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Entry version 227 (07 Oct 2020)
Sequence version 4 (03 Apr 2007)
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Protein

Aminopeptidase N

Gene

ANPEP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).By similarity7 Publications
(Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein.4 Publications
(Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection.1 Publication

Miscellaneous

Found to serve as a receptor for tumor-homing peptides, more specifically NGR peptides. It could serve thus as a target for delivering drugs into tumors. Concentration in human hepatic bile, varies from 17.3 to 57.6 micrograms/ml.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi388Zinc; catalyticCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei389Proton acceptorPROSITE-ProRule annotation1 Publication1
Metal bindingi392Zinc; catalyticCombined sources1 Publication1
Metal bindingi411Zinc; catalyticCombined sources1 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei477Transition state stabilizer1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminopeptidase, Developmental protein, Host cell receptor for virus entry, Hydrolase, Metalloprotease, Protease, Receptor
Biological processAngiogenesis, Differentiation, Host-virus interaction
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.11.2, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P15144

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2022377, Metabolism of Angiotensinogen to Angiotensins
R-HSA-6798695, Neutrophil degranulation

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P15144

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P15144

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M01.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aminopeptidase NCurated (EC:3.4.11.24 Publications)
Short name:
AP-N
Short name:
hAPN
Alternative name(s):
Alanyl aminopeptidase
Aminopeptidase M
Short name:
AP-M
Microsomal aminopeptidase
Myeloid plasma membrane glycoprotein CD13
gp150
CD_antigen: CD13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANPEP
Synonyms:APN, CD13, PEPN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000166825.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:500, ANPEP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
151530, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P15144

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 8Cytoplasmic1 Publication7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 32Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST24
Topological domaini33 – 967Extracellular1 PublicationAdd BLAST935

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi288 – 295DYVEKQAS → QSVEETAQ: No change in receptor activity and HCoV-229E infection. 1 Publication8
Mutagenesisi288 – 295DYVEKQAS → QSVNEQAQ: No change in receptor activity and HCoV-229E infection. 1 Publication8
Mutagenesisi288 – 295DYVEKQAS → QSVNETAQ: Complete loss of receptor activity and blocks HCoV-229E infection. No loss of enzymatic activity. 1 Publication8
Mutagenesisi291 – 293EKQ → NKT: Complete loss of receptor activity and blocks HCoV-229E infection. No loss of enzymatic activity. 3
Mutagenesisi291E → N: No change of receptor activity and HCoV-229E infection. 1
Mutagenesisi293Q → T: No change of receptor activity and HCoV-229E infection. 1
Mutagenesisi392H → A: Loss of aminopeptidase activity. 1 Publication1
Mutagenesisi818N → E: Very low receptor activity and HCoV-229E infection. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
290

Open Targets

More...
OpenTargetsi
ENSG00000166825

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24815

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P15144, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1907

Drug and drug target database

More...
DrugBanki
DB00973, Ezetimibe
DB06773, Human calcitonin
DB06196, Icatibant

DrugCentral

More...
DrugCentrali
P15144

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1560

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANPEP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143811362

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved3 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000950812 – 967Aminopeptidase NAdd BLAST966

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi128N-linked (GlcNAc...) asparagine3 Publications1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei176SulfotyrosineSequence analysis1
Glycosylationi234N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi265N-linked (GlcNAc...) asparagine4 Publications1
Glycosylationi319N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei419SulfotyrosineSequence analysis1
Modified residuei424SulfotyrosineSequence analysis1
Glycosylationi527N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi573N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi625N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi681N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi735N-linked (GlcNAc...) asparagine1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi761 ↔ 7681 Publication
Disulfide bondi798 ↔ 8341 Publication
Glycosylationi818N-linked (GlcNAc...) asparagine3 Publications1
Modified residuei913SulfotyrosineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sulfated.By similarity
N- and O-glycosylated.6 Publications
May undergo proteolysis and give rise to a soluble form.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-460
CPTAC-461

Encyclopedia of Proteome Dynamics

More...
EPDi
P15144

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P15144

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P15144

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P15144

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15144

PeptideAtlas

More...
PeptideAtlasi
P15144

PRoteomics IDEntifications database

More...
PRIDEi
P15144

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
53109

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
815, 35 N-Linked glycans (6 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P15144, 17 sites, 9 N-linked glycans (5 sites), 7 O-linked glycans (4 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P15144

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
P15144

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P15144

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P15144

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P15144

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Estradiol and IL8/interleukin-8 decrease enzymatic activity in vitro in endometrial stromal cells by 40% and 30%, respectively.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166825, Expressed in intestine and 193 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P15144, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P15144, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166825, Tissue enhanced (intestine, kidney, pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with SLC6A19 (By similarity).

By similarity2 Publications

(Microbial infection) Interacts with the S1 domain of human coronavirus 229E/HCoV-229E spike protein.

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
106787, 7 interactors

Protein interaction database and analysis system

More...
IntActi
P15144, 12 interactors

Molecular INTeraction database

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MINTi
P15144

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000300060

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P15144

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P15144, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1967
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P15144

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni33 – 68Cytosolic Ser/Thr-rich junctionAdd BLAST36
Regioni69 – 967MetalloproteaseAdd BLAST899
Regioni288 – 295Necessary and sufficient to mediate interaction with HCoV-229E2 Publications8
Regioni352 – 356Substrate binding1 Publication5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M1 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1046, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154876

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003705_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P15144

KEGG Orthology (KO)

More...
KOi
K11140

Identification of Orthologs from Complete Genome Data

More...
OMAi
TAKWFIF

Database of Orthologous Groups

More...
OrthoDBi
110058at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P15144

TreeFam database of animal gene trees

More...
TreeFami
TF300395

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09601, M1_APN-Q_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1730, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042097, Aminopeptidase_N-like_N
IPR024571, ERAP1-like_C_dom
IPR034016, M1_APN-typ
IPR001930, Peptidase_M1
IPR014782, Peptidase_M1_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11838, ERAP1_C, 1 hit
PF01433, Peptidase_M1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00756, ALADIPTASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63737, SSF63737, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00142, ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P15144-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKGFYISKS LGILGILLGV AAVCTIIALS VVYSQEKNKN ANSSPVASTT
60 70 80 90 100
PSASATTNPA SATTLDQSKA WNRYRLPNTL KPDSYRVTLR PYLTPNDRGL
110 120 130 140 150
YVFKGSSTVR FTCKEATDVI IIHSKKLNYT LSQGHRVVLR GVGGSQPPDI
160 170 180 190 200
DKTELVEPTE YLVVHLKGSL VKDSQYEMDS EFEGELADDL AGFYRSEYME
210 220 230 240 250
GNVRKVVATT QMQAADARKS FPCFDEPAMK AEFNITLIHP KDLTALSNML
260 270 280 290 300
PKGPSTPLPE DPNWNVTEFH TTPKMSTYLL AFIVSEFDYV EKQASNGVLI
310 320 330 340 350
RIWARPSAIA AGHGDYALNV TGPILNFFAG HYDTPYPLPK SDQIGLPDFN
360 370 380 390 400
AGAMENWGLV TYRENSLLFD PLSSSSSNKE RVVTVIAHEL AHQWFGNLVT
410 420 430 440 450
IEWWNDLWLN EGFASYVEYL GADYAEPTWN LKDLMVLNDV YRVMAVDALA
460 470 480 490 500
SSHPLSTPAS EINTPAQISE LFDAISYSKG ASVLRMLSSF LSEDVFKQGL
510 520 530 540 550
ASYLHTFAYQ NTIYLNLWDH LQEAVNNRSI QLPTTVRDIM NRWTLQMGFP
560 570 580 590 600
VITVDTSTGT LSQEHFLLDP DSNVTRPSEF NYVWIVPITS IRDGRQQQDY
610 620 630 640 650
WLIDVRAQND LFSTSGNEWV LLNLNVTGYY RVNYDEENWR KIQTQLQRDH
660 670 680 690 700
SAIPVINRAQ IINDAFNLAS AHKVPVTLAL NNTLFLIEER QYMPWEAALS
710 720 730 740 750
SLSYFKLMFD RSEVYGPMKN YLKKQVTPLF IHFRNNTNNW REIPENLMDQ
760 770 780 790 800
YSEVNAISTA CSNGVPECEE MVSGLFKQWM ENPNNNPIHP NLRSTVYCNA
810 820 830 840 850
IAQGGEEEWD FAWEQFRNAT LVNEADKLRA ALACSKELWI LNRYLSYTLN
860 870 880 890 900
PDLIRKQDAT STIISITNNV IGQGLVWDFV QSNWKKLFND YGGGSFSFSN
910 920 930 940 950
LIQAVTRRFS TEYELQQLEQ FKKDNEETGF GSGTRALEQA LEKTKANIKW
960
VKENKEVVLQ WFTENSK
Length:967
Mass (Da):109,540
Last modified:April 3, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37B6BC1BF0D6B1F2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMC1H0YMC1_HUMAN
Aminopeptidase N
ANPEP
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKT6H0YKT6_HUMAN
Aminopeptidase N
ANPEP
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YM04H0YM04_HUMAN
Aminopeptidase N
ANPEP
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLZ8H0YLZ8_HUMAN
Aminopeptidase N
ANPEP
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti536V → E in CAA31640 (PubMed:2901990).Curated1
Sequence conflicti887L → P in CAA31640 (PubMed:2901990).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03126220V → M. Corresponds to variant dbSNP:rs10152474Ensembl.1
Natural variantiVAR_01473686R → Q3 PublicationsCorresponds to variant dbSNP:rs25653Ensembl.1
Natural variantiVAR_006727242D → Y1 Publication1
Natural variantiVAR_006728243L → P1 Publication1
Natural variantiVAR_031263311A → V. Corresponds to variant dbSNP:rs17240268Ensembl.1
Natural variantiVAR_031264321T → M. Corresponds to variant dbSNP:rs8179199Ensembl.1
Natural variantiVAR_031265603I → K. Corresponds to variant dbSNP:rs17240212Ensembl.1
Natural variantiVAR_031266603I → M1 PublicationCorresponds to variant dbSNP:rs8192297Ensembl.1
Natural variantiVAR_014737752S → N. Corresponds to variant dbSNP:rs25651Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X13276 mRNA Translation: CAA31640.1
M22324 mRNA Translation: AAA51719.1
AC018988 Genomic DNA No translation available.
AC079075 Genomic DNA No translation available.
BC058928 mRNA Translation: AAH58928.1
M55522 Genomic DNA Translation: AAA83399.1
AJ421875, AJ421876 Genomic DNA Translation: CAD19098.2
AJ426050 Genomic DNA Translation: CAD19802.1
AJ427985 AJ427988 Genomic DNA Translation: CAD20931.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10356.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A30325

NCBI Reference Sequences

More...
RefSeqi
NP_001141.2, NM_001150.2
XP_005254949.1, XM_005254892.4
XP_011519775.1, XM_011521473.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000300060; ENSP00000300060; ENSG00000166825

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
290

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:290

UCSC genome browser

More...
UCSCi
uc002bop.5, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13276 mRNA Translation: CAA31640.1
M22324 mRNA Translation: AAA51719.1
AC018988 Genomic DNA No translation available.
AC079075 Genomic DNA No translation available.
BC058928 mRNA Translation: AAH58928.1
M55522 Genomic DNA Translation: AAA83399.1
AJ421875, AJ421876 Genomic DNA Translation: CAD19098.2
AJ426050 Genomic DNA Translation: CAD19802.1
AJ427985 AJ427988 Genomic DNA Translation: CAD20931.1
CCDSiCCDS10356.1
PIRiA30325
RefSeqiNP_001141.2, NM_001150.2
XP_005254949.1, XM_005254892.4
XP_011519775.1, XM_011521473.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FYQX-ray1.90A66-967[»]
4FYRX-ray1.91A66-967[»]
4FYSX-ray2.01A66-967[»]
4FYTX-ray1.85A66-967[»]
5LHDX-ray2.60A/B/C/D36-967[»]
6ATKX-ray3.50A/B/C66-967[»]
6U7EX-ray3.00A/B66-967[»]
6U7FX-ray2.75A/B66-967[»]
6U7GX-ray2.35A/B66-967[»]
SMRiP15144
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106787, 7 interactors
IntActiP15144, 12 interactors
MINTiP15144
STRINGi9606.ENSP00000300060

Chemistry databases

BindingDBiP15144
ChEMBLiCHEMBL1907
DrugBankiDB00973, Ezetimibe
DB06773, Human calcitonin
DB06196, Icatibant
DrugCentraliP15144
GuidetoPHARMACOLOGYi1560

Protein family/group databases

MEROPSiM01.001

PTM databases

GlyConnecti815, 35 N-Linked glycans (6 sites)
GlyGeniP15144, 17 sites, 9 N-linked glycans (5 sites), 7 O-linked glycans (4 sites)
iPTMnetiP15144
MetOSiteiP15144
PhosphoSitePlusiP15144
SwissPalmiP15144
UniCarbKBiP15144

Polymorphism and mutation databases

BioMutaiANPEP
DMDMi143811362

Proteomic databases

CPTACiCPTAC-460
CPTAC-461
EPDiP15144
jPOSTiP15144
MassIVEiP15144
MaxQBiP15144
PaxDbiP15144
PeptideAtlasiP15144
PRIDEiP15144
ProteomicsDBi53109

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P15144, 5 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3713, 1872 antibodies

The DNASU plasmid repository

More...
DNASUi
290

Genome annotation databases

EnsembliENST00000300060; ENSP00000300060; ENSG00000166825
GeneIDi290
KEGGihsa:290
UCSCiuc002bop.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
290
DisGeNETi290
EuPathDBiHostDB:ENSG00000166825.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ANPEP
HGNCiHGNC:500, ANPEP
HPAiENSG00000166825, Tissue enhanced (intestine, kidney, pancreas)
MIMi151530, gene
neXtProtiNX_P15144
OpenTargetsiENSG00000166825
PharmGKBiPA24815

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1046, Eukaryota
GeneTreeiENSGT00940000154876
HOGENOMiCLU_003705_2_0_1
InParanoidiP15144
KOiK11140
OMAiTAKWFIF
OrthoDBi110058at2759
PhylomeDBiP15144
TreeFamiTF300395

Enzyme and pathway databases

BRENDAi3.4.11.2, 2681
PathwayCommonsiP15144
ReactomeiR-HSA-2022377, Metabolism of Angiotensinogen to Angiotensins
R-HSA-6798695, Neutrophil degranulation
SABIO-RKiP15144
SIGNORiP15144

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
290, 0 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ANPEP, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Alanine_aminopeptidase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
290
PharosiP15144, Tchem

Protein Ontology

More...
PROi
PR:P15144
RNActiP15144, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166825, Expressed in intestine and 193 other tissues
ExpressionAtlasiP15144, baseline and differential
GenevisibleiP15144, HS

Family and domain databases

CDDicd09601, M1_APN-Q_like, 1 hit
Gene3Di2.60.40.1730, 1 hit
InterProiView protein in InterPro
IPR042097, Aminopeptidase_N-like_N
IPR024571, ERAP1-like_C_dom
IPR034016, M1_APN-typ
IPR001930, Peptidase_M1
IPR014782, Peptidase_M1_dom
PfamiView protein in Pfam
PF11838, ERAP1_C, 1 hit
PF01433, Peptidase_M1, 1 hit
PRINTSiPR00756, ALADIPTASE
SUPFAMiSSF63737, SSF63737, 1 hit
PROSITEiView protein in PROSITE
PS00142, ZINC_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMPN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15144
Secondary accession number(s): Q16728
, Q6GT90, Q8IUK3, Q8IVH3, Q9UCE0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 3, 2007
Last modified: October 7, 2020
This is version 227 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
  8. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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