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UniProtKB - P14949 (THIO_BACSU)
Protein
Thioredoxin
Gene
trxA
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
GO - Molecular functioni
- oxidoreductase activity Source: GO_Central
- protein-disulfide reductase activity Source: GO_Central
GO - Biological processi
- cell redox homeostasis Source: GO_Central
- glycerol ether metabolic process Source: InterPro
Keywordsi
Biological process | Electron transport, Transport |
Enzyme and pathway databases
BioCyci | BSUB:BSU28500-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: ThioredoxinShort name: Trx |
Gene namesi | Name:trxA Synonyms:trx Ordered Locus Names:BSU28500 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000120076 | 2 – 104 | ThioredoxinAdd BLAST | 103 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 29 ↔ 32 | Redox-activePROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
jPOSTi | P14949 |
PaxDbi | P14949 |
PRIDEi | P14949 |
Interactioni
Protein-protein interaction databases
IntActi | P14949, 1 interactor |
MINTi | P14949 |
STRINGi | 224308.BSU28500 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P14949 |
SMRi | P14949 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P14949 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 104 | ThioredoxinPROSITE-ProRule annotationAdd BLAST | 103 |
Sequence similaritiesi
Belongs to the thioredoxin family.Curated
Keywords - Domaini
Redox-active centerPhylogenomic databases
eggNOGi | COG3118, Bacteria |
InParanoidi | P14949 |
OMAi | QVGVAPK |
PhylomeDBi | P14949 |
Family and domain databases
InterProi | View protein in InterPro IPR005746, Thioredoxin IPR036249, Thioredoxin-like_sf IPR017937, Thioredoxin_CS IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF00085, Thioredoxin, 1 hit |
PIRSFi | PIRSF000077, Thioredoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR01068, thioredoxin, 1 hit |
PROSITEi | View protein in PROSITE PS00194, THIOREDOXIN_1, 1 hit PS51352, THIOREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P14949-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAIVKATDQS FSAETSEGVV LADFWAPWCG PCKMIAPVLE ELDQEMGDKL
60 70 80 90 100
KIVKIDVDEN QETAGKYGVM SIPTLLVLKD GEVVETSVGF KPKEALQELV
NKHL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03294 Genomic DNA Translation: AAA87315.1 Z75208 Genomic DNA Translation: CAA99577.1 AL009126 Genomic DNA Translation: CAB14810.1 X79976 Genomic DNA Translation: CAA56300.1 X99275 Genomic DNA Translation: CAA67667.1 |
PIRi | B37192 |
RefSeqi | NP_390728.1, NC_000964.3 WP_003222500.1, NZ_JNCM01000036.1 |
Genome annotation databases
EnsemblBacteriai | CAB14810; CAB14810; BSU_28500 |
GeneIDi | 50136691 64304575 938187 |
KEGGi | bsu:BSU28500 |
PATRICi | fig|224308.179.peg.3095 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03294 Genomic DNA Translation: AAA87315.1 Z75208 Genomic DNA Translation: CAA99577.1 AL009126 Genomic DNA Translation: CAB14810.1 X79976 Genomic DNA Translation: CAA56300.1 X99275 Genomic DNA Translation: CAA67667.1 |
PIRi | B37192 |
RefSeqi | NP_390728.1, NC_000964.3 WP_003222500.1, NZ_JNCM01000036.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2GZY | NMR | - | A | 1-104 | [»] | |
2GZZ | NMR | - | A | 1-104 | [»] | |
2IPA | NMR | - | A | 1-104 | [»] | |
2VOC | X-ray | 1.50 | A/B | 1-104 | [»] | |
BMRBi | P14949 | |||||
SMRi | P14949 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P14949, 1 interactor |
MINTi | P14949 |
STRINGi | 224308.BSU28500 |
Proteomic databases
jPOSTi | P14949 |
PaxDbi | P14949 |
PRIDEi | P14949 |
Genome annotation databases
EnsemblBacteriai | CAB14810; CAB14810; BSU_28500 |
GeneIDi | 50136691 64304575 938187 |
KEGGi | bsu:BSU28500 |
PATRICi | fig|224308.179.peg.3095 |
Phylogenomic databases
eggNOGi | COG3118, Bacteria |
InParanoidi | P14949 |
OMAi | QVGVAPK |
PhylomeDBi | P14949 |
Enzyme and pathway databases
BioCyci | BSUB:BSU28500-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P14949 |
PROi | PR:P14949 |
Family and domain databases
InterProi | View protein in InterPro IPR005746, Thioredoxin IPR036249, Thioredoxin-like_sf IPR017937, Thioredoxin_CS IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF00085, Thioredoxin, 1 hit |
PIRSFi | PIRSF000077, Thioredoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR01068, thioredoxin, 1 hit |
PROSITEi | View protein in PROSITE PS00194, THIOREDOXIN_1, 1 hit PS51352, THIOREDOXIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | THIO_BACSU | |
Accessioni | P14949Primary (citable) accession number: P14949 Secondary accession number(s): O07960, Q45687 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 154 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families