Junction plakoglobin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• alpha-catenin binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Mutations in the area composita protein alphaT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy."
    van Hengel J., Calore M., Bauce B., Dazzo E., Mazzotti E., De Bortoli M., Lorenzon A., Li Mura I.E., Beffagna G., Rigato I., Vleeschouwers M., Tyberghein K., Hulpiau P., van Hamme E., Zaglia T., Corrado D., Basso C., Thiene G.

    , Daliento L., Nava A., van Roy F., Rampazzo A.
    Eur. Heart J. 34:201-210(2013) [PubMed] [Europe PMC] [Abstract]
  • "Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin."
    Sacco P.A., McGranahan T.M., Wheelock M.J., Johnson K.R.
    J. Biol. Chem. 270:20201-20206(1995) [PubMed] [Europe PMC] [Abstract]
  • "The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin."
    Rubinfeld B., Souza B., Albert I., Munemitsu S., Polakis P.
    J. Biol. Chem. 270:5549-5555(1995) [PubMed] [Europe PMC] [Abstract]
• cadherin binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin."
    Knudsen K.A., Wheelock M.J.
    J. Cell Biol. 118:671-679(1992) [PubMed] [Europe PMC] [Abstract]
  • "Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin."
    Sacco P.A., McGranahan T.M., Wheelock M.J., Johnson K.R.
    J. Biol. Chem. 270:20201-20206(1995) [PubMed] [Europe PMC] [Abstract]
• cell adhesion molecule binding Source: BHF-UCLInferred from physical interactionⁱ
  • "The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery."
    Cirillo N., Lanza M., De Rosa A., Cammarota M., La Gatta A., Gombos F., Lanza A.
    J. Cell. Biochem. 103:598-606(2008) [PubMed] [Europe PMC] [Abstract]
• cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence <br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • Ref.25

    "A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy."
    Asimaki A., Syrris P., Wichter T., Matthias P., Saffitz J.E., McKenna W.J.
    Am. J. Hum. Genet. 81:964-973(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: VARIANT ARVD12 SER-39 INS, CHARACTERIZATION OF VARIANT ARVD12 SER-39 INS.
• nuclear hormone receptor binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: BHF-UCL
• protein kinase binding Source: Ensembl
• protein phosphatase binding Source: UniProtKBInferred from physical interactionⁱ
  • "Association of human protein-tyrosine phosphatase kappa with members of the armadillo family."
    Fuchs M., Mueller T., Lerch M., Ullrich A.
    J. Biol. Chem. 271:16712-16719(1996) [PubMed] [Europe PMC] [Abstract]
• structural constituent of cell wall Source: BHF-UCLInferred by curatorⁱ
  • "Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin."
    Sacco P.A., McGranahan T.M., Wheelock M.J., Johnson K.R.
    J. Biol. Chem. 270:20201-20206(1995) [PubMed] [Europe PMC] [Abstract]
• structural molecule activity Source: BHF-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy."
    Roberts J.D., Herkert J.C., Rutberg J., Nikkel S.M., Wiesfeld A.C., Dooijes D., Gow R.M., van Tintelen J.P., Gollob M.H.
    Clin. Genet. 83:452-456(2013) [PubMed] [Europe PMC] [Abstract]
• transcription coactivator activity Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line."
    Maeda O., Usami N., Kondo M., Takahashi M., Goto H., Shimokata K., Kusugami K., Sekido Y.
    Oncogene 23:964-972(2004) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• adherens junction organization Source: Reactome
• bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.25

    "A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy."
    Asimaki A., Syrris P., Wichter T., Matthias P., Saffitz J.E., McKenna W.J.
    Am. J. Hum. Genet. 81:964-973(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: VARIANT ARVD12 SER-39 INS, CHARACTERIZATION OF VARIANT ARVD12 SER-39 INS.
• cell-cell adhesion Source: BHF-UCLInferred from direct assayⁱ
  • "Disparate effects of different mutations in plakoglobin on cell mechanical behavior."
    Huang H., Asimaki A., Lo D., McKenna W., Saffitz J.
    Cell Motil. Cytoskeleton 65:964-978(2008) [PubMed] [Europe PMC] [Abstract]
• cell migration Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Disparate effects of different mutations in plakoglobin on cell mechanical behavior."
    Huang H., Asimaki A., Lo D., McKenna W., Saffitz J.
    Cell Motil. Cytoskeleton 65:964-978(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to indole-3-methanol Source: UniProtKBInferred from direct assayⁱ
  • "Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes."
    Meng Q., Qi M., Chen D.Z., Yuan R., Goldberg I.D., Rosen E.M., Auborn K., Fan S.
    J. Mol. Med. 78:155-165(2000) [PubMed] [Europe PMC] [Abstract]
• cornification Source: Reactome
• cytoskeletal anchoring at plasma membrane Source: BHF-UCLNon-traceable author statementⁱ
  • "Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy."
    Roberts J.D., Herkert J.C., Rutberg J., Nikkel S.M., Wiesfeld A.C., Dooijes D., Gow R.M., van Tintelen J.P., Gollob M.H.
    Clin. Genet. 83:452-456(2013) [PubMed] [Europe PMC] [Abstract]
• desmosome assembly Source: BHF-UCLInferred from direct assayⁱ
  • "Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy."
    Roberts J.D., Herkert J.C., Rutberg J., Nikkel S.M., Wiesfeld A.C., Dooijes D., Gow R.M., van Tintelen J.P., Gollob M.H.
    Clin. Genet. 83:452-456(2013) [PubMed] [Europe PMC] [Abstract]
• detection of mechanical stimulus Source: BHF-UCLInferred from direct assayⁱ
  • "Disparate effects of different mutations in plakoglobin on cell mechanical behavior."
    Huang H., Asimaki A., Lo D., McKenna W., Saffitz J.
    Cell Motil. Cytoskeleton 65:964-978(2008) [PubMed] [Europe PMC] [Abstract]
• endothelial cell-cell adhesion Source: BHF-UCL
• keratinization Source: Reactome
• negative regulation of blood vessel endothelial cell migration Source: BHF-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "MicroRNA-939 governs vascular integrity and angiogenesis through targeting gamma-catenin in endothelial cells."
    Hou S., Fang M., Zhu Q., Liu Y., Liu L., Li X.
    Biochem. Biophys. Res. Commun. 484:27-33(2017) [PubMed] [Europe PMC] [Abstract]
• neutrophil degranulation Source: Reactome
• positive regulation of angiogenesis Source: BHF-UCLInferred from genetic interactionⁱ
  • "MicroRNA-939 governs vascular integrity and angiogenesis through targeting gamma-catenin in endothelial cells."
    Hou S., Fang M., Zhu Q., Liu Y., Liu L., Li X.
    Biochem. Biophys. Res. Commun. 484:27-33(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of canonical Wnt signaling pathway Source: BHF-UCLInferred by curatorⁱ
  • "Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line."
    Maeda O., Usami N., Kondo M., Takahashi M., Goto H., Shimokata K., Kusugami K., Sekido Y.
    Oncogene 23:964-972(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell-matrix adhesion Source: BHF-UCLInferred from genetic interactionⁱ
  • "MicroRNA-939 governs vascular integrity and angiogenesis through targeting gamma-catenin in endothelial cells."
    Hou S., Fang M., Zhu Q., Liu Y., Liu L., Li X.
    Biochem. Biophys. Res. Commun. 484:27-33(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA-binding transcription factor activity Source: BHF-UCLInferred from direct assayⁱ
  • "Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line."
    Maeda O., Usami N., Kondo M., Takahashi M., Goto H., Shimokata K., Kusugami K., Sekido Y.
    Oncogene 23:964-972(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein import into nucleus Source: BHF-UCLInferred from direct assayⁱ
  • "Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin."
    Zhurinsky J., Shtutman M., Ben-Ze'ev A.
    Mol. Cell. Biol. 20:4238-4252(2000) [PubMed] [Europe PMC] [Abstract]
  • "Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line."
    Maeda O., Usami N., Kondo M., Takahashi M., Goto H., Shimokata K., Kusugami K., Sekido Y.
    Oncogene 23:964-972(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein heterooligomerization Source: Ensembl
• protein localization to plasma membrane Source: UniProtKBInferred from mutant phenotypeⁱ
  • "E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly."
    Gosavi P., Kundu S.T., Khapare N., Sehgal L., Karkhanis M.S., Dalal S.N.
    Cell. Mol. Life Sci. 68:1439-1454(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of cell population proliferation Source: BHF-UCLInferred from direct assayⁱ
  • Ref.25

    "A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy."
    Asimaki A., Syrris P., Wichter T., Matthias P., Saffitz J.E., McKenna W.J.
    Am. J. Hum. Genet. 81:964-973(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: VARIANT ARVD12 SER-39 INS, CHARACTERIZATION OF VARIANT ARVD12 SER-39 INS.
• regulation of heart rate by cardiac conduction Source: BHF-UCLInferred from mutant phenotypeⁱ
  • Ref.25

    "A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy."
    Asimaki A., Syrris P., Wichter T., Matthias P., Saffitz J.E., McKenna W.J.
    Am. J. Hum. Genet. 81:964-973(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: VARIANT ARVD12 SER-39 INS, CHARACTERIZATION OF VARIANT ARVD12 SER-39 INS.
• regulation of ventricular cardiac muscle cell action potential Source: BHF-UCLInferred from mutant phenotypeⁱ
  • Ref.25

    "A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy."
    Asimaki A., Syrris P., Wichter T., Matthias P., Saffitz J.E., McKenna W.J.
    Am. J. Hum. Genet. 81:964-973(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: VARIANT ARVD12 SER-39 INS, CHARACTERIZATION OF VARIANT ARVD12 SER-39 INS.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Mutagenesis

Keywords - Diseaseⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• alpha-catenin binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Mutations in the area composita protein alphaT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy."
    van Hengel J., Calore M., Bauce B., Dazzo E., Mazzotti E., De Bortoli M., Lorenzon A., Li Mura I.E., Beffagna G., Rigato I., Vleeschouwers M., Tyberghein K., Hulpiau P., van Hamme E., Zaglia T., Corrado D., Basso C., Thiene G.

    , Daliento L., Nava A., van Roy F., Rampazzo A.
    Eur. Heart J. 34:201-210(2013) [PubMed] [Europe PMC] [Abstract]
  • "Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin."
    Sacco P.A., McGranahan T.M., Wheelock M.J., Johnson K.R.
    J. Biol. Chem. 270:20201-20206(1995) [PubMed] [Europe PMC] [Abstract]
  • "The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin."
    Rubinfeld B., Souza B., Albert I., Munemitsu S., Polakis P.
    J. Biol. Chem. 270:5549-5555(1995) [PubMed] [Europe PMC] [Abstract]
• cadherin binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin."
    Knudsen K.A., Wheelock M.J.
    J. Cell Biol. 118:671-679(1992) [PubMed] [Europe PMC] [Abstract]
  • "Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin."
    Sacco P.A., McGranahan T.M., Wheelock M.J., Johnson K.R.
    J. Biol. Chem. 270:20201-20206(1995) [PubMed] [Europe PMC] [Abstract]
• cell adhesion molecule binding Source: BHF-UCLInferred from physical interactionⁱ
  • "The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery."
    Cirillo N., Lanza M., De Rosa A., Cammarota M., La Gatta A., Gombos F., Lanza A.
    J. Cell. Biochem. 103:598-606(2008) [PubMed] [Europe PMC] [Abstract]
• cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication Source: BHF-UCLInferred by curatorⁱ
  • Ref.25

    "A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy."
    Asimaki A., Syrris P., Wichter T., Matthias P., Saffitz J.E., McKenna W.J.
    Am. J. Hum. Genet. 81:964-973(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: VARIANT ARVD12 SER-39 INS, CHARACTERIZATION OF VARIANT ARVD12 SER-39 INS.
• nuclear hormone receptor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: BHF-UCL
• protein kinase binding Source: Ensembl
• protein phosphatase binding Source: UniProtKBInferred from physical interactionⁱ
  • "Association of human protein-tyrosine phosphatase kappa with members of the armadillo family."
    Fuchs M., Mueller T., Lerch M., Ullrich A.
    J. Biol. Chem. 271:16712-16719(1996) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MEVMNLMEQP IKVTEWQQTY TYDSGIHSGA NTCVPSVSSK GIMEEDEACG 
        60         70         80         90        100
RQYTLKKTTT YTQGVPPSQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL 
       110        120        130        140        150
LLATQVEGQA TNLQRLAEPS QLLKSAIVHL INYQDDAELA TRALPELTKL 
       160        170        180        190        200
LNDEDPVVVT KAAMIVNQLS KKEASRRALM GSPQLVAAVV RTMQNTSDLD 
       210        220        230        240        250
TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE SVLFYAITTL 
       260        270        280        290        300
HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ 
       310        320        330        340        350
ESKLIILANG GPQALVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE 
       360        370        380        390        400
AGGMQALGKH LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE SVLKILVNQL 
       410        420        430        440        450
SVDDVNVLTC ATGTLSNLTC NNSKNKTLVT QNSGVEALIH AILRAGDKDD 
       460        470        480        490        500
ITEPAVCALR HLTSRHPEAE MAQNSVRLNY GIPAIVKLLN QPNQWPLVKA 
       510        520        530        540        550
TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR HVAAGTQQPY 
       560        570        580        590        600
TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI 
       610        620        630        640        650
QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF 
       660        670        680        690        700
RISEDKNPDY RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYGDDMDAT 
       710        720        730        740 
YRPMYSSDVP LDPLEMHMDM DGDYPIDTYS DGLRPPYPTA DHMLA      

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 17
   Human chromosome 17: entries, gene names and cross-references to MIM
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families
4. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
5. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
6. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot