UniProtKB - P14923 (PLAK_HUMAN)
Junction plakoglobin
JUP
Functioni
GO - Molecular functioni
- alpha-catenin binding Source: BHF-UCL
- cadherin binding Source: BHF-UCL
- cell adhesion molecule binding Source: BHF-UCL
- cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication Source: BHF-UCL
- cytoskeletal protein-membrane anchor activity Source: BHF-UCL
- nuclear hormone receptor binding Source: GO_Central
- protein-containing complex binding Source: Ensembl
- protein homodimerization activity Source: BHF-UCL
- protein kinase binding Source: Ensembl
- protein phosphatase binding Source: UniProtKB
- structural molecule activity Source: BHF-UCL
- transcription coactivator activity Source: BHF-UCL
GO - Biological processi
- adherens junction organization Source: Reactome
- bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: BHF-UCL
- cell-cell adhesion Source: BHF-UCL
- cell migration Source: BHF-UCL
- cellular response to indole-3-methanol Source: UniProtKB
- cornification Source: Reactome
- desmosome assembly Source: BHF-UCL
- detection of mechanical stimulus Source: BHF-UCL
- endothelial cell-cell adhesion Source: BHF-UCL
- keratinization Source: Reactome
- negative regulation of blood vessel endothelial cell migration Source: BHF-UCL
- neutrophil degranulation Source: Reactome
- positive regulation of angiogenesis Source: BHF-UCL
- positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
- positive regulation of cell-matrix adhesion Source: BHF-UCL
- positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
- positive regulation of protein import into nucleus Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- protein localization to plasma membrane Source: UniProtKB
- regulation of cell population proliferation Source: BHF-UCL
- regulation of heart rate by cardiac conduction Source: BHF-UCL
- regulation of ventricular cardiac muscle cell action potential Source: BHF-UCL
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | P14923 |
Reactomei | R-HSA-418990, Adherens junctions interactions R-HSA-5218920, VEGFR2 mediated vascular permeability R-HSA-6798695, Neutrophil degranulation R-HSA-6805567, Keratinization R-HSA-6809371, Formation of the cornified envelope |
SignaLinki | P14923 |
SIGNORi | P14923 |
Names & Taxonomyi
Protein namesi | Recommended name: Junction plakoglobinAlternative name(s): Catenin gamma Desmoplakin III Desmoplakin-3 |
Gene namesi | Name:JUP Synonyms:CTNNG, DP3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6207, JUP |
MIMi | 173325, gene |
neXtProti | NX_P14923 |
VEuPathDBi | HostDB:ENSG00000173801.16 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Other locations
- adherens junction 1 Publication
- desmosome 1 Publication
- Membrane 1 Publication; Peripheral membrane protein 1 Publication
Note: Cytoplasmic in a soluble and membrane-associated form.
Cytoskeleton
- actin cytoskeleton Source: Ensembl
- cytoskeleton Source: BHF-UCL
- intermediate filament Source: Ensembl
Cytosol
- cytosol Source: BHF-UCL
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Nucleus
- gamma-catenin-TCF7L2 complex Source: BHF-UCL
- nucleus Source: BHF-UCL
Plasma Membrane
- apicolateral plasma membrane Source: Ensembl
- catenin complex Source: BHF-UCL
- cornified envelope Source: Reactome
- cytoplasmic side of plasma membrane Source: BHF-UCL
- lateral plasma membrane Source: Ensembl
- plasma membrane Source: UniProtKB
Other locations
- adherens junction Source: UniProtKB
- cell-cell junction Source: UniProtKB
- cytoplasm Source: BHF-UCL
- desmosome Source: BHF-UCL
- fascia adherens Source: Ensembl
- ficolin-1-rich granule lumen Source: Reactome
- focal adhesion Source: UniProtKB
- intercalated disc Source: BHF-UCL
- protein-DNA complex Source: BHF-UCL
- specific granule lumen Source: Reactome
- Z disc Source: Ensembl
- zonula adherens Source: BHF-UCL
Keywords - Cellular componenti
Cell junction, Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Involvement in diseasei
Naxos disease (NXD)1 Publication
Arrhythmogenic right ventricular dysplasia, familial, 12 (ARVD12)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065698 | 19 | T → I in ARVD12; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs570878629EnsemblClinVar. | 1 | |
Natural variantiVAR_037803 | 39 | S → SS in ARVD12; affects the structure and distribution of mechanical and electrical cell junctions. 1 Publication | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 14 | T → A: Abolishes glycosylation. Does not affect binding to CDH1, DSC1 or DSG1. 1 Publication | 1 | |
Mutagenesisi | 19 | T → A: Reduces glycosylation. 1 Publication | 1 | |
Mutagenesisi | 21 | T → A: Does not affect glycosylation. 1 Publication | 1 | |
Mutagenesisi | 24 | S → A: Does not affect glycosylation. 1 Publication | 1 | |
Mutagenesisi | 28 | S → A: Does not affect glycosylation. 1 Publication | 1 | |
Mutagenesisi | 32 | T → A: Does not affect glycosylation. 1 Publication | 1 |
Keywords - Diseasei
Cardiomyopathy, Disease variant, Palmoplantar keratodermaOrganism-specific databases
DisGeNETi | 3728 |
GeneReviewsi | JUP |
MalaCardsi | JUP |
MIMi | 601214, phenotype 611528, phenotype |
OpenTargetsi | ENSG00000173801 |
Orphaneti | 293899, Familial isolated arrhythmogenic ventricular dysplasia, biventricular form 293888, Familial isolated arrhythmogenic ventricular dysplasia, left dominant form 293910, Familial isolated arrhythmogenic ventricular dysplasia, right dominant form 158687, Lethal acantholytic epidermolysis bullosa 34217, Naxos disease |
PharmGKBi | PA30009 |
Miscellaneous databases
Pharosi | P14923, Tbio |
Chemistry databases
DrugBanki | DB01593, Zinc DB14487, Zinc acetate |
Genetic variation databases
BioMutai | JUP |
DMDMi | 205371866 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064278 | 1 – 745 | Junction plakoglobinAdd BLAST | 745 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources1 Publication | 1 | |
Glycosylationi | 14 | O-linked (GlcNAc) threonine1 Publication | 1 | |
Modified residuei | 99 | PhosphoserineCombined sources | 1 | |
Modified residuei | 125 | PhosphoserineCombined sources | 1 | |
Modified residuei | 182 | PhosphoserineCombined sources | 1 | |
Modified residuei | 665 | PhosphoserineCombined sources | 1 | |
Modified residuei | 730 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P14923 |
jPOSTi | P14923 |
MassIVEi | P14923 |
MaxQBi | P14923 |
PaxDbi | P14923 |
PeptideAtlasi | P14923 |
PRIDEi | P14923 |
ProteomicsDBi | 53098 |
PTM databases
GlyConnecti | 1950, 10 N-Linked glycans (4 sites) |
GlyGeni | P14923, 5 sites |
iPTMneti | P14923 |
MetOSitei | P14923 |
PhosphoSitePlusi | P14923 |
SwissPalmi | P14923 |
Expressioni
Gene expression databases
Bgeei | ENSG00000173801, Expressed in esophagus mucosa and 237 other tissues |
ExpressionAtlasi | P14923, baseline and differential |
Genevisiblei | P14923, HS |
Organism-specific databases
HPAi | ENSG00000173801, Tissue enhanced (esophagus, skin, tongue) |
Interactioni
Subunit structurei
Homodimer.
Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex.
Interacts with MUC1.
Interacts with CAV1 (By similarity).
Interacts with PTPRJ.
Interacts with DSG1.
Interacts with DSC1 and DSC2.
Interacts with PKP2.
By similarity8 PublicationsBinary interactionsi
Hide detailsP14923
GO - Molecular functioni
- alpha-catenin binding Source: BHF-UCL
- cadherin binding Source: BHF-UCL
- cell adhesion molecule binding Source: BHF-UCL
- cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication Source: BHF-UCL
- nuclear hormone receptor binding Source: GO_Central
- protein homodimerization activity Source: BHF-UCL
- protein kinase binding Source: Ensembl
- protein phosphatase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109931, 263 interactors |
CORUMi | P14923 |
DIPi | DIP-36235N |
IntActi | P14923, 120 interactors |
MINTi | P14923 |
STRINGi | 9606.ENSP00000377508 |
Miscellaneous databases
RNActi | P14923, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P14923 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P14923 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 132 – 171 | ARM 1Add BLAST | 40 | |
Repeati | 172 – 215 | ARM 2Add BLAST | 44 | |
Repeati | 216 – 255 | ARM 3Add BLAST | 40 | |
Repeati | 258 – 297 | ARM 4Add BLAST | 40 | |
Repeati | 298 – 341 | ARM 5Add BLAST | 44 | |
Repeati | 342 – 381 | ARM 6Add BLAST | 40 | |
Repeati | 383 – 420 | ARM 7Add BLAST | 38 | |
Repeati | 423 – 464 | ARM 8Add BLAST | 42 | |
Repeati | 470 – 510 | ARM 9Add BLAST | 41 | |
Repeati | 512 – 551 | ARM 10Add BLAST | 40 | |
Repeati | 574 – 613 | ARM 11Add BLAST | 40 | |
Repeati | 615 – 661 | ARM 12Add BLAST | 47 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 132 – 297 | Interaction with DSC1 and DSG1Add BLAST | 166 | |
Regioni | 574 – 661 | Interaction with DSC1Add BLAST | 88 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4203, Eukaryota |
GeneTreei | ENSGT00940000156395 |
HOGENOMi | CLU_008757_1_1_1 |
InParanoidi | P14923 |
OMAi | PYPTSDH |
OrthoDBi | 321213at2759 |
PhylomeDBi | P14923 |
TreeFami | TF317997 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
IDEALi | IID00298 |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR013284, Beta-catenin IPR030461, Plakoglobin |
PANTHERi | PTHR45976, PTHR45976, 1 hit PTHR45976:SF3, PTHR45976:SF3, 1 hit |
Pfami | View protein in Pfam PF00514, Arm, 3 hits |
PRINTSi | PR01869, BCATNINFAMLY |
SMARTi | View protein in SMART SM00185, ARM, 12 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 9 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MEVMNLMEQP IKVTEWQQTY TYDSGIHSGA NTCVPSVSSK GIMEEDEACG
60 70 80 90 100
RQYTLKKTTT YTQGVPPSQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL
110 120 130 140 150
LLATQVEGQA TNLQRLAEPS QLLKSAIVHL INYQDDAELA TRALPELTKL
160 170 180 190 200
LNDEDPVVVT KAAMIVNQLS KKEASRRALM GSPQLVAAVV RTMQNTSDLD
210 220 230 240 250
TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE SVLFYAITTL
260 270 280 290 300
HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ
310 320 330 340 350
ESKLIILANG GPQALVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE
360 370 380 390 400
AGGMQALGKH LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE SVLKILVNQL
410 420 430 440 450
SVDDVNVLTC ATGTLSNLTC NNSKNKTLVT QNSGVEALIH AILRAGDKDD
460 470 480 490 500
ITEPAVCALR HLTSRHPEAE MAQNSVRLNY GIPAIVKLLN QPNQWPLVKA
510 520 530 540 550
TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR HVAAGTQQPY
560 570 580 590 600
TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI
610 620 630 640 650
QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF
660 670 680 690 700
RISEDKNPDY RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYGDDMDAT
710 720 730 740
YRPMYSSDVP LDPLEMHMDM DGDYPIDTYS DGLRPPYPTA DHMLA
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J826 | C9J826_HUMAN | Junction plakoglobin | JUP | 276 | Annotation score: | ||
C9JKY1 | C9JKY1_HUMAN | Junction plakoglobin | JUP | 297 | Annotation score: | ||
C9JK18 | C9JK18_HUMAN | Junction plakoglobin | JUP | 295 | Annotation score: | ||
C9JTX4 | C9JTX4_HUMAN | Junction plakoglobin | JUP | 235 | Annotation score: | ||
C9JPI2 | C9JPI2_HUMAN | Junction plakoglobin | JUP | 86 | Annotation score: | ||
K7ERP3 | K7ERP3_HUMAN | Junction plakoglobin | JUP | 104 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 91 | P → S in AAO85780 (Ref. 4) Curated | 1 | |
Sequence conflicti | 264 – 270 | VRLADGL → CAGRRA in AAA64895 (PubMed:2726765).Curated | 7 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065698 | 19 | T → I in ARVD12; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs570878629EnsemblClinVar. | 1 | |
Natural variantiVAR_037803 | 39 | S → SS in ARVD12; affects the structure and distribution of mechanical and electrical cell junctions. 1 Publication | 1 | |
Natural variantiVAR_065699 | 142 | R → H2 PublicationsCorresponds to variant dbSNP:rs41283425EnsemblClinVar. | 1 | |
Natural variantiVAR_065700 | 648 | V → I1 PublicationCorresponds to variant dbSNP:rs143043662EnsemblClinVar. | 1 | |
Natural variantiVAR_037804 | 697 | M → L6 PublicationsCorresponds to variant dbSNP:rs1126821EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M23410 mRNA Translation: AAA64895.1 Z68228 mRNA Translation: CAA92522.1 AF306723, AF233882 Genomic DNA Translation: AAG16727.1 AY243535 mRNA Translation: AAO85780.1 AC109319 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60762.1 BC000441 mRNA Translation: AAH00441.2 Different initiation. BC011865 mRNA Translation: AAH11865.1 AJ249711 Genomic DNA Translation: CAC04246.1 |
CCDSi | CCDS11407.1 |
PIRi | A32905 |
RefSeqi | NP_002221.1, NM_002230.2 NP_068831.1, NM_021991.2 XP_006721936.1, XM_006721873.2 XP_006721937.1, XM_006721874.2 XP_006721938.1, XM_006721875.1 XP_006721941.1, XM_006721878.1 XP_011523055.1, XM_011524753.2 XP_011523057.1, XM_011524755.1 XP_011523058.1, XM_011524756.1 XP_011523059.1, XM_011524757.2 XP_011523060.1, XM_011524758.1 XP_016880079.1, XM_017024590.1 |
Genome annotation databases
Ensembli | ENST00000310706; ENSP00000311113; ENSG00000173801 ENST00000393930; ENSP00000377507; ENSG00000173801 ENST00000393931; ENSP00000377508; ENSG00000173801 |
GeneIDi | 3728 |
KEGGi | hsa:3728 |
UCSCi | uc002hxq.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M23410 mRNA Translation: AAA64895.1 Z68228 mRNA Translation: CAA92522.1 AF306723, AF233882 Genomic DNA Translation: AAG16727.1 AY243535 mRNA Translation: AAO85780.1 AC109319 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60762.1 BC000441 mRNA Translation: AAH00441.2 Different initiation. BC011865 mRNA Translation: AAH11865.1 AJ249711 Genomic DNA Translation: CAC04246.1 |
CCDSi | CCDS11407.1 |
PIRi | A32905 |
RefSeqi | NP_002221.1, NM_002230.2 NP_068831.1, NM_021991.2 XP_006721936.1, XM_006721873.2 XP_006721937.1, XM_006721874.2 XP_006721938.1, XM_006721875.1 XP_006721941.1, XM_006721878.1 XP_011523055.1, XM_011524753.2 XP_011523057.1, XM_011524755.1 XP_011523058.1, XM_011524756.1 XP_011523059.1, XM_011524757.2 XP_011523060.1, XM_011524758.1 XP_016880079.1, XM_017024590.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3IFQ | X-ray | 2.80 | A/B | 124-676 | [»] | |
SMRi | P14923 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109931, 263 interactors |
CORUMi | P14923 |
DIPi | DIP-36235N |
IntActi | P14923, 120 interactors |
MINTi | P14923 |
STRINGi | 9606.ENSP00000377508 |
Chemistry databases
DrugBanki | DB01593, Zinc DB14487, Zinc acetate |
PTM databases
GlyConnecti | 1950, 10 N-Linked glycans (4 sites) |
GlyGeni | P14923, 5 sites |
iPTMneti | P14923 |
MetOSitei | P14923 |
PhosphoSitePlusi | P14923 |
SwissPalmi | P14923 |
Genetic variation databases
BioMutai | JUP |
DMDMi | 205371866 |
Proteomic databases
EPDi | P14923 |
jPOSTi | P14923 |
MassIVEi | P14923 |
MaxQBi | P14923 |
PaxDbi | P14923 |
PeptideAtlasi | P14923 |
PRIDEi | P14923 |
ProteomicsDBi | 53098 |
Protocols and materials databases
Antibodypediai | 80391, 1238 antibodies |
DNASUi | 3728 |
Genome annotation databases
Ensembli | ENST00000310706; ENSP00000311113; ENSG00000173801 ENST00000393930; ENSP00000377507; ENSG00000173801 ENST00000393931; ENSP00000377508; ENSG00000173801 |
GeneIDi | 3728 |
KEGGi | hsa:3728 |
UCSCi | uc002hxq.3, human |
Organism-specific databases
CTDi | 3728 |
DisGeNETi | 3728 |
GeneCardsi | JUP |
GeneReviewsi | JUP |
HGNCi | HGNC:6207, JUP |
HPAi | ENSG00000173801, Tissue enhanced (esophagus, skin, tongue) |
MalaCardsi | JUP |
MIMi | 173325, gene 601214, phenotype 611528, phenotype |
neXtProti | NX_P14923 |
OpenTargetsi | ENSG00000173801 |
Orphaneti | 293899, Familial isolated arrhythmogenic ventricular dysplasia, biventricular form 293888, Familial isolated arrhythmogenic ventricular dysplasia, left dominant form 293910, Familial isolated arrhythmogenic ventricular dysplasia, right dominant form 158687, Lethal acantholytic epidermolysis bullosa 34217, Naxos disease |
PharmGKBi | PA30009 |
VEuPathDBi | HostDB:ENSG00000173801.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4203, Eukaryota |
GeneTreei | ENSGT00940000156395 |
HOGENOMi | CLU_008757_1_1_1 |
InParanoidi | P14923 |
OMAi | PYPTSDH |
OrthoDBi | 321213at2759 |
PhylomeDBi | P14923 |
TreeFami | TF317997 |
Enzyme and pathway databases
PathwayCommonsi | P14923 |
Reactomei | R-HSA-418990, Adherens junctions interactions R-HSA-5218920, VEGFR2 mediated vascular permeability R-HSA-6798695, Neutrophil degranulation R-HSA-6805567, Keratinization R-HSA-6809371, Formation of the cornified envelope |
SignaLinki | P14923 |
SIGNORi | P14923 |
Miscellaneous databases
BioGRID-ORCSi | 3728, 17 hits in 881 CRISPR screens |
ChiTaRSi | JUP, human |
EvolutionaryTracei | P14923 |
GeneWikii | Plakoglobin |
GenomeRNAii | 3728 |
Pharosi | P14923, Tbio |
PROi | PR:P14923 |
RNActi | P14923, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000173801, Expressed in esophagus mucosa and 237 other tissues |
ExpressionAtlasi | P14923, baseline and differential |
Genevisiblei | P14923, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
IDEALi | IID00298 |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR013284, Beta-catenin IPR030461, Plakoglobin |
PANTHERi | PTHR45976, PTHR45976, 1 hit PTHR45976:SF3, PTHR45976:SF3, 1 hit |
Pfami | View protein in Pfam PF00514, Arm, 3 hits |
PRINTSi | PR01869, BCATNINFAMLY |
SMARTi | View protein in SMART SM00185, ARM, 12 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLAK_HUMAN | |
Accessioni | P14923Primary (citable) accession number: P14923 Secondary accession number(s): Q15093 Q9HCX9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | September 2, 2008 | |
Last modified: | February 10, 2021 | |
This is version 213 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families