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UniProtKB - P15146 (MTAP2_RAT)

Entry version 177 (02 Jun 2021)
Sequence version 3 (01 Jun 1994)
Previous versions | rss
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Protein

Microtubule-associated protein 2

Gene

Map2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: CAFA
  • calmodulin binding Source: UniProtKB-KW
  • dystroglycan binding Source: RGD
  • microtubule binding Source: CAFA
  • protein kinase binding Source: ARUK-UCL
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated protein 2
Short name:
MAP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Map2
Synonyms:Mtap2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...RGDi		3044, Map2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000727491 – 1861Microtubule-associated protein 2Add BLAST1861

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei28PhosphoserineBy similarity1
Modified residuei37PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei143PhosphoserineBy similarity1
Modified residuei221PhosphoserineCombined sources1
Modified residuei224PhosphoserineCombined sources1
Modified residuei285PhosphoserineBy similarity1
Modified residuei348PhosphoserineCombined sources1
Modified residuei478PhosphoserineBy similarity1
Modified residuei498PhosphoserineCombined sources1
Modified residuei522PhosphoserineCombined sources1
Modified residuei552PhosphoserineBy similarity1
Modified residuei598PhosphoserineBy similarity1
Modified residuei605PhosphoserineBy similarity1
Modified residuei610PhosphoserineCombined sources1
Modified residuei628PhosphoserineCombined sources1
Modified residuei728PhosphoserineBy similarity1
Modified residuei732PhosphoserineBy similarity1
Modified residuei736PhosphothreonineBy similarity1
Modified residuei739PhosphoserineBy similarity1
Modified residuei741PhosphoserineCombined sources1
Modified residuei748PhosphotyrosineBy similarity1
Modified residuei825PhosphoserineBy similarity1
Modified residuei884PhosphoserineCombined sources1
Modified residuei893PhosphoserineCombined sources1
Modified residuei939PhosphoserineCombined sources1
Modified residuei1051PhosphoserineCombined sources1
Modified residuei1140PhosphoserineCombined sources1
Modified residuei1141PhosphoserineCombined sources1
Modified residuei1146PhosphoserineBy similarity1
Modified residuei1161PhosphothreonineCombined sources1
Modified residuei1162PhosphoserineCombined sources1
Modified residuei1166PhosphoserineBy similarity1
Modified residuei1353PhosphoserineCombined sources1
Modified residuei1359PhosphothreonineCombined sources1
Modified residuei1541PhosphoserineCombined sources1
Modified residuei1562PhosphoserineBy similarity1
Modified residuei1594PhosphoserineBy similarity1
Modified residuei1608PhosphothreonineBy similarity1
Modified residuei1611PhosphothreonineCombined sources1
Modified residuei1622PhosphothreonineCombined sources1
Modified residuei1625PhosphothreonineCombined sources1
Modified residuei1652PhosphothreonineCombined sources1
Modified residuei1656PhosphoserineCombined sources1
Modified residuei1682Phosphoserine; by MARK11 Publication1
Modified residuei1816PhosphoserineCombined sources1
Modified residuei1821PhosphoserineBy similarity1
Modified residuei1824PhosphoserineCombined sources1
Modified residuei1829PhosphoserineCombined sources1
Modified residuei1842PhosphoserineCombined sources1
Isoform 3 (identifier: P15146-3)
Modified residuei319Phosphoserine1 Publication1
Modified residuei350Phosphoserine1 Publication1
Modified residuei382Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Isoform 3/MAP2c is probably phosphorylated by PKA at Ser-319, Ser-350 and Ser-382 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).By similarity2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P15146

PRoteomics IDEntifications database

More...PRIDEi		P15146

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P15146

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P15146

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P15146

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 3/MAP2c is expressed during embryonic brain development and until postanatal day 10. Isoform 2 is expressed throughout brain development.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KNDC1 (via KIND2); the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		247625, 7 interactors

Protein interaction database and analysis system

More...IntActi		P15146, 6 interactors

Molecular INTeraction database

More...MINTi		P15146

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000050877

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Small Angle Scattering Biological Data Bank

More...SASBDBi		P15146

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P15146

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1664 – 1694Tau/MAP 1Add BLAST31
Repeati1695 – 1725Tau/MAP 2Add BLAST31
Repeati1726 – 1756Tau/MAP 3Add BLAST31
Repeati1757 – 1788Tau/MAP 4Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 86DisorderedSequence analysisAdd BLAST86
Regioni109 – 231DisorderedSequence analysisAdd BLAST123
Regioni305 – 469DisorderedSequence analysisAdd BLAST165
Regioni575 – 688DisorderedSequence analysisAdd BLAST114
Regioni704 – 747Interaction with KNDC1By similarityAdd BLAST44
Regioni766 – 797DisorderedSequence analysisAdd BLAST32
Regioni826 – 866DisorderedSequence analysisAdd BLAST41
Regioni884 – 903DisorderedSequence analysisAdd BLAST20
Regioni929 – 987DisorderedSequence analysisAdd BLAST59
Regioni1006 – 1026DisorderedSequence analysisAdd BLAST21
Regioni1087 – 1170DisorderedSequence analysisAdd BLAST84
Regioni1207 – 1247DisorderedSequence analysisAdd BLAST41
Regioni1343 – 1384DisorderedSequence analysisAdd BLAST42
Regioni1406 – 1643DisorderedSequence analysisAdd BLAST238
Regioni1454 – 1474Calmodulin-bindingSequence analysisAdd BLAST21
Regioni1816 – 1835DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi63 – 80Polar residuesSequence analysisAdd BLAST18
Compositional biasi172 – 190Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi363 – 382Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi425 – 439Polar residuesSequence analysisAdd BLAST15
Compositional biasi440 – 466Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi579 – 610Polar residuesSequence analysisAdd BLAST32
Compositional biasi631 – 652Polar residuesSequence analysisAdd BLAST22
Compositional biasi666 – 684Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi777 – 792Polar residuesSequence analysisAdd BLAST16
Compositional biasi884 – 898Polar residuesSequence analysisAdd BLAST15
Compositional biasi949 – 987Basic and acidic residuesSequence analysisAdd BLAST39
Compositional biasi1107 – 1165Basic and acidic residuesSequence analysisAdd BLAST59
Compositional biasi1355 – 1384Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi1406 – 1486Basic and acidic residuesSequence analysisAdd BLAST81
Compositional biasi1507 – 1524Polar residuesSequence analysisAdd BLAST18
Compositional biasi1566 – 1582Polar residuesSequence analysisAdd BLAST17
Compositional biasi1589 – 1624Polar residuesSequence analysisAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2418, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P15146

Database for complete collections of gene phylogenies

More...PhylomeDBi		P15146

Family and domain databases

Database of protein disorder

More...DisProti		DP00122

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR030797, MAP2
IPR013588, MAP2_projctn
IPR001084, MAP_tubulin-bd_rpt

The PANTHER Classification System

More...PANTHERi		PTHR11501:SF15, PTHR11501:SF15, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08377, MAP2_projctn, 1 hit
PF00418, Tubulin-binding, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00229, TAU_MAP_1, 3 hits
PS51491, TAU_MAP_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P15146-1) [UniParc]FASTAAdd to basket
Also known as: MAP2x

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADERKDEGK APHWTSASLT EAAAHPHSPE MKDQGGSGEG LSRSANGFPY 
        60         70         80         90        100
REEEEGAFGE HGSQGTYSDT KENGINGELT SADRETAEEV SARIVQVVTA 
       110        120        130        140        150
EAVAVLKGEQ EKEAQHKDQP AALPLAAEET VNLPPSPPPS PASEQTAALE 
       160        170        180        190        200
EDLLTASKME FPEQQKLPSS FAEPLDKEET EFKMQSKPGE DFEHAALVPQ 
       210        220        230        240        250
PDTSKTPQDK KDPQDMEGEK SPASPFAQTF GTNLEDIKQI TEPSITVPSI 
       260        270        280        290        300
GLSAEPLAPK DQKDWFIEMP VESKKDEWGL AAPISPGPLT PMREKDVLED 
       310        320        330        340        350
IPRWEGKQFD SPMPSPFHGG SFTLPLDTVK DERVTEGSQP FAPVFFQSDD 
       360        370        380        390        400
KMSLQDTSGS ATSKESSKDE EPQKDKADKV ADVPVSEATT VLGDVHSPAV 
       410        420        430        440        450
EGFVGENISG EEKGTTDQEK KETSTPSVQE PTLTETEPQT KLEETSKVSI 
       460        470        480        490        500
EETVAKEEES LKLKDDKAGV IQTSTEQSFS KEDQKGQEQT IEALKQDSFP 
       510        520        530        540        550
ISLEQAVTDA AMATKTLEKV TSEPEAVSEK REIQGLFEED IADKSKLEGA 
       560        570        580        590        600
GSATVAEVEM PFYEDKSGMS KYFETSALKE DVTRSTGLGS DYYELSDSRG 
       610        620        630        640        650
NAQESLDTVS PKNQQDEKEL LAKASQPSPP AHEAGYSTLA QSYTSDHPSE 
       660        670        680        690        700
LPEEPSSPQE RMFTIDPKVY GEKRDLHSKN KDDLTLSRSL GLGGRSAIEQ 
       710        720        730        740        750
RSMSINLPMS CLDSIALGFN FGRGHDLSPL ASDILTNTSG SMDEGDDYLP 
       760        770        780        790        800
PTTPAVEKIP CFPIESKEEE DKTEQAKVTG GQTTQVETSS ESPFPAKEYY 
       810        820        830        840        850
KNGTVMAPDL PEMLDLAGTR SRLASVSADA EVARRKSVPS EAVVAESSTG 
       860        870        880        890        900
LPPVADDSQP VKPDSQLEDM GYCVFNKYTV PLPSPVQDSE NLSGESGSFY 
       910        920        930        940        950
EGTDDKVRRD LATDLSLIEV KLAAAGRVKD EFTAEKEASP PSSADKSGLS 
       960        970        980        990       1000
REFDQDRKAN DKLDTVLEKS EEHVDSKEHA KESEEVGDKV ELFGLGVTYE 
      1010       1020       1030       1040       1050
QTSAKELITT KETAPERAEK GLSSVPEVAE VETTTKADQG LDVAAKKDDQ 
      1060       1070       1080       1090       1100
SPLDIKVSDF GQMASGMSVD AGKTIELKFE VDQQLTLSSE APQETDSFMG 
      1110       1120       1130       1140       1150
IESSHVKDGA KVSETEVKEK VAKPDLVHQE AVDKEESYES SGEHESLTME 
      1160       1170       1180       1190       1200
SLKPDEGKKE TSPETSLIQD EVALKLSVEI PCPPPVSEAD SSIDEKAEVQ 
      1210       1220       1230       1240       1250
MEFIQLPKEE STETPDIPAI PSDVTQPQPE AVVSEPAEVR GEEEEIEAEG 
      1260       1270       1280       1290       1300
EYDKLLFRSD TLQITDLLVP GSREEFVETC PGEHKGVVES VVTIEDDFIT 
      1310       1320       1330       1340       1350
VVQTTTDEGE LGSHSVRFAA PVQPEEERRP YPHDEELEVL MAAEAQAEPK 
      1360       1370       1380       1390       1400
DGSPDAPATP EKEEVPFSEY KTETYDDYKD ETTIDDSIMD ADSLWVDTQD 
      1410       1420       1430       1440       1450
DDRSILTEQL ETIPKEERAE KEARRPSLEK HRKEKPFKTG RGRISTPERR 
      1460       1470       1480       1490       1500
EVAKKEPSTV SRDEVRRKKA VYKKAELAKE SEVQAHSPSR KLILKPAIKY 
      1510       1520       1530       1540       1550
TRPTHLSCVK RKTTATSGES AQAPSAFKQA KDKVTDGITK SPEKRSSLPR 
      1560       1570       1580       1590       1600
PSSILPPRRG VSGDREENSF SLNSSISSAR RTTRSEPIRR AGKSGTSTPT 
      1610       1620       1630       1640       1650
TPGSTAITPG TPPSYSSRTP GTPGTPSYPR TPGTPKSGIL VPSEKKVAII 
      1660       1670       1680       1690       1700
RTPPKSPATP KQLRLINQPL PDLKNVKSKI GSTDNIKYQP KGGQVRILNK 
      1710       1720       1730       1740       1750
KMDFSKVQSR CGSKDNIKHS AGGGNVQIVT KKIDLSHVTS KCGSLKNIRH 
      1760       1770       1780       1790       1800
RPGGGRVKIE SVKLDFKEKA QAKVGSLDNA HHVPGGGNVK IDSQKLNFRE 
      1810       1820       1830       1840       1850
HAKARVDHGA EIITQSPSRS SVASPRRLSN VSSSGSINLL ESPQLATLAE 
      1860 
DVTAALAKQG L
Length:1,861
Mass (Da):202,411
Last modified:June 1, 1994 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42DCF116D21EF54E
GO
Isoform 2 (identifier: P15146-2) [UniParc]FASTAAdd to basket
Also known as: MAP2b

The sequence of this isoform differs from the canonical sequence as follows:
     1695-1725: Missing.

Show »
Length:1,830
Mass (Da):199,053
Checksum:i2A52B720268B0551
GO
Isoform 3 (identifier: P15146-3) [UniParc]FASTAAdd to basket
Also known as: MAP2c

The sequence of this isoform differs from the canonical sequence as follows:
     152-1514: Missing.
     1695-1725: Missing.

Show »
Length:467
Mass (Da):49,300
Checksum:i35ACB5CA6E542606
GO
Isoform 4 (identifier: P15146-4) [UniParc]FASTAAdd to basket
Also known as: MAP2d

The sequence of this isoform differs from the canonical sequence as follows:
     152-1514: Missing.

Show »
Length:498
Mass (Da):52,658
Checksum:iD0CE2BD6CE0ABA3E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q78DZ1Q78DZ1_RAT
Microtubule-associated protein
Map2 MAP2, Mtap2, rCG_24983
498Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1MAQ5F1MAQ5_RAT
Microtubule-associated protein
Map2 Mtap2, rCG_24983
1,825Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LNK0F1LNK0_RAT
Microtubule-associated protein
Map2
1,942Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RRX4A0A0U1RRX4_RAT
Microtubule-associated protein
Map2
1,829Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RRQ0A0A0U1RRQ0_RAT
Microtubule-associated protein
Map2
336Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RS27A0A0U1RS27_RAT
Microtubule-associated protein 2
Map2
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RS09A0A0U1RS09_RAT
Microtubule-associated protein 2
Map2
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003198152 – 1514Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST1363
Alternative sequenceiVSP_0031991695 – 1725Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X51842 mRNA Translation: CAA36135.1
X17682 mRNA Translation: CAA35667.1
X71487 mRNA Translation: CAA50588.1

Protein sequence database of the Protein Information Resource

More...PIRi		A37981
I55502, S33176

NCBI Reference Sequences

More...RefSeqi		XP_008765430.1, XM_008767208.2 [P15146-3]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25595

UCSC genome browser

More...UCSCi		RGD:3044, rat [P15146-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51842 mRNA Translation: CAA36135.1
X17682 mRNA Translation: CAA35667.1
X71487 mRNA Translation: CAA50588.1
PIRiA37981
I55502, S33176
RefSeqiXP_008765430.1, XM_008767208.2 [P15146-3]

3D structure databases

SASBDBiP15146
SMRiP15146
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi247625, 7 interactors
IntActiP15146, 6 interactors
MINTiP15146
STRINGi10116.ENSRNOP00000050877

PTM databases

iPTMnetiP15146
PhosphoSitePlusiP15146
SwissPalmiP15146

Proteomic databases

PaxDbiP15146
PRIDEiP15146

Genome annotation databases

GeneIDi25595
UCSCiRGD:3044, rat [P15146-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4133
RGDi3044, Map2

Phylogenomic databases

eggNOGiKOG2418, Eukaryota
InParanoidiP15146
PhylomeDBiP15146

Miscellaneous databases

Protein Ontology

More...PROi		PR:P15146

Family and domain databases

DisProtiDP00122
InterProiView protein in InterPro
IPR030797, MAP2
IPR013588, MAP2_projctn
IPR001084, MAP_tubulin-bd_rpt
PANTHERiPTHR11501:SF15, PTHR11501:SF15, 2 hits
PfamiView protein in Pfam
PF08377, MAP2_projctn, 1 hit
PF00418, Tubulin-binding, 4 hits
PROSITEiView protein in PROSITE
PS00229, TAU_MAP_1, 3 hits
PS51491, TAU_MAP_2, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTAP2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15146
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: June 1, 1994
Last modified: June 2, 2021
This is version 177 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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