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Entry version 146 (07 Apr 2021)
Sequence version 2 (07 Jul 2009)
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Protein

UvrABC system protein C

Gene

uvrC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU28490-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:BSU28490
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001382881 – 590UvrABC system protein CAdd BLAST590

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P14951

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with UvrB in an incision complex.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224308.BSU28490

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P14951

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 91GIY-YIGUniRule annotationAdd BLAST78
Domaini196 – 231UVRUniRule annotationAdd BLAST36

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0322, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P14951

Identification of Orthologs from Complete Genome Data

More...
OMAi
LFPIRQC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P14951

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.340, 1 hit
3.40.1440.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00203, UvrC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000305, GIY-YIG_endonuc
IPR035901, GIY-YIG_endonuc_sf
IPR010994, RuvA_2-like
IPR001943, UVR_dom
IPR036876, UVR_dom_sf
IPR004791, UvrC
IPR001162, UvrC_homol_region
IPR038476, UvrC_homol_region_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01541, GIY-YIG, 1 hit
PF02151, UVR, 1 hit
PF08459, UvrC_HhH_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00465, GIYc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46600, SSF46600, 1 hit
SSF47781, SSF47781, 1 hit
SSF82771, SSF82771, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00194, uvrC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50164, GIY_YIG, 1 hit
PS50151, UVR, 1 hit
PS50165, UVRC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P14951-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKQLKEKLA LLPDQPGCYL MKDRQQTVIY VGKAKVLKNR VRSYFTGSHD
60 70 80 90 100
AKTQRLVTEI EDFEYIVTSS NLEALILEMN LIKKHDPKYN VMLKDDKTYP
110 120 130 140 150
FIKLTHERHP RLIVTRNVKK DKGRYFGPYP NVQAARETKK LLDRLYPLRK
160 170 180 190 200
CSKLPDRVCL YYHLGQCLAP CVKDISEETN RELVESITRF LRGGYNEVKK
210 220 230 240 250
ELEEKMHEAA ENLEFERAKE LRDQIAHIES TMEKQKMTMN DLVDRDVFAY
260 270 280 290 300
AYDKGWMCVQ VFFIRQGKLI ERDVSMFPLY QEADEEFLTF IGQFYSKNNH
310 320 330 340 350
FLPKEILVPD SIDQSMIEQL LETNVHQPKK GPKKELLMLA HKNAKIALKE
360 370 380 390 400
KFSLIERDEE RSIGAVQKLG EALNIYTPHR IEAFDNSNIQ GTNPVSAMIV
410 420 430 440 450
FIDGKPYKKE YRKYKIKTVT GPDDYGSMRE VVRRRYTRVL RENLPLPDLI
460 470 480 490 500
IIDGGKGQIN AARDVIENEL GLDIPIAGLA KDEKHRTSNL LIGDPLEVAY
510 520 530 540 550
LERNSQEFYL LQRIQDEVHR FAISFHRQIR GKSAFQSVLD DIPGIGEKRK
560 570 580 590
KMLLKHFGSV KKMKEASLED IKKAGVPAAA AQLLYDKLQK
Length:590
Mass (Da):68,472
Last modified:July 7, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iECB6DE521F13E75A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti382E → V in AAA87316 (PubMed:2559145).Curated1
Sequence conflicti382E → V in CAA99578 (PubMed:8969504).Curated1
Sequence conflicti578 – 590AAAAQ…DKLQK → QRRLSSFTTNCKNNVVLLNK I in AAA87316 (PubMed:2559145).CuratedAdd BLAST13
Sequence conflicti578 – 590AAAAQ…DKLQK → QRRLSSFTTNCKNNVVLLNK I in CAA99578 (PubMed:8969504).CuratedAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J03294 Genomic DNA Translation: AAA87316.1
Z75208 Genomic DNA Translation: CAA99578.1
AL009126 Genomic DNA Translation: CAB14809.2

Protein sequence database of the Protein Information Resource

More...
PIRi
A37192

NCBI Reference Sequences

More...
RefSeqi
NP_390727.2, NC_000964.3
WP_003246045.1, NZ_JNCM01000036.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB14809; CAB14809; BSU_28490

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
937729

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bsu:BSU28490

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224308.179.peg.3094

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03294 Genomic DNA Translation: AAA87316.1
Z75208 Genomic DNA Translation: CAA99578.1
AL009126 Genomic DNA Translation: CAB14809.2
PIRiA37192
RefSeqiNP_390727.2, NC_000964.3
WP_003246045.1, NZ_JNCM01000036.1

3D structure databases

SMRiP14951
ModBaseiSearch...

Protein-protein interaction databases

STRINGi224308.BSU28490

Proteomic databases

PaxDbiP14951

Genome annotation databases

EnsemblBacteriaiCAB14809; CAB14809; BSU_28490
GeneIDi937729
KEGGibsu:BSU28490
PATRICifig|224308.179.peg.3094

Phylogenomic databases

eggNOGiCOG0322, Bacteria
InParanoidiP14951
OMAiLFPIRQC
PhylomeDBiP14951

Enzyme and pathway databases

BioCyciBSUB:BSU28490-MONOMER

Family and domain databases

Gene3Di3.30.420.340, 1 hit
3.40.1440.10, 1 hit
HAMAPiMF_00203, UvrC, 1 hit
InterProiView protein in InterPro
IPR000305, GIY-YIG_endonuc
IPR035901, GIY-YIG_endonuc_sf
IPR010994, RuvA_2-like
IPR001943, UVR_dom
IPR036876, UVR_dom_sf
IPR004791, UvrC
IPR001162, UvrC_homol_region
IPR038476, UvrC_homol_region_sf
PfamiView protein in Pfam
PF01541, GIY-YIG, 1 hit
PF02151, UVR, 1 hit
PF08459, UvrC_HhH_N, 1 hit
SMARTiView protein in SMART
SM00465, GIYc, 1 hit
SUPFAMiSSF46600, SSF46600, 1 hit
SSF47781, SSF47781, 1 hit
SSF82771, SSF82771, 1 hit
TIGRFAMsiTIGR00194, uvrC, 1 hit
PROSITEiView protein in PROSITE
PS50164, GIY_YIG, 1 hit
PS50151, UVR, 1 hit
PS50165, UVRC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUVRC_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14951
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 7, 2009
Last modified: April 7, 2021
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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