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Protein

Protein C-ets-2

Gene

Ets2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi362 – 442ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

  • ectodermal cell fate commitment Source: MGI
  • mesoderm development Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • primitive streak formation Source: MGI
  • regulation of transcription by RNA polymerase II Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-2559585 Oncogene Induced Senescence

Names & Taxonomyi

Protein namesi
Recommended name:
Protein C-ets-2
Gene namesi
Name:Ets2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:95456 Ets2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002040781 – 468Protein C-ets-2Add BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei220PhosphoserineBy similarity1
Modified residuei225PhosphoserineBy similarity1
Modified residuei294PhosphoserineBy similarity1
Modified residuei297PhosphoserineCombined sources1
Modified residuei300PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP15037
PRIDEiP15037

PTM databases

iPTMnetiP15037
PhosphoSitePlusiP15037

Expressioni

Gene expression databases

BgeeiENSMUSG00000022895
CleanExiMM_ETS2
ExpressionAtlasiP15037 baseline and differential
GenevisibleiP15037 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204766, 6 interactors
CORUMiP15037
DIPiDIP-41847N
IntActiP15037, 1 interactor
STRINGi10090.ENSMUSP00000023612

Structurei

3D structure databases

ProteinModelPortaliP15037
SMRiP15037
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 170PNTPROSITE-ProRule annotationAdd BLAST86

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000285953
HOVERGENiHBG003088
InParanoidiP15037
KOiK21932
OMAiFGMNGQV
OrthoDBiEOG091G0HJF
PhylomeDBiP15037
TreeFamiTF316214

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR016311 Transform_prot_C-ets
IPR027276 Transform_prot_C-ets-2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PIRSFiPIRSF501032 C-ets-2, 1 hit
PIRSF001698 Transforming_factor_C-ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

Sequencei

Sequence statusi: Complete.

P15037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDFGIKNMD QVAPVANSFR GTLKRQPAFD TFDGSLFAVL PSLSEDQTLQ
60 70 80 90 100
EVPTGLDSVS HDSASCELPL LTPCSKAVMS QALKATFSGF QKEQRRLGIP
110 120 130 140 150
KNPWLWSEQQ VCQWLLWATN EFSLVNVNLH QFGMNGQMLC NLGKERFLEL
160 170 180 190 200
APDFVGDILW EHLEQMIKEN QEKTEDQYEE NSHLNAVPHW INSNTLGFSM
210 220 230 240 250
EQAPYGMQAP NYPKDNLLDS MCPPSATPAA LGSELQMLPK SRLNTVNVNY
260 270 280 290 300
CSISQDFPSS NVNLLNNNSG KPKDHDSPEN GGDSFESSDS LLRSWNSQSS
310 320 330 340 350
LLDVQRVPSF ESFEEDCSQS LCLSKLTMSF KDYIQERSDP VEQGKPVIPA
360 370 380 390 400
AVLAGFTGSG PIQLWQFLLE LLSDKSCQSF ISWTGDGWEF KLADPDEVAR
410 420 430 440 450
RWGKRKNKPK MNYEKLSRGL RYYYDKNIIH KTSGKRYVYR FVCDLQNLLG
460
FTPEELHAIL GVQPDTED
Length:468
Mass (Da):52,827
Last modified:April 1, 1990 - v1
Checksum:i5260F3085B7EB831
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04103 mRNA Translation: AAA37581.1
BC005504 mRNA Translation: AAH05504.1
CCDSiCCDS37412.1
PIRiC32066 TVMSE2
RefSeqiNP_035939.3, NM_011809.3
UniGeneiMm.290207

Genome annotation databases

EnsembliENSMUST00000023612; ENSMUSP00000023612; ENSMUSG00000022895
GeneIDi23872
KEGGimmu:23872
UCSCiuc008ace.2 mouse

Similar proteinsi

Entry informationi

Entry nameiETS2_MOUSE
AccessioniPrimary (citable) accession number: P15037
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 20, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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