UniProtKB - P15030 (FECC_ECOLI)
Protein
Fe(3+) dicitrate transport system permease protein FecC
Gene
fecC
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the binding-protein-dependent transport system for citrate-dependent Fe3+. Probably responsible for the translocation of the substrate across the membrane.
GO - Molecular functioni
- iron chelate transmembrane transporter activity Source: EcoCyc
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- siderophore-dependent iron import into cell Source: EcoCyc
Keywordsi
Biological process | Ion transport, Iron transport, Transport |
Ligand | Iron |
Enzyme and pathway databases
BioCyci | EcoCyc:FECC-MONOMER ECOL316407:JW4249-MONOMER MetaCyc:FECC-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.14.1 the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Fe(3+) dicitrate transport system permease protein FecCAlternative name(s): Iron(III) dicitrate transport system permease protein FecC |
Gene namesi | Name:fecC Ordered Locus Names:b4289, JW4249 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 7 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 8 – 28 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 29 – 64 | PeriplasmicSequence analysisAdd BLAST | 36 | |
Transmembranei | 65 – 85 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 86 – 118 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 119 – 139 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 140 – 152 | PeriplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 153 – 173 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 174 – 199 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 200 – 220 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 221 – 244 | PeriplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 245 – 265 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 266 – 280 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 281 – 301 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 302 – 307 | PeriplasmicSequence analysis | 6 | |
Transmembranei | 308 – 328 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 329 – 332 | CytoplasmicSequence analysis | 4 |
GO - Cellular componenti
- cell Source: GOC
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000060020 | 1 – 332 | Fe(3+) dicitrate transport system permease protein FecCAdd BLAST | 332 |
Proteomic databases
PaxDbi | P15030 |
PRIDEi | P15030 |
Expressioni
Inductioni
Induced 1.8-fold by hydroxyurea.1 Publication
Interactioni
Protein-protein interaction databases
BioGridi | 4262741, 360 interactors |
STRINGi | 511145.b4289 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4105DQ5 Bacteria COG0609 LUCA |
HOGENOMi | HOG000045410 |
InParanoidi | P15030 |
KOi | K23183 |
PhylomeDBi | P15030 |
Family and domain databases
Gene3Di | 1.10.3470.10, 1 hit |
InterProi | View protein in InterPro IPR037294 ABC_BtuC-like IPR000522 ABC_transptr_permease_BtuC |
PANTHERi | PTHR30472 PTHR30472, 1 hit |
Pfami | View protein in Pfam PF01032 FecCD, 1 hit |
SUPFAMi | SSF81345 SSF81345, 1 hit |
i Sequence
Sequence statusi: Complete.
P15030-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTAIKHPVLL WGLPVAALII IFWLSLFCYS AIPVSGADAT RALLPGHTPT
60 70 80 90 100
LPEALVQNLR LPRSLVAVLI GASLALAGTL LQTLTHNPMA SPSLLGINSG
110 120 130 140 150
AALAMALTSA LSPTPIAGYS LSFIAACGGG VSWLLVMTAG GGFRHTHDRN
160 170 180 190 200
KLILAGIALS AFCMGLTRIT LLLAEDHAYG IFYWLAGGVS HARWQDVWQL
210 220 230 240 250
LPVVVTAVPV VLLLANQLNL LNLSDSTAHT LGVNLTRLRL VINMLVLLLV
260 270 280 290 300
GACVSVAGPV AFIGLLVPHL ARFWAGFDQR NVLPVSMLLG ATLMLLADVL
310 320 330
ARALAFPGDL PAGAVLALIG SPCFVWLVRR RG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 103 – 123 | LAMAL…YSLSF → WLWRYQRAESDADCRLFSVV in AAA23763 (PubMed:2651410).CuratedAdd BLAST | 21 | |
Sequence conflicti | 178 | A → AS in AAA23763 (PubMed:2651410).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26397 Genomic DNA Translation: AAA23763.1 U14003 Genomic DNA Translation: AAA97185.1 U00096 Genomic DNA Translation: AAC77245.1 AP009048 Genomic DNA Translation: BAE78280.1 |
PIRi | S56514 QRECD1 |
RefSeqi | NP_418709.1, NC_000913.3 WP_000125187.1, NZ_STEB01000013.1 |
Genome annotation databases
EnsemblBacteriai | AAC77245; AAC77245; b4289 BAE78280; BAE78280; BAE78280 |
GeneIDi | 948826 |
KEGGi | ecj:JW4249 eco:b4289 |
PATRICi | fig|1411691.4.peg.2410 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26397 Genomic DNA Translation: AAA23763.1 U14003 Genomic DNA Translation: AAA97185.1 U00096 Genomic DNA Translation: AAC77245.1 AP009048 Genomic DNA Translation: BAE78280.1 |
PIRi | S56514 QRECD1 |
RefSeqi | NP_418709.1, NC_000913.3 WP_000125187.1, NZ_STEB01000013.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 4262741, 360 interactors |
STRINGi | 511145.b4289 |
Protein family/group databases
TCDBi | 3.A.1.14.1 the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | P15030 |
PRIDEi | P15030 |
Genome annotation databases
EnsemblBacteriai | AAC77245; AAC77245; b4289 BAE78280; BAE78280; BAE78280 |
GeneIDi | 948826 |
KEGGi | ecj:JW4249 eco:b4289 |
PATRICi | fig|1411691.4.peg.2410 |
Organism-specific databases
EchoBASEi | EB0284 |
Phylogenomic databases
eggNOGi | ENOG4105DQ5 Bacteria COG0609 LUCA |
HOGENOMi | HOG000045410 |
InParanoidi | P15030 |
KOi | K23183 |
PhylomeDBi | P15030 |
Enzyme and pathway databases
BioCyci | EcoCyc:FECC-MONOMER ECOL316407:JW4249-MONOMER MetaCyc:FECC-MONOMER |
Miscellaneous databases
PROi | PR:P15030 |
Family and domain databases
Gene3Di | 1.10.3470.10, 1 hit |
InterProi | View protein in InterPro IPR037294 ABC_BtuC-like IPR000522 ABC_transptr_permease_BtuC |
PANTHERi | PTHR30472 PTHR30472, 1 hit |
Pfami | View protein in Pfam PF01032 FecCD, 1 hit |
SUPFAMi | SSF81345 SSF81345, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FECC_ECOLI | |
Accessioni | P15030Primary (citable) accession number: P15030 Secondary accession number(s): Q2M626 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | February 1, 1995 | |
Last modified: | November 13, 2019 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene