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UniProtKB - P15030 (FECC_ECOLI)

Entry version 167 (25 May 2022)
Sequence version 2 (01 Feb 1995)
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Protein

Fe(3+) dicitrate transport system permease protein FecC

Gene

fecC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the binding-protein-dependent transport system for citrate-dependent Fe3+. Probably responsible for the translocation of the substrate across the membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • iron chelate transmembrane transporter activity Source: EcoCyc
  • transmembrane transporter activity Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:FECC-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.1.14.1, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fe(3+) dicitrate transport system permease protein FecC
Alternative name(s):
Iron(III) dicitrate transport system permease protein FecC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fecC
Ordered Locus Names:b4289, JW4249
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 7CytoplasmicSequence analysis7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 64PeriplasmicSequence analysisAdd BLAST36
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 118CytoplasmicSequence analysisAdd BLAST33
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 152PeriplasmicSequence analysisAdd BLAST13
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 199CytoplasmicSequence analysisAdd BLAST26
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Topological domaini221 – 244PeriplasmicSequence analysisAdd BLAST24
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 280CytoplasmicSequence analysisAdd BLAST15
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Topological domaini302 – 307PeriplasmicSequence analysis6
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 332CytoplasmicSequence analysis4

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pathogen-Host Interaction database

More...PHI-basei		PHI:8008

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000600201 – 332Fe(3+) dicitrate transport system permease protein FecCAdd BLAST332

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P15030

PRoteomics IDEntifications database

More...PRIDEi		P15030

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced 1.8-fold by hydroxyurea.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4262741, 360 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-4403, Ferric-citrate ABC transporter complex

STRING: functional protein association networks

More...STRINGi		511145.b4289

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P15030

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P15030

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0609, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013016_1_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P15030

Identification of Orthologs from Complete Genome Data

More...OMAi		GAPCFVW

Database for complete collections of gene phylogenies

More...PhylomeDBi		P15030

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.3470.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037294, ABC_BtuC-like
IPR000522, ABC_transptr_permease_BtuC

The PANTHER Classification System

More...PANTHERi		PTHR30472, PTHR30472, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01032, FecCD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81345, SSF81345, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P15030-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAIKHPVLL WGLPVAALII IFWLSLFCYS AIPVSGADAT RALLPGHTPT 
        60         70         80         90        100
LPEALVQNLR LPRSLVAVLI GASLALAGTL LQTLTHNPMA SPSLLGINSG 
       110        120        130        140        150
AALAMALTSA LSPTPIAGYS LSFIAACGGG VSWLLVMTAG GGFRHTHDRN 
       160        170        180        190        200
KLILAGIALS AFCMGLTRIT LLLAEDHAYG IFYWLAGGVS HARWQDVWQL 
       210        220        230        240        250
LPVVVTAVPV VLLLANQLNL LNLSDSTAHT LGVNLTRLRL VINMLVLLLV 
       260        270        280        290        300
GACVSVAGPV AFIGLLVPHL ARFWAGFDQR NVLPVSMLLG ATLMLLADVL 
       310        320        330 
ARALAFPGDL PAGAVLALIG SPCFVWLVRR RG
Length:332
Mass (Da):34,893
Last modified:February 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1BCE861FEE5E16DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti103 – 123LAMAL…YSLSF → WLWRYQRAESDADCRLFSVV in AAA23763 (PubMed:2651410).CuratedAdd BLAST21
Sequence conflicti178A → AS in AAA23763 (PubMed:2651410).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M26397 Genomic DNA Translation: AAA23763.1
U14003 Genomic DNA Translation: AAA97185.1
U00096 Genomic DNA Translation: AAC77245.1
AP009048 Genomic DNA Translation: BAE78280.1

Protein sequence database of the Protein Information Resource

More...PIRi		S56514, QRECD1

NCBI Reference Sequences

More...RefSeqi		NP_418709.1, NC_000913.3
WP_000125187.1, NZ_STEB01000013.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC77245; AAC77245; b4289
BAE78280; BAE78280; BAE78280

Database of genes from NCBI RefSeq genomes

More...GeneIDi		948826

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW4249
eco:b4289

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.2410

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26397 Genomic DNA Translation: AAA23763.1
U14003 Genomic DNA Translation: AAA97185.1
U00096 Genomic DNA Translation: AAC77245.1
AP009048 Genomic DNA Translation: BAE78280.1
PIRiS56514, QRECD1
RefSeqiNP_418709.1, NC_000913.3
WP_000125187.1, NZ_STEB01000013.1

3D structure databases

AlphaFoldDBiP15030
SMRiP15030
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4262741, 360 interactors
ComplexPortaliCPX-4403, Ferric-citrate ABC transporter complex
STRINGi511145.b4289

Protein family/group databases

TCDBi3.A.1.14.1, the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbiP15030
PRIDEiP15030

Genome annotation databases

EnsemblBacteriaiAAC77245; AAC77245; b4289
BAE78280; BAE78280; BAE78280
GeneIDi948826
KEGGiecj:JW4249
eco:b4289
PATRICifig|1411691.4.peg.2410

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0284

Phylogenomic databases

eggNOGiCOG0609, Bacteria
HOGENOMiCLU_013016_1_0_6
InParanoidiP15030
OMAiGAPCFVW
PhylomeDBiP15030

Enzyme and pathway databases

BioCyciEcoCyc:FECC-MONOMER

Miscellaneous databases

PHI-baseiPHI:8008

Protein Ontology

More...PROi		PR:P15030

Family and domain databases

Gene3Di1.10.3470.10, 1 hit
InterProiView protein in InterPro
IPR037294, ABC_BtuC-like
IPR000522, ABC_transptr_permease_BtuC
PANTHERiPTHR30472, PTHR30472, 1 hit
PfamiView protein in Pfam
PF01032, FecCD, 1 hit
SUPFAMiSSF81345, SSF81345, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFECC_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15030
Secondary accession number(s): Q2M626
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: February 1, 1995
Last modified: May 25, 2022
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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