ETS1

Functionⁱ

Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.4 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	335 – 415	ETSPROSITE-ProRule annotationAdd BLAST		81

GO - Molecular functionⁱ

DNA binding Source: UniProtKB
DNA-binding transcription factor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 11909962
- 15247905
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
histone acetyltransferase binding Source: Ensembl
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 25609649
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 12119294
transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 21711453
transcription factor binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10698492

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis involved in wound healing Source: Ensembl
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell motility
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15247905
cellular response to hydrogen peroxide Source: Ensembl
estrous cycle Source: Ensembl
female pregnancy Source: Ensembl
hypothalamus development Source: Ensembl
immune response
Source: ProtInc
Traceable author statementⁱ
- 2187191
negative regulation of cell cycle
Source: UniProtKB
Inferred from direct assayⁱ
- 9266972
negative regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 2187191
negative regulation of inflammatory response Source: Ensembl
pituitary gland development Source: Ensembl
PML body organization
Source: BHF-UCL
Inferred from direct assayⁱ
- 11909962
- 15247905
positive regulation of angiogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21081489
positive regulation of blood vessel endothelial cell migration
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21081489
positive regulation of cell proliferation Source: Ensembl
positive regulation of cellular component movement
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15247905
positive regulation of endothelial cell migration
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15592518
positive regulation of erythrocyte differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 8620536
positive regulation of gene expression
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21081489
positive regulation of inflammatory response
Source: BHF-UCL
Inferred from direct assayⁱ
- 21310411
positive regulation of leukocyte adhesion to vascular endothelial cell
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21310411
positive regulation of transcription, DNA-templated
Source: BHF-UCL
Inferred from direct assayⁱ
- 11909962
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 15001984
pri-miRNA transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 21711453
regulation of angiogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15592518
regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 9266972
regulation of extracellular matrix disassembly Source: Ensembl
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to antibiotic
Source: UniProtKB
Inferred from direct assayⁱ
- 9266972
response to estradiol Source: Ensembl
response to hypoxia Source: Ensembl
response to interleukin-1 Source: Ensembl
response to laminar fluid shear stress Source: Ensembl
response to mechanical stimulus Source: Ensembl
transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 7753825

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Immunity, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2559585 Oncogene Induced Senescence
SignaLinkⁱ	P14921
SIGNORⁱ	P14921

Protein family/group databases

MoonDBⁱ	P14921 Predicted

MoonDBⁱ

P14921 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein C-ets-1 Alternative name(s): p54
Gene namesⁱ	Name:ETS1 Synonyms:EWSR2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134954.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3488 ETS1
MIMⁱ	164720 gene
neXtProtⁱ	NX_P14921

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2113
Open Targets More...OpenTargetsⁱ	ENSG00000134954
Orphanetⁱ	536 NON RARE IN EUROPE: Systemic lupus erythematosus
PharmGKBⁱ	PA27902

Polymorphism and mutation databases

BioMutaⁱ	ETS1
DMDMⁱ	119641

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204069	1 – 441	Protein C-ets-1Add BLAST		441

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	8	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	8	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	15	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	15	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	38	Phosphothreonine; by MAPKBy similarity	1
Cross-linkⁱ	138	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	223	PhosphotyrosineCombined sources	1
Cross-linkⁱ	227	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residueⁱ	251	PhosphoserineCombined sources	1
Modified residueⁱ	254	PhosphoserineBy similarity	1
Modified residueⁱ	265	PhosphothreonineCombined sources	1
Modified residueⁱ	267	PhosphoserineCombined sources	1
Modified residueⁱ	270	PhosphoserineCombined sources	1
Modified residueⁱ	282	PhosphoserineBy similarity	1
Modified residueⁱ	285	PhosphoserineCombined sources	1
Modified residueⁱ	305	N6-acetyllysineCombined sources	1

Post-translational modificationⁱ

Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity.By similarity

Ubiquitinated; which induces proteasomal degradation.By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P14921
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P14921
PaxDbⁱ	P14921
PeptideAtlas More...PeptideAtlasⁱ	P14921
PRIDEⁱ	P14921
ProteomicsDBⁱ	53095 53096 [P14921-2] 53097 [P14921-3]

PTM databases

iPTMnetⁱ	P14921
PhosphoSitePlusⁱ	P14921

Expressionⁱ

Tissue specificityⁱ

Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney.2 Publications

Inductionⁱ

Up-regulated by retinoic acid, VEGF, TNF-alpha/TNFA, lipopolysaccharide and in response to hypoxia (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000134954 Expressed in 208 organ(s), highest expression level in blood
CleanExⁱ	HS_ETS1
ExpressionAtlasⁱ	P14921 baseline and differential
Genevisibleⁱ	P14921 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002575 HPA063230

HPAⁱ

CAB002575
HPA063230

Interactionⁱ

Subunit structureⁱ

Binds DNA as a homodimer; homodimerization is required for transcription activation. Interacts with MAF and MAFB. Interacts with PAX5; the interaction alters DNA-binding properties (By similarity). Interacts with DAXX. Interacts with UBE2I. Interacts with SP100; the interaction is direct and modulates ETS1 transcriptional activity.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		2	EBI-913209,EBI-913209
APLP2	Q06481	2	EBI-913209,EBI-79306
ARID4B	Q4LE39	2	EBI-913209,EBI-2680990
COP1	Q8NHY2	3	EBI-913224,EBI-1176214
CYBC1	Q9BQA9	3	EBI-913209,EBI-2680384
DAXX	Q9UER7-1	3	EBI-913224,EBI-287635
EIF5B	O60841	2	EBI-913209,EBI-928530
Gfi1	P70338	2	EBI-913209,EBI-3954754	From Mus musculus.
JUN	P05412	3	EBI-913209,EBI-852823
MAPK1	P28482	3	EBI-913209,EBI-959949
MEIS1	O00470	2	EBI-913209,EBI-1210694
PRKDC	P78527	2	EBI-913209,EBI-352053
SP100	P23497	4	EBI-913209,EBI-751145
SRC	P12931	2	EBI-913224,EBI-621482
SRSF11	Q05519	2	EBI-913209,EBI-1051785
TAL1	P17542	2	EBI-913209,EBI-1753878

GO - Molecular functionⁱ

histone acetyltransferase binding Source: Ensembl
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 25609649
transcription factor binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10698492

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108414, 53 interactors
CORUMⁱ	P14921
Database of interacting proteins More...DIPⁱ	DIP-35183N
IntActⁱ	P14921, 73 interactors
Molecular INTeraction database More...MINTⁱ	P14921
STRINGⁱ	9606.ENSP00000376436

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	304 – 313	Combined sources	10
Helixⁱ	323 – 330	Combined sources	8
Beta strandⁱ	331 – 334	Combined sources	4
Helixⁱ	337 – 345	Combined sources	9
Helixⁱ	348 – 350	Combined sources	3
Turnⁱ	351 – 353	Combined sources	3
Beta strandⁱ	354 – 356	Combined sources	3
Beta strandⁱ	358 – 361	Combined sources	4
Beta strandⁱ	362 – 364	Combined sources	3
Helixⁱ	368 – 379	Combined sources	12
Helixⁱ	386 – 395	Combined sources	10
Turnⁱ	396 – 400	Combined sources	5
Beta strandⁱ	401 – 404	Combined sources	4
Beta strandⁱ	408 – 414	Combined sources	7
Helixⁱ	418 – 422	Combined sources	5
Helixⁱ	426 – 432	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	P14921
SMRⁱ	P14921
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P14921

EvolutionaryTraceⁱ

P14921

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	51 – 136	PNTPROSITE-ProRule annotationAdd BLAST		86

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	130 – 243	Activation domain; required for transcription activationAdd BLAST		114

Sequence similaritiesⁱ

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3806 Eukaryota ENOG410Z0ZF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118907
HOGENOMⁱ	HOG000285953
HOVERGENⁱ	HBG003088
InParanoidⁱ	P14921
KEGG Orthology (KO) More...KOⁱ	K02678
OMAⁱ	TDMECAD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HJF
PhylomeDBⁱ	P14921
TreeFamⁱ	TF316214

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000418 Ets_dom IPR003118 Pointed_dom IPR013761 SAM/pointed_sf IPR016311 Transform_prot_C-ets IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00178 Ets, 1 hit PF02198 SAM_PNT, 1 hit
PIRSFⁱ	PIRSF001698 Transforming_factor_C-ets, 1 hit
PRINTSⁱ	PR00454 ETSDOMAIN
SMARTⁱ	View protein in SMART SM00413 ETS, 1 hit SM00251 SAM_PNT, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF47769 SSF47769, 1 hit
PROSITEⁱ	View protein in PROSITE PS00345 ETS_DOMAIN_1, 1 hit PS00346 ETS_DOMAIN_2, 1 hit PS50061 ETS_DOMAIN_3, 1 hit PS51433 PNT, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform c-ETS-1A (identifier: P14921-1) [UniParc]FASTA Add to basket

Also known as: Ets-1 p51

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK 
        60         70         80         90        100
ATFSGFTKEQ QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM 
       110        120        130        140        150
NGAALCALGK DCFLELAPDF VGDILWEHLE ILQKEDVKPY QVNGVNPAYP 
       160        170        180        190        200
ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF ITESYQTLHP ISSEELLSLK 
       210        220        230        240        250
YENDYPSVIL RDPLQTDTLQ NDYFAIKQEV VTPDNMCMGR TSRGKLGGQD 
       260        270        280        290        300
SFESIESYDS CDRLTQSWSS QSSFNSLQRV PSYDSFDSED YPAALPNHKP 
       310        320        330        340        350
KGTFKDYVRD RADLNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC 
       360        370        380        390        400
QSFISWTGDG WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKN 
       410        420        430        440 
IIHKTAGKRY VYRFVCDLQS LLGYTPEELH AMLDVKPDAD E

Length:441

Mass (Da):50,408

Last modified:April 1, 1990 - v1

Checksum:ⁱ3B66BCC464B393FB

GO

Isoform c-ETS-1B (identifier: P14921-2) [UniParc]FASTA Add to basket

Also known as: Ets-1 p42

The sequence of this isoform differs from the canonical sequence as follows:
244-330: Missing.

« Hide

        10         20         30         40         50
MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK 
        60         70         80         90        100
ATFSGFTKEQ QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM 
       110        120        130        140        150
NGAALCALGK DCFLELAPDF VGDILWEHLE ILQKEDVKPY QVNGVNPAYP 
       160        170        180        190        200
ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF ITESYQTLHP ISSEELLSLK 
       210        220        230        240        250
YENDYPSVIL RDPLQTDTLQ NDYFAIKQEV VTPDNMCMGR TSRGSGPIQL 
       260        270        280        290        300
WQFLLELLTD KSCQSFISWT GDGWEFKLSD PDEVARRWGK RKNKPKMNYE 
       310        320        330        340        350
KLSRGLRYYY DKNIIHKTAG KRYVYRFVCD LQSLLGYTPE ELHAMLDVKP 

DADE

Show »

Length:354

Mass (Da):40,786

Checksum:ⁱ6C3313F2DBE3CF88

GO

Isoform 3 (identifier: P14921-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-27: MKAAVDLKPTLTIIKTEKVDLELFPSP → MSYFVDSAGS...VPTGLEHCVS

« Hide

        10         20         30         40         50
MSYFVDSAGS SPVPYSAPRP AVVRQGPSNT YEDPRMNCGF QSNYHQQRPC 
        60         70         80         90        100
YPFWDEMATQ EVPTGLEHCV SDMECADVPL LTPSSKEMMS QALKATFSGF 
       110        120        130        140        150
TKEQQRLGIP KDPRQWTETH VRDWVMWAVN EFSLKGVDFQ KFCMNGAALC 
       160        170        180        190        200
ALGKDCFLEL APDFVGDILW EHLEILQKED VKPYQVNGVN PAYPESRYTS 
       210        220        230        240        250
DYFISYGIEH AQCVPPSEFS EPSFITESYQ TLHPISSEEL LSLKYENDYP 
       260        270        280        290        300
SVILRDPLQT DTLQNDYFAI KQEVVTPDNM CMGRTSRGKL GGQDSFESIE 
       310        320        330        340        350
SYDSCDRLTQ SWSSQSSFNS LQRVPSYDSF DSEDYPAALP NHKPKGTFKD 
       360        370        380        390        400
YVRDRADLNK DKPVIPAAAL AGYTGSGPIQ LWQFLLELLT DKSCQSFISW 
       410        420        430        440        450
TGDGWEFKLS DPDEVARRWG KRKNKPKMNY EKLSRGLRYY YDKNIIHKTA 
       460        470        480 
GKRYVYRFVC DLQSLLGYTP EELHAMLDVK PDADE

Note: No experimental confirmation available.

Show »

Length:485

Mass (Da):55,412

Checksum:ⁱ8A6B816BAEB91149

GO

Isoform Ets-1 p27 (identifier: P14921-4) [UniParc]FASTA Add to basket

Also known as: Ets-1Delta(III-VI)

The sequence of this isoform differs from the canonical sequence as follows:
28-243: Missing.

« Hide

        10         20         30         40         50
MKAAVDLKPT LTIIKTEKVD LELFPSPGKL GGQDSFESIE SYDSCDRLTQ 
        60         70         80         90        100
SWSSQSSFNS LQRVPSYDSF DSEDYPAALP NHKPKGTFKD YVRDRADLNK 
       110        120        130        140        150
DKPVIPAAAL AGYTGSGPIQ LWQFLLELLT DKSCQSFISW TGDGWEFKLS 
       160        170        180        190        200
DPDEVARRWG KRKNKPKMNY EKLSRGLRYY YDKNIIHKTA GKRYVYRFVC 
       210        220 
DLQSLLGYTP EELHAMLDVK PDADE

Note: Acts as a dominant-negative for isoform c-ETS-1A.

Show »

Length:225

Mass (Da):25,697

Checksum:ⁱ5A01096FCEDE9FEA

GO

Isoform 5 (identifier: P14921-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
262-272: DRLTQSWSSQS → GQEMGKEEKQT
273-441: Missing.

« Hide

        10         20         30         40         50
MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK 
        60         70         80         90        100
ATFSGFTKEQ QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM 
       110        120        130        140        150
NGAALCALGK DCFLELAPDF VGDILWEHLE ILQKEDVKPY QVNGVNPAYP 
       160        170        180        190        200
ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF ITESYQTLHP ISSEELLSLK 
       210        220        230        240        250
YENDYPSVIL RDPLQTDTLQ NDYFAIKQEV VTPDNMCMGR TSRGKLGGQD 
       260        270 
SFESIESYDS CGQEMGKEEK QT

Note: No experimental confirmation available.

Show »

Length:272

Mass (Da):30,860

Checksum:ⁱ20D7FF9557D80D46

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	V9GYD6	V9GYD6_HUMAN		Protein C-ets-1 Protein C-ets-1	ETS1	46	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	162	Y → C in AAB28747 (PubMed:8231246).Curated	1
Sequence conflictⁱ	236 – 243	MCMGRTSR → FLPPPLPP in AAA52409 (PubMed:2997781).Curated	8
Sequence conflictⁱ	255	I → V in AAY19514 (PubMed:19377509).Curated	1
Sequence conflictⁱ	332 – 337	SGPIQL → RRPPAA in AAA52409 (PubMed:2997781).Curated	6

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_043152	1 – 27	MKAAV…LFPSP → MSYFVDSAGSSPVPYSAPRP AVVRQGPSNTYEDPRMNCGF QSNYHQQRPCYPFWDEMATQ EVPTGLEHCVS in isoform 3. 1 PublicationAdd BLAST	27
Alternative sequenceⁱVSP_046056	28 – 243	Missing in isoform Ets-1 p27. 1 PublicationAdd BLAST	216
Alternative sequenceⁱVSP_001464	244 – 330	Missing in isoform c-ETS-1B. CuratedAdd BLAST	87
Alternative sequenceⁱVSP_055485	262 – 272	DRLTQSWSSQS → GQEMGKEEKQT in isoform 5. 1 PublicationAdd BLAST	11
Alternative sequenceⁱVSP_055486	273 – 441	Missing in isoform 5. 1 PublicationAdd BLAST	169

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14798 mRNA Translation: CAA32904.1 X14798 mRNA Translation: CAA32903.1 J04101 mRNA Translation: AAA52410.1 X65469 Genomic DNA No translation available. S67063 mRNA Translation: AAB28747.1 AY943926 mRNA Translation: AAY19514.1 BT019452 mRNA Translation: AAV38259.1 BX640634 mRNA Translation: CAE45783.1 AP001995 Genomic DNA No translation available. AP003397 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67709.1 BC017314 mRNA Translation: AAH17314.1 M11921 Genomic DNA Translation: AAA52409.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44767.1 [P14921-3] CCDS53724.1 [P14921-4] CCDS81648.1 [P14921-2] CCDS8475.1 [P14921-1]
PIRⁱ	A32066 TVHUET
NCBI Reference Sequences More...RefSeqⁱ	NP_001137292.1, NM_001143820.1 [P14921-3] NP_001155894.1, NM_001162422.1 [P14921-4] NP_001317380.1, NM_001330451.1 [P14921-2] NP_005229.1, NM_005238.3 [P14921-1] XP_016872803.1, XM_017017314.1 [P14921-3]
UniGeneⁱ	Hs.369438

Genome annotation databases

Ensemblⁱ	ENST00000319397; ENSP00000324578; ENSG00000134954 [P14921-1] ENST00000392668; ENSP00000376436; ENSG00000134954 [P14921-3] ENST00000526145; ENSP00000433500; ENSG00000134954 [P14921-2] ENST00000531611; ENSP00000435666; ENSG00000134954 [P14921-5] ENST00000535549; ENSP00000441430; ENSG00000134954 [P14921-4]
GeneIDⁱ	2113
KEGGⁱ	hsa:2113
UCSC genome browser More...UCSCⁱ	uc001qej.3 human [P14921-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P14921	cDNA FLJ59231, highly similar to C-ets-1 protein		HUMAN		300	UniRef100_P14921
P14921-4	ETS proto-oncogene 1, transcription factor		PANTR		225	UniRef100_P14921-4
ETS proto-oncogene 1, transcription factor		SAIBB		225
Uncharacterized protein		MACMU		225
Uncharacterized protein		CALJA		225
Uncharacterized protein		COLAP		225
+15

Protein	Similar proteins		Species	Score	Length	Source
P14921	Transforming protein p54/c-ets-1		CHICK		441	UniRef90_P14921
Protein C-ets-1	)	MOUSE		440
cDNA FLJ59231, highly similar to C-ets-1 protein		HUMAN		300
Uncharacterized protein		FELCA		475
protein C-ets-1 isoform X1		URSMA		468
+143
P14921-2	transforming protein p68/c-ets-1 isoform X3		BALAS		398	UniRef90_P14921-2
Uncharacterized protein		CAVPO		354
protein C-ets-1 isoform X4		DELLE		354
Uncharacterized protein		MACMU		354
Uncharacterized protein		CALJA		354
+54
P14921-3	Uncharacterized protein		MACNE		548	UniRef90_P14921-3
Uncharacterized protein		RABIT		533
Transforming protein p68/c-ets-1		FUKDA		527
Uncharacterized protein		MACMU		493
ETS proto-oncogene 1, transcription factor		MACFA		485
+119
P14921-4	ETS proto-oncogene 1, transcription factor		PANTR		225	UniRef90_P14921-4
ETS proto-oncogene 1, transcription factor		SAIBB		225
Uncharacterized protein		MACMU		225
Uncharacterized protein		CALJA		225
Uncharacterized protein		COLAP		225
+33
P14921-5	Uncharacterized protein		CAVPO		273	UniRef90_P14921-5
Uncharacterized protein		ICTTR		273
Uncharacterized protein		FELCA		272
Uncharacterized protein		CALJA		272
Uncharacterized protein		MACMU		272
+18

Protein	Similar proteins		Species	Score	Length	Source
P14921	Transforming protein p54/c-ets-1		CHICK		441	UniRef50_P14921
Protein C-ets-1	)	MOUSE		440
p135Gag-Myb-Ets-transforming protein (Fragment)		AVILE		669
cDNA FLJ59231, highly similar to C-ets-1 protein		HUMAN		300
Uncharacterized protein		FELCA		475
+415
P14921-2	Protein c-ets-1-A		XENLA		438	UniRef50_P14921-2
Protein C-ets-1		RAT		441
transforming protein p68/c-ets-1 isoform X3		BALAS		398
protein C-ets-1 isoform X4		DELLE		354
protein C-ets-1 isoform X2		Yangtze finless porpoise		354
+267
P14921-4	ETS proto-oncogene 1, transcription factor		PANTR		225	UniRef50_P14921-4
ETS proto-oncogene 1, transcription factor		SAIBB		225
Uncharacterized protein		MACMU		225
Uncharacterized protein		CALJA		225
Uncharacterized protein		COLAP		225
+34
P14921-5	Uncharacterized protein		CAVPO		273	UniRef50_P14921-5
Uncharacterized protein		ICTTR		273
Uncharacterized protein		PROCO		272
Uncharacterized protein		CALJA		272
Uncharacterized protein		MACMU		272
+27

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14798 mRNA Translation: CAA32904.1 X14798 mRNA Translation: CAA32903.1 J04101 mRNA Translation: AAA52410.1 X65469 Genomic DNA No translation available. S67063 mRNA Translation: AAB28747.1 AY943926 mRNA Translation: AAY19514.1 BT019452 mRNA Translation: AAV38259.1 BX640634 mRNA Translation: CAE45783.1 AP001995 Genomic DNA No translation available. AP003397 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67709.1 BC017314 mRNA Translation: AAH17314.1 M11921 Genomic DNA Translation: AAA52409.1
CCDSⁱ	CCDS44767.1 [P14921-3] CCDS53724.1 [P14921-4] CCDS81648.1 [P14921-2] CCDS8475.1 [P14921-1]
PIRⁱ	A32066 TVHUET
RefSeqⁱ	NP_001137292.1, NM_001143820.1 [P14921-3] NP_001155894.1, NM_001162422.1 [P14921-4] NP_001317380.1, NM_001330451.1 [P14921-2] NP_005229.1, NM_005238.3 [P14921-1] XP_016872803.1, XM_017017314.1 [P14921-3]
UniGeneⁱ	Hs.369438

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1GVJ	X-ray	1.53	A/B	297-441	[»]
	2NNY	X-ray	2.58	A/B	280-441	[»]
	2STT	NMR	-	A	320-415	[»]
	2STW	NMR	-	A	320-415	[»]
	3MFK	X-ray	3.00	A/B	280-441	[»]
	3RI4	X-ray	3.00	A/D	280-441	[»]
	3WTS	X-ray	2.35	C/H	276-441	[»]
	3WTT	X-ray	2.35	C/H	276-441	[»]
	3WTU	X-ray	2.70	C/H	276-441	[»]
	3WTV	X-ray	2.70	C/H	276-441	[»]
	3WTW	X-ray	2.90	C/H	276-441	[»]
	3WTX	X-ray	2.80	C/H	276-441	[»]
	3WTY	X-ray	2.70	C/H	276-441	[»]
	3WTZ	X-ray	2.61	A/B	276-441	[»]
	3WU0	X-ray	2.60	A/B	276-441	[»]
	3WU1	X-ray	2.40	B	333-441	[»]
	4L0Y	X-ray	2.50	B	296-441	[»]
	4L0Z	X-ray	2.70	B	296-441	[»]
	4L18	X-ray	2.30	B/F	296-441	[»]
	4LG0	X-ray	2.19	B	331-440	[»]
	5ZMC	X-ray	2.99	B	331-441	[»]
ProteinModelPortalⁱ	P14921
SMRⁱ	P14921
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108414, 53 interactors
CORUMⁱ	P14921
DIPⁱ	DIP-35183N
IntActⁱ	P14921, 73 interactors
MINTⁱ	P14921
STRINGⁱ	9606.ENSP00000376436

Protein family/group databases

MoonDBⁱ	P14921 Predicted

MoonDBⁱ

P14921 Predicted

PTM databases

iPTMnetⁱ	P14921
PhosphoSitePlusⁱ	P14921

Polymorphism and mutation databases

BioMutaⁱ	ETS1
DMDMⁱ	119641

Proteomic databases

EPDⁱ	P14921
MaxQBⁱ	P14921
PaxDbⁱ	P14921
PeptideAtlasⁱ	P14921
PRIDEⁱ	P14921
ProteomicsDBⁱ	53095 53096 [P14921-2] 53097 [P14921-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2113
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000319397; ENSP00000324578; ENSG00000134954 [P14921-1] ENST00000392668; ENSP00000376436; ENSG00000134954 [P14921-3] ENST00000526145; ENSP00000433500; ENSG00000134954 [P14921-2] ENST00000531611; ENSP00000435666; ENSG00000134954 [P14921-5] ENST00000535549; ENSP00000441430; ENSG00000134954 [P14921-4]
GeneIDⁱ	2113
KEGGⁱ	hsa:2113
UCSCⁱ	uc001qej.3 human [P14921-1]

Organism-specific databases

CTDⁱ	2113
DisGeNETⁱ	2113
EuPathDBⁱ	HostDB:ENSG00000134954.14
GeneCardsⁱ	ETS1
HGNCⁱ	HGNC:3488 ETS1
HPAⁱ	CAB002575 HPA063230
MIMⁱ	164720 gene
neXtProtⁱ	NX_P14921
OpenTargetsⁱ	ENSG00000134954
Orphanetⁱ	536 NON RARE IN EUROPE: Systemic lupus erythematosus
PharmGKBⁱ	PA27902
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3806 Eukaryota ENOG410Z0ZF LUCA
GeneTreeⁱ	ENSGT00760000118907
HOGENOMⁱ	HOG000285953
HOVERGENⁱ	HBG003088
InParanoidⁱ	P14921
KOⁱ	K02678
OMAⁱ	TDMECAD
OrthoDBⁱ	EOG091G0HJF
PhylomeDBⁱ	P14921
TreeFamⁱ	TF316214

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2559585 Oncogene Induced Senescence
SignaLinkⁱ	P14921
SIGNORⁱ	P14921

Miscellaneous databases

ChiTaRSⁱ	ETS1 human
EvolutionaryTraceⁱ	P14921
GeneWikiⁱ	ETS1
GenomeRNAiⁱ	2113
Protein Ontology More...PROⁱ	PR:P14921
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134954 Expressed in 208 organ(s), highest expression level in blood
CleanExⁱ	HS_ETS1
ExpressionAtlasⁱ	P14921 baseline and differential
Genevisibleⁱ	P14921 HS

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000418 Ets_dom IPR003118 Pointed_dom IPR013761 SAM/pointed_sf IPR016311 Transform_prot_C-ets IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00178 Ets, 1 hit PF02198 SAM_PNT, 1 hit
PIRSFⁱ	PIRSF001698 Transforming_factor_C-ets, 1 hit
PRINTSⁱ	PR00454 ETSDOMAIN
SMARTⁱ	View protein in SMART SM00413 ETS, 1 hit SM00251 SAM_PNT, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF47769 SSF47769, 1 hit
PROSITEⁱ	View protein in PROSITE PS00345 ETS_DOMAIN_1, 1 hit PS00346 ETS_DOMAIN_2, 1 hit PS50061 ETS_DOMAIN_3, 1 hit PS51433 PNT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ETS1_HUMAN
Accessionⁱ	P14921Primary (citable) accession number: P14921 Secondary accession number(s): A9UL17 , F5GYX9, Q14278, Q16080, Q6N087, Q96AC5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	April 1, 1990
	Last modified:	November 7, 2018
	This is version 206 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniProtKB - P14921 (ETS1_HUMAN)

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Protein C-ets-1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Nucleus

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Experimental Info

Alternative sequence

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Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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PTM databases

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Proteomic databases

Protocols and materials databases

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Gene expression databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ