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Protein

Carboxypeptidase B

Gene

CPB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential release of a C-terminal lysine or arginine amino acid.By similarity

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi176Zinc; catalytic1 Publication1
Metal bindingi179Zinc; catalytic1 Publication1
Binding sitei234SubstrateBy similarity1
Metal bindingi304Zinc; catalytic1 Publication1
Binding sitei356SubstrateBy similarity1
Active sitei378Proton donor/acceptorBy similarity1

GO - Molecular functioni

  • carboxypeptidase activity Source: ProtInc
  • metallocarboxypeptidase activity Source: GO_Central
  • zinc ion binding Source: InterPro

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.17.2 2681
ReactomeiR-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins

Protein family/group databases

MEROPSiM14.003

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase B (EC:3.4.17.2By similarity)
Alternative name(s):
Pancreas-specific protein
Short name:
PASP
Gene namesi
Name:CPB1
Synonyms:CPB, PCPB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000153002.11
HGNCiHGNC:2299 CPB1
MIMi114852 gene
neXtProtiNX_P15086

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1360
OpenTargetsiENSG00000153002
PharmGKBiPA26821

Chemistry databases

ChEMBLiCHEMBL2552
DrugBankiDB07182 (2S)-2-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-3-[(S)-HYDROXY(3-PHENYLPROPYL)PHOSPHORYL]PROPANOIC ACID
DB07269 (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(R)-[(1R)-1-{[(BENZYLOXY)CARBONYL]AMINO}-2-METHYLPROPYL](HYDROXY)PHOSPHORYL]PROPANOIC ACID
DB06921 (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(R)-HYDROXY{(1R)-2-METHYL-1-[(PHENYLSULFONYL)AMINO]PROPYL}PHOSPHORYL]PROPANOIC ACID
DB07136 (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-{(R)-HYDROXY[(1R)-2-METHYL-1-{[(3-PHENYLPROPYL)SULFONYL]AMINO}PROPYL]PHOSPHORYL}PROPANOIC ACID
DB06835 (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-{(S)-HYDROXY[(1R)-2-METHYL-1-{[(2-PHENYLETHYL)SULFONYL]AMINO}PROPYL]PHOSPHORYL}PROPANOIC ACID
DB04723 2-(3-GUANIDINOPHENYL)-3-MERCAPTOPROPANOIC ACID
DB04272 Citric Acid
GuidetoPHARMACOLOGYi1593

Polymorphism and mutation databases

BioMutaiCPB1
DMDMi20532382

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 152 PublicationsAdd BLAST15
PropeptideiPRO_000000437116 – 110Activation peptideAdd BLAST95
ChainiPRO_0000004372111 – 417Carboxypeptidase BAdd BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi173 ↔ 1861 Publication
Disulfide bondi245 ↔ 2681 Publication
Disulfide bondi259 ↔ 2731 Publication

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

MaxQBiP15086
PaxDbiP15086
PeptideAtlasiP15086
PRIDEiP15086
ProteomicsDBi53104

PTM databases

PhosphoSitePlusiP15086

Miscellaneous databases

PMAP-CutDBiP15086

Expressioni

Tissue specificityi

Pancreas.1 Publication

Gene expression databases

BgeeiENSG00000153002 Expressed in 104 organ(s), highest expression level in body of pancreas
CleanExiHS_CPB1
ExpressionAtlasiP15086 baseline and differential
GenevisibleiP15086 HS

Organism-specific databases

HPAiCAB026158
HPA038069
HPA046340

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000282957

Chemistry databases

BindingDBiP15086

Structurei

Secondary structure

1417
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP15086
SMRiP15086
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15086

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni176 – 179Substrate bindingBy similarity4
Regioni251 – 252Substrate bindingBy similarity2
Regioni305 – 306Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2650 Eukaryota
COG2866 LUCA
GeneTreeiENSGT00760000119103
HOGENOMiHOG000252968
HOVERGENiHBG050815
InParanoidiP15086
KOiK01291
OMAiWETIEAW
OrthoDBiEOG091G0HUI
PhylomeDBiP15086
TreeFamiTF317197

Family and domain databases

CDDicd03871 M14_CPB, 1 hit
Gene3Di3.30.70.340, 1 hit
InterProiView protein in InterPro
IPR034253 CPB_M14_CPD
IPR036990 M14A-like_propep
IPR003146 M14A_act_pep
IPR000834 Peptidase_M14
PfamiView protein in Pfam
PF00246 Peptidase_M14, 1 hit
PF02244 Propep_M14, 1 hit
PRINTSiPR00765 CRBOXYPTASEA
SMARTiView protein in SMART
SM00631 Zn_pept, 1 hit
PROSITEiView protein in PROSITE
PS00132 CARBOXYPEPT_ZN_1, 1 hit
PS00133 CARBOXYPEPT_ZN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

P15086-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLALLVLVTV ALASAHHGGE HFEGEKVFRV NVEDENHINI IRELASTTQI
60 70 80 90 100
DFWKPDSVTQ IKPHSTVDFR VKAEDTVTVE NVLKQNELQY KVLISNLRNV
110 120 130 140 150
VEAQFDSRVR ATGHSYEKYN KWETIEAWTQ QVATENPALI SRSVIGTTFE
160 170 180 190 200
GRAIYLLKVG KAGQNKPAIF MDCGFHAREW ISPAFCQWFV REAVRTYGRE
210 220 230 240 250
IQVTELLDKL DFYVLPVLNI DGYIYTWTKS RFWRKTRSTH TGSSCIGTDP
260 270 280 290 300
NRNFDAGWCE IGASRNPCDE TYCGPAAESE KETKALADFI RNKLSSIKAY
310 320 330 340 350
LTIHSYSQMM IYPYSYAYKL GENNAELNAL AKATVKELAS LHGTKYTYGP
360 370 380 390 400
GATTIYPAAG GSDDWAYDQG IRYSFTFELR DTGRYGFLLP ESQIRATCEE
410
TFLAIKYVAS YVLEHLY
Length:417
Mass (Da):47,368
Last modified:May 10, 2002 - v4
Checksum:iEBBB98B27F5D5AF9
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JUX7C9JUX7_HUMAN
Carboxypeptidase B
CPB1
203Annotation score:
C9J5C4C9J5C4_HUMAN
Carboxypeptidase B
CPB1
99Annotation score:
C9JXS3C9JXS3_HUMAN
Carboxypeptidase B
CPB1
59Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16H → A AA sequence (PubMed:1370825).Curated1
Sequence conflicti17H → Q AA sequence (PubMed:1370825).Curated1
Sequence conflicti37H → Q AA sequence (PubMed:2920728).Curated1
Sequence conflicti245Missing in AAA66973 (PubMed:1370825).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048598208D → N1 PublicationCorresponds to variant dbSNP:rs1059502Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81057 mRNA Translation: AAA66973.1
AJ224866 mRNA Translation: CAA12163.1
BT009910 mRNA Translation: AAP88912.1
CH471052 Genomic DNA Translation: EAW78903.1
BC015338 mRNA Translation: AAH15338.1
CCDSiCCDS33874.1
PIRiA42332
RefSeqiNP_001862.2, NM_001871.2
UniGeneiHs.477891

Genome annotation databases

EnsembliENST00000282957; ENSP00000282957; ENSG00000153002
ENST00000491148; ENSP00000417222; ENSG00000153002
GeneIDi1360
KEGGihsa:1360
UCSCiuc003ewl.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCBPB1_HUMAN
AccessioniPrimary (citable) accession number: P15086
Secondary accession number(s): O60834, Q53XJ0, Q96BQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: May 10, 2002
Last modified: September 12, 2018
This is version 186 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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