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Protein

Peptidyl-glycine alpha-amidating monooxygenase

Gene

Pam

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:
  • Zn2+Note: Zn2+ is required for the lyase reaction.
  • Cu2+Note: Binds 2 copper ions per subunit for the monooxygenase reaction.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi107Copper A1
Metal bindingi108Copper A1
Metal bindingi172Copper A1
Metal bindingi242Copper B1
Metal bindingi244Copper B1
Metal bindingi314Copper B1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase, Monooxygenase, Multifunctional enzyme, Oxidoreductase
LigandCopper, Metal-binding, Vitamin C, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.17.3 5301
4.3.2.5 5301

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidyl-glycine alpha-amidating monooxygenase
Short name:
PAM
Including the following 2 domains:
Peptidylglycine alpha-hydroxylating monooxygenase (EC:1.14.17.3)
Short name:
PHM
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC:4.3.2.5)
Alternative name(s):
Peptidylamidoglycolate lyase
Short name:
PAL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pam
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Rat genome database

More...
RGDi
3252 Pam

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini36 – 866IntragranularSequence analysisAdd BLAST831
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei867 – 890HelicalSequence analysisAdd BLAST24
Topological domaini891 – 976CytoplasmicSequence analysisAdd BLAST86

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4963

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 251 PublicationAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000636526 – 3510
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000636636 – 976Peptidyl-glycine alpha-amidating monooxygenaseAdd BLAST941

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi47 ↔ 1861 Publication
Disulfide bondi81 ↔ 1261 Publication
Disulfide bondi114 ↔ 1311 Publication
Disulfide bondi227 ↔ 3341 Publication
Disulfide bondi293 ↔ 3151 Publication
Disulfide bondi634 ↔ 6551 Publication
Disulfide bondi702 ↔ 7131 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi765N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei921PhosphoserineBy similarity1
Modified residuei932PhosphoserineBy similarity1
Modified residuei945PhosphoserineCombined sources1
Modified residuei946PhosphothreonineBy similarity1
Modified residuei949PhosphoserineCombined sources1
Modified residuei959PhosphothreonineCombined sources1
Modified residuei961PhosphoserineCombined sources1
Isoform PAM-3 (identifier: P14925-3)
Modified residuei774SulfotyrosineBy similarity1
Isoform PAM-3A (identifier: P14925-4)
Modified residuei792SulfotyrosineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P14925

PRoteomics IDEntifications database

More...
PRIDEi
P14925

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P14925

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P14925

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000033280 Expressed in 10 organ(s), highest expression level in heart

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P14925 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Interacts with RASSF9.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Rassf9O888693EBI-1395008,EBI-1395057

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
247540, 2 interactors

Protein interaction database and analysis system

More...
IntActi
P14925, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000046774

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P14925

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1976
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P14925

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P14925

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P14925

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati501 – 544NHL 1Add BLAST44
Repeati570 – 611NHL 2Add BLAST42
Repeati620 – 665NHL 3Add BLAST46
Repeati673 – 717NHL 4Add BLAST45
Repeati769 – 812NHL 5Add BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 497Peptidylglycine alpha-hydroxylating monooxygenaseAdd BLAST497
Regioni498 – 820Peptidyl-alpha-hydroxyglycine alpha-amidating lyaseAdd BLAST323
Regioni928 – 945Interaction with RASSF91 PublicationAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.Curated
In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3567 Eukaryota
ENOG410XS0X LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156369

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293368

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004218

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P14925

KEGG Orthology (KO)

More...
KOi
K00504
K18200

Identification of Orthologs from Complete Genome Data

More...
OMAi
SCHYKKY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P14925

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 1 hit
2.60.120.230, 1 hit
2.60.120.310, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR014784 Cu2_ascorb_mOase-like_C
IPR020611 Cu2_ascorb_mOase_CS-1
IPR014783 Cu2_ascorb_mOase_CS-2
IPR000323 Cu2_ascorb_mOase_N
IPR036939 Cu2_ascorb_mOase_N_sf
IPR024548 Cu2_monoox_C
IPR001258 NHL_repeat
IPR013017 NHL_repeat_subgr
IPR000720 PHM/PAL
IPR008977 PHM/PNGase_F_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03712 Cu2_monoox_C, 1 hit
PF01082 Cu2_monooxygen, 1 hit
PF01436 NHL, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00790 PAMONOXGNASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49742 SSF49742, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00084 CU2_MONOOXYGENASE_1, 1 hit
PS00085 CU2_MONOOXYGENASE_2, 1 hit
PS51125 NHL, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform PAM-1 (identifier: P14925-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGRARSGLL LLLLGLLALQ SSCLAFRSPL SVFKRFKETT RSFSNECLGT
60 70 80 90 100
IGPVTPLDAS DFALDIRMPG VTPKESDTYF CMSMRLPVDE EAFVIDFKPR
110 120 130 140 150
ASMDTVHHML LFGCNMPSST GSYWFCDEGT CTDKANILYA WARNAPPTRL
160 170 180 190 200
PKGVGFRVGG ETGSKYFVLQ VHYGDISAFR DNHKDCSGVS VHLTRVPQPL
210 220 230 240 250
IAGMYLMMSV DTVIPPGEKV VNADISCQYK MYPMHVFAYR VHTHHLGKVV
260 270 280 290 300
SGYRVRNGQW TLIGRQNPQL PQAFYPVEHP VDVTFGDILA ARCVFTGEGR
310 320 330 340 350
TEATHIGGTS SDEMCNLYIM YYMEAKYALS FMTCTKNVAP DMFRTIPAEA
360 370 380 390 400
NIPIPVKPDM VMMHGHHKEA ENKEKSALMQ QPKQGEEEVL EQGDFYSLLS
410 420 430 440 450
KLLGEREDVH VHKYNPTEKT ESGSDLVAEI ANVVQKKDLG RSDAREGAEH
460 470 480 490 500
EEWGNAILVR DRIHRFHQLE STLRPAESRA FSFQQPGEGP WEPEPSGDFH
510 520 530 540 550
VEEELDWPGV YLLPGQVSGV ALDSKNNLVI FHRGDHVWDG NSFDSKFVYQ
560 570 580 590 600
QRGLGPIEED TILVIDPNNA EILQSSGKNL FYLPHGLSID TDGNYWVTDV
610 620 630 640 650
ALHQVFKLDP HSKEGPLLIL GRSMQPGSDQ NHFCQPTDVA VEPSTGAVFV
660 670 680 690 700
SDGYCNSRIV QFSPSGKFVT QWGEESSGSS PRPGQFSVPH SLALVPHLDQ
710 720 730 740 750
LCVADRENGR IQCFKTDTKE FVREIKHASF GRNVFAISYI PGFLFAVNGK
760 770 780 790 800
PYFGDQEPVQ GFVMNFSSGE IIDVFKPVRK HFDMPHDIVA SEDGTVYIGD
810 820 830 840 850
AHTNTVWKFT LTEKMEHRSV KKAGIEVQEI KEAEAVVEPK VENKPTSSEL
860 870 880 890 900
QKMQEKQKLS TEPGSGVSVV LITTLLVIPV LVLLAIVMFI RWKKSRAFGD
910 920 930 940 950
HDRKLESSSG RVLGRFRGKG SGGLNLGNFF ASRKGYSRKG FDRVSTEGSD
960 970
QEKDEDDGTE SEEEYSAPLP KPAPSS
Note: Membrane-bound.
Length:976
Mass (Da):108,675
Last modified:April 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7233021BEBEFD9B9
GO
Isoform PAM-2 (identifier: P14925-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     393-497: Missing.

Note: Membrane-bound.
Show »
Length:871
Mass (Da):96,825
Checksum:iBA1F40E92F7B8C02
GO
Isoform PAM-3 (identifier: P14925-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     393-497: Missing.
     832-917: Missing.

Note: Soluble.By similarity
Show »
Length:785
Mass (Da):87,253
Checksum:iD49246033AEA388B
GO
Isoform PAM-3A (identifier: P14925-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     393-497: Missing.
     832-899: Missing.

Note: Soluble.By similarity
Show »
Length:803
Mass (Da):89,350
Checksum:iA9C822E643E870D0
GO
Isoform PAM-3B (identifier: P14925-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     393-497: Missing.
     900-917: Missing.

Note: Membrane-bound.
Show »
Length:853
Mass (Da):94,728
Checksum:iD4620879E16C381F
GO
Isoform PAM-4 (identifier: P14925-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     498-517: DFHVEEELDWPGVYLLPGQV → GASRISFTQKKKCVKHCNPH
     518-917: Missing.

Note: Soluble.
Show »
Length:576
Mass (Da):64,102
Checksum:iDA702AEAC95B0F49
GO
Isoform PAM-5 (identifier: P14925-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-312: GTSSD → FKDTF
     313-976: Missing.

Note: Soluble.
Show »
Length:312
Mass (Da):34,676
Checksum:i0150C054899C8326
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA42068 differs from that shown.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti959T → S no nucleotide entry (PubMed:2337358).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001230308 – 312GTSSD → FKDTF in isoform PAM-5. Curated5
Alternative sequenceiVSP_001231313 – 976Missing in isoform PAM-5. CuratedAdd BLAST664
Alternative sequenceiVSP_001232393 – 497Missing in isoform PAM-2, isoform PAM-3, isoform PAM-3A and isoform PAM-3B. CuratedAdd BLAST105
Alternative sequenceiVSP_001236498 – 517DFHVE…LPGQV → GASRISFTQKKKCVKHCNPH in isoform PAM-4. CuratedAdd BLAST20
Alternative sequenceiVSP_001237518 – 917Missing in isoform PAM-4. CuratedAdd BLAST400
Alternative sequenceiVSP_001234832 – 917Missing in isoform PAM-3. CuratedAdd BLAST86
Alternative sequenceiVSP_001233832 – 899Missing in isoform PAM-3A. CuratedAdd BLAST68
Alternative sequenceiVSP_001235900 – 917Missing in isoform PAM-3B. CuratedAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U52650
, U52639, U52640, U52641, U52642, U52643, U52644, U52645, U52646, U52647, U52648, U52649 Genomic DNA Translation: AAC05602.1
U52653
, U52639, U52640, U52641, U52642, U52643, U52644, U52645, U52646, U52647, U52648, U52649, U52651, U52652 Genomic DNA Translation: AAC05603.1
U52664
, U52639, U52640, U52641, U52642, U52643, U52644, U52645, U52646, U52647, U52648, U52649, U52651, U52652, U52653, U52654, U52655, U52656, U52657, U52658, U52659, U52660, U52661, U52662, U52663 Genomic DNA Translation: AAC05607.1
U52664
, U52639, U52640, U52641, U52642, U52643, U52644, U52645, U52646, U52647, U52648, U52649, U52651, U52652, U52654, U52655, U52656, U52657, U52658, U52659, U52660, U52661, U52662, U52663 Genomic DNA Translation: AAC05605.1
U52664
, U52639, U52640, U52641, U52642, U52643, U52644, U52645, U52646, U52647, U52648, U52649, U52651, U52652, U52654, U52655, U52656, U52657, U52658, U52659, U52660, U52661, U52662 Genomic DNA Translation: AAC05604.1
U52664
, U52639, U52640, U52641, U52642, U52643, U52644, U52645, U52646, U52647, U52648, U52649, U52651, U52652, U52654, U52655, U52656, U52657, U52658, U52659, U52660, U52661 Genomic DNA Translation: AAC05608.1
U52664
, U52639, U52640, U52641, U52642, U52643, U52644, U52645, U52646, U52647, U52648, U52649, U52651, U52652, U52654, U52655, U52656, U52657, U52658, U52659, U52660, U52661, U52663 Genomic DNA Translation: AAC05606.1
M25732 mRNA Translation: AAA41803.1
M25719 mRNA Translation: AAA41804.1
M63662 mRNA Translation: AAA42068.1 Sequence problems.
X59685 mRNA Translation: CAA42206.1
X59686 mRNA Translation: CAA42207.1
X59687 mRNA Translation: CAA42208.1
X59688 mRNA Translation: CAA42209.1
X59689 mRNA Translation: CAA42210.1
M82845 mRNA Translation: AAB00162.1

Protein sequence database of the Protein Information Resource

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PIRi
A32193 URRTAP

NCBI Reference Sequences

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RefSeqi
NP_037132.2, NM_013000.2 [P14925-1]
XP_006245660.1, XM_006245598.3 [P14925-2]
XP_006245661.1, XM_006245599.3 [P14925-5]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Rn.1121

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSRNOT00000041418; ENSRNOP00000050784; ENSRNOG00000033280 [P14925-7]
ENSRNOT00000043451; ENSRNOP00000046774; ENSRNOG00000033280 [P14925-1]
ENSRNOT00000056457; ENSRNOP00000053295; ENSRNOG00000033280 [P14925-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
25508

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:25508

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52650
, U52639, U52640, U52641, U52642, U52643, U52644, U52645, U52646, U52647, U52648, U52649 Genomic DNA Translation: AAC05602.1
U52653
, U52639, U52640, U52641, U52642, U52643, U52644, U52645, U52646, U52647, U52648, U52649, U52651, U52652 Genomic DNA Translation: AAC05603.1
U52664
, U52639, U52640, U52641, U52642, U52643, U52644, U52645, U52646, U52647, U52648, U52649, U52651, U52652, U52653, U52654, U52655, U52656, U52657, U52658, U52659, U52660, U52661, U52662, U52663 Genomic DNA Translation: AAC05607.1
U52664
, U52639, U52640, U52641, U52642, U52643, U52644, U52645, U52646, U52647, U52648, U52649, U52651, U52652, U52654, U52655, U52656, U52657, U52658, U52659, U52660, U52661, U52662, U52663 Genomic DNA Translation: AAC05605.1
U52664
, U52639, U52640, U52641, U52642, U52643, U52644, U52645, U52646, U52647, U52648, U52649, U52651, U52652, U52654, U52655, U52656, U52657, U52658, U52659, U52660, U52661, U52662 Genomic DNA Translation: AAC05604.1
U52664
, U52639, U52640, U52641, U52642, U52643, U52644, U52645, U52646, U52647, U52648, U52649, U52651, U52652, U52654, U52655, U52656, U52657, U52658, U52659, U52660, U52661 Genomic DNA Translation: AAC05608.1
U52664
, U52639, U52640, U52641, U52642, U52643, U52644, U52645, U52646, U52647, U52648, U52649, U52651, U52652, U52654, U52655, U52656, U52657, U52658, U52659, U52660, U52661, U52663 Genomic DNA Translation: AAC05606.1
M25732 mRNA Translation: AAA41803.1
M25719 mRNA Translation: AAA41804.1
M63662 mRNA Translation: AAA42068.1 Sequence problems.
X59685 mRNA Translation: CAA42206.1
X59686 mRNA Translation: CAA42207.1
X59687 mRNA Translation: CAA42208.1
X59688 mRNA Translation: CAA42209.1
X59689 mRNA Translation: CAA42210.1
M82845 mRNA Translation: AAB00162.1
PIRiA32193 URRTAP
RefSeqiNP_037132.2, NM_013000.2 [P14925-1]
XP_006245660.1, XM_006245598.3 [P14925-2]
XP_006245661.1, XM_006245599.3 [P14925-5]
UniGeneiRn.1121

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OPMX-ray2.10A45-354[»]
1PHMX-ray1.90A45-354[»]
1SDWX-ray1.85A43-356[»]
1YI9X-ray1.70A47-355[»]
1YIPX-ray2.20A45-355[»]
1YJKX-ray2.00A50-355[»]
1YJLX-ray2.40A50-355[»]
3FVZX-ray2.35A498-820[»]
3FW0X-ray2.52A498-820[»]
3MIBX-ray2.35A43-356[»]
3MICX-ray2.42A43-356[»]
3MIDX-ray3.06A43-356[»]
3MIEX-ray3.26A43-356[»]
3MIFX-ray2.00A43-356[»]
3MIGX-ray2.70A43-356[»]
3MIHX-ray2.74A43-356[»]
3MLJX-ray2.15A43-356[»]
3MLKX-ray3.10A43-356[»]
3MLLX-ray3.25A43-356[»]
3PHMX-ray2.10A45-354[»]
4E4ZX-ray1.98A45-356[»]
5WJAX-ray2.30A/D45-356[»]
5WKWX-ray1.79A45-356[»]
5WM0X-ray2.40A1-976[»]
6ALAX-ray2.59A/C45-356[»]
6ALVX-ray3.50A45-356[»]
6AMPX-ray2.48A45-356[»]
6AN3X-ray2.05A45-356[»]
6AO6X-ray2.98A45-356[»]
6AY0X-ray2.60A45-356[»]
ProteinModelPortaliP14925
SMRiP14925
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247540, 2 interactors
IntActiP14925, 3 interactors
STRINGi10116.ENSRNOP00000046774

Chemistry databases

BindingDBiP14925
ChEMBLiCHEMBL4963

PTM databases

iPTMnetiP14925
PhosphoSitePlusiP14925

Proteomic databases

PaxDbiP14925
PRIDEiP14925

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000041418; ENSRNOP00000050784; ENSRNOG00000033280 [P14925-7]
ENSRNOT00000043451; ENSRNOP00000046774; ENSRNOG00000033280 [P14925-1]
ENSRNOT00000056457; ENSRNOP00000053295; ENSRNOG00000033280 [P14925-5]
GeneIDi25508
KEGGirno:25508

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5066
RGDi3252 Pam

Phylogenomic databases

eggNOGiKOG3567 Eukaryota
ENOG410XS0X LUCA
GeneTreeiENSGT00940000156369
HOGENOMiHOG000293368
HOVERGENiHBG004218
InParanoidiP14925
KOiK00504
K18200
OMAiSCHYKKY
PhylomeDBiP14925

Enzyme and pathway databases

BRENDAi1.14.17.3 5301
4.3.2.5 5301

Miscellaneous databases

EvolutionaryTraceiP14925

Protein Ontology

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PROi
PR:P14925

Gene expression databases

BgeeiENSRNOG00000033280 Expressed in 10 organ(s), highest expression level in heart
GenevisibleiP14925 RN

Family and domain databases

Gene3Di2.120.10.30, 1 hit
2.60.120.230, 1 hit
2.60.120.310, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR014784 Cu2_ascorb_mOase-like_C
IPR020611 Cu2_ascorb_mOase_CS-1
IPR014783 Cu2_ascorb_mOase_CS-2
IPR000323 Cu2_ascorb_mOase_N
IPR036939 Cu2_ascorb_mOase_N_sf
IPR024548 Cu2_monoox_C
IPR001258 NHL_repeat
IPR013017 NHL_repeat_subgr
IPR000720 PHM/PAL
IPR008977 PHM/PNGase_F_dom_sf
PfamiView protein in Pfam
PF03712 Cu2_monoox_C, 1 hit
PF01082 Cu2_monooxygen, 1 hit
PF01436 NHL, 3 hits
PRINTSiPR00790 PAMONOXGNASE
SUPFAMiSSF49742 SSF49742, 2 hits
PROSITEiView protein in PROSITE
PS00084 CU2_MONOOXYGENASE_1, 1 hit
PS00085 CU2_MONOOXYGENASE_2, 1 hit
PS51125 NHL, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMD_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14925
Secondary accession number(s): P70710, Q64616, Q64668
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: December 5, 2018
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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