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UniProtKB - P15101 (DOPO_BOVIN)

Entry version 160 (05 Jun 2019)
Sequence version 2 (02 Oct 2007)
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Protein

Dopamine beta-hydroxylase

Gene

DBH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Conversion of dopamine to noradrenaline.1 Publication

Caution

Contrary to earlier results, does not contain a pyrroloquinoline quinone (PQQ) cofactor.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Cu2+2 PublicationsNote: Binds 2 copper ions per subunit.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: (R)-noradrenaline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-noradrenaline from dopamine.1 Publication
Proteins known to be involved in this subpathway in this organism are:
  1. Dopamine beta-hydroxylase (DBH)
This subpathway is part of the pathway (R)-noradrenaline biosynthesis, which is itself part of Catecholamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-noradrenaline from dopamine, the pathway (R)-noradrenaline biosynthesis and in Catecholamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei223Sequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi255Copper ABy similarity1
Metal bindingi256Copper ABy similarity1
Metal bindingi326Copper ABy similarity1
Active sitei405Sequence analysis1
Metal bindingi405Copper BBy similarity1
Metal bindingi407Copper BBy similarity1
Metal bindingi480Copper BBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processCatecholamine biosynthesis
LigandCopper, Metal-binding, Vitamin C

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-BTA-209905 Catecholamine biosynthesis

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P15101

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00748;UER00735

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dopamine beta-hydroxylase (EC:1.14.17.12 Publications)
Alternative name(s):
Dopamine beta-monooxygenase
Cleaved into the following chain:
Soluble dopamine beta-hydroxylase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DBH
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9CytoplasmicSequence analysis9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini31 – 610IntragranularSequence analysisAdd BLAST580

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4702

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000063551 – 610Dopamine beta-hydroxylaseAdd BLAST610
ChainiPRO_000030820633 – 610Soluble dopamine beta-hydroxylase1 PublicationAdd BLAST578

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi147 ↔ 5891 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi177N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi225 ↔ 2761 Publication
Disulfide bondi262 ↔ 2881 Publication
Disulfide bondi383 ↔ 4961 Publication
Disulfide bondi387 ↔ 5581 Publication
Disulfide bondi459 ↔ 4811 Publication
Disulfide bondi521Interchain1 Publication
Disulfide bondi523Interchain1 Publication
Glycosylationi559N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form.1 Publication
N-glycosylated.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei32 – 33Cleavage3 Publications2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P15101

PRoteomics IDEntifications database

More...PRIDEi		P15101

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P15101

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in chromaffin granules in the adrenal medulla (at protein level) (PubMed:2620060, PubMed:843373, PubMed:4525162). Detected in adrenal medulla (PubMed:2620060).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSBTAG00000004508 Expressed in 2 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P15101 differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer; composed of two disulfide-linked dimers.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		158157, 1 interactor

STRING: functional protein association networks

More...STRINGi		9913.ENSBTAP00000005924

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P15101

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P15101

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 166DOMONPROSITE-ProRule annotationAdd BLAST117

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the copper type II ascorbate-dependent monooxygenase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3568 Eukaryota
ENOG410XR89 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000063669

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P15101

KEGG Orthology (KO)

More...KOi		K00503

Identification of Orthologs from Complete Genome Data

More...OMAi		MYEPIVT

Database of Orthologous Groups

More...OrthoDBi		1472750at2759

TreeFam database of animal gene trees

More...TreeFami		TF320698

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.230, 1 hit
2.60.120.310, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR014784 Cu2_ascorb_mOase-like_C
IPR020611 Cu2_ascorb_mOase_CS-1
IPR014783 Cu2_ascorb_mOase_CS-2
IPR000323 Cu2_ascorb_mOase_N
IPR036939 Cu2_ascorb_mOase_N_sf
IPR024548 Cu2_monoox_C
IPR005018 DOMON_domain
IPR008977 PHM/PNGase_F_dom_sf
IPR028460 Tbh/DBH

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03712 Cu2_monoox_C, 1 hit
PF01082 Cu2_monooxygen, 1 hit
PF03351 DOMON, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00767 DBMONOXGNASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00664 DoH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49742 SSF49742, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00084 CU2_MONOOXYGENASE_1, 1 hit
PS00085 CU2_MONOOXYGENASE_2, 1 hit
PS50836 DOMON, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P15101-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQVPSPSVRE AASMYGTAVA VFLVILVAAL QGSAPAESPF PFHIPLDPEG 
        60         70         80         90        100
TLELSWNISY AQETIYFQLL VRELKAGVLF GMSDRGELEN ADLVVLWTDR 
       110        120        130        140        150
DGAYFGDAWS DQKGQVHLDS QQDYQLLRAQ RTPEGLYLLF KRPFGTCDPN 
       160        170        180        190        200
DYLIEDGTVH LVYGFLEEPL RSLESINTSG LHTGLQRVQL LKPSIPKPAL 
       210        220        230        240        250
PADTRTMEIR APDVLIPGQQ TTYWCYVTEL PDGFPRHHIV MYEPIVTEGN 
       260        270        280        290        300
EALVHHMEVF QCAAEFETIP HFSGPCDSKM KPQRLNFCRH VLAAWALGAK 
       310        320        330        340        350
AFYYPEEAGL AFGGPGSSRF LRLEVHYHNP LVITGRRDSS GIRLYYTAAL 
       360        370        380        390        400
RRFDAGIMEL GLAYTPVMAI PPQETAFVLT GYCTDKCTQL ALPASGIHIF 
       410        420        430        440        450
ASQLHTHLTG RKVVTVLARD GRETEIVNRD NHYSPHFQEI RMLKKVVSVQ 
       460        470        480        490        500
PGDVLITSCT YNTEDRRLAT VGGFGILEEM CVNYVHYYPQ TQLELCKSAV 
       510        520        530        540        550
DPGFLHKYFR LVNRFNSEEV CTCPQASVPE QFASVPWNSF NREVLKALYG 
       560        570        580        590        600
FAPISMHCNR SSAVRFQGEW NRQPLPEIVS RLEEPTPHCP ASQAQSPAGP 
       610
TVLNISGGKG
Length:610
Mass (Da):68,141
Last modified:October 2, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i709D23860617CD3A
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA30490 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti35P → T AA sequence (PubMed:843373).Curated1
Sequence conflicti40F → S in AAD09829 (PubMed:1693949).Curated1
Sequence conflicti48P → T AA sequence (PubMed:843373).Curated1
Sequence conflicti55 – 57SWN → RYV AA sequence (PubMed:2295597).Curated3
Sequence conflicti74L → F AA sequence (PubMed:2295597).Curated1
Sequence conflicti104Y → D in AAD09829 (PubMed:1693949).Curated1
Sequence conflicti205R → C in AAA30356 (PubMed:2620060).Curated1
Sequence conflicti215L → F in ABG81467 (PubMed:16305752).Curated1
Sequence conflicti267 – 269ETI → RDH in AAA30356 (PubMed:2620060).Curated3
Sequence conflicti349A → R in AAA30491 (PubMed:2207088).Curated1
Sequence conflicti376A → P in AAD09829 (PubMed:1693949).Curated1
Sequence conflicti560R → C AA sequence (PubMed:2295597).Curated1
Sequence conflicti566 – 567FQ → LE in AAD09829 (PubMed:1693949).Curated2
Sequence conflicti588H → Q in AAA30356 (PubMed:2620060).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J02890 mRNA Translation: AAA30356.1
J05160 mRNA Translation: AAA30490.1 Different initiation.
BT026311 mRNA Translation: ABG81467.1
AF118638 mRNA Translation: AAD09829.1
J02909 mRNA Translation: AAA30491.1

Protein sequence database of the Protein Information Resource

More...PIRi		A33650

NCBI Reference Sequences

More...RefSeqi		NP_851338.1, NM_180995.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		280758

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		bta:280758

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02890 mRNA Translation: AAA30356.1
J05160 mRNA Translation: AAA30490.1 Different initiation.
BT026311 mRNA Translation: ABG81467.1
AF118638 mRNA Translation: AAD09829.1
J02909 mRNA Translation: AAA30491.1
PIRiA33650
RefSeqiNP_851338.1, NM_180995.2

3D structure databases

SMRiP15101
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi158157, 1 interactor
STRINGi9913.ENSBTAP00000005924

Chemistry databases

BindingDBiP15101
ChEMBLiCHEMBL4702

PTM databases

iPTMnetiP15101

Proteomic databases

PaxDbiP15101
PRIDEiP15101

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280758
KEGGibta:280758

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1621

Phylogenomic databases

eggNOGiKOG3568 Eukaryota
ENOG410XR89 LUCA
HOGENOMiHOG000063669
InParanoidiP15101
KOiK00503
OMAiMYEPIVT
OrthoDBi1472750at2759
TreeFamiTF320698

Enzyme and pathway databases

UniPathwayiUPA00748;UER00735
ReactomeiR-BTA-209905 Catecholamine biosynthesis
SABIO-RKiP15101

Miscellaneous databases

Protein Ontology

More...PROi		PR:P15101

Gene expression databases

BgeeiENSBTAG00000004508 Expressed in 2 organ(s), highest expression level in brain
ExpressionAtlasiP15101 differential

Family and domain databases

Gene3Di2.60.120.230, 1 hit
2.60.120.310, 1 hit
InterProiView protein in InterPro
IPR014784 Cu2_ascorb_mOase-like_C
IPR020611 Cu2_ascorb_mOase_CS-1
IPR014783 Cu2_ascorb_mOase_CS-2
IPR000323 Cu2_ascorb_mOase_N
IPR036939 Cu2_ascorb_mOase_N_sf
IPR024548 Cu2_monoox_C
IPR005018 DOMON_domain
IPR008977 PHM/PNGase_F_dom_sf
IPR028460 Tbh/DBH
PfamiView protein in Pfam
PF03712 Cu2_monoox_C, 1 hit
PF01082 Cu2_monooxygen, 1 hit
PF03351 DOMON, 1 hit
PRINTSiPR00767 DBMONOXGNASE
SMARTiView protein in SMART
SM00664 DoH, 1 hit
SUPFAMiSSF49742 SSF49742, 2 hits
PROSITEiView protein in PROSITE
PS00084 CU2_MONOOXYGENASE_1, 1 hit
PS00085 CU2_MONOOXYGENASE_2, 1 hit
PS50836 DOMON, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOPO_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15101
Secondary accession number(s): Q0V8A8, Q28094, Q9TVD1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 2, 2007
Last modified: June 5, 2019
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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