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UniProtKB - P14913 (4CL2_PETCR)
Protein
4-coumarate--CoA ligase 1
Gene
4CL2
Organism
Petroselinum crispum (Parsley) (Petroselinum hortense)
Status
Functioni
Catalytic activityi
- EC:6.2.1.12
: 3,4',5-trihydroxystilbene biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes 3,4',5-trihydroxystilbene from trans-4-coumarate. This subpathway is part of the pathway 3,4',5-trihydroxystilbene biosynthesis, which is itself part of Phytoalexin biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes 3,4',5-trihydroxystilbene from trans-4-coumarate, the pathway 3,4',5-trihydroxystilbene biosynthesis and in Phytoalexin biosynthesis.
GO - Molecular functioni
- 4-coumarate-CoA ligase activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- phenylpropanoid metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Ligase |
Biological process | Phenylpropanoid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 6.2.1.12, 4694 |
UniPathwayi | UPA00372;UER00547 |
Names & Taxonomyi
Protein namesi | Recommended name: 4-coumarate--CoA ligase 1 (EC:6.2.1.12)Short name: 4CL 1 Alternative name(s): 4-coumaroyl-CoA synthase 1 |
Gene namesi | Name:4CL2 Synonyms:4CL-2 |
Organismi | Petroselinum crispum (Parsley) (Petroselinum hortense) |
Taxonomic identifieri | 4043 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › asterids › campanulids › Apiales › Apiaceae › Apioideae › apioid superclade › Apieae › Petroselinum |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193034 | 1 – 544 | 4-coumarate--CoA ligase 1Add BLAST | 544 |
Proteomic databases
PRIDEi | P14913 |
Expressioni
Inductioni
By fungal elicitor and UV irradiation.
Family & Domainsi
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.Curated
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
i Sequence
Sequence statusi: Complete.
P14913-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDCVAPKED LIFRSKLPDI YIPKHLPLHT YCFENISKVG DKSCLINGAT
60 70 80 90 100
GETFTYSQVE LLSRKVASGL NKLGIQQGDT IMLLLPNSPE YFFAFLGASY
110 120 130 140 150
RGAISTMANP FFTSAEVIKQ LKASLAKLII TQACYVDKVK DYAAEKNIQI
160 170 180 190 200
ICIDDAPQDC LHFSKLMEAD ESEMPEVVID SDDVVALPYS SGTTGLPKGV
210 220 230 240 250
MLTHKGLVTS VAQQVDGDNP NLYMHSEDVM ICILPLFHIY SLNAVLCCGL
260 270 280 290 300
RAGVTILIMQ KFDIVPFLEL IQKYKVTIGP FVPPIVLAIA KSPVVDKYDL
310 320 330 340 350
SSVRTVMSGA APLGKELEDA VRAKFPNAKL GQGYGMTEAG PVLAMCLAFA
360 370 380 390 400
KEPYEIKSGA CGTVVRNAEM KIVDPETNAS LPRNQRGEIC IRGDQIMKGY
410 420 430 440 450
LNDPESTRTT IDEEGWLHTG DIGFIDDDDE LFIVDRLKEI IKYKGFQVAP
460 470 480 490 500
AELEALLLTH PTISDAAVVP MIDEKAGEVP VAFVVRTNGF TTTEEEIKQF
510 520 530 540
VSKQVVFYKR IFRVFFVDAI PKSPSGKILR KDLRAKIASG DLPK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13325 mRNA Translation: CAA31697.1 X05351 Genomic DNA Translation: CAA28960.1 |
PIRi | S15695 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13325 mRNA Translation: CAA31697.1 X05351 Genomic DNA Translation: CAA28960.1 |
PIRi | S15695 |
3D structure databases
SMRi | P14913 |
ModBasei | Search... |
Proteomic databases
PRIDEi | P14913 |
Enzyme and pathway databases
UniPathwayi | UPA00372;UER00547 |
BRENDAi | 6.2.1.12, 4694 |
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | 4CL2_PETCR | |
Accessioni | P14913Primary (citable) accession number: P14913 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families