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Protein

Metallothionein-2

Gene

MT-II

more
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The metallothioneins are involved in the cellular sequestration of toxic metal ions.

Miscellaneous

MT-II might bind nearly 10 mol eq of Cu+.

GO - Molecular functioni

  • copper ion binding Source: CGD

GO - Biological processi

Keywordsi

LigandCopper, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2
Short name:
MT-2
Alternative name(s):
Metallothionein-II
Short name:
MT-II
Cleaved into the following chain:
Metallothionein-2'
Short name:
MT-2'
Alternative name(s):
Metallothionein-II'
Short name:
MT-II'
Gene namesi
Name:MT-II
Ordered Locus Names:CAGL0H04257g
AND
Name:MT-IIB
Ordered Locus Names:CAGL0H04279g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome H

Organism-specific databases

CGDiCAL0135114 CAGL0L01831g
CAL0131544 MT-II
CAL0129811 MT-IIB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000458872 – 52Metallothionein-2Add BLAST51
ChainiPRO_00000458888 – 52Metallothionein-2'Add BLAST45

Expressioni

Inductioni

Both MT-I and MT-II genes are regulated by copper ion in a concentration-dependent fashion, and both are inducible by silver but not by cadmium salts.

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_002999586.1

Structurei

3D structure databases

SMRiP15114
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 475
Repeati48 – 525

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

OMAiCACENTC

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15114-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEQVNCQYD CHCSNCACEN TCNCCAKPAC ACTNSASNEC SCQTCKCQTC

KC
Length:52
Mass (Da):5,585
Last modified:January 23, 2007 - v2
Checksum:iABD19E284CC34D22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05134 Genomic DNA Translation: AAA35273.1
J05398 Genomic DNA Translation: AAA35274.1
M86727 Genomic DNA Translation: AAA35275.1
CR380954 Genomic DNA Translation: CAG59913.1
CR380954 Genomic DNA Translation: CAG59914.1
PIRiB31252
JC1197
RefSeqiXP_002999586.1, XM_002999540.1
XP_446980.1, XM_446980.1
XP_446981.1, XM_446981.1

Genome annotation databases

EnsemblFungiiCAG59913; CAG59913; CAGL0H04257g
CAG59914; CAG59914; CAGL0H04279g
GeneIDi2888780
2888781
9488054
KEGGicgr:CAGL0H04257g
cgr:CAGL0H04279g
cgr:CAGL0L01831g

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05134 Genomic DNA Translation: AAA35273.1
J05398 Genomic DNA Translation: AAA35274.1
M86727 Genomic DNA Translation: AAA35275.1
CR380954 Genomic DNA Translation: CAG59913.1
CR380954 Genomic DNA Translation: CAG59914.1
PIRiB31252
JC1197
RefSeqiXP_002999586.1, XM_002999540.1
XP_446980.1, XM_446980.1
XP_446981.1, XM_446981.1

3D structure databases

SMRiP15114
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284593.XP_002999586.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG59913; CAG59913; CAGL0H04257g
CAG59914; CAG59914; CAGL0H04279g
GeneIDi2888780
2888781
9488054
KEGGicgr:CAGL0H04257g
cgr:CAGL0H04279g
cgr:CAGL0L01831g

Organism-specific databases

CGDiCAL0135114 CAGL0L01831g
CAL0131544 MT-II
CAL0129811 MT-IIB

Phylogenomic databases

OMAiCACENTC

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiMT2_CANGA
AccessioniPrimary (citable) accession number: P15114
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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