JUP

Functionⁱ

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).By similarity

GO - Molecular functionⁱ

alpha-catenin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
cadherin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 1639850
- 7650039
cell adhesion molecule binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17559062
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
Source: BHF-UCL
Inferred by curatorⁱ
- 17924338
nuclear hormone receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein homodimerization activity Source: BHF-UCL
protein kinase binding Source: Ensembl
protein phosphatase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 8663237
structural constituent of cell wall
Source: BHF-UCL
Inferred by curatorⁱ
- 7650039
structural molecule activity
Source: BHF-UCL
Non-traceable author statementⁱ
- 22889254
transcription coactivator activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 14661054

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adherens junction organization Source: Reactome
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17924338
cell-cell adhesion
Source: BHF-UCL
Inferred from direct assayⁱ
- 18937352
cell migration
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18937352
cellular response to indole-3-methanol
Source: UniProtKB
Inferred from direct assayⁱ
- 10868478
cornification Source: Reactome
cytoskeletal anchoring at plasma membrane
Source: BHF-UCL
Non-traceable author statementⁱ
- 22889254
desmosome assembly
Source: BHF-UCL
Inferred from direct assayⁱ
- 22889254
detection of mechanical stimulus
Source: BHF-UCL
Inferred from direct assayⁱ
- 18937352
endothelial cell-cell adhesion Source: BHF-UCL
keratinization Source: Reactome
negative regulation of blood vessel endothelial cell migration
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 28115160
neutrophil degranulation Source: Reactome
positive regulation of angiogenesis
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 28115160
positive regulation of canonical Wnt signaling pathway
Source: BHF-UCL
Inferred by curatorⁱ
- 14661054
positive regulation of cell-matrix adhesion
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 28115160
positive regulation of DNA-binding transcription factor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 14661054
positive regulation of protein import into nucleus
Source: BHF-UCL
Inferred from direct assayⁱ
- 10825188
- 14661054
positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein heterooligomerization Source: Ensembl
protein localization to plasma membrane
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20859650
regulation of cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 17924338
regulation of heart rate by cardiac conduction
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17924338
regulation of ventricular cardiac muscle cell action potential
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17924338

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion

Biological process

Cell adhesion

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418990 Adherens junctions interactions R-HSA-5218920 VEGFR2 mediated vascular permeability R-HSA-6798695 Neutrophil degranulation R-HSA-6805567 Keratinization R-HSA-6809371 Formation of the cornified envelope
SignaLinkⁱ	P14923
SIGNORⁱ	P14923

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Junction plakoglobin Alternative name(s): Catenin gamma Desmoplakin III Desmoplakin-3
Gene namesⁱ	Name:JUP Synonyms:CTNNG, DP3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173801.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6207 JUP
MIMⁱ	173325 gene
neXtProtⁱ	NX_P14923

Keywords - Cellular componentⁱ

Cell junction, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Naxos disease (NXD)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive disorder characterized by the association of diffuse non-epidermolytic palmoplantar keratoderma with woolly hair and cardiac abnormalities such as dilated cardiomyopathy and arrhythmogenic right ventricular dysplasia.

Arrhythmogenic right ventricular dysplasia, familial, 12 (ARVD12)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	14	T → A: Abolishes glycosylation. Does not affect binding to CDH1, DSC1 or DSG1. 1 Publication	1
Mutagenesisⁱ	19	T → A: Reduces glycosylation. 1 Publication	1
Mutagenesisⁱ	21	T → A: Does not affect glycosylation. 1 Publication	1
Mutagenesisⁱ	24	S → A: Does not affect glycosylation. 1 Publication	1
Mutagenesisⁱ	28	S → A: Does not affect glycosylation. 1 Publication	1
Mutagenesisⁱ	32	T → A: Does not affect glycosylation. 1 Publication	1

Keywords - Diseaseⁱ

Cardiomyopathy, Disease mutation, Palmoplantar keratoderma

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3728
GeneReviewsⁱ	JUP
MalaCards human disease database More...MalaCardsⁱ	JUP
MIMⁱ	601214 phenotype 611528 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000173801
Orphanetⁱ	293899 Familial isolated arrhythmogenic ventricular dysplasia, biventricular form 293888 Familial isolated arrhythmogenic ventricular dysplasia, left dominant form 293910 Familial isolated arrhythmogenic ventricular dysplasia, right dominant form 158687 Lethal acantholytic epidermolysis bullosa 34217 Naxos disease
PharmGKBⁱ	PA30009

Polymorphism and mutation databases

BioMutaⁱ	JUP
DMDMⁱ	205371866

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000064278	1 – 745	Junction plakoglobinAdd BLAST		745

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources1 Publication	1
Glycosylationⁱ	14	O-linked (GlcNAc) threonine1 Publication	1
Modified residueⁱ	99	PhosphoserineCombined sources	1
Modified residueⁱ	125	PhosphoserineCombined sources	1
Modified residueⁱ	182	PhosphoserineCombined sources	1
Modified residueⁱ	665	PhosphoserineCombined sources	1
Modified residueⁱ	730	PhosphoserineCombined sources	1

Post-translational modificationⁱ

May be phosphorylated by FER.1 Publication

Keywords - PTMⁱ

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P14923
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P14923
PaxDbⁱ	P14923
PeptideAtlas More...PeptideAtlasⁱ	P14923
PRIDEⁱ	P14923
ProteomicsDBⁱ	53098

PTM databases

iPTMnetⁱ	P14923
PhosphoSitePlusⁱ	P14923
SwissPalmⁱ	P14923

Miscellaneous databases

PMAP-CutDBⁱ	P14923

PMAP-CutDBⁱ

P14923

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000173801 Expressed in 222 organ(s), highest expression level in esophagus mucosa
CleanExⁱ	HS_JUP
ExpressionAtlasⁱ	P14923 baseline and differential
Genevisibleⁱ	P14923 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002139 HPA032047

HPAⁱ

CAB002139
HPA032047

Interactionⁱ

Subunit structureⁱ

Homodimer. Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1 (By similarity). Interacts with PTPRJ. Interacts with DSG1. Interacts with DSC1 and DSC2. Interacts with PKP2.By similarity8 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
APC	P25054	3	EBI-702484,EBI-727707
AXIN1	A0A0S2Z4M1	3	EBI-702484,EBI-16429430
AXIN1	O15169	4	EBI-702484,EBI-710484
CDH2	P19022	2	EBI-702484,EBI-2256711
CTNNA1	P35221	2	EBI-702484,EBI-701918
CTNNB1	P35222	3	EBI-702484,EBI-491549
CTNNBIP1	Q9NSA3	3	EBI-702484,EBI-747082
FHL2	Q14192	5	EBI-702484,EBI-701903
PECAM1	P16284	7	EBI-702484,EBI-716404
WDYHV1	Q96HA8	3	EBI-702484,EBI-741158

GO - Molecular functionⁱ

alpha-catenin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
cadherin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 1639850
- 7650039
cell adhesion molecule binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17559062
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
Source: BHF-UCL
Inferred by curatorⁱ
- 17924338
nuclear hormone receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein homodimerization activity Source: BHF-UCL
protein kinase binding Source: Ensembl
protein phosphatase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 8663237

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109931, 158 interactors
CORUMⁱ	P14923
Database of interacting proteins More...DIPⁱ	DIP-36235N
IntActⁱ	P14923, 83 interactors
Molecular INTeraction database More...MINTⁱ	P14923
STRINGⁱ	9606.ENSP00000311113

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	127 – 131	Combined sources	5
Helixⁱ	133 – 142	Combined sources	10
Helixⁱ	144 – 151	Combined sources	8
Helixⁱ	156 – 169	Combined sources	14
Helixⁱ	173 – 180	Combined sources	8
Helixⁱ	183 – 193	Combined sources	11
Helixⁱ	199 – 212	Combined sources	14
Helixⁱ	216 – 224	Combined sources	9
Helixⁱ	227 – 233	Combined sources	7
Helixⁱ	234 – 236	Combined sources	3
Helixⁱ	240 – 256	Combined sources	17
Helixⁱ	260 – 266	Combined sources	7
Helixⁱ	269 – 272	Combined sources	4
Helixⁱ	274 – 278	Combined sources	5
Helixⁱ	282 – 296	Combined sources	15
Helixⁱ	300 – 308	Combined sources	9
Helixⁱ	311 – 321	Combined sources	11
Helixⁱ	325 – 338	Combined sources	14
Helixⁱ	344 – 350	Combined sources	7
Helixⁱ	353 – 358	Combined sources	6
Helixⁱ	359 – 362	Combined sources	4
Helixⁱ	366 – 380	Combined sources	15
Helixⁱ	390 – 397	Combined sources	8
Turnⁱ	398 – 401	Combined sources	4
Helixⁱ	405 – 418	Combined sources	14
Turnⁱ	419 – 421	Combined sources	3
Helixⁱ	423 – 429	Combined sources	7
Turnⁱ	430 – 433	Combined sources	4
Helixⁱ	434 – 445	Combined sources	12
Helixⁱ	449 – 462	Combined sources	14
Beta strandⁱ	464 – 466	Combined sources	3
Helixⁱ	469 – 477	Combined sources	9
Turnⁱ	478 – 480	Combined sources	3
Helixⁱ	481 – 487	Combined sources	7
Helixⁱ	488 – 490	Combined sources	3
Helixⁱ	495 – 508	Combined sources	14
Helixⁱ	512 – 514	Combined sources	3
Helixⁱ	515 – 520	Combined sources	6
Helixⁱ	523 – 543	Combined sources	21
Helixⁱ	556 – 570	Combined sources	15
Helixⁱ	574 – 582	Combined sources	9
Helixⁱ	586 – 592	Combined sources	7
Helixⁱ	598 – 611	Combined sources	14
Helixⁱ	615 – 623	Combined sources	9
Turnⁱ	624 – 626	Combined sources	3
Helixⁱ	627 – 633	Combined sources	7
Helixⁱ	639 – 651	Combined sources	13
Helixⁱ	662 – 667	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	P14923
SMRⁱ	P14923
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P14923

EvolutionaryTraceⁱ

P14923

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	132 – 171	ARM 1Add BLAST	40
Repeatⁱ	172 – 215	ARM 2Add BLAST	44
Repeatⁱ	216 – 255	ARM 3Add BLAST	40
Repeatⁱ	258 – 297	ARM 4Add BLAST	40
Repeatⁱ	298 – 341	ARM 5Add BLAST	44
Repeatⁱ	342 – 381	ARM 6Add BLAST	40
Repeatⁱ	383 – 420	ARM 7Add BLAST	38
Repeatⁱ	423 – 464	ARM 8Add BLAST	42
Repeatⁱ	470 – 510	ARM 9Add BLAST	41
Repeatⁱ	512 – 551	ARM 10Add BLAST	40
Repeatⁱ	574 – 613	ARM 11Add BLAST	40
Repeatⁱ	615 – 661	ARM 12Add BLAST	47

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	132 – 297	Interaction with DSC1 and DSG1Add BLAST		166
Regionⁱ	574 – 661	Interaction with DSC1Add BLAST		88

Domainⁱ

The entire ARM repeats region mediates binding to CDH1/E-cadherin. The N-terminus and first three ARM repeats are sufficient for binding to DSG1. The N-terminus and first ARM repeat are sufficient for association with CTNNA1. DSC1 association requires both ends of the ARM repeat region.2 Publications

Sequence similaritiesⁱ

Belongs to the beta-catenin family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG4203 Eukaryota COG0035 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110821
HOVERGENⁱ	HBG000919
InParanoidⁱ	P14923
KEGG Orthology (KO) More...KOⁱ	K10056
OMAⁱ	NEPYADD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03A5
PhylomeDBⁱ	P14923
TreeFamⁱ	TF317997

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR000225 Armadillo IPR013284 Beta-catenin IPR030461 Plakoglobin/HMP-2
PANTHERⁱ	PTHR23315:SF12 PTHR23315:SF12, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00514 Arm, 3 hits
PRINTSⁱ	PR01869 BCATNINFAMLY
SMARTⁱ	View protein in SMART SM00185 ARM, 12 hits
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
PROSITEⁱ	View protein in PROSITE PS50176 ARM_REPEAT, 9 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show all Align All

P14923-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEVMNLMEQP IKVTEWQQTY TYDSGIHSGA NTCVPSVSSK GIMEEDEACG 
        60         70         80         90        100
RQYTLKKTTT YTQGVPPSQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL 
       110        120        130        140        150
LLATQVEGQA TNLQRLAEPS QLLKSAIVHL INYQDDAELA TRALPELTKL 
       160        170        180        190        200
LNDEDPVVVT KAAMIVNQLS KKEASRRALM GSPQLVAAVV RTMQNTSDLD 
       210        220        230        240        250
TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE SVLFYAITTL 
       260        270        280        290        300
HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ 
       310        320        330        340        350
ESKLIILANG GPQALVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE 
       360        370        380        390        400
AGGMQALGKH LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE SVLKILVNQL 
       410        420        430        440        450
SVDDVNVLTC ATGTLSNLTC NNSKNKTLVT QNSGVEALIH AILRAGDKDD 
       460        470        480        490        500
ITEPAVCALR HLTSRHPEAE MAQNSVRLNY GIPAIVKLLN QPNQWPLVKA 
       510        520        530        540        550
TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR HVAAGTQQPY 
       560        570        580        590        600
TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI 
       610        620        630        640        650
QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF 
       660        670        680        690        700
RISEDKNPDY RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYGDDMDAT 
       710        720        730        740 
YRPMYSSDVP LDPLEMHMDM DGDYPIDTYS DGLRPPYPTA DHMLA

Length:745

Mass (Da):81,745

Last modified:September 2, 2008 - v3

Checksum:ⁱ3519A0973748BCF4

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JK18	C9JK18_HUMAN	Junction plakoglobin Junction plakoglobin	JUP	295	Annotation score:
C9J826	C9J826_HUMAN	Junction plakoglobin Junction plakoglobin	JUP	276	Annotation score:
C9JKY1	C9JKY1_HUMAN	Junction plakoglobin Junction plakoglobin	JUP	297	Annotation score:
C9JTX4	C9JTX4_HUMAN	Junction plakoglobin Junction plakoglobin	JUP	235	Annotation score:
C9JPI2	C9JPI2_HUMAN	Junction plakoglobin Junction plakoglobin	JUP	86	Annotation score:
K7ERP3	K7ERP3_HUMAN	Junction plakoglobin Junction plakoglobin	JUP	104	Annotation score:

Sequence cautionⁱ

The sequence AAH00441 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	91	P → S in AAO85780 (Ref. 4) Curated		1
Sequence conflictⁱ	264 – 270	VRLADGL → CAGRRA in AAA64895 (PubMed:2726765).Curated		7

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_065698	19	T → I in ARVD12. 1 PublicationCorresponds to variant dbSNP:rs570878629EnsemblClinVar.	1
Natural variantⁱVAR_037803	39	S → SS in ARVD12; affects the structure and distribution of mechanical and electrical cell junctions. 1 Publication	1
Natural variantⁱVAR_065699	142	R → H2 PublicationsCorresponds to variant dbSNP:rs41283425EnsemblClinVar.	1
Natural variantⁱVAR_065700	648	V → I1 PublicationCorresponds to variant dbSNP:rs143043662EnsemblClinVar.	1
Natural variantⁱVAR_037804	697	M → L6 PublicationsCorresponds to variant dbSNP:rs1126821EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M23410 mRNA Translation: AAA64895.1 Z68228 mRNA Translation: CAA92522.1 AF306723, AF233882 Genomic DNA Translation: AAG16727.1 AY243535 mRNA Translation: AAO85780.1 AC109319 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60762.1 BC000441 mRNA Translation: AAH00441.2 Different initiation. BC011865 mRNA Translation: AAH11865.1 AJ249711 Genomic DNA Translation: CAC04246.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11407.1
PIRⁱ	A32905
NCBI Reference Sequences More...RefSeqⁱ	NP_002221.1, NM_002230.2 NP_068831.1, NM_021991.2 XP_006721936.1, XM_006721873.2 XP_006721937.1, XM_006721874.2 XP_006721938.1, XM_006721875.1 XP_006721941.1, XM_006721878.1 XP_011523055.1, XM_011524753.2 XP_011523057.1, XM_011524755.1 XP_011523058.1, XM_011524756.1 XP_011523059.1, XM_011524757.2 XP_011523060.1, XM_011524758.1 XP_016880079.1, XM_017024590.1
UniGeneⁱ	Hs.514174

Genome annotation databases

Ensemblⁱ	ENST00000310706; ENSP00000311113; ENSG00000173801 ENST00000393930; ENSP00000377507; ENSG00000173801 ENST00000393931; ENSP00000377508; ENSG00000173801
GeneIDⁱ	3728
KEGGⁱ	hsa:3728
UCSC genome browser More...UCSCⁱ	uc002hxq.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P14923	Junction plakoglobin isoform 1 (Fragment)		HUMAN		745	UniRef100_P14923
JUP isoform 1		PONAB		745
Uncharacterized protein		COLAP		745
Uncharacterized protein		PANPA		745
Junction plakoglobin		GORGO		745
+12

Protein	Similar proteins		Species	Score	Length	Source
P14923	Junction plakoglobin		BOVIN		745	UniRef90_P14923
Junction plakoglobin		MOUSE		745
Junction plakoglobin		PIG		745
Junction plakoglobin		RAT		745
Junction plakoglobin isoform 1 (Fragment)		HUMAN		745
+128

Protein	Similar proteins		Species	Score	Length	Source
P14923	Junction plakoglobin		RAT		745	UniRef50_P14923
Junction plakoglobin		BOVIN		745
Junction plakoglobin		MOUSE		745
Junction plakoglobin		PIG		745
Armadillo segment polarity protein		DROME		843
+706

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M23410 mRNA Translation: AAA64895.1 Z68228 mRNA Translation: CAA92522.1 AF306723, AF233882 Genomic DNA Translation: AAG16727.1 AY243535 mRNA Translation: AAO85780.1 AC109319 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60762.1 BC000441 mRNA Translation: AAH00441.2 Different initiation. BC011865 mRNA Translation: AAH11865.1 AJ249711 Genomic DNA Translation: CAC04246.1
CCDSⁱ	CCDS11407.1
PIRⁱ	A32905
RefSeqⁱ	NP_002221.1, NM_002230.2 NP_068831.1, NM_021991.2 XP_006721936.1, XM_006721873.2 XP_006721937.1, XM_006721874.2 XP_006721938.1, XM_006721875.1 XP_006721941.1, XM_006721878.1 XP_011523055.1, XM_011524753.2 XP_011523057.1, XM_011524755.1 XP_011523058.1, XM_011524756.1 XP_011523059.1, XM_011524757.2 XP_011523060.1, XM_011524758.1 XP_016880079.1, XM_017024590.1
UniGeneⁱ	Hs.514174

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3IFQ	X-ray	2.80	A/B	124-676	[»]
ProteinModelPortalⁱ	P14923
SMRⁱ	P14923
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109931, 158 interactors
CORUMⁱ	P14923
DIPⁱ	DIP-36235N
IntActⁱ	P14923, 83 interactors
MINTⁱ	P14923
STRINGⁱ	9606.ENSP00000311113

PTM databases

iPTMnetⁱ	P14923
PhosphoSitePlusⁱ	P14923
SwissPalmⁱ	P14923

Polymorphism and mutation databases

BioMutaⁱ	JUP
DMDMⁱ	205371866

Proteomic databases

EPDⁱ	P14923
MaxQBⁱ	P14923
PaxDbⁱ	P14923
PeptideAtlasⁱ	P14923
PRIDEⁱ	P14923
ProteomicsDBⁱ	53098

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3728
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000310706; ENSP00000311113; ENSG00000173801 ENST00000393930; ENSP00000377507; ENSG00000173801 ENST00000393931; ENSP00000377508; ENSG00000173801
GeneIDⁱ	3728
KEGGⁱ	hsa:3728
UCSCⁱ	uc002hxq.3 human

Organism-specific databases

CTDⁱ	3728
DisGeNETⁱ	3728
EuPathDBⁱ	HostDB:ENSG00000173801.16
GeneCardsⁱ	JUP
GeneReviewsⁱ	JUP
HGNCⁱ	HGNC:6207 JUP
HPAⁱ	CAB002139 HPA032047
MalaCardsⁱ	JUP
MIMⁱ	173325 gene 601214 phenotype 611528 phenotype
neXtProtⁱ	NX_P14923
OpenTargetsⁱ	ENSG00000173801
Orphanetⁱ	293899 Familial isolated arrhythmogenic ventricular dysplasia, biventricular form 293888 Familial isolated arrhythmogenic ventricular dysplasia, left dominant form 293910 Familial isolated arrhythmogenic ventricular dysplasia, right dominant form 158687 Lethal acantholytic epidermolysis bullosa 34217 Naxos disease
PharmGKBⁱ	PA30009
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4203 Eukaryota COG0035 LUCA
GeneTreeⁱ	ENSGT00730000110821
HOVERGENⁱ	HBG000919
InParanoidⁱ	P14923
KOⁱ	K10056
OMAⁱ	NEPYADD
OrthoDBⁱ	EOG091G03A5
PhylomeDBⁱ	P14923
TreeFamⁱ	TF317997

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418990 Adherens junctions interactions R-HSA-5218920 VEGFR2 mediated vascular permeability R-HSA-6798695 Neutrophil degranulation R-HSA-6805567 Keratinization R-HSA-6809371 Formation of the cornified envelope
SignaLinkⁱ	P14923
SIGNORⁱ	P14923

Miscellaneous databases

ChiTaRSⁱ	JUP human
EvolutionaryTraceⁱ	P14923
GeneWikiⁱ	Plakoglobin
GenomeRNAiⁱ	3728
PMAP-CutDBⁱ	P14923
Protein Ontology More...PROⁱ	PR:P14923
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000173801 Expressed in 222 organ(s), highest expression level in esophagus mucosa
CleanExⁱ	HS_JUP
ExpressionAtlasⁱ	P14923 baseline and differential
Genevisibleⁱ	P14923 HS

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR000225 Armadillo IPR013284 Beta-catenin IPR030461 Plakoglobin/HMP-2
PANTHERⁱ	PTHR23315:SF12 PTHR23315:SF12, 1 hit
Pfamⁱ	View protein in Pfam PF00514 Arm, 3 hits
PRINTSⁱ	PR01869 BCATNINFAMLY
SMARTⁱ	View protein in SMART SM00185 ARM, 12 hits
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
PROSITEⁱ	View protein in PROSITE PS50176 ARM_REPEAT, 9 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLAK_HUMAN
Accessionⁱ	P14923Primary (citable) accession number: P14923 Secondary accession number(s): Q15093 , Q15151, Q7L3S5, Q86W21, Q9BWC4, Q9HCX9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	September 2, 2008
	Last modified:	November 7, 2018
	This is version 196 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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UniProtKB - P14923 (PLAK_HUMAN)

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Junction plakoglobin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

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Cytoskeleton

Cytosol

Extracellular region or secreted

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ