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Entry version 206 (23 Feb 2022)
Sequence version 2 (01 Nov 1997)
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Protein

Protein translocation protein SEC63

Gene

SEC63

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC63 may affect SEC1-polypeptide interactions by increasing the affinity of targeting pathways for SEC61 and/or by modifying SEC61 to allow more efficient polypeptide interaction. May also be involved in SRP-dependent cotranslational translocation. Is essential for cell growth and for germination.

1 Publication

Miscellaneous

Present with 17700 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processProtein transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.5.8.1, the general secretory pathway (sec) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein translocation protein SEC63
Alternative name(s):
Protein NPL1
Sec62/63 complex 73 kDa subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC63
Synonyms:NPL1, PTL1
Ordered Locus Names:YOR254C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000005780, SEC63

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YOR254C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13LumenalSequence analysisAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 41HelicalSequence analysisAdd BLAST28
Topological domaini42 – 92CytoplasmicSequence analysisAdd BLAST51
Transmembranei93 – 108HelicalSequence analysisAdd BLAST16
Topological domaini109 – 220LumenalSequence analysisAdd BLAST112
Transmembranei221 – 239HelicalSequence analysisAdd BLAST19
Topological domaini240 – 663CytoplasmicSequence analysisAdd BLAST424

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi179A → T: Temperature-sensitive. 1 Publication1
Mutagenesisi426P → L: Temperature-sensitive. 1 Publication1
Mutagenesisi431I → N: Temperature-sensitive. 1 Publication1
Mutagenesisi503P → A: Temperature-sensitive. 1 Publication1
Mutagenesisi511G → R: Temperature-sensitive. 1 Publication1
Mutagenesisi652T → A: Abolishes interaction with SEC62; defect in protein translocation. 1 Publication1
Mutagenesisi654T → A: Abolishes interaction with SEC62; defect in protein translocation. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000710951 – 663Protein translocation protein SEC63Add BLAST663

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei512PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphotylated by casein kinase II.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P14906

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P14906

PRoteomics IDEntifications database

More...
PRIDEi
P14906

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P14906

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the heterotetrameric Sec62/63complex composed of SEC62, SEC63, SEC66 and SEC72. The Sec62/63 complex associates with the Sec61 complex to form the Sec complex. SEC63 interacts in its phosphorylated form with SEC62. May physically associate with KAR2 in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.

Part of a complex consisting of KAR2, SEC63, SEC66 and SEC72.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
34644, 652 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3055, Translocon complex
CPX-3056, SEC62-SEC63 complex

Database of interacting proteins

More...
DIPi
DIP-2396N

Protein interaction database and analysis system

More...
IntActi
P14906, 18 interactors

Molecular INTeraction database

More...
MINTi
P14906

STRING: functional protein association networks

More...
STRINGi
4932.YOR254C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P14906, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1663
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P14906

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini123 – 198JPROSITE-ProRule annotationAdd BLAST76
Domaini228 – 532SEC63Add BLAST305
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati461 – 4711Add BLAST11
Repeati493 – 5032Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni461 – 5032 X 11 AA repeatsAdd BLAST43
Regioni615 – 663DisorderedSequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi619 – 663Acidic residuesSequence analysisAdd BLAST45

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001965

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014210_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P14906

Identification of Orthologs from Complete Genome Data

More...
OMAi
SETWPFF

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06257, DnaJ, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.110, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001623, DnaJ_domain
IPR018253, DnaJ_domain_CS
IPR014756, Ig_E-set
IPR036869, J_dom_sf
IPR027137, Sec63
IPR004179, Sec63-dom

The PANTHER Classification System

More...
PANTHERi
PTHR24075:SF0, PTHR24075:SF0, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00226, DnaJ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00625, JDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00271, DnaJ, 1 hit
SM00973, Sec63, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46565, SSF46565, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00636, DNAJ_1, 1 hit
PS50076, DNAJ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P14906-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTNYEYDEA SETWPSFILT GLLMVVGPMT LLQIYQIFFG ANAEDGNSGK
60 70 80 90 100
SKEFNEEVFK NLNEEYTSDE IKQFRRKFDK NSNKKSKIWS RRNIIIIVGW
110 120 130 140 150
ILVAILLQRI NSNDAIKDAA TKLFDPYEIL GISTSASDRD IKSAYRKLSV
160 170 180 190 200
KFHPDKLAKG LTPDEKSVME ETYVQITKAY ESLTDELVRQ NYLKYGHPDG
210 220 230 240 250
PQSTSHGIAL PRFLVDGSAS PLLVVCYVAL LGLILPYFVS RWWARTQSYT
260 270 280 290 300
KKGIHNVTAS NFVSNLVNYK PSEIVTTDLI LHWLSFAHEF KQFFPDLQPT
310 320 330 340 350
DFEKLLQDHI NRRDSGKLNN AKFRIVAKCH SLLHGLLDIA CGFRNLDIAL
360 370 380 390 400
GAINTFKCIV QAVPLTPNCQ ILQLPNVDKE HFITKTGDIH TLGKLFTLED
410 420 430 440 450
AKIGEVLGIK DQAKLNETLR VASHIPNLKI IKADFLVPGE NQVTPSSTPY
460 470 480 490 500
ISLKVLVRSA KQPLIPTSLI PEENLTEPQD FESQRDPFAM MSKQPLVPYS
510 520 530 540 550
FAPFFPTKRR GSWCCLVSSQ KDGKILQTPI IIEKLSYKNL NDDKDFFDKR
560 570 580 590 600
IKMDLTKHEK FDINDWEIGT IKIPLGQPAP ETVGDFFFRV IVKSTDYFTT
610 620 630 640 650
DLDITMNMKV RDSPAVEQVE VYSEEDDEYS TDDDETESDD ESDASDYTDI
660
DTDTEAEDDE SPE
Length:663
Mass (Da):75,345
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D6757144C8A301F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti263V → I in CAA34424 (PubMed:2556404).Curated1
Sequence conflicti293F → L in CAA34424 (PubMed:2556404).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X16388 Genomic DNA Translation: CAA34424.1
Z75162 Genomic DNA Translation: CAA99476.1
BK006948 Genomic DNA Translation: DAA11021.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A33618

NCBI Reference Sequences

More...
RefSeqi
NP_014897.1, NM_001183673.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YOR254C_mRNA; YOR254C; YOR254C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854428

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YOR254C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16388 Genomic DNA Translation: CAA34424.1
Z75162 Genomic DNA Translation: CAA99476.1
BK006948 Genomic DNA Translation: DAA11021.1
PIRiA33618
RefSeqiNP_014897.1, NM_001183673.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6N3Qelectron microscopy3.68D1-663[»]
6ND1electron microscopy4.10A1-663[»]
7AFTelectron microscopy4.40D1-663[»]
7KAHelectron microscopy3.10D2-663[»]
7KAIelectron microscopy3.20D2-663[»]
7KAJelectron microscopy3.10D2-663[»]
7KAOelectron microscopy4.00D2-663[»]
7KAPelectron microscopy4.10D2-663[»]
7KAQelectron microscopy4.00D2-663[»]
7KARelectron microscopy4.00D2-663[»]
7KASelectron microscopy3.90D2-663[»]
7KATelectron microscopy4.40D2-663[»]
7KAUelectron microscopy4.00D2-663[»]
7KB5electron microscopy3.80D2-663[»]
SMRiP14906
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi34644, 652 interactors
ComplexPortaliCPX-3055, Translocon complex
CPX-3056, SEC62-SEC63 complex
DIPiDIP-2396N
IntActiP14906, 18 interactors
MINTiP14906
STRINGi4932.YOR254C

Protein family/group databases

TCDBi3.A.5.8.1, the general secretory pathway (sec) family

PTM databases

iPTMnetiP14906

Proteomic databases

MaxQBiP14906
PaxDbiP14906
PRIDEiP14906

Genome annotation databases

EnsemblFungiiYOR254C_mRNA; YOR254C; YOR254C
GeneIDi854428
KEGGisce:YOR254C

Organism-specific databases

SGDiS000005780, SEC63
VEuPathDBiFungiDB:YOR254C

Phylogenomic databases

eggNOGiKOG0721, Eukaryota
GeneTreeiENSGT00390000001965
HOGENOMiCLU_014210_0_0_1
InParanoidiP14906
OMAiSETWPFF

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P14906
RNActiP14906, protein

Family and domain databases

CDDicd06257, DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623, DnaJ_domain
IPR018253, DnaJ_domain_CS
IPR014756, Ig_E-set
IPR036869, J_dom_sf
IPR027137, Sec63
IPR004179, Sec63-dom
PANTHERiPTHR24075:SF0, PTHR24075:SF0, 1 hit
PfamiView protein in Pfam
PF00226, DnaJ, 1 hit
PRINTSiPR00625, JDOMAIN
SMARTiView protein in SMART
SM00271, DnaJ, 1 hit
SM00973, Sec63, 1 hit
SUPFAMiSSF46565, SSF46565, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00636, DNAJ_1, 1 hit
PS50076, DNAJ_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEC63_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14906
Secondary accession number(s): D6W2V5, Q08690
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 1, 1997
Last modified: February 23, 2022
This is version 206 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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