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Entry version 166 (16 Oct 2019)
Sequence version 3 (01 Jun 1994)
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Protein

Microtubule-associated protein 2

Gene

Map2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: CAFA
  • calmodulin binding Source: UniProtKB-KW
  • microtubule binding Source: CAFA
  • protein kinase binding Source: ARUK-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated protein 2
Short name:
MAP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Map2
Synonyms:Mtap2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
3044 Map2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000727491 – 1861Microtubule-associated protein 2Add BLAST1861

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei28PhosphoserineBy similarity1
Modified residuei37PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei143PhosphoserineBy similarity1
Modified residuei221PhosphoserineCombined sources1
Modified residuei224PhosphoserineCombined sources1
Modified residuei285PhosphoserineBy similarity1
Modified residuei348PhosphoserineCombined sources1
Modified residuei478PhosphoserineBy similarity1
Modified residuei498PhosphoserineCombined sources1
Modified residuei522PhosphoserineCombined sources1
Modified residuei552PhosphoserineBy similarity1
Modified residuei598PhosphoserineBy similarity1
Modified residuei605PhosphoserineBy similarity1
Modified residuei610PhosphoserineCombined sources1
Modified residuei628PhosphoserineCombined sources1
Modified residuei728PhosphoserineBy similarity1
Modified residuei732PhosphoserineBy similarity1
Modified residuei736PhosphothreonineBy similarity1
Modified residuei739PhosphoserineBy similarity1
Modified residuei741PhosphoserineCombined sources1
Modified residuei748PhosphotyrosineBy similarity1
Modified residuei825PhosphoserineBy similarity1
Modified residuei884PhosphoserineCombined sources1
Modified residuei893PhosphoserineCombined sources1
Modified residuei939PhosphoserineCombined sources1
Modified residuei1051PhosphoserineCombined sources1
Modified residuei1140PhosphoserineCombined sources1
Modified residuei1141PhosphoserineCombined sources1
Modified residuei1146PhosphoserineBy similarity1
Modified residuei1161PhosphothreonineCombined sources1
Modified residuei1162PhosphoserineCombined sources1
Modified residuei1166PhosphoserineBy similarity1
Modified residuei1353PhosphoserineCombined sources1
Modified residuei1359PhosphothreonineCombined sources1
Modified residuei1541PhosphoserineCombined sources1
Modified residuei1562PhosphoserineBy similarity1
Modified residuei1594PhosphoserineBy similarity1
Modified residuei1608PhosphothreonineBy similarity1
Modified residuei1611PhosphothreonineCombined sources1
Modified residuei1622PhosphothreonineCombined sources1
Modified residuei1625PhosphothreonineCombined sources1
Modified residuei1652PhosphothreonineCombined sources1
Modified residuei1656PhosphoserineCombined sources1
Modified residuei1682Phosphoserine; by MARK11 Publication1
Modified residuei1816PhosphoserineCombined sources1
Modified residuei1821PhosphoserineBy similarity1
Modified residuei1824PhosphoserineCombined sources1
Modified residuei1829PhosphoserineCombined sources1
Modified residuei1842PhosphoserineCombined sources1
Isoform 3 (identifier: P15146-3)
Modified residuei319Phosphoserine1 Publication1
Modified residuei350Phosphoserine1 Publication1
Modified residuei382Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Isoform 3/MAP2c is probably phosphorylated by PKA at Ser-319, Ser-350 and Ser-382 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).By similarity2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P15146

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15146

PRoteomics IDEntifications database

More...
PRIDEi
P15146

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P15146

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P15146

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P15146

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 3/MAP2c is expressed during embryonic brain development and until postanatal day 10. Isoform 2 is expressed throughout brain development.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KNDC1 (via KIND2); the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
247625, 6 interactors

Protein interaction database and analysis system

More...
IntActi
P15146, 4 interactors

Molecular INTeraction database

More...
MINTi
P15146

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000050877

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P15146

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1664 – 1694Tau/MAP 1Add BLAST31
Repeati1695 – 1725Tau/MAP 2Add BLAST31
Repeati1726 – 1756Tau/MAP 3Add BLAST31
Repeati1757 – 1788Tau/MAP 4Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni704 – 747Interaction with KNDC1By similarityAdd BLAST44
Regioni1454 – 1474Calmodulin-bindingSequence analysisAdd BLAST21

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2418 Eukaryota
ENOG4111J07 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113477

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P15146

Database of Orthologous Groups

More...
OrthoDBi
716848at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P15146

Family and domain databases

Database of protein disorder

More...
DisProti
DP00122

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030797 MAP2
IPR027324 MAP2/MAP4/Tau
IPR013588 MAP2_projctn
IPR001084 MAP_tubulin-bd_rpt

The PANTHER Classification System

More...
PANTHERi
PTHR11501 PTHR11501, 2 hits
PTHR11501:SF15 PTHR11501:SF15, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08377 MAP2_projctn, 1 hit
PF00418 Tubulin-binding, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00229 TAU_MAP_1, 3 hits
PS51491 TAU_MAP_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P15146-1) [UniParc]FASTAAdd to basket
Also known as: MAP2x

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADERKDEGK APHWTSASLT EAAAHPHSPE MKDQGGSGEG LSRSANGFPY
60 70 80 90 100
REEEEGAFGE HGSQGTYSDT KENGINGELT SADRETAEEV SARIVQVVTA
110 120 130 140 150
EAVAVLKGEQ EKEAQHKDQP AALPLAAEET VNLPPSPPPS PASEQTAALE
160 170 180 190 200
EDLLTASKME FPEQQKLPSS FAEPLDKEET EFKMQSKPGE DFEHAALVPQ
210 220 230 240 250
PDTSKTPQDK KDPQDMEGEK SPASPFAQTF GTNLEDIKQI TEPSITVPSI
260 270 280 290 300
GLSAEPLAPK DQKDWFIEMP VESKKDEWGL AAPISPGPLT PMREKDVLED
310 320 330 340 350
IPRWEGKQFD SPMPSPFHGG SFTLPLDTVK DERVTEGSQP FAPVFFQSDD
360 370 380 390 400
KMSLQDTSGS ATSKESSKDE EPQKDKADKV ADVPVSEATT VLGDVHSPAV
410 420 430 440 450
EGFVGENISG EEKGTTDQEK KETSTPSVQE PTLTETEPQT KLEETSKVSI
460 470 480 490 500
EETVAKEEES LKLKDDKAGV IQTSTEQSFS KEDQKGQEQT IEALKQDSFP
510 520 530 540 550
ISLEQAVTDA AMATKTLEKV TSEPEAVSEK REIQGLFEED IADKSKLEGA
560 570 580 590 600
GSATVAEVEM PFYEDKSGMS KYFETSALKE DVTRSTGLGS DYYELSDSRG
610 620 630 640 650
NAQESLDTVS PKNQQDEKEL LAKASQPSPP AHEAGYSTLA QSYTSDHPSE
660 670 680 690 700
LPEEPSSPQE RMFTIDPKVY GEKRDLHSKN KDDLTLSRSL GLGGRSAIEQ
710 720 730 740 750
RSMSINLPMS CLDSIALGFN FGRGHDLSPL ASDILTNTSG SMDEGDDYLP
760 770 780 790 800
PTTPAVEKIP CFPIESKEEE DKTEQAKVTG GQTTQVETSS ESPFPAKEYY
810 820 830 840 850
KNGTVMAPDL PEMLDLAGTR SRLASVSADA EVARRKSVPS EAVVAESSTG
860 870 880 890 900
LPPVADDSQP VKPDSQLEDM GYCVFNKYTV PLPSPVQDSE NLSGESGSFY
910 920 930 940 950
EGTDDKVRRD LATDLSLIEV KLAAAGRVKD EFTAEKEASP PSSADKSGLS
960 970 980 990 1000
REFDQDRKAN DKLDTVLEKS EEHVDSKEHA KESEEVGDKV ELFGLGVTYE
1010 1020 1030 1040 1050
QTSAKELITT KETAPERAEK GLSSVPEVAE VETTTKADQG LDVAAKKDDQ
1060 1070 1080 1090 1100
SPLDIKVSDF GQMASGMSVD AGKTIELKFE VDQQLTLSSE APQETDSFMG
1110 1120 1130 1140 1150
IESSHVKDGA KVSETEVKEK VAKPDLVHQE AVDKEESYES SGEHESLTME
1160 1170 1180 1190 1200
SLKPDEGKKE TSPETSLIQD EVALKLSVEI PCPPPVSEAD SSIDEKAEVQ
1210 1220 1230 1240 1250
MEFIQLPKEE STETPDIPAI PSDVTQPQPE AVVSEPAEVR GEEEEIEAEG
1260 1270 1280 1290 1300
EYDKLLFRSD TLQITDLLVP GSREEFVETC PGEHKGVVES VVTIEDDFIT
1310 1320 1330 1340 1350
VVQTTTDEGE LGSHSVRFAA PVQPEEERRP YPHDEELEVL MAAEAQAEPK
1360 1370 1380 1390 1400
DGSPDAPATP EKEEVPFSEY KTETYDDYKD ETTIDDSIMD ADSLWVDTQD
1410 1420 1430 1440 1450
DDRSILTEQL ETIPKEERAE KEARRPSLEK HRKEKPFKTG RGRISTPERR
1460 1470 1480 1490 1500
EVAKKEPSTV SRDEVRRKKA VYKKAELAKE SEVQAHSPSR KLILKPAIKY
1510 1520 1530 1540 1550
TRPTHLSCVK RKTTATSGES AQAPSAFKQA KDKVTDGITK SPEKRSSLPR
1560 1570 1580 1590 1600
PSSILPPRRG VSGDREENSF SLNSSISSAR RTTRSEPIRR AGKSGTSTPT
1610 1620 1630 1640 1650
TPGSTAITPG TPPSYSSRTP GTPGTPSYPR TPGTPKSGIL VPSEKKVAII
1660 1670 1680 1690 1700
RTPPKSPATP KQLRLINQPL PDLKNVKSKI GSTDNIKYQP KGGQVRILNK
1710 1720 1730 1740 1750
KMDFSKVQSR CGSKDNIKHS AGGGNVQIVT KKIDLSHVTS KCGSLKNIRH
1760 1770 1780 1790 1800
RPGGGRVKIE SVKLDFKEKA QAKVGSLDNA HHVPGGGNVK IDSQKLNFRE
1810 1820 1830 1840 1850
HAKARVDHGA EIITQSPSRS SVASPRRLSN VSSSGSINLL ESPQLATLAE
1860
DVTAALAKQG L
Length:1,861
Mass (Da):202,411
Last modified:June 1, 1994 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42DCF116D21EF54E
GO
Isoform 2 (identifier: P15146-2) [UniParc]FASTAAdd to basket
Also known as: MAP2b

The sequence of this isoform differs from the canonical sequence as follows:
     1695-1725: Missing.

Show »
Length:1,830
Mass (Da):199,053
Checksum:i2A52B720268B0551
GO
Isoform 3 (identifier: P15146-3) [UniParc]FASTAAdd to basket
Also known as: MAP2c

The sequence of this isoform differs from the canonical sequence as follows:
     152-1514: Missing.
     1695-1725: Missing.

Show »
Length:467
Mass (Da):49,300
Checksum:i35ACB5CA6E542606
GO
Isoform 4 (identifier: P15146-4) [UniParc]FASTAAdd to basket
Also known as: MAP2d

The sequence of this isoform differs from the canonical sequence as follows:
     152-1514: Missing.

Show »
Length:498
Mass (Da):52,658
Checksum:iD0CE2BD6CE0ABA3E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1MAQ5F1MAQ5_RAT
Microtubule-associated protein
Map2 Mtap2, rCG_24983
1,825Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q78DZ1Q78DZ1_RAT
Microtubule-associated protein
Map2 MAP2, Mtap2, rCG_24983
498Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LNK0F1LNK0_RAT
Microtubule-associated protein
Map2
1,942Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RRX4A0A0U1RRX4_RAT
Microtubule-associated protein
Map2
1,829Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RRQ0A0A0U1RRQ0_RAT
Microtubule-associated protein
Map2
336Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RS27A0A0U1RS27_RAT
Microtubule-associated protein 2
Map2
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RS09A0A0U1RS09_RAT
Microtubule-associated protein 2
Map2
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003198152 – 1514Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST1363
Alternative sequenceiVSP_0031991695 – 1725Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X51842 mRNA Translation: CAA36135.1
X17682 mRNA Translation: CAA35667.1
X71487 mRNA Translation: CAA50588.1

Protein sequence database of the Protein Information Resource

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PIRi
A37981
I55502 S33176

NCBI Reference Sequences

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RefSeqi
XP_008765430.1, XM_008767208.2 [P15146-3]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
25595

UCSC genome browser

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UCSCi
RGD:3044 rat [P15146-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51842 mRNA Translation: CAA36135.1
X17682 mRNA Translation: CAA35667.1
X71487 mRNA Translation: CAA50588.1
PIRiA37981
I55502 S33176
RefSeqiXP_008765430.1, XM_008767208.2 [P15146-3]

3D structure databases

SMRiP15146
ModBaseiSearch...

Protein-protein interaction databases

BioGridi247625, 6 interactors
IntActiP15146, 4 interactors
MINTiP15146
STRINGi10116.ENSRNOP00000050877

PTM databases

iPTMnetiP15146
PhosphoSitePlusiP15146
SwissPalmiP15146

Proteomic databases

jPOSTiP15146
PaxDbiP15146
PRIDEiP15146

Genome annotation databases

GeneIDi25595
UCSCiRGD:3044 rat [P15146-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4133
RGDi3044 Map2

Phylogenomic databases

eggNOGiKOG2418 Eukaryota
ENOG4111J07 LUCA
HOGENOMiHOG000113477
InParanoidiP15146
OrthoDBi716848at2759
PhylomeDBiP15146

Miscellaneous databases

Protein Ontology

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PROi
PR:P15146

Family and domain databases

DisProtiDP00122
InterProiView protein in InterPro
IPR030797 MAP2
IPR027324 MAP2/MAP4/Tau
IPR013588 MAP2_projctn
IPR001084 MAP_tubulin-bd_rpt
PANTHERiPTHR11501 PTHR11501, 2 hits
PTHR11501:SF15 PTHR11501:SF15, 2 hits
PfamiView protein in Pfam
PF08377 MAP2_projctn, 1 hit
PF00418 Tubulin-binding, 4 hits
PROSITEiView protein in PROSITE
PS00229 TAU_MAP_1, 3 hits
PS51491 TAU_MAP_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTAP2_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15146
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: June 1, 1994
Last modified: October 16, 2019
This is version 166 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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