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Entry version 193 (29 Sep 2021)
Sequence version 1 (01 Apr 1990)
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Protein

Indoleamine 2,3-dioxygenase 1

Gene

IDO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174).

Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885).

Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885).

Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885).

Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885).

Protects the fetus from maternal immune rejection (PubMed:25691885).

3 Publications2 Publications

Miscellaneous

IDO1 is the target for therapy in a range of clinical settings, including cancer, chronic infections, autoimmune and allergic syndromes, and transplantation.1 Publication
IDO1 and IDO2 are 2 distinct enzymes which catalyze the same reaction. IDO2 affinity for tryptophan is much lower than that of IDO1. 50% of Caucasians harbor polymorphisms which abolish IDO2 enzymatic activity. IDO2 is expressed in human tumors in an inactive form: tryptophan degradation is entirely provided by IDO1 in these cells (PubMed:18418598). IDO2 may play a role as a negative regulator of IDO1 by competing for heme-binding with IDO1 (PubMed:25394548). Low efficiency IDO2 enzymes have been conserved throughout vertebrate evolution, whereas higher efficiency IDO1 enzymes are dispensable in many lower vertebrate lineages (PubMed:25950090). IDO1 may have arisen by gene duplication of a more ancient proto-IDO gene before the divergence of marsupial and eutherian (placental) mammals.3 Publications
Elevated IDO1 expression is a hallmark of major viral infections including HIV, HBV, HCV or influenza and also of major bacteria infections, such as Tb, CAP, listeriosis and sepsis. Depletion of tryptophan and production of tryptophan metabolites with bactericidal activity are important as direct anti-pathogen mechanisms. Pathogens are able to highjack the immunosuppressive effects of IDO1 and make use of them to facilitate their own life cycle.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

heme2 PublicationsNote: Binds 1 heme group per subunit (PubMed:16477023, PubMed:25313323). In the active form, the heme iron is in its ferrous state Fe(+2). The catalytic cycle does not alter the oxidation state of the heme, but IDO1 is prone to autoxidation (PubMed:16574111).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activity is inhibited by and MTH-trp (methylthiohydantoin-DL-tryptophan), modestly inhibited by L-1MT (1-methyl-L-tryptophan) but not D-1MT (1-methyl-D-tryptophan).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Catalytic efficiency for L-tryptophan is 150 times higher than for D-tryptophan.
  1. KM=21.23 µM for L-tryptophan1 Publication
  2. KM=4.6 mM for D-tryptophan1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-tryptophan degradation via kynurenine pathway

This protein is involved in step 1 of the subpathway that synthesizes L-kynurenine from L-tryptophan. This subpathway is part of the pathway L-tryptophan degradation via kynurenine pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-kynurenine from L-tryptophan, the pathway L-tryptophan degradation via kynurenine pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi346Iron (heme proximal ligand)Combined sources2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processImmunity, Tryptophan catabolism
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS05502-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.13.11.11, 2681
1.13.11.52, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P14902

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-71240, Tryptophan catabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P14902

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00333;UER00453

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Indoleamine 2,3-dioxygenase 1 (EC:1.13.11.521 Publication)
Short name:
IDO-1
Alternative name(s):
Indoleamine-pyrrole 2,3-dioxygenase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IDO1
Synonyms:IDO, INDO
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6059, IDO1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
147435, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P14902

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000131203

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3620

Open Targets

More...
OpenTargetsi
ENSG00000131203

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA29869

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P14902, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4685

Drug and drug target database

More...
DrugBanki
DB09061, Cannabidiol
DB14009, Medical Cannabis
DB01065, Melatonin
DB14011, Nabiximols
DB00435, Nitric Oxide
DB00150, Tryptophan

DrugCentral

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DrugCentrali
P14902

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2829

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
IDO1

Domain mapping of disease mutations (DMDM)

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DMDMi
123948

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002152041 – 403Indoleamine 2,3-dioxygenase 1Add BLAST403

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P14902

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P14902

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P14902

PeptideAtlas

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PeptideAtlasi
P14902

PRoteomics IDEntifications database

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PRIDEi
P14902

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
15758
53093

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P14902

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P14902

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in mature dendritic cells located in lymphoid organs (including lymph nodes, spleen, tonsils, Peyers's patches, the gut lamina propria, and the thymic medulla), in some epithelial cells of the female genital tract, as well as in endothelial cells of term placenta and in lung parenchyma (PubMed:25691885). Weakly or not expressed in most normal tissues, but mostly inducible in most tissues (PubMed:25691885). Expressed in more than 50% of tumors, either by tumoral, stromal, or endothelial cells (expression in tumor is associated with a worse clinical outcome) (PubMed:18418598). Not overexpressed in tumor-draining lymph nodes (PubMed:26155395, PubMed:25691885).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By IFNG/IFN-gamma in most cells (PubMed:2109605, PubMed:1907934). Exogenous inflammatory stimuli induce the expression of IDO1 in antigen-presenting cells such as dendritic cells, macrophages and B-cells (PubMed:25157255).2 Publications1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000131203, Expressed in epithelium of bronchus and 139 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P14902, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P14902, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000131203, Tissue enhanced (blood, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
109832, 5 interactors

Protein interaction database and analysis system

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IntActi
P14902, 6 interactors

Molecular INTeraction database

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MINTi
P14902

STRING: functional protein association networks

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STRINGi
9606.ENSP00000430950

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P14902

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P14902, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1403
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P14902

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P14902

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni360 – 381DisorderedSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the indoleamine 2,3-dioxygenase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502RZ6X, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000161410

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_010089_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P14902

Identification of Orthologs from Complete Genome Data

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OMAi
TMAYVWN

Database of Orthologous Groups

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OrthoDBi
1206249at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P14902

TreeFam database of animal gene trees

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TreeFami
TF330978

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000898, Indolamine_dOase
IPR037217, Trp/Indoleamine_2_3_dOase-like

The PANTHER Classification System

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PANTHERi
PTHR28657, PTHR28657, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01231, IDO, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF140959, SSF140959, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00876, IDO_1, 1 hit
PS00877, IDO_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P14902-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHAMENSWT ISKEYHIDEE VGFALPNPQE NLPDFYNDWM FIAKHLPDLI
60 70 80 90 100
ESGQLRERVE KLNMLSIDHL TDHKSQRLAR LVLGCITMAY VWGKGHGDVR
110 120 130 140 150
KVLPRNIAVP YCQLSKKLEL PPILVYADCV LANWKKKDPN KPLTYENMDV
160 170 180 190 200
LFSFRDGDCS KGFFLVSLLV EIAAASAIKV IPTVFKAMQM QERDTLLKAL
210 220 230 240 250
LEIASCLEKA LQVFHQIHDH VNPKAFFSVL RIYLSGWKGN PQLSDGLVYE
260 270 280 290 300
GFWEDPKEFA GGSAGQSSVF QCFDVLLGIQ QTAGGGHAAQ FLQDMRRYMP
310 320 330 340 350
PAHRNFLCSL ESNPSVREFV LSKGDAGLRE AYDACVKALV SLRSYHLQIV
360 370 380 390 400
TKYILIPASQ QPKENKTSED PSKLEAKGTG GTDLMNFLKT VRSTTEKSLL

KEG
Length:403
Mass (Da):45,326
Last modified:April 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE92CF57AD0D0BA8D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RIX2E5RIX2_HUMAN
Indoleamine 2,3-dioxygenase 1
IDO1
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RH36E5RH36_HUMAN
Indoleamine 2,3-dioxygenase 1
IDO1
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KN03J3KN03_HUMAN
Indoleamine 2,3-dioxygenase 1
IDO1
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9Z2A0A140T9Z2_HUMAN
Indoleamine 2,3-dioxygenase 1
IDO1
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AC007991 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti251G → R in AEF30540 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0533684A → T. Corresponds to variant dbSNP:rs35059413EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M34455 mRNA Translation: AAA36081.1
X17668 mRNA Translation: CAA35663.1
M86472 Genomic DNA No translation available.
M86473 Genomic DNA No translation available.
M86474 Genomic DNA No translation available.
M86475 Genomic DNA No translation available.
M86476 Genomic DNA No translation available.
M86477 Genomic DNA No translation available.
M86478 Genomic DNA No translation available.
M86479 Genomic DNA No translation available.
M86480 Genomic DNA No translation available.
M86481 Genomic DNA No translation available.
JF772862 mRNA Translation: AEF30540.1
AY221100 mRNA Translation: AAO34405.1
AK313259 mRNA Translation: BAG36069.1
AC007991 Genomic DNA No translation available.
BC027882 mRNA Translation: AAH27882.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47847.1

Protein sequence database of the Protein Information Resource

More...
PIRi
PC1161

NCBI Reference Sequences

More...
RefSeqi
NP_002155.1, NM_002164.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000518237; ENSP00000430950; ENSG00000131203
ENST00000522495; ENSP00000430505; ENSG00000131203

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3620

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3620

UCSC genome browser

More...
UCSCi
uc003xnm.5, human
uc064mfy.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34455 mRNA Translation: AAA36081.1
X17668 mRNA Translation: CAA35663.1
M86472 Genomic DNA No translation available.
M86473 Genomic DNA No translation available.
M86474 Genomic DNA No translation available.
M86475 Genomic DNA No translation available.
M86476 Genomic DNA No translation available.
M86477 Genomic DNA No translation available.
M86478 Genomic DNA No translation available.
M86479 Genomic DNA No translation available.
M86480 Genomic DNA No translation available.
M86481 Genomic DNA No translation available.
JF772862 mRNA Translation: AEF30540.1
AY221100 mRNA Translation: AAO34405.1
AK313259 mRNA Translation: BAG36069.1
AC007991 Genomic DNA No translation available.
BC027882 mRNA Translation: AAH27882.1
CCDSiCCDS47847.1
PIRiPC1161
RefSeqiNP_002155.1, NM_002164.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D0TX-ray2.30A/B1-403[»]
2D0UX-ray3.40A/B1-403[»]
4PK5X-ray2.79A/B1-403[»]
4PK6X-ray3.45A/B1-403[»]
4U72X-ray2.00A/B1-403[»]
4U74X-ray2.31A/B1-403[»]
5EK2X-ray2.68A/B1-403[»]
5EK3X-ray2.21A/B1-403[»]
5EK4X-ray2.64A/B1-403[»]
5ETWX-ray2.70A/B1-403[»]
5WHRX-ray2.28A/B12-403[»]
5WMUX-ray2.40A/B11-403[»]
5WMVX-ray2.60A/B11-403[»]
5WMWX-ray3.03A/B11-403[»]
5WMXX-ray2.69A/B11-403[»]
5WN8X-ray2.50A/B12-403[»]
5XE1X-ray3.20A/B1-403[»]
6AZUX-ray2.82A/B/C/D5-403[»]
6AZVX-ray2.75A/B/C/D5-403[»]
6AZWX-ray2.78A/B11-403[»]
6CXUX-ray2.49A/B11-403[»]
6CXVX-ray2.60A/B11-403[»]
6DPQX-ray2.94A/B11-403[»]
6DPRX-ray3.20A/B13-403[»]
6E35X-ray2.41A/B11-403[»]
6E40X-ray2.31A/B/C/D15-403[»]
6E41X-ray2.29A/B/C/D15-403[»]
6E42X-ray2.10A/B/C/D15-403[»]
6E43X-ray1.71A/B/C/D15-403[»]
6E44X-ray1.90A/B/C/D15-403[»]
6E45X-ray2.00A/B/C/D15-403[»]
6E46X-ray2.09A/B/C/D15-403[»]
6F0AX-ray2.26A/C11-403[»]
6KOFX-ray2.26A/B1-403[»]
6KPSX-ray2.25A/B1-403[»]
6KW7X-ray3.02A/B1-403[»]
6MQ6X-ray3.05A/B11-403[»]
6O3IX-ray2.69A/B2-403[»]
6PU7X-ray2.43A/B11-402[»]
6PZ1X-ray2.65A/B11-403[»]
6R63X-ray2.89A/B1-403[»]
6UBPX-ray2.95A/B11-403[»]
6V52X-ray1.78A/B11-403[»]
6WJYX-ray1.91A/B11-403[»]
6WPEX-ray2.43A/B11-403[»]
6X5YX-ray2.65A/B11-403[»]
7A62X-ray2.44A/B/C/D15-403[»]
7AH4X-ray2.40A/B1-403[»]
7AH5X-ray2.90A/B1-403[»]
7AH6X-ray3.00A/B1-403[»]
SMRiP14902
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109832, 5 interactors
IntActiP14902, 6 interactors
MINTiP14902
STRINGi9606.ENSP00000430950

Chemistry databases

BindingDBiP14902
ChEMBLiCHEMBL4685
DrugBankiDB09061, Cannabidiol
DB14009, Medical Cannabis
DB01065, Melatonin
DB14011, Nabiximols
DB00435, Nitric Oxide
DB00150, Tryptophan
DrugCentraliP14902
GuidetoPHARMACOLOGYi2829

PTM databases

iPTMnetiP14902
PhosphoSitePlusiP14902

Genetic variation databases

BioMutaiIDO1
DMDMi123948

Proteomic databases

EPDiP14902
MassIVEiP14902
PaxDbiP14902
PeptideAtlasiP14902
PRIDEiP14902
ProteomicsDBi15758
53093

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
5705, 960 antibodies

The CPTC Antibody Portal

More...
CPTCi
P14902, 3 antibodies

The DNASU plasmid repository

More...
DNASUi
3620

Genome annotation databases

EnsembliENST00000518237; ENSP00000430950; ENSG00000131203
ENST00000522495; ENSP00000430505; ENSG00000131203
GeneIDi3620
KEGGihsa:3620
UCSCiuc003xnm.5, human
uc064mfy.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3620
DisGeNETi3620

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IDO1
HGNCiHGNC:6059, IDO1
HPAiENSG00000131203, Tissue enhanced (blood, placenta)
MIMi147435, gene
neXtProtiNX_P14902
OpenTargetsiENSG00000131203
PharmGKBiPA29869
VEuPathDBiHostDB:ENSG00000131203

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RZ6X, Eukaryota
GeneTreeiENSGT00940000161410
HOGENOMiCLU_010089_1_0_1
InParanoidiP14902
OMAiTMAYVWN
OrthoDBi1206249at2759
PhylomeDBiP14902
TreeFamiTF330978

Enzyme and pathway databases

UniPathwayiUPA00333;UER00453
BioCyciMetaCyc:HS05502-MONOMER
BRENDAi1.13.11.11, 2681
1.13.11.52, 2681
PathwayCommonsiP14902
ReactomeiR-HSA-71240, Tryptophan catabolism
SABIO-RKiP14902

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3620, 7 hits in 1015 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IDO1, human
EvolutionaryTraceiP14902

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Indoleamine_2,3-dioxygenase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3620
PharosiP14902, Tchem

Protein Ontology

More...
PROi
PR:P14902
RNActiP14902, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000131203, Expressed in epithelium of bronchus and 139 other tissues
ExpressionAtlasiP14902, baseline and differential
GenevisibleiP14902, HS

Family and domain databases

InterProiView protein in InterPro
IPR000898, Indolamine_dOase
IPR037217, Trp/Indoleamine_2_3_dOase-like
PANTHERiPTHR28657, PTHR28657, 1 hit
PfamiView protein in Pfam
PF01231, IDO, 1 hit
SUPFAMiSSF140959, SSF140959, 1 hit
PROSITEiView protein in PROSITE
PS00876, IDO_1, 1 hit
PS00877, IDO_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI23O1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14902
Secondary accession number(s): E5RGR8, F6M9T7, Q540B4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 29, 2021
This is version 193 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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