UniProtKB - P15066 (JUND_MOUSE)
Transcription factor JunD
Jund
Functioni
Transcription factor binding AP-1 sites (By similarity).
Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing its transcriptional activity (By similarity).
By similarityGO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- double-stranded DNA binding Source: MGI
- enzyme binding Source: MGI
- nuclear receptor binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
- transcription cis-regulatory region binding Source: MGI
- transcription coregulator binding Source: ParkinsonsUK-UCL
GO - Biological processi
- aging Source: Ensembl
- cellular response to calcium ion Source: MGI
- circadian rhythm Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- osteoblast development Source: MGI
- positive regulation of macrophage activation Source: MGI
- positive regulation of osteoblast differentiation Source: MGI
- positive regulation of transcription by RNA polymerase II Source: ParkinsonsUK-UCL
- regulation of cell cycle Source: GO_Central
- regulation of cell population proliferation Source: GO_Central
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to light stimulus Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to mechanical stimulus Source: Ensembl
- response to organic cyclic compound Source: Ensembl
- response to peptide hormone Source: Ensembl
- transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor JunDCuratedAlternative name(s): Transcription factor AP-1 subunit JunDCurated |
Gene namesi | Name:Jund Synonyms:Jun-d, Jund1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96648, Jund |
VEuPathDBi | HostDB:ENSMUSG00000071076 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
- transcription factor AP-1 complex Source: MGI
Other locations
- protein-containing complex Source: MGI
- protein-DNA complex Source: MGI
- transcription regulator complex Source: GO_Central
- transcription repressor complex Source: Ensembl
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076443 | 1 – 341 | Transcription factor JunDAdd BLAST | 341 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 90 | PhosphoserineBy similarity | 1 | |
Modified residuei | 100 | Phosphoserine; by MAPK8By similarity | 1 | |
Modified residuei | 117 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 245 | PhosphoserineBy similarity | 1 | |
Modified residuei | 249 | PhosphoserineCombined sources | 1 | |
Modified residuei | 253 | PhosphoserineCombined sources | 1 | |
Disulfide bondi | 279 | Interchain (with C-172 in FOSB)By similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
EPDi | P15066 |
jPOSTi | P15066 |
MaxQBi | P15066 |
PaxDbi | P15066 |
PeptideAtlasi | P15066 |
PRIDEi | P15066 |
ProteomicsDBi | 269429 |
PTM databases
iPTMneti | P15066 |
PhosphoSitePlusi | P15066 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000071076, Expressed in trachea and 326 other tissues |
Genevisiblei | P15066, MM |
Interactioni
Subunit structurei
Heterodimer; binds DNA as a heterodimer (By similarity).
Component of an AP-1 transcription factor complex composed of JUN-FOS heterodimers (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with FOS proteins, thereby binding to the AP-1 consensus sequence and stimulating transcription (By similarity). Forms heterodimers with FOSB; thereby binding to the AP-1 consensus sequence (By similarity).
Interacts (via MBM motif) with MEN1; this interaction represses transcriptional activation (PubMed:9989505).
Interacts with MAPK10; this interaction is inhibited in the presence of MEN1 (By similarity).
By similarity1 PublicationGO - Molecular functioni
- enzyme binding Source: MGI
- nuclear receptor binding Source: MGI
- transcription coregulator binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 200873, 6 interactors |
ComplexPortali | CPX-628, Menin-JUND transcription inhibition complex |
ELMi | P15066 |
IntActi | P15066, 2 interactors |
STRINGi | 10090.ENSMUSP00000092901 |
Miscellaneous databases
RNActi | P15066, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 262 – 325 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 18 – 49 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 62 – 85 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 155 – 176 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 262 – 289 | Basic motifPROSITE-ProRule annotationAdd BLAST | 28 | |
Regioni | 290 – 318 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 29 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 35 – 47 | Menin-binding motif (MBM)By similarityAdd BLAST | 13 | |
Motifi | 51 – 60 | MAP kinase docking motif; essential for its phosphorylationBy similarity | 10 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0837, Eukaryota |
GeneTreei | ENSGT00940000162806 |
HOGENOMi | CLU_057007_0_0_1 |
InParanoidi | P15066 |
OMAi | YSQNTMM |
OrthoDBi | 1090460at2759 |
PhylomeDBi | P15066 |
TreeFami | TF323952 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR005643, JNK IPR029823, JunD IPR002112, Leuzip_Jun IPR008917, TF_DNA-bd_sf |
PANTHERi | PTHR11462:SF7, PTHR11462:SF7, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit PF03957, Jun, 1 hit |
PRINTSi | PR00043, LEUZIPPRJUN |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
METPFYGEEA LSGLAAGASS VAGATGAPGG GGFAPPGRAF PGAPPTSSML
60 70 80 90 100
KKDALTLSLA EQGAAGLKPG SATAPSALRP DGAPDGLLAS PDLGLLKLAS
110 120 130 140 150
PELERLIIQS NGLVTTTPTS TQFLYPKVAA SEEQEFAEGF VKALEDLHKQ
160 170 180 190 200
SQLGAATAAT SGAPAPPAPA DLAATPGATE TPVYANLSSF AGGAGPPGGA
210 220 230 240 250
ATVAFAAEPV PFPPPPGALG PPPPPHPPRL AALKDEPQTV PDVPSFGDSP
260 270 280 290 300
PLSPIDMDTQ ERIKAERKRL RNRIAASKCR KRKLERISRL EEKVKTLKSQ
310 320 330 340
NTELASTASL LREQVAQLKQ KVLSHVNSGC QLLPQHQVPA Y
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 5 | F → L in AAA39345 (PubMed:2104845).Curated | 1 | |
Sequence conflicti | 61 – 62 | EQ → DE in AAA39345 (PubMed:2104845).Curated | 2 | |
Sequence conflicti | 317 – 318 | QL → HV in AAA39345 (PubMed:2104845).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04509 Genomic DNA Translation: AAA39344.1 X15358 mRNA Translation: CAA33418.1 J05205 mRNA Translation: AAA39345.1 BC010572 mRNA Translation: AAH10572.1 |
CCDSi | CCDS40375.1 |
PIRi | A32158, TVMSJD |
RefSeqi | NP_034722.1, NM_010592.5 |
Genome annotation databases
Ensembli | ENSMUST00000095267; ENSMUSP00000092901; ENSMUSG00000071076 |
GeneIDi | 16478 |
KEGGi | mmu:16478 |
UCSCi | uc009mbe.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04509 Genomic DNA Translation: AAA39344.1 X15358 mRNA Translation: CAA33418.1 J05205 mRNA Translation: AAA39345.1 BC010572 mRNA Translation: AAH10572.1 |
CCDSi | CCDS40375.1 |
PIRi | A32158, TVMSJD |
RefSeqi | NP_034722.1, NM_010592.5 |
3D structure databases
SMRi | P15066 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200873, 6 interactors |
ComplexPortali | CPX-628, Menin-JUND transcription inhibition complex |
ELMi | P15066 |
IntActi | P15066, 2 interactors |
STRINGi | 10090.ENSMUSP00000092901 |
PTM databases
iPTMneti | P15066 |
PhosphoSitePlusi | P15066 |
Proteomic databases
EPDi | P15066 |
jPOSTi | P15066 |
MaxQBi | P15066 |
PaxDbi | P15066 |
PeptideAtlasi | P15066 |
PRIDEi | P15066 |
ProteomicsDBi | 269429 |
Protocols and materials databases
Antibodypediai | 3936, 655 antibodies from 40 providers |
DNASUi | 16478 |
Genome annotation databases
Ensembli | ENSMUST00000095267; ENSMUSP00000092901; ENSMUSG00000071076 |
GeneIDi | 16478 |
KEGGi | mmu:16478 |
UCSCi | uc009mbe.2, mouse |
Organism-specific databases
CTDi | 3727 |
MGIi | MGI:96648, Jund |
VEuPathDBi | HostDB:ENSMUSG00000071076 |
Phylogenomic databases
eggNOGi | KOG0837, Eukaryota |
GeneTreei | ENSGT00940000162806 |
HOGENOMi | CLU_057007_0_0_1 |
InParanoidi | P15066 |
OMAi | YSQNTMM |
OrthoDBi | 1090460at2759 |
PhylomeDBi | P15066 |
TreeFami | TF323952 |
Miscellaneous databases
BioGRID-ORCSi | 16478, 6 hits in 50 CRISPR screens |
ChiTaRSi | Jund, mouse |
PROi | PR:P15066 |
RNActi | P15066, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000071076, Expressed in trachea and 326 other tissues |
Genevisiblei | P15066, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR005643, JNK IPR029823, JunD IPR002112, Leuzip_Jun IPR008917, TF_DNA-bd_sf |
PANTHERi | PTHR11462:SF7, PTHR11462:SF7, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit PF03957, Jun, 1 hit |
PRINTSi | PR00043, LEUZIPPRJUN |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | JUND_MOUSE | |
Accessioni | P15066Primary (citable) accession number: P15066 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 186 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families