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UniProtKB - P14920 (OXDA_HUMAN)

Entry version 199 (29 Sep 2021)
Sequence version 3 (25 Nov 2002)
Previous versions | rss
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Protein

D-amino-acid oxidase

Gene

DAO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.6 mM for D-serine2 Publications
  2. KM=1.7 mM for D-proline2 Publications
  3. KM=1.1 mM for D-tyrosine2 Publications
  4. KM=1.5 mM for D-DOPA2 Publications
  5. KM=1.2 mM for D-phenylalanine2 Publications
  6. KM=0.9 mM for D-alanine2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei53Substrate1
Binding sitei164FAD; via amide nitrogen and carbonyl oxygen2 Publications1
Binding sitei182FAD2 Publications1
Binding sitei217Substrate1
Binding sitei228Substrate1
Binding sitei283Substrate1
Binding sitei313Substrate; via carbonyl oxygen1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi3 – 17FAD2 PublicationsAdd BLAST15
Nucleotide bindingi37 – 38FAD2 Publications2
Nucleotide bindingi44 – 45FAD2 Publications2
Nucleotide bindingi49 – 51FAD2 Publications3
Nucleotide bindingi312 – 317FAD2 Publications6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS03351-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.4.3.3, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P14920

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-389661, Glyoxylate metabolism and glycine degradation
R-HSA-9033241, Peroxisomal protein import

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P14920

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
D-amino-acid oxidase (EC:1.4.3.3)
Short name:
DAAO
Short name:
DAMOX
Short name:
DAO
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DAO
Synonyms:DAMOX
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2671, DAO

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		124050, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P14920

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000110887

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Schizophrenia (SCZD)1 Publication
Disease susceptibility may be associated with variants affecting the gene represented in this entry.
Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
Related information in OMIM

Keywords - Diseasei

Schizophrenia

Organism-specific databases

DisGeNET

More...DisGeNETi		1610

MalaCards human disease database

More...MalaCardsi		DAO
MIMi181500, phenotype

Open Targets

More...OpenTargetsi		ENSG00000110887

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		803, Amyotrophic lateral sclerosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27139

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P14920, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5485

Drug and drug target database

More...DrugBanki		DB07979, (2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID
DB02838, 3,4-Dihydro-2h-Pyrrolium-5-Carboxylate
DB04166, Anthranilic acid
DB03793, Benzoic acid
DB03225, D-Tryptophan
DB03147, Flavin adenine dinucleotide
DB03531, Flavin-adenine dinucleotide-N5-isobutyl ketone
DB02988, Imino-Tryptophan

DrugCentral

More...DrugCentrali		P14920

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DAO

Domain mapping of disease mutations (DMDM)

More...DMDMi		25453448

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001627611 – 347D-amino-acid oxidaseAdd BLAST347

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P14920

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P14920

PeptideAtlas

More...PeptideAtlasi		P14920

PRoteomics IDEntifications database

More...PRIDEi		P14920

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53094

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P14920

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P14920

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P14920

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000110887, Expressed in liver and 110 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P14920, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P14920, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000110887, Group enriched (brain, kidney, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:17088322, PubMed:18455394).

Interacts with DAOA (PubMed:12364586).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107980, 10 interactors

Protein interaction database and analysis system

More...IntActi		P14920, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000228476

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P14920

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P14920, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1347
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P14920

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P14920

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi345 – 347Microbody targeting signal3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DAMOX/DASOX family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3923, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018635

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P14920

Identification of Orthologs from Complete Genome Data

More...OMAi		LWWPYRI

Database of Orthologous Groups

More...OrthoDBi		1363414at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P14920

TreeFam database of animal gene trees

More...TreeFami		TF313887

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006181, D-amino_acid_oxidase_CS
IPR023209, DAO
IPR006076, FAD-dep_OxRdtase

The PANTHER Classification System

More...PANTHERi		PTHR11530, PTHR11530, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01266, DAO, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000189, D-aa_oxidase, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00677, DAO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P14920-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVVVIGAGV IGLSTALCIH ERYHSVLQPL DIKVYADRFT PLTTTDVAAG 
        60         70         80         90        100
LWQPYLSDPN NPQEADWSQQ TFDYLLSHVH SPNAENLGLF LISGYNLFHE 
       110        120        130        140        150
AIPDPSWKDT VLGFRKLTPR ELDMFPDYGY GWFHTSLILE GKNYLQWLTE 
       160        170        180        190        200
RLTERGVKFF QRKVESFEEV AREGADVIVN CTGVWAGALQ RDPLLQPGRG 
       210        220        230        240        250
QIMKVDAPWM KHFILTHDPE RGIYNSPYII PGTQTVTLGG IFQLGNWSEL 
       260        270        280        290        300
NNIQDHNTIW EGCCRLEPTL KNARIIGERT GFRPVRPQIR LEREQLRTGP 
       310        320        330        340 
SNTEVIHNYG HGGYGLTIHW GCALEAAKLF GRILEEKKLS RMPPSHL
Length:347
Mass (Da):39,474
Last modified:November 25, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA508E603872F3072
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J250A0A0B4J250_HUMAN
D-amino-acid oxidase
DAO
281Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VV35F8VV35_HUMAN
D-amino-acid oxidase
DAO
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W152F8W152_HUMAN
D-amino-acid oxidase
DAO
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVT2F8VVT2_HUMAN
D-amino-acid oxidase
DAO
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J257A0A0B4J257_HUMAN
D-amino-acid oxidase
DAO
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti31D → H in CAA31614 (PubMed:2901986).Curated1
Sequence conflicti279R → A in CAA31614 (PubMed:2901986).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X13227 mRNA Translation: CAA31614.1
AK312995 mRNA Translation: BAG35832.1
CH471054 Genomic DNA Translation: EAW97837.1
BC029057 mRNA Translation: AAH29057.1
BC074770 mRNA Translation: AAH74770.1
D11370 Genomic DNA Translation: BAA20974.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9122.1

Protein sequence database of the Protein Information Resource

More...PIRi		S01340

NCBI Reference Sequences

More...RefSeqi		NP_001908.3, NM_001917.4
XP_011536306.1, XM_011538004.2
XP_011536307.1, XM_011538005.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000228476; ENSP00000228476; ENSG00000110887

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1610

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1610

UCSC genome browser

More...UCSCi		uc001tnr.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13227 mRNA Translation: CAA31614.1
AK312995 mRNA Translation: BAG35832.1
CH471054 Genomic DNA Translation: EAW97837.1
BC029057 mRNA Translation: AAH29057.1
BC074770 mRNA Translation: AAH74770.1
D11370 Genomic DNA Translation: BAA20974.1
CCDSiCCDS9122.1
PIRiS01340
RefSeqiNP_001908.3, NM_001917.4
XP_011536306.1, XM_011538004.2
XP_011536307.1, XM_011538005.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DU8X-ray2.50A/B/G/J1-347[»]
2E48X-ray2.90A/B/C/D1-347[»]
2E49X-ray3.20A/B/C/D1-347[»]
2E4AX-ray2.60A/B/C/D1-347[»]
2E82X-ray2.70A/B/C/D1-347[»]
2GNZmodel-A1-339[»]
3CUKX-ray2.49A/B/C/D1-347[»]
3G3EX-ray2.20A/B/C/D1-347[»]
3W4IX-ray2.50A/B/C/D1-347[»]
3W4JX-ray2.74A/B/C/D1-347[»]
3W4KX-ray2.86A/B/C/D1-347[»]
3ZNNX-ray1.90A/B1-347[»]
3ZNOX-ray2.30A/B1-347[»]
3ZNPX-ray2.40A/B1-347[»]
3ZNQX-ray2.75A/B1-347[»]
4QFCX-ray2.40A/B1-347[»]
4QFDX-ray2.85A/B1-347[»]
5ZJ9X-ray2.60A/B/C/D1-340[»]
5ZJAX-ray2.60A/B/C/D1-340[»]
6KBPX-ray2.25A/B/C/D1-338[»]
SMRiP14920
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107980, 10 interactors
IntActiP14920, 5 interactors
STRINGi9606.ENSP00000228476

Chemistry databases

BindingDBiP14920
ChEMBLiCHEMBL5485
DrugBankiDB07979, (2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID
DB02838, 3,4-Dihydro-2h-Pyrrolium-5-Carboxylate
DB04166, Anthranilic acid
DB03793, Benzoic acid
DB03225, D-Tryptophan
DB03147, Flavin adenine dinucleotide
DB03531, Flavin-adenine dinucleotide-N5-isobutyl ketone
DB02988, Imino-Tryptophan
DrugCentraliP14920

PTM databases

iPTMnetiP14920
PhosphoSitePlusiP14920

Genetic variation databases

BioMutaiDAO
DMDMi25453448

Proteomic databases

MassIVEiP14920
PaxDbiP14920
PeptideAtlasiP14920
PRIDEiP14920
ProteomicsDBi53094
TopDownProteomicsiP14920

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30788, 296 antibodies

The DNASU plasmid repository

More...DNASUi		1610

Genome annotation databases

EnsembliENST00000228476; ENSP00000228476; ENSG00000110887
GeneIDi1610
KEGGihsa:1610
UCSCiuc001tnr.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1610
DisGeNETi1610

GeneCards: human genes, protein and diseases

More...GeneCardsi		DAO
HGNCiHGNC:2671, DAO
HPAiENSG00000110887, Group enriched (brain, kidney, liver)
MalaCardsiDAO
MIMi124050, gene
181500, phenotype
neXtProtiNX_P14920
OpenTargetsiENSG00000110887
Orphaneti803, Amyotrophic lateral sclerosis
PharmGKBiPA27139
VEuPathDBiHostDB:ENSG00000110887

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3923, Eukaryota
GeneTreeiENSGT00390000018635
InParanoidiP14920
OMAiLWWPYRI
OrthoDBi1363414at2759
PhylomeDBiP14920
TreeFamiTF313887

Enzyme and pathway databases

BioCyciMetaCyc:HS03351-MONOMER
BRENDAi1.4.3.3, 2681
PathwayCommonsiP14920
ReactomeiR-HSA-389661, Glyoxylate metabolism and glycine degradation
R-HSA-9033241, Peroxisomal protein import
SABIO-RKiP14920

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1610, 8 hits in 1009 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DAO, human
EvolutionaryTraceiP14920

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1610
PharosiP14920, Tchem

Protein Ontology

More...PROi		PR:P14920
RNActiP14920, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000110887, Expressed in liver and 110 other tissues
ExpressionAtlasiP14920, baseline and differential
GenevisibleiP14920, HS

Family and domain databases

InterProiView protein in InterPro
IPR006181, D-amino_acid_oxidase_CS
IPR023209, DAO
IPR006076, FAD-dep_OxRdtase
PANTHERiPTHR11530, PTHR11530, 1 hit
PfamiView protein in Pfam
PF01266, DAO, 1 hit
PIRSFiPIRSF000189, D-aa_oxidase, 1 hit
PROSITEiView protein in PROSITE
PS00677, DAO, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOXDA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14920
Secondary accession number(s): B2R7I5, Q16758, Q8N6R2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 25, 2002
Last modified: September 29, 2021
This is version 199 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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