAdd to basket
Also known as: MAP2d

The sequence of this isoform differs from the canonical sequence as follows:
     152-1514: Missing.

Show »
Length:498
Mass (Da):52,658
Checksum:iD0CE2BD6CE0ABA3E
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1MAQ5F1MAQ5_RAT
Microtubule-associated protein
Map2 Mtap2, rCG_24983
1,825Annotation score:
Q78DZ1Q78DZ1_RAT
Microtubule-associated protein
Map2 MAP2, Mtap2, rCG_24983
498Annotation score:
F1LNK0F1LNK0_RAT
Microtubule-associated protein
Map2
1,942Annotation score:
A0A0U1RRX4A0A0U1RRX4_RAT
Microtubule-associated protein
Map2
1,829Annotation score:
A0A0U1RRQ0A0A0U1RRQ0_RAT
Microtubule-associated protein
Map2
336Annotation score:
A0A0U1RS27A0A0U1RS27_RAT
Microtubule-associated protein 2
Map2
143Annotation score:
A0A0U1RS09A0A0U1RS09_RAT
Microtubule-associated protein 2
Map2
89Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003198152 – 1514Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST1363
Alternative sequenceiVSP_0031991695 – 1725Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51842 mRNA Translation: CAA36135.1
X17682 mRNA Translation: CAA35667.1
X71487 mRNA Translation: CAA50588.1
PIRiA37981
I55502 S33176
RefSeqiXP_008765430.1, XM_008767208.2 [P15146-3]
UniGeneiRn.10484
Rn.136301
Rn.230443

Genome annotation databases

GeneIDi25595
UCSCiRGD:3044 rat [P15146-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51842 mRNA Translation: CAA36135.1
X17682 mRNA Translation: CAA35667.1
X71487 mRNA Translation: CAA50588.1
PIRiA37981
I55502 S33176
RefSeqiXP_008765430.1, XM_008767208.2 [P15146-3]
UniGeneiRn.10484
Rn.136301
Rn.230443

3D structure databases

DisProtiDP00122
SMRiP15146
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247625, 5 interactors
IntActiP15146, 4 interactors
MINTiP15146
STRINGi10116.ENSRNOP00000050877

PTM databases

iPTMnetiP15146
PhosphoSitePlusiP15146
SwissPalmiP15146

Proteomic databases

PaxDbiP15146
PRIDEiP15146

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25595
UCSCiRGD:3044 rat [P15146-1]

Organism-specific databases

CTDi4133
RGDi3044 Map2

Phylogenomic databases

eggNOGiKOG2418 Eukaryota
ENOG4111J07 LUCA
HOGENOMiHOG000113477
HOVERGENiHBG006322
InParanoidiP15146
PhylomeDBiP15146

Miscellaneous databases

PROiPR:P15146

Family and domain databases

InterProiView protein in InterPro
IPR030797 MAP2
IPR013588 MAP2_projctn
IPR001084 MAP_tubulin-bd_rpt
PANTHERiPTHR11501:SF15 PTHR11501:SF15, 2 hits
PfamiView protein in Pfam
PF08377 MAP2_projctn, 1 hit
PF00418 Tubulin-binding, 4 hits
PROSITEiView protein in PROSITE
PS00229 TAU_MAP_1, 3 hits
PS51491 TAU_MAP_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMTAP2_RAT
AccessioniPrimary (citable) accession number: P15146
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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