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Entry version 149 (07 Oct 2020)
Sequence version 3 (01 Nov 1997)
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Protein

Peptide transporter CstA

Gene

cstA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in peptide utilization during carbon starvation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPeptide transport, Protein transport, Stress response, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:EG10167-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.114.1.1, the putative peptide transporter carbon starvation csta (csta) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptide transporter CstACurated
Alternative name(s):
Carbon starvation protein ACurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cstA1 Publication
Synonyms:ybdC
Ordered Locus Names:b0598, JW0590
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6CytoplasmicCurated6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 33PeriplasmicCurated6
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 86CytoplasmicCuratedAdd BLAST32
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 117PeriplasmicCurated10
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 160CytoplasmicCuratedAdd BLAST22
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 189PeriplasmicCurated8
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 217CytoplasmicCurated7
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 255PeriplasmicCuratedAdd BLAST17
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 280CytoplasmicCurated4
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Topological domaini302 – 324PeriplasmicCuratedAdd BLAST23
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Topological domaini346 – 372CytoplasmicCuratedAdd BLAST27
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 395PeriplasmicCurated2
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 439CytoplasmicCuratedAdd BLAST23
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Topological domaini461 – 463PeriplasmicCurated3
Transmembranei464 – 484HelicalSequence analysisAdd BLAST21
Topological domaini485 – 523CytoplasmicCuratedAdd BLAST39
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545 – 550PeriplasmicCurated6
Transmembranei551 – 571HelicalSequence analysisAdd BLAST21
Topological domaini572 – 577CytoplasmicCurated6
Transmembranei578 – 598HelicalSequence analysisAdd BLAST21
Topological domaini599 – 643PeriplasmicCuratedAdd BLAST45
Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
Topological domaini665 – 701Cytoplasmic1 PublicationAdd BLAST37

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001900461 – 701Peptide transporter CstAAdd BLAST701

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P15078

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15078

PRoteomics IDEntifications database

More...
PRIDEi
P15078

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by carbon starvation. Induction requires the cAMP-cAMP receptor protein (CRP) complex (PubMed:1848300). The carbon storage regulator CsrA regulates translation of cstA by sterically interfering with ribosome binding (PubMed:12867454).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4260985, 5 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b0598

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P15078

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1966, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P15078

KEGG Orthology (KO)

More...
KOi
K06200

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P15078

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025299, CstA_C
IPR003706, CstA_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02554, CstA, 1 hit
PF13722, CstA_5TM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P15078-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKSGKYLVW TVLSVMGAFA LGYIALNRGE QINALWIVVA SVCIYLIAYR
60 70 80 90 100
FYGLYIAKNV LAVDPTRMTP AVRHNDGLDY VPTDKKVLFG HHFAAIAGAG
110 120 130 140 150
PLVGPVLAAQ MGYLPGMIWL LAGVVLAGAV QDFMVLFVST RRDGRSLGEL
160 170 180 190 200
VKEEMGPTAG VIALVACFMI MVIILAVLAM IVVKALTHSP WGTYTVAFTI
210 220 230 240 250
PLALFMGIYL RYLRPGRIGE VSVIGLVFLI FAIISGGWVA ESPTWAPYFD
260 270 280 290 300
FTGVQLTWML VGYGFVAAVL PVWLLLAPRD YLSTFLKIGT IVGLAVGILI
310 320 330 340 350
MRPTLTMPAL TKFVDGTGPV WTGNLFPFLF ITIACGAVSG FHALISSGTT
360 370 380 390 400
PKMLANEGQA CFIGYGGMLM ESFVAIMALV SACIIDPGVY FAMNSPMAVL
410 420 430 440 450
APAGTADVVA SAAQVVSSWG FSITPDTLNQ IASEVGEQSI ISRAGGAPTL
460 470 480 490 500
AVGMAYILHG ALGGMMDVAF WYHFAILFEA LFILTAVDAG TRAARFMLQD
510 520 530 540 550
LLGVVSPGLK RTDSLPANLL ATALCVLAWG YFLHQGVVDP LGGINTLWPL
560 570 580 590 600
FGIANQMLAG MALMLCAVVL FKMKRQRYAW VALVPTAWLL ICTLTAGWQK
610 620 630 640 650
AFSPDAKVGF LAIANKFQAM IDSGNIPSQY TESQLAQLVF NNRLDAGLTI
660 670 680 690 700
FFMVVVVVLA LFSIKTALAA LKDPKPTAKE TPYEPMPENV EEIVAQAKGA

H
Length:701
Mass (Da):75,105
Last modified:November 1, 1997 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2DA85B2D96FD19E5
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA37087 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti129A → G in CAA37086 (PubMed:1848300).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X52904 Genomic DNA Translation: CAA37086.1 Frameshift.
X52904 Genomic DNA Translation: CAA37087.1 Frameshift.
U82598 Genomic DNA Translation: AAB40798.1
U00096 Genomic DNA Translation: AAC73699.1
AP009048 Genomic DNA Translation: BAA35227.1
M24148 Unassigned DNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
D64793, Q0ECNA

NCBI Reference Sequences

More...
RefSeqi
NP_415130.1, NC_000913.3
WP_001043156.1, NZ_SSZK01000032.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC73699; AAC73699; b0598
BAA35227; BAA35227; BAA35227

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
945213

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW0590
eco:b0598

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.1671

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52904 Genomic DNA Translation: CAA37086.1 Frameshift.
X52904 Genomic DNA Translation: CAA37087.1 Frameshift.
U82598 Genomic DNA Translation: AAB40798.1
U00096 Genomic DNA Translation: AAC73699.1
AP009048 Genomic DNA Translation: BAA35227.1
M24148 Unassigned DNA No translation available.
PIRiD64793, Q0ECNA
RefSeqiNP_415130.1, NC_000913.3
WP_001043156.1, NZ_SSZK01000032.1

3D structure databases

SMRiP15078
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4260985, 5 interactors
STRINGi511145.b0598

Protein family/group databases

TCDBi2.A.114.1.1, the putative peptide transporter carbon starvation csta (csta) family

Proteomic databases

jPOSTiP15078
PaxDbiP15078
PRIDEiP15078

Genome annotation databases

EnsemblBacteriaiAAC73699; AAC73699; b0598
BAA35227; BAA35227; BAA35227
GeneIDi945213
KEGGiecj:JW0590
eco:b0598
PATRICifig|1411691.4.peg.1671

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0165

Phylogenomic databases

eggNOGiCOG1966, Bacteria
InParanoidiP15078
KOiK06200
PhylomeDBiP15078

Enzyme and pathway databases

BioCyciEcoCyc:EG10167-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P15078

Family and domain databases

InterProiView protein in InterPro
IPR025299, CstA_C
IPR003706, CstA_N
PfamiView protein in Pfam
PF02554, CstA, 1 hit
PF13722, CstA_5TM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSTA_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15078
Secondary accession number(s): P23517, P77740
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 1, 1997
Last modified: October 7, 2020
This is version 149 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
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