Jund

Functionⁱ

Transcription factor binding AP-1 sites.By similarity

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 12220541
DNA-binding transcription factor activity Source: MGI
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
double-stranded DNA binding Source: MGI
enzyme binding Source: MGI
nuclear receptor binding Source: MGI
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 2504580
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 10837920
sequence-specific DNA binding Source: MGI
transcription coactivator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 10523647
transcription regulatory region DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aging Source: Ensembl
cellular response to calcium ion
Source: MGI
Inferred from direct assayⁱ
- 19303854
cellular response to hormone stimulus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
circadian rhythm Source: Ensembl
negative regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
osteoblast development
Source: MGI
Inferred from genetic interactionⁱ
- 15563473
positive regulation of cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of osteoblast differentiation
Source: MGI
Inferred from genetic interactionⁱ
- 15563473
positive regulation of transcription by RNA polymerase II
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 10523647
regulation of cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of transcription, DNA-templated Source: MGI
response to cAMP
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to cytokine
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to drug
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to light stimulus Source: Ensembl
response to lipopolysaccharide
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to mechanical stimulus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to organic substance
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to peptide hormone Source: Ensembl
response to radiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription by RNA polymerase II Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor jun-D
Gene namesⁱ	Name:Jund Synonyms:Jun-d, Jund1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:96648 Jund

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076443	1 – 341	Transcription factor jun-DAdd BLAST		341

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	245	PhosphoserineBy similarity	1
Modified residueⁱ	249	PhosphoserineCombined sources	1
Modified residueⁱ	253	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P15066
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P15066
PaxDbⁱ	P15066
PeptideAtlas More...PeptideAtlasⁱ	P15066
PRIDEⁱ	P15066

PTM databases

iPTMnetⁱ	P15066
PhosphoSitePlusⁱ	P15066

Expressionⁱ

Tissue specificityⁱ

Brain and kidney.

Gene expression databases

Bgeeⁱ	ENSMUSG00000071076 Expressed in 306 organ(s), highest expression level in trachea
CleanExⁱ	MM_JUND
Genevisibleⁱ	P15066 MM

Interactionⁱ

Subunit structureⁱ

Binds DNA as a dimer (By similarity). Interacts with MEN1.By similarity1 Publication

GO - Molecular functionⁱ

enzyme binding Source: MGI
nuclear receptor binding Source: MGI
transcription factor binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 10523647

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	200873, 6 interactors
ComplexPortalⁱ	CPX-628 Menin-JUND transcription inhibition complex
ELMⁱ	P15066
IntActⁱ	P15066, 2 interactors
Molecular INTeraction database More...MINTⁱ	P15066
STRINGⁱ	10090.ENSMUSP00000092901

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P15066
SMRⁱ	P15066
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	262 – 325	bZIPPROSITE-ProRule annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	262 – 289	Basic motifPROSITE-ProRule annotationAdd BLAST		28
Regionⁱ	290 – 318	Leucine-zipperPROSITE-ProRule annotationAdd BLAST		29

Sequence similaritiesⁱ

Belongs to the bZIP family. Jun subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0837 Eukaryota ENOG410XRWH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009929
HOGENOMⁱ	HOG000006648
HOVERGENⁱ	HBG001722
InParanoidⁱ	P15066
KEGG Orthology (KO) More...KOⁱ	K04449
OMAⁱ	APVYANL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N0L
PhylomeDBⁱ	P15066
TreeFamⁱ	TF323952

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR005643 JNK IPR029823 JunD IPR002112 Leuzip_Jun IPR008917 TF_DNA-bd_sf
PANTHERⁱ	PTHR11462:SF7 PTHR11462:SF7, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit PF03957 Jun, 1 hit
PRINTSⁱ	PR00043 LEUZIPPRJUN
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
SUPFAMⁱ	SSF47454 SSF47454, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P15066-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
METPFYGEEA LSGLAAGASS VAGATGAPGG GGFAPPGRAF PGAPPTSSML 
        60         70         80         90        100
KKDALTLSLA EQGAAGLKPG SATAPSALRP DGAPDGLLAS PDLGLLKLAS 
       110        120        130        140        150
PELERLIIQS NGLVTTTPTS TQFLYPKVAA SEEQEFAEGF VKALEDLHKQ 
       160        170        180        190        200
SQLGAATAAT SGAPAPPAPA DLAATPGATE TPVYANLSSF AGGAGPPGGA 
       210        220        230        240        250
ATVAFAAEPV PFPPPPGALG PPPPPHPPRL AALKDEPQTV PDVPSFGDSP 
       260        270        280        290        300
PLSPIDMDTQ ERIKAERKRL RNRIAASKCR KRKLERISRL EEKVKTLKSQ 
       310        320        330        340 
NTELASTASL LREQVAQLKQ KVLSHVNSGC QLLPQHQVPA Y

Length:341

Mass (Da):34,905

Last modified:April 1, 1990 - v1

Checksum:ⁱ2727392F6B65188D

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	5	F → L in AAA39345 (PubMed:2104845).Curated	1
Sequence conflictⁱ	61 – 62	EQ → DE in AAA39345 (PubMed:2104845).Curated	2
Sequence conflictⁱ	317 – 318	QL → HV in AAA39345 (PubMed:2104845).Curated	2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04509 Genomic DNA Translation: AAA39344.1 X15358 mRNA Translation: CAA33418.1 J05205 mRNA Translation: AAA39345.1 BC010572 mRNA Translation: AAH10572.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS40375.1
PIRⁱ	A32158 TVMSJD
NCBI Reference Sequences More...RefSeqⁱ	NP_034722.1, NM_010592.5
UniGeneⁱ	Mm.419851

Genome annotation databases

Ensemblⁱ	ENSMUST00000095267; ENSMUSP00000092901; ENSMUSG00000071076 ENSMUST00000216625; ENSMUSP00000150017; ENSMUSG00000110974
GeneIDⁱ	16478
KEGGⁱ	mmu:16478
UCSC genome browser More...UCSCⁱ	uc009mbe.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P15066	Transcription factor jun-D		Daphnia magna		341	UniRef100_P15066
UPI0003C524C3		MOUSE		293
Putative Transcription factor jun-D (Fragment)		Daphnia magna		174

Protein	Similar proteins		Species	Score	Length	Source
P15066	Transcription factor jun-D		RAT		341	UniRef90_P52909
Transcription factor jun-D		Daphnia magna		341
transcription factor jun-D		MESAU		341
Transcription factor AP-1-like protein		CRIGR		341
Uncharacterized protein		NEOLE		293
+6

Protein	Similar proteins		Species	Score	Length	Source
P15066	Transcription factor AP-1	)	HUMAN		331	UniRef50_P05412
Transcription factor AP-1		BOVIN		335
Transcription factor AP-1		RAT		334
Transcription factor AP-1		MOUSE		334
Transcription factor AP-1		PIG		331
+177

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04509 Genomic DNA Translation: AAA39344.1 X15358 mRNA Translation: CAA33418.1 J05205 mRNA Translation: AAA39345.1 BC010572 mRNA Translation: AAH10572.1
CCDSⁱ	CCDS40375.1
PIRⁱ	A32158 TVMSJD
RefSeqⁱ	NP_034722.1, NM_010592.5
UniGeneⁱ	Mm.419851

3D structure databases

ProteinModelPortalⁱ	P15066
SMRⁱ	P15066
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	200873, 6 interactors
ComplexPortalⁱ	CPX-628 Menin-JUND transcription inhibition complex
ELMⁱ	P15066
IntActⁱ	P15066, 2 interactors
MINTⁱ	P15066
STRINGⁱ	10090.ENSMUSP00000092901

PTM databases

iPTMnetⁱ	P15066
PhosphoSitePlusⁱ	P15066

Proteomic databases

EPDⁱ	P15066
MaxQBⁱ	P15066
PaxDbⁱ	P15066
PeptideAtlasⁱ	P15066
PRIDEⁱ	P15066

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000095267; ENSMUSP00000092901; ENSMUSG00000071076 ENSMUST00000216625; ENSMUSP00000150017; ENSMUSG00000110974
GeneIDⁱ	16478
KEGGⁱ	mmu:16478
UCSCⁱ	uc009mbe.2 mouse

Organism-specific databases

CTDⁱ	3727
MGIⁱ	MGI:96648 Jund

Phylogenomic databases

eggNOGⁱ	KOG0837 Eukaryota ENOG410XRWH LUCA
GeneTreeⁱ	ENSGT00390000009929
HOGENOMⁱ	HOG000006648
HOVERGENⁱ	HBG001722
InParanoidⁱ	P15066
KOⁱ	K04449
OMAⁱ	APVYANL
OrthoDBⁱ	EOG091G0N0L
PhylomeDBⁱ	P15066
TreeFamⁱ	TF323952

Miscellaneous databases

ChiTaRSⁱ	Jund mouse
Protein Ontology More...PROⁱ	PR:P15066
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000071076 Expressed in 306 organ(s), highest expression level in trachea
CleanExⁱ	MM_JUND
Genevisibleⁱ	P15066 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR005643 JNK IPR029823 JunD IPR002112 Leuzip_Jun IPR008917 TF_DNA-bd_sf
PANTHERⁱ	PTHR11462:SF7 PTHR11462:SF7, 1 hit
Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit PF03957 Jun, 1 hit
PRINTSⁱ	PR00043 LEUZIPPRJUN
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
SUPFAMⁱ	SSF47454 SSF47454, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	JUND_MOUSE
Accessionⁱ	P15066Primary (citable) accession number: P15066
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	April 1, 1990
	Last modified:	November 7, 2018
	This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P15066 (JUND_MOUSE)

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Transcription factor jun-D

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ