Protein C-ets-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: UniProtKB
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1."
    Jinnin M., Ihn H., Asano Y., Yamane K., Trojanowska M., Tamaki K.
    Oncogene 23:1656-1667(2004) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: BHF-UCLInferred from direct assayⁱ
  • Ref.14

    "Sp100 interacts with ETS-1 and stimulates its transcriptional activity."
    Wasylyk C., Schlumberger S.E., Criqui-Filipe P., Wasylyk B.
    Mol. Cell. Biol. 22:2687-2702(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION AS A TRANSCRIPTIONAL ACTIVATOR, INTERACTION WITH SP100, SUBCELLULAR LOCATION, ACTIVATION DOMAIN.
  • Ref.15

    "SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion."
    Yordy J.S., Li R., Sementchenko V.I., Pei H., Muise-Helmericks R.C., Watson D.K.
    Oncogene 23:6654-6665(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION AS A TRANSCRIPTIONAL ACTIVATOR, INTERACTION WITH SP100.
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCLInferred from direct assayⁱ
  • "Constitutive activation of the ETS-1-miR-222 circuitry in metastatic melanoma."
    Mattia G., Errico M.C., Felicetti F., Petrini M., Bottero L., Tomasello L., Romania P., Boe A., Segnalini P., Di Virgilio A., Colombo M.P., Care A.
    Pigment Cell Melanoma Res 24:953-965(2011) [PubMed] [Europe PMC] [Abstract]
• histone acetyltransferase binding Source: Ensembl
• identical protein binding Source: IntAct <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes."
    Li X., Wang W., Wang J., Malovannaya A., Xi Y., Li W., Guerra R., Hawke D.H., Qin J., Chen J.
    Mol Syst Biol 11:775-775(2015) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • "Basal transcription of the mouse sarco(endo)plasmic reticulum Ca2+-ATPase type 3 gene in endothelial cells is controlled by Ets-1 and Sp1."
    Hadri L., Ozog A., Soncin F., Lompre A.M.
    J Biol Chem 277:36471-36478(2002) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • Ref.13

    "EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes."
    Li R., Pei H., Watson D.K., Papas T.S.
    Oncogene 19:745-753(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.

GO - Biological processⁱ

• angiogenesis involved in wound healing Source: Ensembl
• cell differentiation Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell motility Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.15

    "SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion."
    Yordy J.S., Li R., Sementchenko V.I., Pei H., Muise-Helmericks R.C., Watson D.K.
    Oncogene 23:6654-6665(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION AS A TRANSCRIPTIONAL ACTIVATOR, INTERACTION WITH SP100.
• cellular response to hydrogen peroxide Source: Ensembl
• estrous cycle Source: Ensembl
• female pregnancy Source: Ensembl
• hypothalamus development Source: Ensembl
• immune response Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1."
    Bhat N.K., Thompson C.B., Lindsten T., June C.H., Fujiwara S., Koizumi S., Fisher R.J., Papas T.S.
    Proc Natl Acad Sci U S A 87:3723-3727(1990) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell cycle Source: UniProtKBInferred from direct assayⁱ
  • "A variant form of ETS1 induces apoptosis in human colon cancer cells."
    Huang C.C., Papas T.S., Bhat N.K.
    Oncogene 15:851-856(1997) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: ProtIncTraceable author statementⁱ
  • "Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1."
    Bhat N.K., Thompson C.B., Lindsten T., June C.H., Fujiwara S., Koizumi S., Fisher R.J., Papas T.S.
    Proc Natl Acad Sci U S A 87:3723-3727(1990) [PubMed] [Europe PMC] [Abstract]
• negative regulation of inflammatory response Source: Ensembl
• pituitary gland development Source: Ensembl
• PML body organization Source: BHF-UCLInferred from direct assayⁱ
  • Ref.14

    "Sp100 interacts with ETS-1 and stimulates its transcriptional activity."
    Wasylyk C., Schlumberger S.E., Criqui-Filipe P., Wasylyk B.
    Mol. Cell. Biol. 22:2687-2702(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION AS A TRANSCRIPTIONAL ACTIVATOR, INTERACTION WITH SP100, SUBCELLULAR LOCATION, ACTIVATION DOMAIN.
  • Ref.15

    "SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion."
    Yordy J.S., Li R., Sementchenko V.I., Pei H., Muise-Helmericks R.C., Watson D.K.
    Oncogene 23:6654-6665(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION AS A TRANSCRIPTIONAL ACTIVATOR, INTERACTION WITH SP100.
• positive regulation of angiogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "miR-200b targets Ets-1 and is down-regulated by hypoxia to induce angiogenic response of endothelial cells."
    Chan Y.C., Khanna S., Roy S., Sen C.K.
    J Biol Chem 286:2047-2056(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of blood vessel endothelial cell migration Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "miR-200b targets Ets-1 and is down-regulated by hypoxia to induce angiogenic response of endothelial cells."
    Chan Y.C., Khanna S., Roy S., Sen C.K.
    J Biol Chem 286:2047-2056(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: Ensembl
• positive regulation of cellular component movement Source: BHF-UCLInferred from mutant phenotypeⁱ
  • Ref.15

    "SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion."
    Yordy J.S., Li R., Sementchenko V.I., Pei H., Muise-Helmericks R.C., Watson D.K.
    Oncogene 23:6654-6665(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION AS A TRANSCRIPTIONAL ACTIVATOR, INTERACTION WITH SP100.
• positive regulation of endothelial cell migration Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.17

    "SP100 inhibits ETS1 activity in primary endothelial cells."
    Yordy J.S., Moussa O., Pei H., Chaussabel D., Li R., Watson D.K.
    Oncogene 24:916-931(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN ENDOTHELIAL CELL MIGRATION, INDUCTION.
• positive regulation of erythrocyte differentiation Source: UniProtKBInferred from direct assayⁱ
  • "MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation."
    Sieweke M.H., Tekotte H., Frampton J., Graf T.
    Cell 85:49-60(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "miR-200b targets Ets-1 and is down-regulated by hypoxia to induce angiogenic response of endothelial cells."
    Chan Y.C., Khanna S., Roy S., Sen C.K.
    J Biol Chem 286:2047-2056(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of inflammatory response Source: BHF-UCLInferred from direct assayⁱ
  • "Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration."
    Zhu N., Zhang D., Chen S., Liu X., Lin L., Huang X., Guo Z., Liu J., Wang Y., Yuan W., Qin Y.
    Atherosclerosis 215:286-293(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of leukocyte adhesion to vascular endothelial cell Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration."
    Zhu N., Zhang D., Chen S., Liu X., Lin L., Huang X., Guo Z., Liu J., Wang Y., Yuan W., Qin Y.
    Atherosclerosis 215:286-293(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "Constitutive activation of the ETS-1-miR-222 circuitry in metastatic melanoma."
    Mattia G., Errico M.C., Felicetti F., Petrini M., Bottero L., Tomasello L., Romania P., Boe A., Segnalini P., Di Virgilio A., Colombo M.P., Care A.
    Pigment Cell Melanoma Res 24:953-965(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: BHF-UCLInferred from direct assayⁱ
  • Ref.14

    "Sp100 interacts with ETS-1 and stimulates its transcriptional activity."
    Wasylyk C., Schlumberger S.E., Criqui-Filipe P., Wasylyk B.
    Mol. Cell. Biol. 22:2687-2702(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION AS A TRANSCRIPTIONAL ACTIVATOR, INTERACTION WITH SP100, SUBCELLULAR LOCATION, ACTIVATION DOMAIN.
• positive regulation of transcription by RNA polymerase II Source: NTNU_SBInferred from direct assayⁱ
  • "Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1."
    Jinnin M., Ihn H., Asano Y., Yamane K., Trojanowska M., Tamaki K.
    Oncogene 23:1656-1667(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of angiogenesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.17

    "SP100 inhibits ETS1 activity in primary endothelial cells."
    Yordy J.S., Moussa O., Pei H., Chaussabel D., Li R., Watson D.K.
    Oncogene 24:916-931(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN ENDOTHELIAL CELL MIGRATION, INDUCTION.
• regulation of apoptotic process Source: UniProtKBInferred from direct assayⁱ
  • "A variant form of ETS1 induces apoptosis in human colon cancer cells."
    Huang C.C., Papas T.S., Bhat N.K.
    Oncogene 15:851-856(1997) [PubMed] [Europe PMC] [Abstract]
• regulation of extracellular matrix disassembly Source: Ensembl
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to antibiotic Source: UniProtKBInferred from direct assayⁱ
  • "A variant form of ETS1 induces apoptosis in human colon cancer cells."
    Huang C.C., Papas T.S., Bhat N.K.
    Oncogene 15:851-856(1997) [PubMed] [Europe PMC] [Abstract]
• response to estradiol Source: Ensembl
• response to hypoxia Source: Ensembl
• response to interleukin-1 Source: Ensembl
• response to laminar fluid shear stress Source: Ensembl
• response to mechanical stimulus Source: Ensembl
• transcription by RNA polymerase II Source: UniProtKBInferred from direct assayⁱ
  • "ETS1 suppresses tumorigenicity of human colon cancer cells."
    Suzuki H., Romano-Spica V., Papas T.S., Bhat N.K.
    Proc Natl Acad Sci U S A 92:4442-4446(1995) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• histone acetyltransferase binding Source: Ensembl
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes."
    Li X., Wang W., Wang J., Malovannaya A., Xi Y., Li W., Guerra R., Hawke D.H., Qin J., Chen J.
    Mol Syst Biol 11:775-775(2015) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: UniProtKBNon-traceable author statementⁱ
  • Ref.13

    "EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes."
    Li R., Pei H., Watson D.K., Papas T.S.
    Oncogene 19:745-753(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK 
        60         70         80         90        100
ATFSGFTKEQ QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM 
       110        120        130        140        150
NGAALCALGK DCFLELAPDF VGDILWEHLE ILQKEDVKPY QVNGVNPAYP 
       160        170        180        190        200
ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF ITESYQTLHP ISSEELLSLK 
       210        220        230        240        250
YENDYPSVIL RDPLQTDTLQ NDYFAIKQEV VTPDNMCMGR TSRGKLGGQD 
       260        270        280        290        300
SFESIESYDS CDRLTQSWSS QSSFNSLQRV PSYDSFDSED YPAALPNHKP 
       310        320        330        340        350
KGTFKDYVRD RADLNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC 
       360        370        380        390        400
QSFISWTGDG WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKN 
       410        420        430        440 
IIHKTAGKRY VYRFVCDLQS LLGYTPEELH AMLDVKPDAD E          

        10         20         30         40         50
MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK 
        60         70         80         90        100
ATFSGFTKEQ QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM 
       110        120        130        140        150
NGAALCALGK DCFLELAPDF VGDILWEHLE ILQKEDVKPY QVNGVNPAYP 
       160        170        180        190        200
ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF ITESYQTLHP ISSEELLSLK 
       210        220        230        240        250
YENDYPSVIL RDPLQTDTLQ NDYFAIKQEV VTPDNMCMGR TSRGSGPIQL 
       260        270        280        290        300
WQFLLELLTD KSCQSFISWT GDGWEFKLSD PDEVARRWGK RKNKPKMNYE 
       310        320        330        340        350
KLSRGLRYYY DKNIIHKTAG KRYVYRFVCD LQSLLGYTPE ELHAMLDVKP 

DADE                                                   

        10         20         30         40         50
MSYFVDSAGS SPVPYSAPRP AVVRQGPSNT YEDPRMNCGF QSNYHQQRPC 
        60         70         80         90        100
YPFWDEMATQ EVPTGLEHCV SDMECADVPL LTPSSKEMMS QALKATFSGF 
       110        120        130        140        150
TKEQQRLGIP KDPRQWTETH VRDWVMWAVN EFSLKGVDFQ KFCMNGAALC 
       160        170        180        190        200
ALGKDCFLEL APDFVGDILW EHLEILQKED VKPYQVNGVN PAYPESRYTS 
       210        220        230        240        250
DYFISYGIEH AQCVPPSEFS EPSFITESYQ TLHPISSEEL LSLKYENDYP 
       260        270        280        290        300
SVILRDPLQT DTLQNDYFAI KQEVVTPDNM CMGRTSRGKL GGQDSFESIE 
       310        320        330        340        350
SYDSCDRLTQ SWSSQSSFNS LQRVPSYDSF DSEDYPAALP NHKPKGTFKD 
       360        370        380        390        400
YVRDRADLNK DKPVIPAAAL AGYTGSGPIQ LWQFLLELLT DKSCQSFISW 
       410        420        430        440        450
TGDGWEFKLS DPDEVARRWG KRKNKPKMNY EKLSRGLRYY YDKNIIHKTA 
       460        470        480 
GKRYVYRFVC DLQSLLGYTP EELHAMLDVK PDADE                 

        10         20         30         40         50
MKAAVDLKPT LTIIKTEKVD LELFPSPGKL GGQDSFESIE SYDSCDRLTQ 
        60         70         80         90        100
SWSSQSSFNS LQRVPSYDSF DSEDYPAALP NHKPKGTFKD YVRDRADLNK 
       110        120        130        140        150
DKPVIPAAAL AGYTGSGPIQ LWQFLLELLT DKSCQSFISW TGDGWEFKLS 
       160        170        180        190        200
DPDEVARRWG KRKNKPKMNY EKLSRGLRYY YDKNIIHKTA GKRYVYRFVC 
       210        220 
DLQSLLGYTP EELHAMLDVK PDADE                            

        10         20         30         40         50
MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK 
        60         70         80         90        100
ATFSGFTKEQ QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM 
       110        120        130        140        150
NGAALCALGK DCFLELAPDF VGDILWEHLE ILQKEDVKPY QVNGVNPAYP 
       160        170        180        190        200
ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF ITESYQTLHP ISSEELLSLK 
       210        220        230        240        250
YENDYPSVIL RDPLQTDTLQ NDYFAIKQEV VTPDNMCMGR TSRGKLGGQD 
       260        270 
SFESIESYDS CGQEMGKEEK QT                               

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families
4. Human chromosome 11
   Human chromosome 11: entries, gene names and cross-references to MIM