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Protein

Transcription factor jun-D

Gene

Jund

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor binding AP-1 sites.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor jun-D
Gene namesi
Name:Jund
Synonyms:Jun-d, Jund1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:96648 Jund

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764431 – 341Transcription factor jun-DAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei245PhosphoserineBy similarity1
Modified residuei249PhosphoserineCombined sources1
Modified residuei253PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP15066
MaxQBiP15066
PaxDbiP15066
PeptideAtlasiP15066
PRIDEiP15066

PTM databases

iPTMnetiP15066
PhosphoSitePlusiP15066

Expressioni

Tissue specificityi

Brain and kidney.

Gene expression databases

BgeeiENSMUSG00000071076
CleanExiMM_JUND
GenevisibleiP15066 MM

Interactioni

Subunit structurei

Binds DNA as a dimer (By similarity). Interacts with MEN1.By similarity1 Publication

GO - Molecular functioni

  • enzyme binding Source: MGI
  • ligand-dependent nuclear receptor binding Source: MGI
  • transcription factor binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi200873, 6 interactors
ComplexPortaliCPX-628 Menin-JUND transcription inhibition complex
ELMiP15066
IntActiP15066, 2 interactors
MINTiP15066
STRINGi10090.ENSMUSP00000092901

Structurei

3D structure databases

ProteinModelPortaliP15066
SMRiP15066
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini262 – 325bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni262 – 289Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni290 – 318Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated

Phylogenomic databases

eggNOGiKOG0837 Eukaryota
ENOG410XRWH LUCA
GeneTreeiENSGT00390000009929
HOGENOMiHOG000006648
HOVERGENiHBG001722
InParanoidiP15066
KOiK04449
OMAiAPVYANL
OrthoDBiEOG091G0N0L
PhylomeDBiP15066
TreeFamiTF323952

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR005643 JNK
IPR029823 JunD
IPR002112 Leuzip_Jun
IPR008917 TF_DNA-bd_sf
PANTHERiPTHR11462:SF7 PTHR11462:SF7, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PF03957 Jun, 1 hit
PRINTSiPR00043 LEUZIPPRJUN
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

P15066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPFYGEEA LSGLAAGASS VAGATGAPGG GGFAPPGRAF PGAPPTSSML
60 70 80 90 100
KKDALTLSLA EQGAAGLKPG SATAPSALRP DGAPDGLLAS PDLGLLKLAS
110 120 130 140 150
PELERLIIQS NGLVTTTPTS TQFLYPKVAA SEEQEFAEGF VKALEDLHKQ
160 170 180 190 200
SQLGAATAAT SGAPAPPAPA DLAATPGATE TPVYANLSSF AGGAGPPGGA
210 220 230 240 250
ATVAFAAEPV PFPPPPGALG PPPPPHPPRL AALKDEPQTV PDVPSFGDSP
260 270 280 290 300
PLSPIDMDTQ ERIKAERKRL RNRIAASKCR KRKLERISRL EEKVKTLKSQ
310 320 330 340
NTELASTASL LREQVAQLKQ KVLSHVNSGC QLLPQHQVPA Y
Length:341
Mass (Da):34,905
Last modified:April 1, 1990 - v1
Checksum:i2727392F6B65188D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5F → L in AAA39345 (PubMed:2104845).Curated1
Sequence conflicti61 – 62EQ → DE in AAA39345 (PubMed:2104845).Curated2
Sequence conflicti317 – 318QL → HV in AAA39345 (PubMed:2104845).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04509 Genomic DNA Translation: AAA39344.1
X15358 mRNA Translation: CAA33418.1
J05205 mRNA Translation: AAA39345.1
BC010572 mRNA Translation: AAH10572.1
CCDSiCCDS40375.1
PIRiA32158 TVMSJD
RefSeqiNP_034722.1, NM_010592.5
UniGeneiMm.419851

Genome annotation databases

EnsembliENSMUST00000095267; ENSMUSP00000092901; ENSMUSG00000071076
ENSMUST00000216625; ENSMUSP00000150017; ENSMUSG00000110974
GeneIDi16478
KEGGimmu:16478
UCSCiuc009mbe.2 mouse

Similar proteinsi

Entry informationi

Entry nameiJUND_MOUSE
AccessioniPrimary (citable) accession number: P15066
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 20, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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