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Entry version 188 (16 Oct 2019)
Sequence version 3 (25 Nov 2002)
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Protein

D-amino-acid oxidase

Gene

DAO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.6 mM for D-serine2 Publications
  2. KM=1.7 mM for D-proline2 Publications
  3. KM=1.1 mM for D-tyrosine2 Publications
  4. KM=1.5 mM for D-DOPA2 Publications
  5. KM=1.2 mM for D-phenylalanine2 Publications
  6. KM=0.9 mM for D-alanine2 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei53Substrate1
    Binding sitei164FAD; via amide nitrogen and carbonyl oxygen2 Publications1
    Binding sitei182FAD2 Publications1
    Binding sitei217Substrate1
    Binding sitei228Substrate1
    Binding sitei283Substrate1
    Binding sitei313Substrate; via carbonyl oxygen1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi3 – 17FAD2 PublicationsAdd BLAST15
    Nucleotide bindingi37 – 38FAD2 Publications2
    Nucleotide bindingi44 – 45FAD2 Publications2
    Nucleotide bindingi49 – 51FAD2 Publications3
    Nucleotide bindingi312 – 317FAD2 Publications6

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandFAD, Flavoprotein

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS03351-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.4.3.3 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-389661 Glyoxylate metabolism and glycine degradation
    R-HSA-9033241 Peroxisomal protein import

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P14920

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    D-amino-acid oxidase (EC:1.4.3.3)
    Short name:
    DAAO
    Short name:
    DAMOX
    Short name:
    DAO
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:DAO
    Synonyms:DAMOX
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:2671 DAO

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    124050 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P14920

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Peroxisome

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Schizophrenia (SCZD)1 Publication
    Disease susceptibility may be associated with variations affecting the gene represented in this entry.
    Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
    Related information in OMIM

    Keywords - Diseasei

    Schizophrenia

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    1610

    MalaCards human disease database

    More...
    MalaCardsi
    DAO
    MIMi181500 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000110887

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    803 Amyotrophic lateral sclerosis

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA27139

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    P14920

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL5485

    Drug and drug target database

    More...
    DrugBanki
    DB07979 (2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID
    DB02838 3,4-Dihydro-2h-Pyrrolium-5-Carboxylate
    DB04166 Anthranilic acid
    DB03793 Benzoic Acid
    DB03225 D-Tryptophan
    DB03147 Flavin adenine dinucleotide
    DB03531 Flavin-Adenine Dinucleotide-N5-Isobutyl Ketone
    DB02988 Imino-Tryptophan

    DrugCentral

    More...
    DrugCentrali
    P14920

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    DAO

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    25453448

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001627611 – 347D-amino-acid oxidaseAdd BLAST347

    Proteomic databases

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P14920

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P14920

    PeptideAtlas

    More...
    PeptideAtlasi
    P14920

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P14920

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    53094

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    P14920

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P14920

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P14920

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000110887 Expressed in 85 organ(s), highest expression level in cerebellum

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P14920 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P14920 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA038653
    HPA038654

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer (PubMed:17088322, PubMed:18455394).

    Interacts with DAOA (PubMed:12364586).

    3 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    PRKAB2O437415EBI-3908043,EBI-1053424

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    107980, 7 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P14920, 5 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000228476

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P14920

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1347
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P14920

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P14920

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi345 – 347Microbody targeting signal3

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the DAMOX/DASOX family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3923 Eukaryota
    COG0665 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000018635

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000046303

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P14920

    KEGG Orthology (KO)

    More...
    KOi
    K00273

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    ITIHWGC

    Database of Orthologous Groups

    More...
    OrthoDBi
    1363414at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P14920

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313887

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR006181 D-amino_acid_oxidase_CS
    IPR023209 DAO
    IPR006076 FAD-dep_OxRdtase

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11530 PTHR11530, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01266 DAO, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000189 D-aa_oxidase, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00677 DAO, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

    P14920-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MRVVVIGAGV IGLSTALCIH ERYHSVLQPL DIKVYADRFT PLTTTDVAAG
    60 70 80 90 100
    LWQPYLSDPN NPQEADWSQQ TFDYLLSHVH SPNAENLGLF LISGYNLFHE
    110 120 130 140 150
    AIPDPSWKDT VLGFRKLTPR ELDMFPDYGY GWFHTSLILE GKNYLQWLTE
    160 170 180 190 200
    RLTERGVKFF QRKVESFEEV AREGADVIVN CTGVWAGALQ RDPLLQPGRG
    210 220 230 240 250
    QIMKVDAPWM KHFILTHDPE RGIYNSPYII PGTQTVTLGG IFQLGNWSEL
    260 270 280 290 300
    NNIQDHNTIW EGCCRLEPTL KNARIIGERT GFRPVRPQIR LEREQLRTGP
    310 320 330 340
    SNTEVIHNYG HGGYGLTIHW GCALEAAKLF GRILEEKKLS RMPPSHL
    Length:347
    Mass (Da):39,474
    Last modified:November 25, 2002 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA508E603872F3072
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A0B4J250A0A0B4J250_HUMAN
    D-amino-acid oxidase
    DAO
    281Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8VV35F8VV35_HUMAN
    D-amino-acid oxidase
    DAO
    166Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8VVT2F8VVT2_HUMAN
    D-amino-acid oxidase
    DAO
    123Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8W152F8W152_HUMAN
    D-amino-acid oxidase
    DAO
    196Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0B4J257A0A0B4J257_HUMAN
    D-amino-acid oxidase
    DAO
    78Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti31D → H in CAA31614 (PubMed:2901986).Curated1
    Sequence conflicti279R → A in CAA31614 (PubMed:2901986).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    X13227 mRNA Translation: CAA31614.1
    AK312995 mRNA Translation: BAG35832.1
    CH471054 Genomic DNA Translation: EAW97837.1
    BC029057 mRNA Translation: AAH29057.1
    BC074770 mRNA Translation: AAH74770.1
    D11370 Genomic DNA Translation: BAA20974.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS9122.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S01340

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001908.3, NM_001917.4
    XP_011536306.1, XM_011538004.2
    XP_011536307.1, XM_011538005.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000228476; ENSP00000228476; ENSG00000110887

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    1610

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:1610

    UCSC genome browser

    More...
    UCSCi
    uc001tnr.5 human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X13227 mRNA Translation: CAA31614.1
    AK312995 mRNA Translation: BAG35832.1
    CH471054 Genomic DNA Translation: EAW97837.1
    BC029057 mRNA Translation: AAH29057.1
    BC074770 mRNA Translation: AAH74770.1
    D11370 Genomic DNA Translation: BAA20974.1
    CCDSiCCDS9122.1
    PIRiS01340
    RefSeqiNP_001908.3, NM_001917.4
    XP_011536306.1, XM_011538004.2
    XP_011536307.1, XM_011538005.2

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

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    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2DU8X-ray2.50A/B/G/J1-347[»]
    2E48X-ray2.90A/B/C/D1-347[»]
    2E49X-ray3.20A/B/C/D1-347[»]
    2E4AX-ray2.60A/B/C/D1-347[»]
    2E82X-ray2.70A/B/C/D1-347[»]
    2GNZmodel-A1-339[»]
    3CUKX-ray2.49A/B/C/D1-347[»]
    3G3EX-ray2.20A/B/C/D1-347[»]
    3W4IX-ray2.50A/B/C/D1-347[»]
    3W4JX-ray2.74A/B/C/D1-347[»]
    3W4KX-ray2.86A/B/C/D1-347[»]
    3ZNNX-ray1.90A/B1-347[»]
    3ZNOX-ray2.30A/B1-347[»]
    3ZNPX-ray2.40A/B1-347[»]
    3ZNQX-ray2.75A/B1-347[»]
    4QFCX-ray2.40A/B1-347[»]
    4QFDX-ray2.85A/B1-347[»]
    5ZJ9X-ray2.60A/B/C/D1-340[»]
    5ZJAX-ray2.60A/B/C/D1-340[»]
    SMRiP14920
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi107980, 7 interactors
    IntActiP14920, 5 interactors
    STRINGi9606.ENSP00000228476

    Chemistry databases

    BindingDBiP14920
    ChEMBLiCHEMBL5485
    DrugBankiDB07979 (2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID
    DB02838 3,4-Dihydro-2h-Pyrrolium-5-Carboxylate
    DB04166 Anthranilic acid
    DB03793 Benzoic Acid
    DB03225 D-Tryptophan
    DB03147 Flavin adenine dinucleotide
    DB03531 Flavin-Adenine Dinucleotide-N5-Isobutyl Ketone
    DB02988 Imino-Tryptophan
    DrugCentraliP14920

    PTM databases

    iPTMnetiP14920
    PhosphoSitePlusiP14920

    Polymorphism and mutation databases

    BioMutaiDAO
    DMDMi25453448

    Proteomic databases

    MassIVEiP14920
    PaxDbiP14920
    PeptideAtlasiP14920
    PRIDEiP14920
    ProteomicsDBi53094
    TopDownProteomicsiP14920

    Genome annotation databases

    EnsembliENST00000228476; ENSP00000228476; ENSG00000110887
    GeneIDi1610
    KEGGihsa:1610
    UCSCiuc001tnr.5 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    1610
    DisGeNETi1610

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    DAO
    HGNCiHGNC:2671 DAO
    HPAiHPA038653
    HPA038654
    MalaCardsiDAO
    MIMi124050 gene
    181500 phenotype
    neXtProtiNX_P14920
    OpenTargetsiENSG00000110887
    Orphaneti803 Amyotrophic lateral sclerosis
    PharmGKBiPA27139

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3923 Eukaryota
    COG0665 LUCA
    GeneTreeiENSGT00390000018635
    HOGENOMiHOG000046303
    InParanoidiP14920
    KOiK00273
    OMAiITIHWGC
    OrthoDBi1363414at2759
    PhylomeDBiP14920
    TreeFamiTF313887

    Enzyme and pathway databases

    BioCyciMetaCyc:HS03351-MONOMER
    BRENDAi1.4.3.3 2681
    ReactomeiR-HSA-389661 Glyoxylate metabolism and glycine degradation
    R-HSA-9033241 Peroxisomal protein import
    SABIO-RKiP14920

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    DAO human
    EvolutionaryTraceiP14920

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    1610
    PharosiP14920

    Protein Ontology

    More...
    PROi
    PR:P14920

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000110887 Expressed in 85 organ(s), highest expression level in cerebellum
    ExpressionAtlasiP14920 baseline and differential
    GenevisibleiP14920 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR006181 D-amino_acid_oxidase_CS
    IPR023209 DAO
    IPR006076 FAD-dep_OxRdtase
    PANTHERiPTHR11530 PTHR11530, 1 hit
    PfamiView protein in Pfam
    PF01266 DAO, 1 hit
    PIRSFiPIRSF000189 D-aa_oxidase, 1 hit
    PROSITEiView protein in PROSITE
    PS00677 DAO, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOXDA_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14920
    Secondary accession number(s): B2R7I5, Q16758, Q8N6R2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: November 25, 2002
    Last modified: October 16, 2019
    This is version 188 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
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