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UniProtKB - P14921 (ETS1_HUMAN)

Entry version 209 (13 Feb 2019)
Sequence version 1 (01 Apr 1990)
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Protein

Protein C-ets-1

Gene

ETS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi335 – 415ETSPROSITE-ProRule annotationAdd BLAST81

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processImmunity, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2559585 Oncogene Induced Senescence

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P14921

SIGNOR Signaling Network Open Resource

More...SIGNORi		P14921

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		P14921 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein C-ets-1
Alternative name(s):
p54
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ETS1
Synonyms:EWSR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000134954.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:3488 ETS1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		164720 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P14921

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		2113

Open Targets

More...OpenTargetsi		ENSG00000134954

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		536 Systemic lupus erythematosus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27902

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ETS1

Domain mapping of disease mutations (DMDM)

More...DMDMi		119641

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002040691 – 441Protein C-ets-1Add BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki8Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei15N6-acetyllysine; alternateCombined sources1
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei38Phosphothreonine; by MAPKBy similarity1
Cross-linki138Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei223PhosphotyrosineCombined sources1
Cross-linki227Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei251PhosphoserineCombined sources1
Modified residuei254PhosphoserineBy similarity1
Modified residuei265PhosphothreonineCombined sources1
Modified residuei267PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Modified residuei282PhosphoserineBy similarity1
Modified residuei285PhosphoserineCombined sources1
Modified residuei305N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity.By similarity
Ubiquitinated; which induces proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P14921

MaxQB - The MaxQuant DataBase

More...MaxQBi		P14921

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P14921

PeptideAtlas

More...PeptideAtlasi		P14921

PRoteomics IDEntifications database

More...PRIDEi		P14921

ProteomicsDB human proteome resource

More...ProteomicsDBi		53095
53096 [P14921-2]
53097 [P14921-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P14921

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P14921

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by retinoic acid, VEGF, TNF-alpha/TNFA, lipopolysaccharide and in response to hypoxia (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134954 Expressed in 208 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P14921 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P14921 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB002575
HPA063230

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a homodimer; homodimerization is required for transcription activation. Interacts with MAF and MAFB. Interacts with PAX5; the interaction alters DNA-binding properties (By similarity). Interacts with DAXX. Interacts with UBE2I. Interacts with SP100; the interaction is direct and modulates ETS1 transcriptional activity.By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		108414, 53 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P14921

Database of interacting proteins

More...DIPi		DIP-35183N

Protein interaction database and analysis system

More...IntActi		P14921, 73 interactors

Molecular INTeraction database

More...MINTi		P14921

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000376436

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1441
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GVJX-ray1.53A/B297-441[»]
2NNYX-ray2.58A/B280-441[»]
2STTNMR-A320-415[»]
2STWNMR-A320-415[»]
3MFKX-ray3.00A/B280-441[»]
3RI4X-ray3.00A/D280-441[»]
3WTSX-ray2.35C/H276-441[»]
3WTTX-ray2.35C/H276-441[»]
3WTUX-ray2.70C/H276-441[»]
3WTVX-ray2.70C/H276-441[»]
3WTWX-ray2.90C/H276-441[»]
3WTXX-ray2.80C/H276-441[»]
3WTYX-ray2.70C/H276-441[»]
3WTZX-ray2.61A/B276-441[»]
3WU0X-ray2.60A/B276-441[»]
3WU1X-ray2.40B333-441[»]
4L0YX-ray2.50B296-441[»]
4L0ZX-ray2.70B296-441[»]
4L18X-ray2.30B/F296-441[»]
4LG0X-ray2.19B331-440[»]
5ZMCX-ray2.99B331-441[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P14921

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P14921

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P14921

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 136PNTPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni130 – 243Activation domain; required for transcription activationAdd BLAST114

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3806 Eukaryota
ENOG410Z0ZF LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159519

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000285953

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG003088

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P14921

KEGG Orthology (KO)

More...KOi		K02678

Identification of Orthologs from Complete Genome Data

More...OMAi		TDMECAD

Database of Orthologous Groups

More...OrthoDBi		570797at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P14921

TreeFam database of animal gene trees

More...TreeFami		TF316214

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR016311 Transform_prot_C-ets
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001698 Transforming_factor_C-ets, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00454 ETSDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform c-ETS-1A (identifier: P14921-1) [UniParc]FASTAAdd to basket
Also known as: Ets-1 p51

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK 
        60         70         80         90        100
ATFSGFTKEQ QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM 
       110        120        130        140        150
NGAALCALGK DCFLELAPDF VGDILWEHLE ILQKEDVKPY QVNGVNPAYP 
       160        170        180        190        200
ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF ITESYQTLHP ISSEELLSLK 
       210        220        230        240        250
YENDYPSVIL RDPLQTDTLQ NDYFAIKQEV VTPDNMCMGR TSRGKLGGQD 
       260        270        280        290        300
SFESIESYDS CDRLTQSWSS QSSFNSLQRV PSYDSFDSED YPAALPNHKP 
       310        320        330        340        350
KGTFKDYVRD RADLNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC 
       360        370        380        390        400
QSFISWTGDG WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKN 
       410        420        430        440 
IIHKTAGKRY VYRFVCDLQS LLGYTPEELH AMLDVKPDAD E
Length:441
Mass (Da):50,408
Last modified:April 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B66BCC464B393FB
GO
Isoform c-ETS-1B (identifier: P14921-2) [UniParc]FASTAAdd to basket
Also known as: Ets-1 p42

The sequence of this isoform differs from the canonical sequence as follows:
     244-330: Missing.

Show »
Length:354
Mass (Da):40,786
Checksum:i6C3313F2DBE3CF88
GO
Isoform 3 (identifier: P14921-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MKAAVDLKPTLTIIKTEKVDLELFPSP → MSYFVDSAGS...VPTGLEHCVS

Note: No experimental confirmation available.
Show »
Length:485
Mass (Da):55,412
Checksum:i8A6B816BAEB91149
GO
Isoform Ets-1 p27 (identifier: P14921-4) [UniParc]FASTAAdd to basket
Also known as: Ets-1Delta(III-VI)

The sequence of this isoform differs from the canonical sequence as follows:
     28-243: Missing.

Note: Acts as a dominant-negative for isoform c-ETS-1A.
Show »
Length:225
Mass (Da):25,697
Checksum:i5A01096FCEDE9FEA
GO
Isoform 5 (identifier: P14921-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     262-272: DRLTQSWSSQS → GQEMGKEEKQT
     273-441: Missing.

Note: No experimental confirmation available.
Show »
Length:272
Mass (Da):30,860
Checksum:i20D7FF9557D80D46
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYD6V9GYD6_HUMAN
Protein C-ets-1
ETS1
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti162Y → C in AAB28747 (PubMed:8231246).Curated1
Sequence conflicti236 – 243MCMGRTSR → FLPPPLPP in AAA52409 (PubMed:2997781).Curated8
Sequence conflicti255I → V in AAY19514 (PubMed:19377509).Curated1
Sequence conflicti332 – 337SGPIQL → RRPPAA in AAA52409 (PubMed:2997781).Curated6

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0431521 – 27MKAAV…LFPSP → MSYFVDSAGSSPVPYSAPRP AVVRQGPSNTYEDPRMNCGF QSNYHQQRPCYPFWDEMATQ EVPTGLEHCVS in isoform 3. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_04605628 – 243Missing in isoform Ets-1 p27. 1 PublicationAdd BLAST216
Alternative sequenceiVSP_001464244 – 330Missing in isoform c-ETS-1B. CuratedAdd BLAST87
Alternative sequenceiVSP_055485262 – 272DRLTQSWSSQS → GQEMGKEEKQT in isoform 5. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_055486273 – 441Missing in isoform 5. 1 PublicationAdd BLAST169

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X14798 mRNA Translation: CAA32904.1
X14798 mRNA Translation: CAA32903.1
J04101 mRNA Translation: AAA52410.1
X65469 Genomic DNA No translation available.
S67063 mRNA Translation: AAB28747.1
AY943926 mRNA Translation: AAY19514.1
BT019452 mRNA Translation: AAV38259.1
BX640634 mRNA Translation: CAE45783.1
AP001995 Genomic DNA No translation available.
AP003397 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67709.1
BC017314 mRNA Translation: AAH17314.1
M11921 Genomic DNA Translation: AAA52409.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44767.1 [P14921-3]
CCDS53724.1 [P14921-4]
CCDS81648.1 [P14921-2]
CCDS8475.1 [P14921-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A32066 TVHUET

NCBI Reference Sequences

More...RefSeqi		NP_001137292.1, NM_001143820.1 [P14921-3]
NP_001155894.1, NM_001162422.1 [P14921-4]
NP_001317380.1, NM_001330451.1 [P14921-2]
NP_005229.1, NM_005238.3 [P14921-1]
XP_016872803.1, XM_017017314.1 [P14921-3]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.369438

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000319397; ENSP00000324578; ENSG00000134954 [P14921-1]
ENST00000392668; ENSP00000376436; ENSG00000134954 [P14921-3]
ENST00000526145; ENSP00000433500; ENSG00000134954 [P14921-2]
ENST00000531611; ENSP00000435666; ENSG00000134954 [P14921-5]
ENST00000535549; ENSP00000441430; ENSG00000134954 [P14921-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2113

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2113

UCSC genome browser

More...UCSCi		uc001qej.3 human [P14921-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14798 mRNA Translation: CAA32904.1
X14798 mRNA Translation: CAA32903.1
J04101 mRNA Translation: AAA52410.1
X65469 Genomic DNA No translation available.
S67063 mRNA Translation: AAB28747.1
AY943926 mRNA Translation: AAY19514.1
BT019452 mRNA Translation: AAV38259.1
BX640634 mRNA Translation: CAE45783.1
AP001995 Genomic DNA No translation available.
AP003397 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67709.1
BC017314 mRNA Translation: AAH17314.1
M11921 Genomic DNA Translation: AAA52409.1
CCDSiCCDS44767.1 [P14921-3]
CCDS53724.1 [P14921-4]
CCDS81648.1 [P14921-2]
CCDS8475.1 [P14921-1]
PIRiA32066 TVHUET
RefSeqiNP_001137292.1, NM_001143820.1 [P14921-3]
NP_001155894.1, NM_001162422.1 [P14921-4]
NP_001317380.1, NM_001330451.1 [P14921-2]
NP_005229.1, NM_005238.3 [P14921-1]
XP_016872803.1, XM_017017314.1 [P14921-3]
UniGeneiHs.369438

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GVJX-ray1.53A/B297-441[»]
2NNYX-ray2.58A/B280-441[»]
2STTNMR-A320-415[»]
2STWNMR-A320-415[»]
3MFKX-ray3.00A/B280-441[»]
3RI4X-ray3.00A/D280-441[»]
3WTSX-ray2.35C/H276-441[»]
3WTTX-ray2.35C/H276-441[»]
3WTUX-ray2.70C/H276-441[»]
3WTVX-ray2.70C/H276-441[»]
3WTWX-ray2.90C/H276-441[»]
3WTXX-ray2.80C/H276-441[»]
3WTYX-ray2.70C/H276-441[»]
3WTZX-ray2.61A/B276-441[»]
3WU0X-ray2.60A/B276-441[»]
3WU1X-ray2.40B333-441[»]
4L0YX-ray2.50B296-441[»]
4L0ZX-ray2.70B296-441[»]
4L18X-ray2.30B/F296-441[»]
4LG0X-ray2.19B331-440[»]
5ZMCX-ray2.99B331-441[»]
ProteinModelPortaliP14921
SMRiP14921
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108414, 53 interactors
CORUMiP14921
DIPiDIP-35183N
IntActiP14921, 73 interactors
MINTiP14921
STRINGi9606.ENSP00000376436

Protein family/group databases

MoonDBiP14921 Predicted

PTM databases

iPTMnetiP14921
PhosphoSitePlusiP14921

Polymorphism and mutation databases

BioMutaiETS1
DMDMi119641

Proteomic databases

EPDiP14921
MaxQBiP14921
PaxDbiP14921
PeptideAtlasiP14921
PRIDEiP14921
ProteomicsDBi53095
53096 [P14921-2]
53097 [P14921-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		2113
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319397; ENSP00000324578; ENSG00000134954 [P14921-1]
ENST00000392668; ENSP00000376436; ENSG00000134954 [P14921-3]
ENST00000526145; ENSP00000433500; ENSG00000134954 [P14921-2]
ENST00000531611; ENSP00000435666; ENSG00000134954 [P14921-5]
ENST00000535549; ENSP00000441430; ENSG00000134954 [P14921-4]
GeneIDi2113
KEGGihsa:2113
UCSCiuc001qej.3 human [P14921-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2113
DisGeNETi2113
EuPathDBiHostDB:ENSG00000134954.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		ETS1
HGNCiHGNC:3488 ETS1
HPAiCAB002575
HPA063230
MIMi164720 gene
neXtProtiNX_P14921
OpenTargetsiENSG00000134954
Orphaneti536 Systemic lupus erythematosus
PharmGKBiPA27902

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00940000159519
HOGENOMiHOG000285953
HOVERGENiHBG003088
InParanoidiP14921
KOiK02678
OMAiTDMECAD
OrthoDBi570797at2759
PhylomeDBiP14921
TreeFamiTF316214

Enzyme and pathway databases

ReactomeiR-HSA-2559585 Oncogene Induced Senescence
SignaLinkiP14921
SIGNORiP14921

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ETS1 human
EvolutionaryTraceiP14921

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ETS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2113

Protein Ontology

More...PROi		PR:P14921

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000134954 Expressed in 208 organ(s), highest expression level in blood
ExpressionAtlasiP14921 baseline and differential
GenevisibleiP14921 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR016311 Transform_prot_C-ets
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PIRSFiPIRSF001698 Transforming_factor_C-ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiETS1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14921
Secondary accession number(s): A9UL17
, F5GYX9, Q14278, Q16080, Q6N087, Q96AC5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: February 13, 2019
This is version 209 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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