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Protein

Metallothionein-1

Gene

MT-I

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The metallothioneins are involved in the cellular sequestration of toxic metal ions.

Miscellaneous

MT-I might bind approximately 11-12 mol eq of Cu+.

GO - Molecular functioni

  • copper ion binding Source: CGD

GO - Biological processi

Keywordsi

LigandCopper, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Short name:
MT-1
Alternative name(s):
Metallothionein-I
Short name:
MT-I
Gene namesi
Name:MT-I
Ordered Locus Names:CAGL0D01265g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome D

Organism-specific databases

CGDiCAL0128003 MT-I
EuPathDBiFungiDB:CAGL0D01265g

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001973652 – 63Metallothionein-1Add BLAST62

Proteomic databases

PRIDEiP15113

Expressioni

Inductioni

Both MT-I and MT-II genes are regulated by copper ion in a concentration-dependent fashion, and both are inducible by silver but not by cadmium salts.

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_002999527.1

Structurei

3D structure databases

ProteinModelPortaliP15113
SMRiP15113
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 308
Repeati56 – 638

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

OrthoDBiEOG092C5SLR

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15113-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANDCKCPNG CSCPNCANGG CQCGDKCECK KQSCHGCGEQ CKCGSHGSSC
60
HGSCGCGDKC ECK
Length:63
Mass (Da):6,374
Last modified:January 23, 2007 - v2
Checksum:i80B1FE306C44BAEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05133 Genomic DNA Translation: AAA35272.1
CR380950 Genomic DNA Translation: CAR58010.1
PIRiA31252
A34484
RefSeqiXP_002999527.1, XM_002999481.1

Genome annotation databases

EnsemblFungiiCAR58010; CAR58010; CAGL0D01265g
GeneIDi9487975
KEGGicgr:CAGL0D01265g

Similar proteinsi

Entry informationi

Entry nameiMT1_CANGA
AccessioniPrimary (citable) accession number: P15113
Secondary accession number(s): B4UMY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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