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Protein

N-acetylmuramoyl-L-alanine amidase CwlA

Gene

cwlA

Organism
Bacillus sp.
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation.

Miscellaneous

Retention of enzymatic activity was limited to the N-terminal fragment (AA 1-196).

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Hydrolase
Biological processCell wall biogenesis/degradation, Competence, Sporulation

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase CwlA (EC:3.5.1.28)
Alternative name(s):
Autolysin
Cell wall hydrolase
Gene namesi
Name:cwlA
OrganismiBacillus sp.
Taxonomic identifieri1409 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Add BLAST37
ChainiPRO_000000645238 – 251N-acetylmuramoyl-L-alanine amidase CwlAAdd BLAST214

Proteomic databases

PRIDEiP14892

Structurei

3D structure databases

ProteinModelPortaliP14892
SMRiP14892
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

CDDicd06583 PGRP, 1 hit
Gene3Di3.40.80.10, 1 hit
InterProiView protein in InterPro
IPR036505 Amidase/PGRP_sf
IPR021976 Amidase02_C
IPR002502 Amidase_domain
PfamiView protein in Pfam
PF12123 Amidase02_C, 1 hit
PF01510 Amidase_2, 1 hit
SMARTiView protein in SMART
SM00644 Ami_2, 1 hit
SUPFAMiSSF55846 SSF55846, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14892-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIKQMLVPV SRYSVLCPYE MNPTEITFHN TYNDAPAINE RNNVANNSTG
60 70 80 90 100
TSFHIAVDDK EAIQLIPFNR NAWHAGDGTN GRGNRHSIGV EICYSQSGGA
110 120 130 140 150
RYRKAELNAV EVIAQLMIQF DIPISKVKTH QERNGKYCPH RMLDEGRVQW
160 170 180 190 200
FKNQCANRAS SIKNSNKTQE TGKVEIIVNK FNKVVTYEFG TALVPEMLGM
210 220 230 240 250
MDALGYESRI ISYGDKQGLV RFETAYRQGN ELDKATAWLD AKGLKYFYTK

E
Length:251
Mass (Da):28,473
Last modified:April 1, 1990 - v1
Checksum:i1F52F36B20576F0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13524 Genomic DNA Translation: CAA31877.1
PIRiS08306

Similar proteinsi

Entry informationi

Entry nameiCWLA_BACSP
AccessioniPrimary (citable) accession number: P14892
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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