Cadherin-2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• alpha-catenin binding Source: MGI
• beta-catenin binding Source: MGI
• cadherin binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• calcium ion binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.20

    "Structure-function analysis of cell adhesion by neural (N-) cadherin."
    Tamura K., Shan W.S., Hendrickson W.A., Colman D.R., Shapiro L.
    Neuron 20:1153-1163(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (3.40 ANGSTROMS) OF 160-374 IN COMPLEX WITH CALCIUM, FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF TRP-161; VAL-162; ALA-237 AND ALA-239.
• enzyme binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.15

    "MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin."
    Porlan E., Marti-Prado B., Morante-Redolat J.M., Consiglio A., Delgado A.C., Kypta R., Lopez-Otin C., Kirstein M., Farinas I.
    Nat. Cell Biol. 16:629-638(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, PROTEOLYTIC PROCESSING.
• gamma-catenin binding Source: MGI
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "Two-step adhesive binding by classical cadherins."
    Harrison O.J., Bahna F., Katsamba P.S., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll K.J., Price S.R., Honig B., Shapiro L.
    Nat Struct Mol Biol 17:348-357(2010) [PubMed] [Europe PMC] [Abstract]
  • Ref.21

    "The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins."
    Harrison O.J., Jin X., Hong S., Bahna F., Ahlsen G., Brasch J., Wu Y., Vendome J., Felsovalyi K., Hampton C.M., Troyanovsky R.B., Ben-Shaul A., Frank J., Troyanovsky S.M., Shapiro L., Honig B.
    Structure 19:244-256(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 160-712 IN COMPLEX WITH CALCIUM, SUBUNIT, DOMAIN, GLYCOSYLATION ON SER AND THR RESIDUES, GLYCOSYLATION AT ASN-273; ASN-325; ASN-402; ASN-572 AND ASN-651.
  • "Molecular design principles underlying beta-strand swapping in the adhesive dimerization of cadherins."
    Vendome J., Posy S., Jin X., Bahna F., Ahlsen G., Shapiro L., Honig B.
    Nat Struct Mol Biol 18:693-700(2011) [PubMed] [Europe PMC] [Abstract]
• nitric-oxide synthase binding Source: MGI
• protein-containing complex binding Source: MGI
• protein kinase binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.12

    "The kinase domains of obscurin interact with intercellular adhesion proteins."
    Hu L.Y., Kontrogianni-Konstantopoulos A.
    FASEB J. 27:2001-2012(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH OBSCN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION.
• protein phosphatase binding Source: UniProtKBInferred from physical interactionⁱ
  • "Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT)."
    Besco J.A., Hooft van Huijsduijnen R., Frostholm A., Rotter A.
    Brain Res 1116:50-57(2006) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• blood vessel morphogenesis Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis."
    Luo Y., Radice G.L.
    J Cell Biol 169:29-34(2005) [PubMed] [Europe PMC] [Abstract]
• brain development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• brain morphogenesis Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon."
    Gil-Sanz C., Landeira B., Ramos C., Costa M.R., Muller U.
    J Neurosci 34:10475-10487(2014) [PubMed] [Europe PMC] [Abstract]
• calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGIInferred from direct assayⁱ
  • "N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways."
    Guo H.B., Lee I., Kamar M., Pierce M.
    J. Biol. Chem. 278:52412-52424(2003) [PubMed] [Europe PMC] [Abstract]
• cell adhesion Source: MGIInferred from direct assayⁱ
  • "Beating is necessary for transdifferentiation of skeletal muscle-derived cells into cardiomyocytes."
    Iijima Y., Nagai T., Mizukami M., Matsuura K., Ogura T., Wada H., Toko H., Akazawa H., Takano H., Nakaya H., Komuro I.
    FASEB J 17:1361-1363(2003) [PubMed] [Europe PMC] [Abstract]
  • "Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways."
    Gavard J., Lambert M., Grosheva I., Marthiens V., Irinopoulou T., Riou J.F., Bershadsky A., Mege R.M.
    J Cell Sci 117:257-270(2004) [PubMed] [Europe PMC] [Abstract]
• cell-cell adhesion Source: UniProtKBInferred from direct assayⁱ
  • Ref.20

    "Structure-function analysis of cell adhesion by neural (N-) cadherin."
    Tamura K., Shan W.S., Hendrickson W.A., Colman D.R., Shapiro L.
    Neuron 20:1153-1163(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (3.40 ANGSTROMS) OF 160-374 IN COMPLEX WITH CALCIUM, FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF TRP-161; VAL-162; ALA-237 AND ALA-239.
• cell-cell adhesion mediated by cadherin Source: UniProtKBInferred from direct assayⁱ
  • Ref.15

    "MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin."
    Porlan E., Marti-Prado B., Morante-Redolat J.M., Consiglio A., Delgado A.C., Kypta R., Lopez-Otin C., Kirstein M., Farinas I.
    Nat. Cell Biol. 16:629-638(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, PROTEOLYTIC PROCESSING.
• cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell-cell junction assembly Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.17

    "Knock-down of ZBED6 in insulin-producing cells promotes N-cadherin junctions between beta-cells and neural crest stem cells in vitro."
    Wang X., Xie B., Qi Y., Wallerman O., Vasylovska S., Andersson L., Kozlova E.N., Welsh N.
    Sci. Rep. 6:19006-19006(2016) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION.
• cell migration Source: MGIInferred from direct assayⁱ
  • "N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways."
    Guo H.B., Lee I., Kamar M., Pierce M.
    J. Biol. Chem. 278:52412-52424(2003) [PubMed] [Europe PMC] [Abstract]
• cerebral cortex development Source: MGIInferred from genetic interactionⁱ
  • "Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon."
    Gil-Sanz C., Landeira B., Ramos C., Costa M.R., Muller U.
    J Neurosci 34:10475-10487(2014) [PubMed] [Europe PMC] [Abstract]
• glial cell differentiation Source: UniProtKBInferred from direct assayⁱ
  • Ref.15

    "MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin."
    Porlan E., Marti-Prado B., Morante-Redolat J.M., Consiglio A., Delgado A.C., Kypta R., Lopez-Otin C., Kirstein M., Farinas I.
    Nat. Cell Biol. 16:629-638(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, PROTEOLYTIC PROCESSING.
• heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGIInferred from direct assayⁱ
  • "Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene."
    Matsunami H., Miyatani S., Inoue T., Copeland N.G., Gilbert D., Jenkins N.A., Takeichi M.
    J. Cell Sci. 106:401-409(1993) [PubMed] [Europe PMC] [Abstract]
• homeostasis of number of cells Source: MGIInferred from genetic interactionⁱ
  • "Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon."
    Gil-Sanz C., Landeira B., Ramos C., Costa M.R., Muller U.
    J Neurosci 34:10475-10487(2014) [PubMed] [Europe PMC] [Abstract]
• homophilic cell adhesion via plasma membrane adhesion molecules Source: MGIInferred from direct assayⁱ
  • "N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways."
    Guo H.B., Lee I., Kamar M., Pierce M.
    J. Biol. Chem. 278:52412-52424(2003) [PubMed] [Europe PMC] [Abstract]
  • "Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene."
    Matsunami H., Miyatani S., Inoue T., Copeland N.G., Gilbert D., Jenkins N.A., Takeichi M.
    J. Cell Sci. 106:401-409(1993) [PubMed] [Europe PMC] [Abstract]
• mesenchymal cell migration Source: MGIInferred from mutant phenotypeⁱ
  • "E-cadherin inhibits cell surface localization of the pro-migratory 5T4 oncofetal antigen in mouse embryonic stem cells."
    Spencer H.L., Eastham A.M., Merry C.L., Southgate T.D., Perez-Campo F., Soncin F., Ritson S., Kemler R., Stern P.L., Ward C.M.
    Mol Biol Cell 18:2838-2851(2007) [PubMed] [Europe PMC] [Abstract]
• modulation of chemical synaptic transmission Source: MGI
• negative regulation of canonical Wnt signaling pathway Source: MGIInferred from genetic interactionⁱ
  • "N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation."
    Hay E., Laplantine E., Geoffroy V., Frain M., Kohler T., Muller R., Marie P.J.
    Mol Cell Biol 29:953-964(2009) [PubMed] [Europe PMC] [Abstract]
• neural crest cell development Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.17

    "Knock-down of ZBED6 in insulin-producing cells promotes N-cadherin junctions between beta-cells and neural crest stem cells in vitro."
    Wang X., Xie B., Qi Y., Wallerman O., Vasylovska S., Andersson L., Kozlova E.N., Welsh N.
    Sci. Rep. 6:19006-19006(2016) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION.
• neuroepithelial cell differentiation Source: MGIInferred from genetic interactionⁱ
  • "Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon."
    Gil-Sanz C., Landeira B., Ramos C., Costa M.R., Muller U.
    J Neurosci 34:10475-10487(2014) [PubMed] [Europe PMC] [Abstract]
• neuroligin clustering involved in postsynaptic membrane assembly Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation."
    Stan A., Pielarski K.N., Brigadski T., Wittenmayer N., Fedorchenko O., Gohla A., Lessmann V., Dresbach T., Gottmann K.
    Proc Natl Acad Sci U S A 107:11116-11121(2010) [PubMed] [Europe PMC] [Abstract]
• neuronal stem cell population maintenance Source: UniProtKBInferred from direct assayⁱ
  • Ref.15

    "MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin."
    Porlan E., Marti-Prado B., Morante-Redolat J.M., Consiglio A., Delgado A.C., Kypta R., Lopez-Otin C., Kirstein M., Farinas I.
    Nat. Cell Biol. 16:629-638(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, PROTEOLYTIC PROCESSING.
• positive regulation of MAPK cascade Source: MGIInferred from genetic interactionⁱ
  • "N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts."
    Lu M., Krauss R.S.
    Proc Natl Acad Sci U S A 107:4212-4217(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of synaptic vesicle clustering Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation."
    Stan A., Pielarski K.N., Brigadski T., Wittenmayer N., Fedorchenko O., Gohla A., Lessmann V., Dresbach T., Gottmann K.
    Proc Natl Acad Sci U S A 107:11116-11121(2010) [PubMed] [Europe PMC] [Abstract]
• protein localization to plasma membrane Source: UniProtKBInferred from direct assayⁱ
  • "Flotillin microdomains stabilize cadherins at cell-cell junctions."
    Guillaume E., Comunale F., Do Khoa N., Planchon D., Bodin S., Gauthier-Rouviere C.
    J Cell Sci 126:5293-5304(2013) [PubMed] [Europe PMC] [Abstract]
• radial glial cell differentiation Source: MGIInferred from genetic interactionⁱ
  • "Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon."
    Gil-Sanz C., Landeira B., Ramos C., Costa M.R., Muller U.
    J Neurosci 34:10475-10487(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of axonogenesis Source: MGI
• regulation of myelination Source: MGI
• regulation of oligodendrocyte progenitor proliferation Source: MGIInferred from genetic interactionⁱ
  • "Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon."
    Gil-Sanz C., Landeira B., Ramos C., Costa M.R., Muller U.
    J Neurosci 34:10475-10487(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of postsynaptic density protein 95 clustering Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation."
    Stan A., Pielarski K.N., Brigadski T., Wittenmayer N., Fedorchenko O., Gohla A., Lessmann V., Dresbach T., Gottmann K.
    Proc Natl Acad Sci U S A 107:11116-11121(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of protein localization Source: MGI
• regulation of Rho protein signal transduction Source: MGI
• regulation of synaptic transmission, glutamatergic Source: MGI
• striated muscle cell differentiation Source: MGIInferred from genetic interactionⁱ
  • "N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts."
    Lu M., Krauss R.S.
    Proc Natl Acad Sci U S A 107:4212-4217(2010) [PubMed] [Europe PMC] [Abstract]
• synapse assembly Source: MGI
• telencephalon development Source: MGIInferred from genetic interactionⁱ
  • "Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon."
    Gil-Sanz C., Landeira B., Ramos C., Costa M.R., Muller U.
    J Neurosci 34:10475-10487(2014) [PubMed] [Europe PMC] [Abstract]
• type B pancreatic cell development Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.17

    "Knock-down of ZBED6 in insulin-producing cells promotes N-cadherin junctions between beta-cells and neural crest stem cells in vitro."
    Wang X., Xie B., Qi Y., Wallerman O., Vasylovska S., Andersson L., Kozlova E.N., Welsh N.
    Sci. Rep. 6:19006-19006(2016) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• alpha-catenin binding Source: MGI
• beta-catenin binding Source: MGI
• cadherin binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• enzyme binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.15

    "MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin."
    Porlan E., Marti-Prado B., Morante-Redolat J.M., Consiglio A., Delgado A.C., Kypta R., Lopez-Otin C., Kirstein M., Farinas I.
    Nat. Cell Biol. 16:629-638(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, PROTEOLYTIC PROCESSING.
• gamma-catenin binding Source: MGI
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "Two-step adhesive binding by classical cadherins."
    Harrison O.J., Bahna F., Katsamba P.S., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll K.J., Price S.R., Honig B., Shapiro L.
    Nat Struct Mol Biol 17:348-357(2010) [PubMed] [Europe PMC] [Abstract]
  • Ref.21

    "The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins."
    Harrison O.J., Jin X., Hong S., Bahna F., Ahlsen G., Brasch J., Wu Y., Vendome J., Felsovalyi K., Hampton C.M., Troyanovsky R.B., Ben-Shaul A., Frank J., Troyanovsky S.M., Shapiro L., Honig B.
    Structure 19:244-256(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 160-712 IN COMPLEX WITH CALCIUM, SUBUNIT, DOMAIN, GLYCOSYLATION ON SER AND THR RESIDUES, GLYCOSYLATION AT ASN-273; ASN-325; ASN-402; ASN-572 AND ASN-651.
  • "Molecular design principles underlying beta-strand swapping in the adhesive dimerization of cadherins."
    Vendome J., Posy S., Jin X., Bahna F., Ahlsen G., Shapiro L., Honig B.
    Nat Struct Mol Biol 18:693-700(2011) [PubMed] [Europe PMC] [Abstract]
• nitric-oxide synthase binding Source: MGI
• protein kinase binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.12

    "The kinase domains of obscurin interact with intercellular adhesion proteins."
    Hu L.Y., Kontrogianni-Konstantopoulos A.
    FASEB J. 27:2001-2012(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH OBSCN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION.
• protein phosphatase binding Source: UniProtKBInferred from physical interactionⁱ
  • "Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT)."
    Besco J.A., Hooft van Huijsduijnen R., Frostholm A., Rotter A.
    Brain Res 1116:50-57(2006) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MCRIAGAPRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLPKDVH 
        60         70         80         90        100
EGQPLLNVKF SNCNRKRKVQ YESSEPADFK VDEDGTVYAV RSFPLTAEQA 
       110        120        130        140        150
KFLIYAQDKE TQEKWQVAVN LSREPTLTEE PMKEPHEIEE IVFPRQLAKH 
       160        170        180        190        200
SGALQRQKRD WVIPPINLPE NSRGPFPQEL VRIRSDRDKN LSLRYSVTGP 
       210        220        230        240        250
GADQPPTGIF IINPISGQLS VTKPLDRELI ARFHLRAHAV DINGNQVENP 
       260        270        280        290        300
IDIVINVIDM NDNRPEFLHQ VWNGSVPEGS KPGTYVMTVT AIDADDPNAL 
       310        320        330        340        350
NGMLRYRILS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ 
       360        370        380        390        400
ATDMEGNPTY GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDVIV 
       410        420        430        440        450
ANLTVTDKDQ PHTPAWNAAY RISGGDPTGR FAILTDPNSN DGLVTVVKPI 
       460        470        480        490        500
DFETNRMFVL TVAAENQVPL AKGIQHPPQS TATVSVTVID VNENPYFAPN 
       510        520        530        540        550
PKIIRQEEGL HAGTMLTTLT AQDPDRYMQQ NIRYTKLSDP ANWLKIDPVN 
       560        570        580        590        600
GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 
       610        620        630        640        650
NAPQVLPQEA ETCETPEPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR 
       660        670        680        690        700
NWTINRLNGD FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV 
       710        720        730        740        750
CQCDSNGDCT DVDRIVGAGL GTGAIIAILL CIIILLILVL MFVVWMKRRD 
       760        770        780        790        800
KERQAKQLLI DPEDDVRDNI LKYDEEGGGE EDQDYDLSQL QQPDTVEPDA 
       810        820        830        840        850
IKPVGIRRLD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL KAADNDPTAP 
       860        870        880        890        900
PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG DQDYDYLNDW GPRFKKLADM 

YGGGDD                                                 

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity