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Protein

Fatty acid-binding protein, adipocyte

Gene

FABP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.By similarity

GO - Molecular functioni

  • fatty acid binding Source: ProtInc

GO - Biological processi

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-163560 Triglyceride catabolism
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SIGNORiP15090

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, adipocyte
Alternative name(s):
Adipocyte lipid-binding protein
Short name:
ALBP
Adipocyte-type fatty acid-binding protein
Short name:
A-FABP
Short name:
AFABP
Fatty acid-binding protein 4
Gene namesi
Name:FABP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000170323.8
HGNCiHGNC:3559 FABP4
MIMi600434 gene
neXtProtiNX_P15090

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2167
OpenTargetsiENSG00000170323
PharmGKBiPA27960

Chemistry databases

ChEMBLiCHEMBL2083
DrugBankiDB04474 1-Anilino-8-Naphthalene Sulfonate
DB02776 1-Hexadecanosulfonic Acid
DB03009 2-[(2-Oxo-2-Piperidin-1-Ylethyl)Thio]-6-(Trifluoromethyl)Pyrimidin-4(1h)-One
DB02153 3-Sulfinoalanine
DB04557 Arachidonic Acid
DB03851 Carbazole Butanoic Acid
DB04224 Oleic Acid
DB03796 Palmitic Acid
DB03766 Propanoic Acid
GuidetoPHARMACOLOGYi2534

Polymorphism and mutation databases

BioMutaiFABP4
DMDMi119781

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000673662 – 132Fatty acid-binding protein, adipocyteAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteineCombined sources1
Modified residuei13PhosphoserineBy similarity1
Modified residuei20Phosphotyrosine; by Tyr-kinasesBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP15090
PaxDbiP15090
PeptideAtlasiP15090
PRIDEiP15090
ProteomicsDBi53106

2D gel databases

UCD-2DPAGEiP15090

PTM databases

iPTMnetiP15090
PhosphoSitePlusiP15090
SwissPalmiP15090

Expressioni

Gene expression databases

BgeeiENSG00000170323
CleanExiHS_FABP4
ExpressionAtlasiP15090 baseline and differential
GenevisibleiP15090 HS

Organism-specific databases

HPAiCAB024961
HPA002188

Interactioni

Subunit structurei

Monomer (PubMed:15357969, PubMed:17077479). Homodimer. Interacts with PPARG (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi108465, 14 interactors
IntActiP15090, 8 interactors
MINTiP15090
STRINGi9606.ENSP00000256104

Chemistry databases

BindingDBiP15090

Structurei

Secondary structure

1132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 5Combined sources4
Beta strandi7 – 16Combined sources10
Helixi17 – 24Combined sources8
Helixi28 – 36Combined sources9
Beta strandi40 – 46Combined sources7
Beta strandi49 – 55Combined sources7
Beta strandi61 – 65Combined sources5
Beta strandi71 – 74Combined sources4
Beta strandi80 – 88Combined sources9
Beta strandi91 – 98Combined sources8
Beta strandi101 – 110Combined sources10
Beta strandi113 – 120Combined sources8
Beta strandi123 – 131Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TOUX-ray2.00A2-132[»]
1TOWX-ray2.00A2-132[»]
2HNXX-ray1.50A1-132[»]
2NNQX-ray1.80A2-132[»]
3FR2X-ray2.20A2-132[»]
3FR4X-ray2.16A1-132[»]
3FR5X-ray2.20A2-132[»]
3P6CX-ray1.25A1-132[»]
3P6DX-ray1.06A1-132[»]
3P6EX-ray1.08A1-132[»]
3P6FX-ray1.20A1-132[»]
3P6GX-ray1.20A1-132[»]
3P6HX-ray1.15A1-132[»]
3Q6LX-ray1.40A1-132[»]
3RZYX-ray1.08A1-132[»]
4NNSX-ray1.53A1-132[»]
4NNTX-ray1.53A1-132[»]
5D45X-ray1.65A1-132[»]
5D47X-ray1.70A1-132[»]
5D48X-ray1.81A1-132[»]
5D4AX-ray1.70A1-132[»]
5EDBX-ray1.18A1-132[»]
5EDCX-ray1.29A1-132[»]
5HZ6X-ray1.14A4-132[»]
5HZ8X-ray1.12A1-132[»]
ProteinModelPortaliP15090
SMRiP15090
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15090

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 129Fatty acid binding3

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi22 – 32Nuclear localization signalBy similarityAdd BLAST11

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004829
HOVERGENiHBG005633
InParanoidiP15090
KOiK08753
OMAiATRKMAG
OrthoDBiEOG091G0QSV
PhylomeDBiP15090
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR033073 FABP4
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF83 PTHR11955:SF83, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN MIISVNGDVI
60 70 80 90 100
TIKSESTFKN TEISFILGQE FDEVTADDRK VKSTITLDGG VLVHVQKWDG
110 120 130
KSTTIKRKRE DDKLVVECVM KGVTSTRVYE RA
Length:132
Mass (Da):14,719
Last modified:January 23, 2007 - v3
Checksum:i819D788FF4BF7235
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03632023E → D in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02874 mRNA Translation: AAA51689.1
BT006809 mRNA Translation: AAP35455.1
CR456903 mRNA Translation: CAG33184.1
CH471068 Genomic DNA Translation: EAW87092.1
BC003672 mRNA Translation: AAH03672.1
CCDSiCCDS6230.1
PIRiA33363 FZHUF
RefSeqiNP_001433.1, NM_001442.2
UniGeneiHs.391561

Genome annotation databases

EnsembliENST00000256104; ENSP00000256104; ENSG00000170323
GeneIDi2167
KEGGihsa:2167
UCSCiuc003ycd.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFABP4_HUMAN
AccessioniPrimary (citable) accession number: P15090
Secondary accession number(s): Q6IBA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 185 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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