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UniProtKB - P14923 (PLAK_HUMAN)

Entry version 215 (02 Jun 2021)
Sequence version 3 (02 Sep 2008)
Previous versions | rss
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Protein

Junction plakoglobin

Gene

JUP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P14923

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-418990, Adherens junctions interactions
R-HSA-5218920, VEGFR2 mediated vascular permeability
R-HSA-6798695, Neutrophil degranulation
R-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P14923

SIGNOR Signaling Network Open Resource

More...SIGNORi		P14923

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Junction plakoglobin
Alternative name(s):
Catenin gamma
Desmoplakin III
Desmoplakin-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:JUP
Synonyms:CTNNG, DP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6207, JUP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		173325, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P14923

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000173801.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Naxos disease (NXD)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by the association of diffuse non-epidermolytic palmoplantar keratoderma with woolly hair and cardiac abnormalities such as dilated cardiomyopathy and arrhythmogenic right ventricular dysplasia.
Related information in OMIM
Arrhythmogenic right ventricular dysplasia, familial, 12 (ARVD12)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06569819T → I in ARVD12; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs570878629EnsemblClinVar.1
Natural variantiVAR_03780339S → SS in ARVD12; affects the structure and distribution of mechanical and electrical cell junctions. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi14T → A: Abolishes glycosylation. Does not affect binding to CDH1, DSC1 or DSG1. 1 Publication1
Mutagenesisi19T → A: Reduces glycosylation. 1 Publication1
Mutagenesisi21T → A: Does not affect glycosylation. 1 Publication1
Mutagenesisi24S → A: Does not affect glycosylation. 1 Publication1
Mutagenesisi28S → A: Does not affect glycosylation. 1 Publication1
Mutagenesisi32T → A: Does not affect glycosylation. 1 Publication1

Keywords - Diseasei

Cardiomyopathy, Disease variant, Palmoplantar keratoderma

Organism-specific databases

DisGeNET

More...DisGeNETi		3728

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		JUP

MalaCards human disease database

More...MalaCardsi		JUP
MIMi601214, phenotype
611528, phenotype

Open Targets

More...OpenTargetsi		ENSG00000173801

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		293899, Familial isolated arrhythmogenic ventricular dysplasia, biventricular form
293888, Familial isolated arrhythmogenic ventricular dysplasia, left dominant form
293910, Familial isolated arrhythmogenic ventricular dysplasia, right dominant form
158687, Lethal acantholytic erosive disorder
34217, Naxos disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30009

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P14923, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01593, Zinc
DB14487, Zinc acetate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		JUP

Domain mapping of disease mutations (DMDM)

More...DMDMi		205371866

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000642781 – 745Junction plakoglobinAdd BLAST745

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi14O-linked (GlcNAc) threonine1 Publication1
Modified residuei99PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei665PhosphoserineCombined sources1
Modified residuei730PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be phosphorylated by FER.1 Publication

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P14923

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P14923

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P14923

MaxQB - The MaxQuant DataBase

More...MaxQBi		P14923

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P14923

PeptideAtlas

More...PeptideAtlasi		P14923

PRoteomics IDEntifications database

More...PRIDEi		P14923

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53098

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1950, 10 N-Linked glycans (4 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P14923, 5 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P14923

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P14923

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P14923

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P14923

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000173801, Expressed in esophagus mucosa and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P14923, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P14923, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000173801, Tissue enhanced (esophagus, skin, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex.

Interacts with MUC1.

Interacts with CAV1 (By similarity).

Interacts with PTPRJ.

Interacts with DSG1.

Interacts with DSC1 and DSC2.

Interacts with PKP2.

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109931, 276 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P14923

Database of interacting proteins

More...DIPi		DIP-36235N

Protein interaction database and analysis system

More...IntActi		P14923, 122 interactors

Molecular INTeraction database

More...MINTi		P14923

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377508

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P14923, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1745
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P14923

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P14923

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati132 – 171ARM 1Add BLAST40
Repeati172 – 215ARM 2Add BLAST44
Repeati216 – 255ARM 3Add BLAST40
Repeati258 – 297ARM 4Add BLAST40
Repeati298 – 341ARM 5Add BLAST44
Repeati342 – 381ARM 6Add BLAST40
Repeati383 – 420ARM 7Add BLAST38
Repeati423 – 464ARM 8Add BLAST42
Repeati470 – 510ARM 9Add BLAST41
Repeati512 – 551ARM 10Add BLAST40
Repeati574 – 613ARM 11Add BLAST40
Repeati615 – 661ARM 12Add BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni132 – 297Interaction with DSC1 and DSG1Add BLAST166
Regioni574 – 661Interaction with DSC1Add BLAST88

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The entire ARM repeats region mediates binding to CDH1/E-cadherin. The N-terminus and first three ARM repeats are sufficient for binding to DSG1. The N-terminus and first ARM repeat are sufficient for association with CTNNA1. DSC1 association requires both ends of the ARM repeat region.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta-catenin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4203, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156395

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008757_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P14923

Identification of Orthologs from Complete Genome Data

More...OMAi		PYPTSDH

Database of Orthologous Groups

More...OrthoDBi		321213at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P14923

TreeFam database of animal gene trees

More...TreeFami		TF317997

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00298

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000225, Armadillo
IPR013284, Beta-catenin
IPR030461, Plakoglobin

The PANTHER Classification System

More...PANTHERi		PTHR45976, PTHR45976, 1 hit
PTHR45976:SF3, PTHR45976:SF3, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00514, Arm, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01869, BCATNINFAMLY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00185, ARM, 12 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50176, ARM_REPEAT, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P14923-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVMNLMEQP IKVTEWQQTY TYDSGIHSGA NTCVPSVSSK GIMEEDEACG 
        60         70         80         90        100
RQYTLKKTTT YTQGVPPSQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL 
       110        120        130        140        150
LLATQVEGQA TNLQRLAEPS QLLKSAIVHL INYQDDAELA TRALPELTKL 
       160        170        180        190        200
LNDEDPVVVT KAAMIVNQLS KKEASRRALM GSPQLVAAVV RTMQNTSDLD 
       210        220        230        240        250
TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE SVLFYAITTL 
       260        270        280        290        300
HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ 
       310        320        330        340        350
ESKLIILANG GPQALVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE 
       360        370        380        390        400
AGGMQALGKH LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE SVLKILVNQL 
       410        420        430        440        450
SVDDVNVLTC ATGTLSNLTC NNSKNKTLVT QNSGVEALIH AILRAGDKDD 
       460        470        480        490        500
ITEPAVCALR HLTSRHPEAE MAQNSVRLNY GIPAIVKLLN QPNQWPLVKA 
       510        520        530        540        550
TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR HVAAGTQQPY 
       560        570        580        590        600
TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI 
       610        620        630        640        650
QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF 
       660        670        680        690        700
RISEDKNPDY RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYGDDMDAT 
       710        720        730        740 
YRPMYSSDVP LDPLEMHMDM DGDYPIDTYS DGLRPPYPTA DHMLA
Length:745
Mass (Da):81,745
Last modified:September 2, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3519A0973748BCF4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J826C9J826_HUMAN
Junction plakoglobin
JUP
276Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JKY1C9JKY1_HUMAN
Junction plakoglobin
JUP
297Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JK18C9JK18_HUMAN
Junction plakoglobin
JUP
295Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JTX4C9JTX4_HUMAN
Junction plakoglobin
JUP
235Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JPI2C9JPI2_HUMAN
Junction plakoglobin
JUP
86Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERP3K7ERP3_HUMAN
Junction plakoglobin
JUP
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH00441 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti91P → S in AAO85780 (Ref. 4) Curated1
Sequence conflicti264 – 270VRLADGL → CAGRRA in AAA64895 (PubMed:2726765).Curated7

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06569819T → I in ARVD12; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs570878629EnsemblClinVar.1
Natural variantiVAR_03780339S → SS in ARVD12; affects the structure and distribution of mechanical and electrical cell junctions. 1 Publication1
Natural variantiVAR_065699142R → H2 PublicationsCorresponds to variant dbSNP:rs41283425EnsemblClinVar.1
Natural variantiVAR_065700648V → I1 PublicationCorresponds to variant dbSNP:rs143043662EnsemblClinVar.1
Natural variantiVAR_037804697M → L6 PublicationsCorresponds to variant dbSNP:rs1126821EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M23410 mRNA Translation: AAA64895.1
Z68228 mRNA Translation: CAA92522.1
AF306723, AF233882 Genomic DNA Translation: AAG16727.1
AY243535 mRNA Translation: AAO85780.1
AC109319 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60762.1
BC000441 mRNA Translation: AAH00441.2 Different initiation.
BC011865 mRNA Translation: AAH11865.1
AJ249711 Genomic DNA Translation: CAC04246.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11407.1

Protein sequence database of the Protein Information Resource

More...PIRi		A32905

NCBI Reference Sequences

More...RefSeqi		NP_002221.1, NM_002230.2
NP_068831.1, NM_021991.2
XP_006721936.1, XM_006721873.2
XP_006721937.1, XM_006721874.2
XP_006721938.1, XM_006721875.1
XP_006721941.1, XM_006721878.1
XP_011523055.1, XM_011524753.2
XP_011523057.1, XM_011524755.1
XP_011523058.1, XM_011524756.1
XP_011523059.1, XM_011524757.2
XP_011523060.1, XM_011524758.1
XP_016880079.1, XM_017024590.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000310706; ENSP00000311113; ENSG00000173801
ENST00000393930; ENSP00000377507; ENSG00000173801
ENST00000393931; ENSP00000377508; ENSG00000173801

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3728

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3728

UCSC genome browser

More...UCSCi		uc002hxq.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23410 mRNA Translation: AAA64895.1
Z68228 mRNA Translation: CAA92522.1
AF306723, AF233882 Genomic DNA Translation: AAG16727.1
AY243535 mRNA Translation: AAO85780.1
AC109319 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60762.1
BC000441 mRNA Translation: AAH00441.2 Different initiation.
BC011865 mRNA Translation: AAH11865.1
AJ249711 Genomic DNA Translation: CAC04246.1
CCDSiCCDS11407.1
PIRiA32905
RefSeqiNP_002221.1, NM_002230.2
NP_068831.1, NM_021991.2
XP_006721936.1, XM_006721873.2
XP_006721937.1, XM_006721874.2
XP_006721938.1, XM_006721875.1
XP_006721941.1, XM_006721878.1
XP_011523055.1, XM_011524753.2
XP_011523057.1, XM_011524755.1
XP_011523058.1, XM_011524756.1
XP_011523059.1, XM_011524757.2
XP_011523060.1, XM_011524758.1
XP_016880079.1, XM_017024590.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IFQX-ray2.80A/B124-676[»]
SMRiP14923
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109931, 276 interactors
CORUMiP14923
DIPiDIP-36235N
IntActiP14923, 122 interactors
MINTiP14923
STRINGi9606.ENSP00000377508

Chemistry databases

DrugBankiDB01593, Zinc
DB14487, Zinc acetate

PTM databases

GlyConnecti1950, 10 N-Linked glycans (4 sites)
GlyGeniP14923, 5 sites
iPTMnetiP14923
MetOSiteiP14923
PhosphoSitePlusiP14923
SwissPalmiP14923

Genetic variation databases

BioMutaiJUP
DMDMi205371866

Proteomic databases

EPDiP14923
jPOSTiP14923
MassIVEiP14923
MaxQBiP14923
PaxDbiP14923
PeptideAtlasiP14923
PRIDEiP14923
ProteomicsDBi53098

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		80391, 1258 antibodies

The DNASU plasmid repository

More...DNASUi		3728

Genome annotation databases

EnsembliENST00000310706; ENSP00000311113; ENSG00000173801
ENST00000393930; ENSP00000377507; ENSG00000173801
ENST00000393931; ENSP00000377508; ENSG00000173801
GeneIDi3728
KEGGihsa:3728
UCSCiuc002hxq.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3728
DisGeNETi3728

GeneCards: human genes, protein and diseases

More...GeneCardsi		JUP
GeneReviewsiJUP
HGNCiHGNC:6207, JUP
HPAiENSG00000173801, Tissue enhanced (esophagus, skin, tongue)
MalaCardsiJUP
MIMi173325, gene
601214, phenotype
611528, phenotype
neXtProtiNX_P14923
OpenTargetsiENSG00000173801
Orphaneti293899, Familial isolated arrhythmogenic ventricular dysplasia, biventricular form
293888, Familial isolated arrhythmogenic ventricular dysplasia, left dominant form
293910, Familial isolated arrhythmogenic ventricular dysplasia, right dominant form
158687, Lethal acantholytic erosive disorder
34217, Naxos disease
PharmGKBiPA30009
VEuPathDBiHostDB:ENSG00000173801.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4203, Eukaryota
GeneTreeiENSGT00940000156395
HOGENOMiCLU_008757_1_1_1
InParanoidiP14923
OMAiPYPTSDH
OrthoDBi321213at2759
PhylomeDBiP14923
TreeFamiTF317997

Enzyme and pathway databases

PathwayCommonsiP14923
ReactomeiR-HSA-418990, Adherens junctions interactions
R-HSA-5218920, VEGFR2 mediated vascular permeability
R-HSA-6798695, Neutrophil degranulation
R-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope
SignaLinkiP14923
SIGNORiP14923

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3728, 17 hits in 1001 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		JUP, human
EvolutionaryTraceiP14923

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Plakoglobin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3728
PharosiP14923, Tbio

Protein Ontology

More...PROi		PR:P14923
RNActiP14923, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000173801, Expressed in esophagus mucosa and 238 other tissues
ExpressionAtlasiP14923, baseline and differential
GenevisibleiP14923, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
IDEALiIID00298
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000225, Armadillo
IPR013284, Beta-catenin
IPR030461, Plakoglobin
PANTHERiPTHR45976, PTHR45976, 1 hit
PTHR45976:SF3, PTHR45976:SF3, 1 hit
PfamiView protein in Pfam
PF00514, Arm, 3 hits
PRINTSiPR01869, BCATNINFAMLY
SMARTiView protein in SMART
SM00185, ARM, 12 hits
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176, ARM_REPEAT, 9 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLAK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14923
Secondary accession number(s): Q15093
, Q15151, Q7L3S5, Q86W21, Q9BWC4, Q9HCX9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: September 2, 2008
Last modified: June 2, 2021
This is version 215 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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