DAO

Functionⁱ

Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.1 Publication

Catalytic activityⁱ

A D-amino acid + H₂O + O₂ = a 2-oxo acid + NH₃ + H₂O₂.1 Publication

Cofactorⁱ

FAD

Kineticsⁱ

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	53	Substrate	1
Binding siteⁱ	164	FAD; via amide nitrogen and carbonyl oxygen2 Publications	1
Binding siteⁱ	182	FAD2 Publications	1
Binding siteⁱ	217	Substrate	1
Binding siteⁱ	228	Substrate	1
Binding siteⁱ	283	Substrate	1
Binding siteⁱ	313	Substrate; via carbonyl oxygen	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	3 – 17	FAD2 PublicationsAdd BLAST	15
Nucleotide bindingⁱ	37 – 38	FAD2 Publications	2
Nucleotide bindingⁱ	44 – 45	FAD2 Publications	2
Nucleotide bindingⁱ	49 – 51	FAD2 Publications	3
Nucleotide bindingⁱ	312 – 317	FAD2 Publications	6

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular nitrogen compound metabolic process Source: Reactome
D-alanine catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 16616139
- 20603179
dopamine biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 17303072
D-serine catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 18544534
D-serine metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 21679769
proline catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 16616139
protein targeting to peroxisome Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	FAD, Flavoprotein

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS03351-MONOMER
BRENDAⁱ	1.4.3.3 2681
Reactomeⁱ	R-HSA-389661 Glyoxylate metabolism and glycine degradation R-HSA-9033241 Peroxisomal protein import

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: D-amino-acid oxidase (EC:1.4.3.3) Short name: DAAO Short name: DAMOX Short name: DAO
Gene namesⁱ	Name:DAO Synonyms:DAMOX
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000110887.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2671 DAO
MIMⁱ	124050 gene
neXtProtⁱ	NX_P14920

Keywords - Cellular componentⁱ

Peroxisome

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Schizophrenia (SCZD)1 Publication

Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.

Keywords - Diseaseⁱ

Schizophrenia

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1610
MalaCards human disease database More...MalaCardsⁱ	DAO
MIMⁱ	181500 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000110887
Orphanetⁱ	803 Amyotrophic lateral sclerosis
PharmGKBⁱ	PA27139

Chemistry databases

ChEMBLⁱ	CHEMBL5485
Drug and drug target database More...DrugBankⁱ	DB04166 2-Aminobenzoic Acid DB03793 Benzoic Acid DB03225 D-Tryptophan DB03147 Flavin adenine dinucleotide DB03531 Flavin-Adenine Dinucleotide-N5-Isobutyl Ketone DB02988 Imino-Tryptophan

Polymorphism and mutation databases

BioMutaⁱ	DAO
DMDMⁱ	25453448

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000162761	1 – 347	D-amino-acid oxidaseAdd BLAST		347

Proteomic databases

PaxDbⁱ	P14920
PeptideAtlas More...PeptideAtlasⁱ	P14920
PRIDEⁱ	P14920
ProteomicsDBⁱ	53094
TopDownProteomicsⁱ	P14920

PTM databases

iPTMnetⁱ	P14920
PhosphoSitePlusⁱ	P14920

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000110887 Expressed in 85 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_DAO
ExpressionAtlasⁱ	P14920 baseline and differential
Genevisibleⁱ	P14920 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038653 HPA038654

HPAⁱ

HPA038653
HPA038654

Interactionⁱ

Subunit structureⁱ

Homodimer (PubMed:17088322, PubMed:18455394). Interacts with DAOA (PubMed:12364586).3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PRKAB2	O43741	4	EBI-3908043,EBI-1053424

With

Entry

#Exp.

IntAct

Notes

PRKAB2

O43741

4

EBI-3908043,EBI-1053424

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107980, 7 interactors
IntActⁱ	P14920, 2 interactors
STRINGⁱ	9606.ENSP00000228476

Chemistry databases

BindingDBⁱ

P14920

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	2 – 6	Combined sources	5
Helixⁱ	10 – 23	Combined sources	14
Beta strandⁱ	25 – 28	Combined sources	4
Beta strandⁱ	31 – 37	Combined sources	7
Helixⁱ	40 – 42	Combined sources	3
Helixⁱ	44 – 47	Combined sources	4
Helixⁱ	63 – 77	Combined sources	15
Turnⁱ	78 – 80	Combined sources	3
Helixⁱ	84 – 87	Combined sources	4
Beta strandⁱ	89 – 100	Combined sources	12
Turnⁱ	106 – 110	Combined sources	5
Beta strandⁱ	111 – 116	Combined sources	6
Helixⁱ	119 – 122	Combined sources	4
Beta strandⁱ	129 – 139	Combined sources	11
Helixⁱ	141 – 154	Combined sources	14
Beta strandⁱ	158 – 161	Combined sources	4
Helixⁱ	167 – 172	Combined sources	6
Beta strandⁱ	176 – 180	Combined sources	5
Helixⁱ	183 – 188	Combined sources	6
Beta strandⁱ	196 – 206	Combined sources	11
Beta strandⁱ	212 – 216	Combined sources	5
Turnⁱ	219 – 221	Combined sources	3
Beta strandⁱ	228 – 231	Combined sources	4
Beta strandⁱ	233 – 239	Combined sources	7
Helixⁱ	253 – 266	Combined sources	14
Helixⁱ	268 – 272	Combined sources	5
Beta strandⁱ	274 – 285	Combined sources	12
Beta strandⁱ	290 – 296	Combined sources	7
Beta strandⁱ	298 – 301	Combined sources	4
Beta strandⁱ	303 – 309	Combined sources	7
Helixⁱ	312 – 314	Combined sources	3
Helixⁱ	315 – 336	Combined sources	22

Show more details

3D structure databases

ProteinModelPortalⁱ	P14920
SMRⁱ	P14920
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P14920

EvolutionaryTraceⁱ

P14920

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	345 – 347	Microbody targeting signal		3

Sequence similaritiesⁱ

Belongs to the DAMOX/DASOX family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3923 Eukaryota COG0665 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018635
HOGENOMⁱ	HOG000046303
HOVERGENⁱ	HBG003493
InParanoidⁱ	P14920
KEGG Orthology (KO) More...KOⁱ	K00273
OMAⁱ	TEVIHNY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0G0Y
PhylomeDBⁱ	P14920
TreeFamⁱ	TF313887

Family and domain databases

InterProⁱ	View protein in InterPro IPR006181 D-amino_acid_oxidase_CS IPR023209 DAO IPR006076 FAD-dep_OxRdtase
PANTHERⁱ	PTHR11530 PTHR11530, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01266 DAO, 1 hit
PIRSFⁱ	PIRSF000189 D-aa_oxidase, 1 hit
PROSITEⁱ	View protein in PROSITE PS00677 DAO, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

P14920-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRVVVIGAGV IGLSTALCIH ERYHSVLQPL DIKVYADRFT PLTTTDVAAG 
        60         70         80         90        100
LWQPYLSDPN NPQEADWSQQ TFDYLLSHVH SPNAENLGLF LISGYNLFHE 
       110        120        130        140        150
AIPDPSWKDT VLGFRKLTPR ELDMFPDYGY GWFHTSLILE GKNYLQWLTE 
       160        170        180        190        200
RLTERGVKFF QRKVESFEEV AREGADVIVN CTGVWAGALQ RDPLLQPGRG 
       210        220        230        240        250
QIMKVDAPWM KHFILTHDPE RGIYNSPYII PGTQTVTLGG IFQLGNWSEL 
       260        270        280        290        300
NNIQDHNTIW EGCCRLEPTL KNARIIGERT GFRPVRPQIR LEREQLRTGP 
       310        320        330        340 
SNTEVIHNYG HGGYGLTIHW GCALEAAKLF GRILEEKKLS RMPPSHL

Length:347

Mass (Da):39,474

Last modified:November 25, 2002 - v3

Checksum:ⁱA508E603872F3072

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0B4J250	A0A0B4J250_HUMAN	D-amino-acid oxidase D-amino-acid oxidase	DAO	281	Annotation score:
F8VVT2	F8VVT2_HUMAN	D-amino-acid oxidase D-amino-acid oxidase	DAO	123	Annotation score:
F8W152	F8W152_HUMAN	D-amino-acid oxidase D-amino-acid oxidase	DAO	196	Annotation score:
A0A0B4J257	A0A0B4J257_HUMAN	D-amino-acid oxidase D-amino-acid oxidase	DAO	78	Annotation score:
F8VV35	F8VV35_HUMAN	D-amino-acid oxidase D-amino-acid oxidase	DAO	166	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	31	D → H in CAA31614 (PubMed:2901986).Curated		1
Sequence conflictⁱ	279	R → A in CAA31614 (PubMed:2901986).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X13227 mRNA Translation: CAA31614.1 AK312995 mRNA Translation: BAG35832.1 CH471054 Genomic DNA Translation: EAW97837.1 BC029057 mRNA Translation: AAH29057.1 BC074770 mRNA Translation: AAH74770.1 D11370 Genomic DNA Translation: BAA20974.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9122.1
PIRⁱ	S01340
NCBI Reference Sequences More...RefSeqⁱ	NP_001908.3, NM_001917.4 XP_011536306.1, XM_011538004.2 XP_011536307.1, XM_011538005.2
UniGeneⁱ	Hs.113227

Genome annotation databases

Ensemblⁱ	ENST00000228476; ENSP00000228476; ENSG00000110887
GeneIDⁱ	1610
KEGGⁱ	hsa:1610
UCSC genome browser More...UCSCⁱ	uc001tnr.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P14920	D-amino-acid oxidase isoform 1		HUMAN		347	UniRef100_P14920
D-amino-acid oxidase (Fragment)		HUMAN		196
D-amino-acid oxidase, isoform CRA_a		HUMAN		224
D-amino-acid oxidase (Fragment)		HUMAN		166
UPI0001A7C544		HUMAN		351

Protein	Similar proteins		Species	Score	Length	Source
P14920	D-amino-acid oxidase		MACFA		347	UniRef90_P14920
D-amino-acid oxidase isoform 1		HUMAN		347
Uncharacterized protein		RHIRO		384
DAO isoform 1		PONAB		347
Uncharacterized protein		RHIBE		347
+35

Protein	Similar proteins		Species	Score	Length	Source
P14920	D-amino-acid oxidase		MACFA		347	UniRef50_P14920
D-amino-acid oxidase isoform 1		HUMAN		347
Uncharacterized protein		RHIRO		384
Uncharacterized protein		AOTNA		347
D-amino acid oxidase		MACMU		347
+82

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X13227 mRNA Translation: CAA31614.1 AK312995 mRNA Translation: BAG35832.1 CH471054 Genomic DNA Translation: EAW97837.1 BC029057 mRNA Translation: AAH29057.1 BC074770 mRNA Translation: AAH74770.1 D11370 Genomic DNA Translation: BAA20974.1
CCDSⁱ	CCDS9122.1
PIRⁱ	S01340
RefSeqⁱ	NP_001908.3, NM_001917.4 XP_011536306.1, XM_011538004.2 XP_011536307.1, XM_011538005.2
UniGeneⁱ	Hs.113227

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2DU8	X-ray	2.50	A/B/G/J	1-347	[»]
	2E48	X-ray	2.90	A/B/C/D	1-347	[»]
	2E49	X-ray	3.20	A/B/C/D	1-347	[»]
	2E4A	X-ray	2.60	A/B/C/D	1-347	[»]
	2E82	X-ray	2.70	A/B/C/D	1-347	[»]
	2GNZ	model	-	A	1-339	[»]
	3CUK	X-ray	2.49	A/B/C/D	1-347	[»]
	3G3E	X-ray	2.20	A/B/C/D	1-347	[»]
	3W4I	X-ray	2.50	A/B/C/D	1-347	[»]
	3W4J	X-ray	2.74	A/B/C/D	1-347	[»]
	3W4K	X-ray	2.86	A/B/C/D	1-347	[»]
	3ZNN	X-ray	1.90	A/B	1-347	[»]
	3ZNO	X-ray	2.30	A/B	1-347	[»]
	3ZNP	X-ray	2.40	A/B	1-347	[»]
	3ZNQ	X-ray	2.75	A/B	1-347	[»]
	4QFC	X-ray	2.40	A/B	1-347	[»]
	4QFD	X-ray	2.85	A/B	1-347	[»]
ProteinModelPortalⁱ	P14920
SMRⁱ	P14920
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107980, 7 interactors
IntActⁱ	P14920, 2 interactors
STRINGⁱ	9606.ENSP00000228476

Chemistry databases

BindingDBⁱ	P14920
ChEMBLⁱ	CHEMBL5485
DrugBankⁱ	DB04166 2-Aminobenzoic Acid DB03793 Benzoic Acid DB03225 D-Tryptophan DB03147 Flavin adenine dinucleotide DB03531 Flavin-Adenine Dinucleotide-N5-Isobutyl Ketone DB02988 Imino-Tryptophan

PTM databases

iPTMnetⁱ	P14920
PhosphoSitePlusⁱ	P14920

Polymorphism and mutation databases

BioMutaⁱ	DAO
DMDMⁱ	25453448

Proteomic databases

PaxDbⁱ	P14920
PeptideAtlasⁱ	P14920
PRIDEⁱ	P14920
ProteomicsDBⁱ	53094
TopDownProteomicsⁱ	P14920

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000228476; ENSP00000228476; ENSG00000110887
GeneIDⁱ	1610
KEGGⁱ	hsa:1610
UCSCⁱ	uc001tnr.5 human

Organism-specific databases

CTDⁱ	1610
DisGeNETⁱ	1610
EuPathDBⁱ	HostDB:ENSG00000110887.7
GeneCardsⁱ	DAO
HGNCⁱ	HGNC:2671 DAO
HPAⁱ	HPA038653 HPA038654
MalaCardsⁱ	DAO
MIMⁱ	124050 gene 181500 phenotype
neXtProtⁱ	NX_P14920
OpenTargetsⁱ	ENSG00000110887
Orphanetⁱ	803 Amyotrophic lateral sclerosis
PharmGKBⁱ	PA27139
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3923 Eukaryota COG0665 LUCA
GeneTreeⁱ	ENSGT00390000018635
HOGENOMⁱ	HOG000046303
HOVERGENⁱ	HBG003493
InParanoidⁱ	P14920
KOⁱ	K00273
OMAⁱ	TEVIHNY
OrthoDBⁱ	EOG091G0G0Y
PhylomeDBⁱ	P14920
TreeFamⁱ	TF313887

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS03351-MONOMER
BRENDAⁱ	1.4.3.3 2681
Reactomeⁱ	R-HSA-389661 Glyoxylate metabolism and glycine degradation R-HSA-9033241 Peroxisomal protein import

Miscellaneous databases

ChiTaRSⁱ	DAO human
EvolutionaryTraceⁱ	P14920
GenomeRNAiⁱ	1610
Protein Ontology More...PROⁱ	PR:P14920
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000110887 Expressed in 85 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_DAO
ExpressionAtlasⁱ	P14920 baseline and differential
Genevisibleⁱ	P14920 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR006181 D-amino_acid_oxidase_CS IPR023209 DAO IPR006076 FAD-dep_OxRdtase
PANTHERⁱ	PTHR11530 PTHR11530, 1 hit
Pfamⁱ	View protein in Pfam PF01266 DAO, 1 hit
PIRSFⁱ	PIRSF000189 D-aa_oxidase, 1 hit
PROSITEⁱ	View protein in PROSITE PS00677 DAO, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OXDA_HUMAN
Accessionⁱ	P14920Primary (citable) accession number: P14920 Secondary accession number(s): B2R7I5, Q16758, Q8N6R2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	November 25, 2002
	Last modified:	September 12, 2018
	This is version 178 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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Supporting data

UniProtKB - P14920 (OXDA_HUMAN)

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D-amino-acid oxidase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Peroxisome

Cytosol

Peroxisome

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Documents

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Functionⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ