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UniProtKB - P15037 (ETS2_MOUSE)
Protein
Protein C-ets-2
Gene
Ets2
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 362 – 442 | ETSPROSITE-ProRule annotationAdd BLAST | 81 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
- glucocorticoid receptor binding Source: MGI
- protein domain specific binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- cell differentiation Source: GO_Central
- ectodermal cell fate commitment Source: MGI
- mesoderm development Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- primitive streak formation Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-2559585, Oncogene Induced Senescence |
Names & Taxonomyi
Protein namesi | Recommended name: Protein C-ets-2 |
Gene namesi | Name:Ets2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95456, Ets2 |
VEuPathDBi | HostDB:ENSMUSG00000022895 |
Subcellular locationi
Nucleus
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204078 | 1 – 468 | Protein C-ets-2Add BLAST | 468 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 220 | PhosphoserineBy similarity | 1 | |
Modified residuei | 225 | PhosphoserineBy similarity | 1 | |
Modified residuei | 294 | PhosphoserineBy similarity | 1 | |
Modified residuei | 297 | PhosphoserineCombined sources | 1 | |
Modified residuei | 300 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P15037 |
PRIDEi | P15037 |
ProteomicsDBi | 271504 |
PTM databases
iPTMneti | P15037 |
PhosphoSitePlusi | P15037 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000022895, Expressed in pituitary gland and 358 other tissues |
ExpressionAtlasi | P15037, baseline and differential |
Genevisiblei | P15037, MM |
Interactioni
GO - Molecular functioni
- glucocorticoid receptor binding Source: MGI
- protein domain specific binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204766, 6 interactors |
CORUMi | P15037 |
DIPi | DIP-41847N |
IntActi | P15037, 2 interactors |
STRINGi | 10090.ENSMUSP00000023612 |
Miscellaneous databases
RNActi | P15037, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 85 – 170 | PNTPROSITE-ProRule annotationAdd BLAST | 86 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 262 – 290 | DisorderedSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the ETS family.Curated
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000160202 |
HOGENOMi | CLU_031197_1_1_1 |
InParanoidi | P15037 |
OMAi | RSWNSQS |
OrthoDBi | 526256at2759 |
PhylomeDBi | P15037 |
TreeFami | TF316214 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR045688, Ets1_N_flank IPR000418, Ets_dom IPR003118, Pointed_dom IPR013761, SAM/pointed_sf IPR016311, Transform_prot_C-ets IPR027276, Transform_prot_C-ets-2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF19525, Ets1_N_flank, 1 hit PF02198, SAM_PNT, 1 hit |
PIRSFi | PIRSF501032, C-ets-2, 1 hit PIRSF001698, Transforming_factor_C-ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P15037-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNDFGIKNMD QVAPVANSFR GTLKRQPAFD TFDGSLFAVL PSLSEDQTLQ
60 70 80 90 100
EVPTGLDSVS HDSASCELPL LTPCSKAVMS QALKATFSGF QKEQRRLGIP
110 120 130 140 150
KNPWLWSEQQ VCQWLLWATN EFSLVNVNLH QFGMNGQMLC NLGKERFLEL
160 170 180 190 200
APDFVGDILW EHLEQMIKEN QEKTEDQYEE NSHLNAVPHW INSNTLGFSM
210 220 230 240 250
EQAPYGMQAP NYPKDNLLDS MCPPSATPAA LGSELQMLPK SRLNTVNVNY
260 270 280 290 300
CSISQDFPSS NVNLLNNNSG KPKDHDSPEN GGDSFESSDS LLRSWNSQSS
310 320 330 340 350
LLDVQRVPSF ESFEEDCSQS LCLSKLTMSF KDYIQERSDP VEQGKPVIPA
360 370 380 390 400
AVLAGFTGSG PIQLWQFLLE LLSDKSCQSF ISWTGDGWEF KLADPDEVAR
410 420 430 440 450
RWGKRKNKPK MNYEKLSRGL RYYYDKNIIH KTSGKRYVYR FVCDLQNLLG
460
FTPEELHAIL GVQPDTED
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3B2WCY8 | A0A3B2WCY8_MOUSE | Protein C-ets-2 | Ets2 | 282 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04103 mRNA Translation: AAA37581.1 BC005504 mRNA Translation: AAH05504.1 |
CCDSi | CCDS37412.1 |
PIRi | C32066, TVMSE2 |
RefSeqi | NP_035939.3, NM_011809.3 |
Genome annotation databases
Ensembli | ENSMUST00000023612; ENSMUSP00000023612; ENSMUSG00000022895 |
GeneIDi | 23872 |
KEGGi | mmu:23872 |
UCSCi | uc008ace.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04103 mRNA Translation: AAA37581.1 BC005504 mRNA Translation: AAH05504.1 |
CCDSi | CCDS37412.1 |
PIRi | C32066, TVMSE2 |
RefSeqi | NP_035939.3, NM_011809.3 |
3D structure databases
SMRi | P15037 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204766, 6 interactors |
CORUMi | P15037 |
DIPi | DIP-41847N |
IntActi | P15037, 2 interactors |
STRINGi | 10090.ENSMUSP00000023612 |
PTM databases
iPTMneti | P15037 |
PhosphoSitePlusi | P15037 |
Proteomic databases
PaxDbi | P15037 |
PRIDEi | P15037 |
ProteomicsDBi | 271504 |
Protocols and materials databases
Antibodypediai | 8721, 406 antibodies from 32 providers |
DNASUi | 23872 |
Genome annotation databases
Ensembli | ENSMUST00000023612; ENSMUSP00000023612; ENSMUSG00000022895 |
GeneIDi | 23872 |
KEGGi | mmu:23872 |
UCSCi | uc008ace.2, mouse |
Organism-specific databases
CTDi | 2114 |
MGIi | MGI:95456, Ets2 |
VEuPathDBi | HostDB:ENSMUSG00000022895 |
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000160202 |
HOGENOMi | CLU_031197_1_1_1 |
InParanoidi | P15037 |
OMAi | RSWNSQS |
OrthoDBi | 526256at2759 |
PhylomeDBi | P15037 |
TreeFami | TF316214 |
Enzyme and pathway databases
Reactomei | R-MMU-2559585, Oncogene Induced Senescence |
Miscellaneous databases
BioGRID-ORCSi | 23872, 2 hits in 64 CRISPR screens |
ChiTaRSi | Ets2, mouse |
PROi | PR:P15037 |
RNActi | P15037, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022895, Expressed in pituitary gland and 358 other tissues |
ExpressionAtlasi | P15037, baseline and differential |
Genevisiblei | P15037, MM |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR045688, Ets1_N_flank IPR000418, Ets_dom IPR003118, Pointed_dom IPR013761, SAM/pointed_sf IPR016311, Transform_prot_C-ets IPR027276, Transform_prot_C-ets-2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF19525, Ets1_N_flank, 1 hit PF02198, SAM_PNT, 1 hit |
PIRSFi | PIRSF501032, C-ets-2, 1 hit PIRSF001698, Transforming_factor_C-ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ETS2_MOUSE | |
Accessioni | P15037Primary (citable) accession number: P15037 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families