UniProtKB - P15090 (FABP4_HUMAN)
Protein
Fatty acid-binding protein, adipocyte
Gene
FABP4
Organism
Homo sapiens (Human)
Status
Functioni
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.By similarity
GO - Molecular functioni
- fatty acid binding Source: ProtInc
- hormone receptor binding Source: Ensembl
- long-chain fatty acid binding Source: UniProtKB
- long-chain fatty acid transporter activity Source: UniProtKB
GO - Biological processi
- brown fat cell differentiation Source: Ensembl
- cellular response to lithium ion Source: Ensembl
- cellular response to tumor necrosis factor Source: Ensembl
- cholesterol homeostasis Source: Ensembl
- cytokine production Source: Ensembl
- long-chain fatty acid transport Source: UniProtKB
- negative regulation of protein kinase activity Source: Ensembl
- negative regulation of transcription, DNA-templated Source: Ensembl
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of inflammatory response Source: Ensembl
- response to bacterium Source: Ensembl
- triglyceride catabolic process Source: Reactome
- white fat cell differentiation Source: Ensembl
Keywordsi
Biological process | Transport |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | P15090 |
Reactomei | R-HSA-163560, Triglyceride catabolism R-HSA-381340, Transcriptional regulation of white adipocyte differentiation |
SIGNORi | P15090 |
Names & Taxonomyi
Protein namesi | Recommended name: Fatty acid-binding protein, adipocyteAlternative name(s): Adipocyte lipid-binding protein Short name: ALBP Adipocyte-type fatty acid-binding protein Short name: A-FABP Short name: AFABP Fatty acid-binding protein 4 |
Gene namesi | Name:FABP4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000170323.8 |
HGNCi | HGNC:3559, FABP4 |
MIMi | 600434, gene |
neXtProti | NX_P15090 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- lipid droplet Source: Reactome
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 2167 |
OpenTargetsi | ENSG00000170323 |
PharmGKBi | PA27960 |
Miscellaneous databases
Pharosi | P15090, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2083 |
DrugBanki | DB08607, (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE DB02776, 1-Hexadecanosulfonic Acid DB03009, 2-{[2-Oxo-2-(1-piperidinyl)ethyl]sulfanyl}-6-(trifluoromethyl)-4(1H)-pyrimidinone DB02153, 3-sulfino-L-alanine DB07945, 5-(3-carbamoylbenzyl)-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-4-carboxylic acid DB04474, 8-anilinonaphthalene-1-sulfonic acid DB07283, 9-benzyl-2,3,4,9-tetrahydro-1H-carbazole-8-carboxylic acid DB04557, Arachidonic Acid DB03851, Carbazole Butanoic Acid DB04437, Cysteine-Methylene-Carbamoyl-1,10-Phenanthroline DB04224, Oleic Acid DB03796, Palmitic Acid DB03766, Propanoic acid |
DrugCentrali | P15090 |
GuidetoPHARMACOLOGYi | 2534 |
Polymorphism and mutation databases
BioMutai | FABP4 |
DMDMi | 119781 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000067366 | 2 – 132 | Fatty acid-binding protein, adipocyteAdd BLAST | 131 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylcysteineCombined sources | 1 | |
Modified residuei | 13 | PhosphoserineBy similarity | 1 | |
Modified residuei | 20 | Phosphotyrosine; by Tyr-kinasesBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | P15090 |
MassIVEi | P15090 |
MaxQBi | P15090 |
PaxDbi | P15090 |
PeptideAtlasi | P15090 |
PRIDEi | P15090 |
ProteomicsDBi | 53106 |
2D gel databases
UCD-2DPAGEi | P15090 |
PTM databases
iPTMneti | P15090 |
PhosphoSitePlusi | P15090 |
SwissPalmi | P15090 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170323, Expressed in adipose tissue of abdominal region and 200 other tissues |
ExpressionAtlasi | P15090, baseline and differential |
Genevisiblei | P15090, HS |
Organism-specific databases
HPAi | ENSG00000170323, Group enriched (adipose tissue, breast) |
Interactioni
Subunit structurei
GO - Molecular functioni
- hormone receptor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 108465, 28 interactors |
IntActi | P15090, 10 interactors |
MINTi | P15090 |
STRINGi | 9606.ENSP00000256104 |
Chemistry databases
BindingDBi | P15090 |
Miscellaneous databases
RNActi | P15090, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P15090 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P15090 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 127 – 129 | Fatty acid binding | 3 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 22 – 32 | Nuclear localization signalBy similarityAdd BLAST | 11 |
Domaini
Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4015, Eukaryota |
GeneTreei | ENSGT00940000160340 |
HOGENOMi | CLU_113772_0_0_1 |
InParanoidi | P15090 |
OMAi | GQEFDEI |
OrthoDBi | 1417203at2759 |
PhylomeDBi | P15090 |
TreeFami | TF316894 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR033073, FABP4 IPR000463, Fatty_acid-bd IPR031259, ILBP IPR000566, Lipocln_cytosolic_FA-bd_dom |
PANTHERi | PTHR11955, PTHR11955, 1 hit PTHR11955:SF83, PTHR11955:SF83, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PRINTSi | PR00178, FATTYACIDBP |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00214, FABP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P15090-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN MIISVNGDVI
60 70 80 90 100
TIKSESTFKN TEISFILGQE FDEVTADDRK VKSTITLDGG VLVHVQKWDG
110 120 130
KSTTIKRKRE DDKLVVECVM KGVTSTRVYE RA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE5RIR0 | E5RIR0_HUMAN | Fatty acid-binding protein, adipocy... | FABP4 | 39 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036320 | 23 | E → D in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1319351179Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02874 mRNA Translation: AAA51689.1 BT006809 mRNA Translation: AAP35455.1 CR456903 mRNA Translation: CAG33184.1 CH471068 Genomic DNA Translation: EAW87092.1 BC003672 mRNA Translation: AAH03672.1 |
CCDSi | CCDS6230.1 |
PIRi | A33363, FZHUF |
RefSeqi | NP_001433.1, NM_001442.2 |
Genome annotation databases
Ensembli | ENST00000256104; ENSP00000256104; ENSG00000170323 |
GeneIDi | 2167 |
KEGGi | hsa:2167 |
UCSCi | uc003ycd.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02874 mRNA Translation: AAA51689.1 BT006809 mRNA Translation: AAP35455.1 CR456903 mRNA Translation: CAG33184.1 CH471068 Genomic DNA Translation: EAW87092.1 BC003672 mRNA Translation: AAH03672.1 |
CCDSi | CCDS6230.1 |
PIRi | A33363, FZHUF |
RefSeqi | NP_001433.1, NM_001442.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1TOU | X-ray | 2.00 | A | 2-132 | [»] | |
1TOW | X-ray | 2.00 | A | 2-132 | [»] | |
2HNX | X-ray | 1.50 | A | 1-132 | [»] | |
2NNQ | X-ray | 1.80 | A | 2-132 | [»] | |
3FR2 | X-ray | 2.20 | A | 2-132 | [»] | |
3FR4 | X-ray | 2.16 | A | 1-132 | [»] | |
3FR5 | X-ray | 2.20 | A | 2-132 | [»] | |
3P6C | X-ray | 1.25 | A | 1-132 | [»] | |
3P6D | X-ray | 1.06 | A | 1-132 | [»] | |
3P6E | X-ray | 1.08 | A | 1-132 | [»] | |
3P6F | X-ray | 1.20 | A | 1-132 | [»] | |
3P6G | X-ray | 1.20 | A | 1-132 | [»] | |
3P6H | X-ray | 1.15 | A | 1-132 | [»] | |
3Q6L | X-ray | 1.40 | A | 1-132 | [»] | |
3RZY | X-ray | 1.08 | A | 1-132 | [»] | |
4NNS | X-ray | 1.53 | A | 1-132 | [»] | |
4NNT | X-ray | 1.53 | A | 1-132 | [»] | |
5D45 | X-ray | 1.65 | A | 1-132 | [»] | |
5D47 | X-ray | 1.70 | A | 1-132 | [»] | |
5D48 | X-ray | 1.81 | A | 1-132 | [»] | |
5D4A | X-ray | 1.70 | A | 1-132 | [»] | |
5EDB | X-ray | 1.18 | A | 1-132 | [»] | |
5EDC | X-ray | 1.29 | A | 1-132 | [»] | |
5HZ6 | X-ray | 1.14 | A | 4-132 | [»] | |
5HZ8 | X-ray | 1.12 | A | 1-132 | [»] | |
5Y0F | X-ray | 1.54 | A | 1-132 | [»] | |
5Y0G | X-ray | 1.54 | A | 1-132 | [»] | |
5Y0X | X-ray | 1.60 | A | 1-132 | [»] | |
5Y12 | X-ray | 1.75 | A | 1-132 | [»] | |
5Y13 | X-ray | 1.75 | A | 1-132 | [»] | |
6AYL | X-ray | 1.86 | A | 1-132 | [»] | |
6LJS | X-ray | 1.75 | A | 1-132 | [»] | |
6LJT | X-ray | 1.45 | A | 1-132 | [»] | |
6LJU | X-ray | 1.50 | A | 1-132 | [»] | |
6LJV | X-ray | 1.40 | A | 1-132 | [»] | |
6LJW | X-ray | 1.40 | A | 1-132 | [»] | |
6LJX | X-ray | 1.75 | A | 1-132 | [»] | |
SMRi | P15090 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108465, 28 interactors |
IntActi | P15090, 10 interactors |
MINTi | P15090 |
STRINGi | 9606.ENSP00000256104 |
Chemistry databases
BindingDBi | P15090 |
ChEMBLi | CHEMBL2083 |
DrugBanki | DB08607, (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE DB02776, 1-Hexadecanosulfonic Acid DB03009, 2-{[2-Oxo-2-(1-piperidinyl)ethyl]sulfanyl}-6-(trifluoromethyl)-4(1H)-pyrimidinone DB02153, 3-sulfino-L-alanine DB07945, 5-(3-carbamoylbenzyl)-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-4-carboxylic acid DB04474, 8-anilinonaphthalene-1-sulfonic acid DB07283, 9-benzyl-2,3,4,9-tetrahydro-1H-carbazole-8-carboxylic acid DB04557, Arachidonic Acid DB03851, Carbazole Butanoic Acid DB04437, Cysteine-Methylene-Carbamoyl-1,10-Phenanthroline DB04224, Oleic Acid DB03796, Palmitic Acid DB03766, Propanoic acid |
DrugCentrali | P15090 |
GuidetoPHARMACOLOGYi | 2534 |
PTM databases
iPTMneti | P15090 |
PhosphoSitePlusi | P15090 |
SwissPalmi | P15090 |
Polymorphism and mutation databases
BioMutai | FABP4 |
DMDMi | 119781 |
2D gel databases
UCD-2DPAGEi | P15090 |
Proteomic databases
jPOSTi | P15090 |
MassIVEi | P15090 |
MaxQBi | P15090 |
PaxDbi | P15090 |
PeptideAtlasi | P15090 |
PRIDEi | P15090 |
ProteomicsDBi | 53106 |
Protocols and materials databases
ABCDi | P15090, 2 sequenced antibodies |
Antibodypediai | 994, 801 antibodies |
DNASUi | 2167 |
Genome annotation databases
Ensembli | ENST00000256104; ENSP00000256104; ENSG00000170323 |
GeneIDi | 2167 |
KEGGi | hsa:2167 |
UCSCi | uc003ycd.3, human |
Organism-specific databases
CTDi | 2167 |
DisGeNETi | 2167 |
EuPathDBi | HostDB:ENSG00000170323.8 |
GeneCardsi | FABP4 |
HGNCi | HGNC:3559, FABP4 |
HPAi | ENSG00000170323, Group enriched (adipose tissue, breast) |
MIMi | 600434, gene |
neXtProti | NX_P15090 |
OpenTargetsi | ENSG00000170323 |
PharmGKBi | PA27960 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4015, Eukaryota |
GeneTreei | ENSGT00940000160340 |
HOGENOMi | CLU_113772_0_0_1 |
InParanoidi | P15090 |
OMAi | GQEFDEI |
OrthoDBi | 1417203at2759 |
PhylomeDBi | P15090 |
TreeFami | TF316894 |
Enzyme and pathway databases
PathwayCommonsi | P15090 |
Reactomei | R-HSA-163560, Triglyceride catabolism R-HSA-381340, Transcriptional regulation of white adipocyte differentiation |
SIGNORi | P15090 |
Miscellaneous databases
BioGRID-ORCSi | 2167, 5 hits in 834 CRISPR screens |
ChiTaRSi | FABP4, human |
EvolutionaryTracei | P15090 |
GeneWikii | Adipocyte_protein_2 |
GenomeRNAii | 2167 |
Pharosi | P15090, Tchem |
PROi | PR:P15090 |
RNActi | P15090, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170323, Expressed in adipose tissue of abdominal region and 200 other tissues |
ExpressionAtlasi | P15090, baseline and differential |
Genevisiblei | P15090, HS |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR033073, FABP4 IPR000463, Fatty_acid-bd IPR031259, ILBP IPR000566, Lipocln_cytosolic_FA-bd_dom |
PANTHERi | PTHR11955, PTHR11955, 1 hit PTHR11955:SF83, PTHR11955:SF83, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PRINTSi | PR00178, FATTYACIDBP |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00214, FABP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FABP4_HUMAN | |
Accessioni | P15090Primary (citable) accession number: P15090 Secondary accession number(s): Q6IBA1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 202 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations