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Protein

Carboxypeptidase A1

Gene

CPA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.1 Publication

Catalytic activityi

Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.1 Publication

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi179Zinc; catalyticCombined sources1 Publication1
Metal bindingi182Zinc; catalyticCombined sources1 Publication1
Binding sitei237SubstrateCombined sources1 Publication1
Metal bindingi306Zinc; catalyticCombined sources1 Publication1
Binding sitei358SubstrateCombined sources1 Publication1
Active sitei380Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

  • proteolysis Source: ProtInc

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM14.001

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase A1 (EC:3.4.17.1)
Gene namesi
Name:CPA1
Synonyms:CPA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000091704.9
HGNCiHGNC:2296 CPA1
MIMi114850 gene
neXtProtiNX_P15085

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1357
MalaCardsiCPA1
OpenTargetsiENSG00000091704
Orphaneti676 Hereditary chronic pancreatitis
PharmGKBiPA26816

Chemistry databases

ChEMBLiCHEMBL2088
DrugBankiDB06924 (2R)-2-benzyl-3-nitropropanoic acid
DB03441 2-Benzyl-3-Iodopropanoic Acid
DB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB04058 D-[(Amino)Carbonyl]Phenylalanine
DB04316 D-[(N-Hydroxyamino)Carbonyl]Phenylalanine
DB03201 D-Cysteine
DB11095 Desirudin
DB02652 L-[(N-Hydroxyamino)Carbonyl]Phenylalanine
DB07506 L-BENZYLSUCCINIC ACID
DB07351 O-(((1R)-((N-(PHENYL-METHOXY-CARBONYL)-ALANYL)-AMINO)METHYL)HYDROXYPHOSPHINYL)3-L-PHENYLLACTATE
DB08762 O-(((1R)-((N-PHENYLMETHOXYCARBONYL-L-ALANYL)AMINO)ETHYL)HYDROXYPHOSPHONO)-L-BENZYLACETIC ACID
DB03012 Phenylalanine-N-Sulfonamide
GuidetoPHARMACOLOGYi1587

Polymorphism and mutation databases

BioMutaiCPA1
DMDMi399196

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 162 PublicationsAdd BLAST16
PropeptideiPRO_000000434517 – 110Activation peptideAdd BLAST94
ChainiPRO_0000004346111 – 419Carboxypeptidase A1Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi248 ↔ 2712 Publications

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

EPDiP15085
MaxQBiP15085
PaxDbiP15085
PeptideAtlasiP15085
PRIDEiP15085
ProteomicsDBi53103

PTM databases

iPTMnetiP15085
PhosphoSitePlusiP15085

Expressioni

Gene expression databases

BgeeiENSG00000091704
CleanExiHS_CPA1
ExpressionAtlasiP15085 baseline and differential
GenevisibleiP15085 HS

Organism-specific databases

HPAiCAB025197
HPA021836
HPA052215

Interactioni

Subunit structurei

Monomer. May form a complex with proelastase 2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
P193992EBI-1642148,EBI-15754788From Ascaris suum.

Protein-protein interaction databases

BioGridi107749, 1 interactor
DIPiDIP-48699N
IntActiP15085, 3 interactors
STRINGi9606.ENSP00000011292

Chemistry databases

BindingDBiP15085

Structurei

Secondary structure

1419
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 28Combined sources5
Helixi33 – 43Combined sources11
Helixi46 – 48Combined sources3
Beta strandi51 – 54Combined sources4
Beta strandi63 – 67Combined sources5
Helixi69 – 71Combined sources3
Helixi72 – 81Combined sources10
Beta strandi86 – 91Combined sources6
Helixi93 – 104Combined sources12
Turni114 – 116Combined sources3
Helixi125 – 138Combined sources14
Turni140 – 142Combined sources3
Beta strandi143 – 150Combined sources8
Beta strandi156 – 162Combined sources7
Beta strandi164 – 168Combined sources5
Beta strandi171 – 176Combined sources6
Helixi183 – 199Combined sources17
Turni200 – 202Combined sources3
Helixi204 – 212Combined sources9
Beta strandi214 – 219Combined sources6
Helixi223 – 231Combined sources9
Helixi253 – 255Combined sources3
Beta strandi257 – 260Combined sources4
Beta strandi263 – 268Combined sources6
Helixi284 – 296Combined sources13
Beta strandi299 – 306Combined sources8
Beta strandi311 – 315Combined sources5
Helixi326 – 341Combined sources16
Turni342 – 344Combined sources3
Beta strandi349 – 352Combined sources4
Helixi353 – 356Combined sources4
Helixi364 – 370Combined sources7
Beta strandi374 – 380Combined sources7
Beta strandi384 – 387Combined sources4
Helixi393 – 395Combined sources3
Helixi396 – 416Combined sources21

3D structure databases

ProteinModelPortaliP15085
SMRiP15085
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15085

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni179 – 182Substrate bindingCombined sources1 Publication4
Regioni254 – 255Substrate bindingCombined sources1 Publication2
Regioni307 – 308Substrate bindingCombined sources1 Publication2

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2650 Eukaryota
COG2866 LUCA
GeneTreeiENSGT00760000119103
HOGENOMiHOG000252967
HOVERGENiHBG050815
InParanoidiP15085
KOiK08779
OMAiFDDMMEV
OrthoDBiEOG091G0HUI
PhylomeDBiP15085
TreeFamiTF317197

Family and domain databases

CDDicd03870 M14_CPA, 1 hit
Gene3Di3.30.70.340, 1 hit
InterProiView protein in InterPro
IPR034248 CPA_M14_CPD
IPR036990 M14A-like_propep
IPR003146 M14A_act_pep
IPR000834 Peptidase_M14
PfamiView protein in Pfam
PF00246 Peptidase_M14, 1 hit
PF02244 Propep_M14, 1 hit
PRINTSiPR00765 CRBOXYPTASEA
SMARTiView protein in SMART
SM00631 Zn_pept, 1 hit
PROSITEiView protein in PROSITE
PS00132 CARBOXYPEPT_ZN_1, 1 hit
PS00133 CARBOXYPEPT_ZN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15085-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGLLVLSVL LGAVFGKEDF VGHQVLRISV ADEAQVQKVK ELEDLEHLQL
60 70 80 90 100
DFWRGPAHPG SPIDVRVPFP SIQAVKIFLE SHGISYETMI EDVQSLLDEE
110 120 130 140 150
QEQMFAFRSR ARSTDTFNYA TYHTLEEIYD FLDLLVAENP HLVSKIQIGN
160 170 180 190 200
TYEGRPIYVL KFSTGGSKRP AIWIDTGIHS REWVTQASGV WFAKKITQDY
210 220 230 240 250
GQDAAFTAIL DTLDIFLEIV TNPDGFAFTH STNRMWRKTR SHTAGSLCIG
260 270 280 290 300
VDPNRNWDAG FGLSGASSNP CSETYHGKFA NSEVEVKSIV DFVKDHGNIK
310 320 330 340 350
AFISIHSYSQ LLMYPYGYKT EPVPDQDELD QLSKAAVTAL ASLYGTKFNY
360 370 380 390 400
GSIIKAIYQA SGSTIDWTYS QGIKYSFTFE LRDTGRYGFL LPASQIIPTA
410
KETWLALLTI MEHTLNHPY
Length:419
Mass (Da):47,140
Last modified:July 1, 1993 - v2
Checksum:i439FAFFFAEE958B1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139 – 141NPH → HPG AA sequence (PubMed:8318831).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048593208A → T. Corresponds to variant dbSNP:rs34474469Ensembl.1
Natural variantiVAR_054311276H → R2 PublicationsCorresponds to variant dbSNP:rs17849959Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67318 mRNA Translation: CAA47732.1
AK291493 mRNA Translation: BAF84182.1
BT007313 mRNA Translation: AAP35977.1
CH236950 Genomic DNA Translation: EAL24089.1
CH471070 Genomic DNA Translation: EAW83763.1
BC005279 mRNA Translation: AAH05279.1
CCDSiCCDS5820.1
PIRiS29127
RefSeqiNP_001859.1, NM_001868.3
UniGeneiHs.2879

Genome annotation databases

EnsembliENST00000011292; ENSP00000011292; ENSG00000091704
GeneIDi1357
KEGGihsa:1357
UCSCiuc003vpx.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCBPA1_HUMAN
AccessioniPrimary (citable) accession number: P15085
Secondary accession number(s): A4D1M1
, Q53XU0, Q9BS67, Q9UCF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 1, 1993
Last modified: June 20, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

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