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UniProtKB - P15028 (FECB_ECOLI)
Protein
Fe(3+) dicitrate-binding periplasmic protein
Gene
fecB
Organism
Escherichia coli (strain K12)
Status
Functioni
Binds citrate-dependent Fe3+; part of the binding-protein-dependent transport system for uptake of citrate-dependent Fe3+.
GO - Biological processi
- iron ion homeostasis Source: EcoCyc
- response to iron ion Source: EcoCyc
- siderophore-dependent iron import into cell Source: EcoCyc
Keywordsi
Biological process | Ion transport, Iron transport, Transport |
Ligand | Iron |
Enzyme and pathway databases
BioCyci | EcoCyc:FECB-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.14.1, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Fe(3+) dicitrate-binding periplasmic proteinAlternative name(s): Iron(III) dicitrate-binding periplasmic protein |
Gene namesi | Name:fecB Ordered Locus Names:b4290, JW4250 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Other locations
Other locations
- outer membrane-bounded periplasmic space Source: EcoCyc
Keywords - Cellular componenti
PeriplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000031820 | 22 – 300 | Fe(3+) dicitrate-binding periplasmic proteinAdd BLAST | 279 |
Proteomic databases
jPOSTi | P15028 |
PaxDbi | P15028 |
PRIDEi | P15028 |
Expressioni
Inductioni
Induced 1.8-fold by hydroxyurea.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261562, 224 interactors 851179, 7 interactors |
ComplexPortali | CPX-4403, Ferric-citrate ABC transporter complex |
DIPi | DIP-9584N |
IntActi | P15028, 10 interactors |
STRINGi | 511145.b4290 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 295 | Fe/B12 periplasmic-bindingPROSITE-ProRule annotationAdd BLAST | 257 |
Sequence similaritiesi
Belongs to the bacterial solute-binding protein 8 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG4594, Bacteria |
HOGENOMi | CLU_038034_0_0_6 |
InParanoidi | P15028 |
PhylomeDBi | P15028 |
Family and domain databases
InterProi | View protein in InterPro IPR002491, ABC_transptr_periplasmic_BD |
Pfami | View protein in Pfam PF01497, Peripla_BP_2, 1 hit |
PROSITEi | View protein in PROSITE PS50983, FE_B12_PBP, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P15028-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLAFIRFLFA GLLLVISHAF AATVQDEHGT FTLEKTPQRI VVLELSFADA
60 70 80 90 100
LAAVDVIPIG IADDNDAKRI LPEVRAHLKP WQSVGTRAQP SLEAIAALKP
110 120 130 140 150
DLIIADSSRH AGVYIALQQI APVLLLKSRN ETYAENLQSA AIIGEMVGKK
160 170 180 190 200
REMQARLEQH KERMAQWASQ LPKGTRVAFG TSREQQFNLH TQETWTGSVL
210 220 230 240 250
ASLGLNVPAA MAGASMPSIG LEQLLAVNPA WLLVAHYREE SIVKRWQQDP
260 270 280 290 300
LWQMLTAAQK QQVASVDSNT WARMRGIFAA ERIAADTVKI FHHQPLTVVK
Sequence cautioni
The sequence AAA97186 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 | T → M in AAA23762 (PubMed:2651410).Curated | 1 | |
Sequence conflicti | 57 | I → S in AAA23762 (PubMed:2651410).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 8 | L → V in strain: B. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26397 Genomic DNA Translation: AAA23762.1 U14003 Genomic DNA Translation: AAA97186.1 Different initiation. U00096 Genomic DNA Translation: AAC77246.2 AP009048 Genomic DNA Translation: BAE78281.1 |
PIRi | S56515, QRECD3 |
RefSeqi | NP_418710.4, NC_000913.3 WP_000879155.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC77246; AAC77246; b4290 BAE78281; BAE78281; BAE78281 |
GeneIDi | 946838 |
KEGGi | ecj:JW4250 eco:b4290 |
PATRICi | fig|1411691.4.peg.2409 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26397 Genomic DNA Translation: AAA23762.1 U14003 Genomic DNA Translation: AAA97186.1 Different initiation. U00096 Genomic DNA Translation: AAC77246.2 AP009048 Genomic DNA Translation: BAE78281.1 |
PIRi | S56515, QRECD3 |
RefSeqi | NP_418710.4, NC_000913.3 WP_000879155.1, NZ_LN832404.1 |
3D structure databases
SMRi | P15028 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261562, 224 interactors 851179, 7 interactors |
ComplexPortali | CPX-4403, Ferric-citrate ABC transporter complex |
DIPi | DIP-9584N |
IntActi | P15028, 10 interactors |
STRINGi | 511145.b4290 |
Protein family/group databases
TCDBi | 3.A.1.14.1, the atp-binding cassette (abc) superfamily |
Proteomic databases
jPOSTi | P15028 |
PaxDbi | P15028 |
PRIDEi | P15028 |
Genome annotation databases
EnsemblBacteriai | AAC77246; AAC77246; b4290 BAE78281; BAE78281; BAE78281 |
GeneIDi | 946838 |
KEGGi | ecj:JW4250 eco:b4290 |
PATRICi | fig|1411691.4.peg.2409 |
Organism-specific databases
EchoBASEi | EB0283 |
Phylogenomic databases
eggNOGi | COG4594, Bacteria |
HOGENOMi | CLU_038034_0_0_6 |
InParanoidi | P15028 |
PhylomeDBi | P15028 |
Enzyme and pathway databases
BioCyci | EcoCyc:FECB-MONOMER |
Miscellaneous databases
PROi | PR:P15028 |
Family and domain databases
InterProi | View protein in InterPro IPR002491, ABC_transptr_periplasmic_BD |
Pfami | View protein in Pfam PF01497, Peripla_BP_2, 1 hit |
PROSITEi | View protein in PROSITE PS50983, FE_B12_PBP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FECB_ECOLI | |
Accessioni | P15028Primary (citable) accession number: P15028 Secondary accession number(s): P76816, Q2M625 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | July 19, 2003 | |
Last modified: | February 23, 2022 | |
This is version 154 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families