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Entry version 136 (13 Nov 2019)
Sequence version 3 (01 Nov 1997)
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Protein

Exodeoxyribonuclease 8

Gene

recE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Is involved in the RecE pathway of recombination. Catalyzes the degradation of double-stranded DNA. Acts progressively in a 5' to 3' direction, releasing 5'-phosphomononucleotides. Has a strong preference for linear duplex substrate DNA and appears to be unable to initiate degradation from single-stranded breaks in DNA.

Miscellaneous

Encoded in the Rac prophage.Curated

Caution

The protein sequences in X55956 are all from mutants in which fusions to an internal fragment of recE have occurred.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • double-stranded DNA 5'-3' exodeoxyribonuclease activity Source: EcoCyc
  • identical protein binding Source: IntAct

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:EG10827-MONOMER
ECOL316407:JW1344-MONOMER
MetaCyc:EG10827-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exodeoxyribonuclease 8 (EC:3.1.11.-)
Alternative name(s):
Exodeoxyribonuclease VIII
Short name:
EXO VIII
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:recE
Ordered Locus Names:b1350, JW1344
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Has been used to construct a 2,4,6-trinitrotoluene (TNT) biosensor strain.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000972271 – 866Exodeoxyribonuclease 8Add BLAST866

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P15032

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15032

PRoteomics IDEntifications database

More...
PRIDEi
P15032

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Transcription is increased specifically in response to 2,4,6-trinitrotoluene (TNT) and its indicator compounds 1,3-DNB, 2,4-DNT, and 2,6-DNT.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-553304,EBI-553304

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4260163, 103 interactors

Database of interacting proteins

More...
DIPi
DIP-10652N

Protein interaction database and analysis system

More...
IntActi
P15032, 11 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b1350

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1866
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P15032

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P15032

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG41076J9 Bacteria
ENOG410XPW2 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000120165

KEGG Orthology (KO)

More...
KOi
K10906

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010584 ExoDNase_VIII
IPR024432 Put_RecE_PDDEXK-like_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12684 DUF3799, 1 hit
PF06630 Exonuc_VIII, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P15032-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTKPLFLLR KAKKSSGEPD VVLWASNDFE STCATLDYLI VKSGKKLSSY
60 70 80 90 100
FKAVATNFPV VNDLPAEGEI DFTWSERYQL SKDSMTWELK PGAAPDNAHY
110 120 130 140 150
QGNTNVNGED MTEIEENMLL PISGQELPIR WLAQHGSEKP VTHVSRDGLQ
160 170 180 190 200
ALHIARAEEL PAVTALAVSH KTSLLDPLEI RELHKLVRDT DKVFPNPGNS
210 220 230 240 250
NLGLITAFFE AYLNADYTDR GLLTKEWMKG NRVSHITRTA SGANAGGGNL
260 270 280 290 300
TDRGEGFVHD LTSLARDVAT GVLARSMDLD IYNLHPAHAK RIEEIIAENK
310 320 330 340 350
PPFSVFRDKF ITMPGGLDYS RAIVVASVKE APIGIEVIPA HVTEYLNKVL
360 370 380 390 400
TETDHANPDP EIVDIACGRS SAPMPQRVTE EGKQDDEEKP QPSGTTAVEQ
410 420 430 440 450
GEAETMEPDA TEHHQDTQPL DAQSQVNSVD AKYQELRAEL HEARKNIPSK
460 470 480 490 500
NPVDDDKLLA ASRGEFVDGI SDPNDPKWVK GIQTRDCVYQ NQPETEKTSP
510 520 530 540 550
DMNQPEPVVQ QEPEIACNAC GQTGGDNCPD CGAVMGDATY QETFDEESQV
560 570 580 590 600
EAKENDPEEM EGAEHPHNEN AGSDPHRDCS DETGEVADPV IVEDIEPGIY
610 620 630 640 650
YGISNENYHA GPGISKSQLD DIADTPALYL WRKNAPVDTT KTKTLDLGTA
660 670 680 690 700
FHCRVLEPEE FSNRFIVAPE FNRRTNAGKE EEKAFLMECA STGKTVITAE
710 720 730 740 750
EGRKIELMYQ SVMALPLGQW LVESAGHAES SIYWEDPETG ILCRCRPDKI
760 770 780 790 800
IPEFHWIMDV KTTADIQRFK TAYYDYRYHV QDAFYSDGYE AQFGVQPTFV
810 820 830 840 850
FLVASTTIEC GRYPVEIFMM GEEAKLAGQQ EYHRNLRTLS DCLNTDEWPA
860
IKTLSLPRWA KEYAND
Length:866
Mass (Da):96,368
Last modified:November 1, 1997 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6133E2FDDB12A538
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti366A → G in AAA03212 (PubMed:2649487).Curated1
Sequence conflicti691 – 692ST → TA in AAA16178 (PubMed:8244937).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74432.1
AP009048 Genomic DNA Translation: BAA14950.1
M24905 Unassigned DNA Translation: AAA03212.1
X55956 Genomic DNA Translation: CAA39419.1 Sequence problems.
X55956 Genomic DNA Translation: CAA39420.1 Sequence problems.
X55956 Genomic DNA Translation: CAA39421.1 Sequence problems.
X55956 Genomic DNA Translation: CAA39422.1 Sequence problems.
X55956 Genomic DNA Translation: CAA39423.1 Sequence problems.
L23927 Unassigned DNA Translation: AAA16178.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A64885 NCECX8

NCBI Reference Sequences

More...
RefSeqi
NP_415866.1, NC_000913.3
WP_000105143.1, NZ_CP014272.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74432; AAC74432; b1350
BAA14950; BAA14950; BAA14950

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
945918

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW1344
eco:b1350

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.927

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74432.1
AP009048 Genomic DNA Translation: BAA14950.1
M24905 Unassigned DNA Translation: AAA03212.1
X55956 Genomic DNA Translation: CAA39419.1 Sequence problems.
X55956 Genomic DNA Translation: CAA39420.1 Sequence problems.
X55956 Genomic DNA Translation: CAA39421.1 Sequence problems.
X55956 Genomic DNA Translation: CAA39422.1 Sequence problems.
X55956 Genomic DNA Translation: CAA39423.1 Sequence problems.
L23927 Unassigned DNA Translation: AAA16178.1
PIRiA64885 NCECX8
RefSeqiNP_415866.1, NC_000913.3
WP_000105143.1, NZ_CP014272.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H4RX-ray2.80A606-866[»]
SMRiP15032
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi4260163, 103 interactors
DIPiDIP-10652N
IntActiP15032, 11 interactors
STRINGi511145.b1350

Proteomic databases

jPOSTiP15032
PaxDbiP15032
PRIDEiP15032

Genome annotation databases

EnsemblBacteriaiAAC74432; AAC74432; b1350
BAA14950; BAA14950; BAA14950
GeneIDi945918
KEGGiecj:JW1344
eco:b1350
PATRICifig|1411691.4.peg.927

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0820

Phylogenomic databases

eggNOGiENOG41076J9 Bacteria
ENOG410XPW2 LUCA
HOGENOMiHOG000120165
KOiK10906

Enzyme and pathway databases

BioCyciEcoCyc:EG10827-MONOMER
ECOL316407:JW1344-MONOMER
MetaCyc:EG10827-MONOMER

Miscellaneous databases

EvolutionaryTraceiP15032

Protein Ontology

More...
PROi
PR:P15032

Family and domain databases

InterProiView protein in InterPro
IPR010584 ExoDNase_VIII
IPR024432 Put_RecE_PDDEXK-like_dom
PfamiView protein in Pfam
PF12684 DUF3799, 1 hit
PF06630 Exonuc_VIII, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRECE_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15032
Secondary accession number(s): P76848, P77807
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 1, 1997
Last modified: November 13, 2019
This is version 136 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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