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Protein

Cytochrome P450 4B1

Gene

Cyp4b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei315Heme (covalent; via 1 link)By similarity1
Metal bindingi453Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • aromatase activity Source: UniProtKB-EC
  • drug binding Source: RGD
  • fluorene oxygenase activity Source: RGD
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • monooxygenase activity Source: RGD
  • toxic substance binding Source: RGD

GO - Biological processi

  • biphenyl metabolic process Source: RGD
  • cellular aromatic compound metabolic process Source: RGD
  • exogenous drug catabolic process Source: RGD
  • fluorene metabolic process Source: RGD

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-211935 Fatty acids
R-RNO-211958 Miscellaneous substrates
R-RNO-211979 Eicosanoids
R-RNO-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4B1 (EC:1.14.14.1)
Alternative name(s):
CYPIVB1
Cytochrome P450 L-2
Cytochrome P450 isozyme 5
Gene namesi
Name:Cyp4b1
Synonyms:Cyp4b-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2480 Cyp4b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000518222 – 511Cytochrome P450 4B1Add BLAST510

Proteomic databases

PaxDbiP15129
PRIDEiP15129

PTM databases

iPTMnetiP15129
PhosphoSitePlusiP15129

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSRNOG00000055078
GenevisibleiP15129 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013321

Structurei

3D structure databases

ProteinModelPortaliP15129
SMRiP15129
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140829
HOGENOMiHOG000233833
HOVERGENiHBG000182
InParanoidiP15129
KOiK07426
OMAiQEHLVKH
OrthoDBiEOG091G06KN
PhylomeDBiP15129

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15129-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLNFLSPSL SRLGLWASVV ILMVIVLKLF SLLLRRQKLA RAMDSFPGPP
60 70 80 90 100
THWLFGHALE IQKLGSLDKV VSWAQQFPHA HPLWFGQFVG FLNIYEPDYA
110 120 130 140 150
KAVYSRGDPK AADVYDFFLQ WIGKGLLVLD GPKWFQHRKL LTPGFHYDVL
160 170 180 190 200
KPYVAIFAES TRMMLDKWEK KASENKSFDI FCDVGHMALD TLMKCTFGKG
210 220 230 240 250
DSGLGHRDNS YYLAVSDLTL LMQQRIDSFQ YHNDFIYWLT PHGRRFLRAC
260 270 280 290 300
KIAHDHTDEV IRQRKAALQD EKERKKIQQR RHLDFLDILL GVRDESGIKL
310 320 330 340 350
SDAELRAEVD TFMFEGHDTT TSGISWFLYC MALYPEHQQL CREEVRGILG
360 370 380 390 400
DQDSFQWDDL AKMTYLTMCM KECFRLYPPV PQVYRQLNKP VTFVDGRSLP
410 420 430 440 450
AGSLISLHIY ALHRNSTVWP DPEVFDPLRF SPENAAGRHP FAFMPFSAGP
460 470 480 490 500
RNCIGQQFAM NEMKVVTALC LLRFEFSLDP SKMPIKVPQL ILRSKNGIHL
510
YLKPLASRSG K
Length:511
Mass (Da):58,936
Last modified:January 23, 2007 - v3
Checksum:iCEAAFB5BE2ED9944
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29853 mRNA Translation: AAA41778.1
BC074012 mRNA Translation: AAH74012.1
PIRiB40164
RefSeqiNP_058695.2, NM_016999.2
UniGeneiRn.86651

Genome annotation databases

EnsembliENSRNOT00000013321; ENSRNOP00000013321; ENSRNOG00000055078
GeneIDi24307
KEGGirno:24307
UCSCiRGD:2480 rat

Similar proteinsi

Entry informationi

Entry nameiCP4B1_RAT
AccessioniPrimary (citable) accession number: P15129
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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