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Protein

Protein C-ets-2

Gene

ETS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi363 – 443ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-2559585 Oncogene Induced Senescence
SignaLinkiP15036
SIGNORiP15036

Names & Taxonomyi

Protein namesi
Recommended name:
Protein C-ets-2
Gene namesi
Name:ETS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000157557.11
HGNCiHGNC:3489 ETS2
MIMi164740 gene
neXtProtiNX_P15036

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi2114
OpenTargetsiENSG00000157557
PharmGKBiPA27903

Polymorphism and mutation databases

BioMutaiETS2
DMDMi119645

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002040771 – 469Protein C-ets-2Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei220Phosphoserine1 Publication1
Modified residuei225Phosphoserine1 Publication1
Modified residuei295PhosphoserineCombined sources1
Modified residuei298PhosphoserineBy similarity1
Modified residuei301PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP15036
MaxQBiP15036
PaxDbiP15036
PeptideAtlasiP15036
PRIDEiP15036
ProteomicsDBi53101

PTM databases

iPTMnetiP15036
PhosphoSitePlusiP15036

Expressioni

Gene expression databases

BgeeiENSG00000157557 Expressed in 225 organ(s), highest expression level in skin of abdomen
CleanExiHS_ETS2
ExpressionAtlasiP15036 baseline and differential
GenevisibleiP15036 HS

Organism-specific databases

HPAiHPA003176

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108415, 29 interactors
CORUMiP15036
DIPiDIP-40452N
IntActiP15036, 22 interactors
MINTiP15036
STRINGi9606.ENSP00000353344

Structurei

Secondary structure

1469
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP15036
SMRiP15036
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 170PNTPROSITE-ProRule annotationAdd BLAST86

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000285953
HOVERGENiHBG003088
InParanoidiP15036
KOiK21932
OMAiFGMNGQV
OrthoDBiEOG091G0HJF
PhylomeDBiP15036
TreeFamiTF316214

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR016311 Transform_prot_C-ets
IPR027276 Transform_prot_C-ets-2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PIRSFiPIRSF501032 C-ets-2, 1 hit
PIRSF001698 Transforming_factor_C-ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P15036-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNDFGIKNMD QVAPVANSYR GTLKRQPAFD TFDGSLFAVF PSLNEEQTLQ
60 70 80 90 100
EVPTGLDSIS HDSANCELPL LTPCSKAVMS QALKATFSGF KKEQRRLGIP
110 120 130 140 150
KNPWLWSEQQ VCQWLLWATN EFSLVNVNLQ RFGMNGQMLC NLGKERFLEL
160 170 180 190 200
APDFVGDILW EHLEQMIKEN QEKTEDQYEE NSHLTSVPHW INSNTLGFGT
210 220 230 240 250
EQAPYGMQTQ NYPKGGLLDS MCPASTPSVL SSEQEFQMFP KSRLSSVSVT
260 270 280 290 300
YCSVSQDFPG SNLNLLTNNS GTPKDHDSPE NGADSFESSD SLLQSWNSQS
310 320 330 340 350
SLLDVQRVPS FESFEDDCSQ SLCLNKPTMS FKDYIQERSD PVEQGKPVIP
360 370 380 390 400
AAVLAGFTGS GPIQLWQFLL ELLSDKSCQS FISWTGDGWE FKLADPDEVA
410 420 430 440 450
RRWGKRKNKP KMNYEKLSRG LRYYYDKNII HKTSGKRYVY RFVCDLQNLL
460
GFTPEELHAI LGVQPDTED
Length:469
Mass (Da):53,001
Last modified:April 1, 1990 - v1
Checksum:i5944EC4B5AAB553E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JAG2C9JAG2_HUMAN
Protein C-ets-2
ETS2
270Annotation score:
A0A0C4DG47A0A0C4DG47_HUMAN
Protein C-ets-2
ETS2
168Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04102 mRNA Translation: AAA52412.1
AF017257 Genomic DNA Translation: AAB94057.1
AK315563 mRNA Translation: BAG37939.1
BT006838 mRNA Translation: AAP35484.1
AL163278 Genomic DNA Translation: CAB90468.1
AP001732 Genomic DNA Translation: BAA95514.1
AP001040 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09673.1
CH471079 Genomic DNA Translation: EAX09674.1
CH471079 Genomic DNA Translation: EAX09676.1
BC017040 mRNA Translation: AAH17040.1
BC042954 mRNA Translation: AAH42954.1
X55181 Genomic DNA Translation: CAA38966.1
M11922 mRNA Translation: AAA52411.1
CCDSiCCDS13659.1
PIRiB32066 TVHUE2
RefSeqiNP_005230.1, NM_005239.5
XP_005260992.1, XM_005260935.1
XP_016883779.1, XM_017028290.1
UniGeneiHs.644231

Genome annotation databases

EnsembliENST00000360214; ENSP00000353344; ENSG00000157557
ENST00000360938; ENSP00000354194; ENSG00000157557
GeneIDi2114
KEGGihsa:2114
UCSCiuc002yxf.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04102 mRNA Translation: AAA52412.1
AF017257 Genomic DNA Translation: AAB94057.1
AK315563 mRNA Translation: BAG37939.1
BT006838 mRNA Translation: AAP35484.1
AL163278 Genomic DNA Translation: CAB90468.1
AP001732 Genomic DNA Translation: BAA95514.1
AP001040 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09673.1
CH471079 Genomic DNA Translation: EAX09674.1
CH471079 Genomic DNA Translation: EAX09676.1
BC017040 mRNA Translation: AAH17040.1
BC042954 mRNA Translation: AAH42954.1
X55181 Genomic DNA Translation: CAA38966.1
M11922 mRNA Translation: AAA52411.1
CCDSiCCDS13659.1
PIRiB32066 TVHUE2
RefSeqiNP_005230.1, NM_005239.5
XP_005260992.1, XM_005260935.1
XP_016883779.1, XM_017028290.1
UniGeneiHs.644231

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BQAX-ray2.50A/D/G325-464[»]
4MHVX-ray2.45A/B76-170[»]
ProteinModelPortaliP15036
SMRiP15036
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108415, 29 interactors
CORUMiP15036
DIPiDIP-40452N
IntActiP15036, 22 interactors
MINTiP15036
STRINGi9606.ENSP00000353344

PTM databases

iPTMnetiP15036
PhosphoSitePlusiP15036

Polymorphism and mutation databases

BioMutaiETS2
DMDMi119645

Proteomic databases

EPDiP15036
MaxQBiP15036
PaxDbiP15036
PeptideAtlasiP15036
PRIDEiP15036
ProteomicsDBi53101

Protocols and materials databases

DNASUi2114
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360214; ENSP00000353344; ENSG00000157557
ENST00000360938; ENSP00000354194; ENSG00000157557
GeneIDi2114
KEGGihsa:2114
UCSCiuc002yxf.4 human

Organism-specific databases

CTDi2114
DisGeNETi2114
EuPathDBiHostDB:ENSG00000157557.11
GeneCardsiETS2
HGNCiHGNC:3489 ETS2
HPAiHPA003176
MIMi164740 gene
neXtProtiNX_P15036
OpenTargetsiENSG00000157557
PharmGKBiPA27903
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000285953
HOVERGENiHBG003088
InParanoidiP15036
KOiK21932
OMAiFGMNGQV
OrthoDBiEOG091G0HJF
PhylomeDBiP15036
TreeFamiTF316214

Enzyme and pathway databases

ReactomeiR-HSA-2559585 Oncogene Induced Senescence
SignaLinkiP15036
SIGNORiP15036

Miscellaneous databases

ChiTaRSiETS2 human
GeneWikiiETS2
GenomeRNAii2114
PROiPR:P15036
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157557 Expressed in 225 organ(s), highest expression level in skin of abdomen
CleanExiHS_ETS2
ExpressionAtlasiP15036 baseline and differential
GenevisibleiP15036 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR016311 Transform_prot_C-ets
IPR027276 Transform_prot_C-ets-2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PIRSFiPIRSF501032 C-ets-2, 1 hit
PIRSF001698 Transforming_factor_C-ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiETS2_HUMAN
AccessioniPrimary (citable) accession number: P15036
Secondary accession number(s): A6NM68, D3DSH6, Q53Y89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 7, 2018
This is version 186 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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