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Entry version 176 (18 Sep 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Microtubule-associated protein 1B

Gene

Map1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing (By similarity). Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Required for synaptic maturation.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated protein 1B
Short name:
MAP-1B
Alternative name(s):
MAP1(X)
MAP1.2
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Map1b
Synonyms:Mtap1b, Mtap5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1306778 Map1b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Microtubule, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000186062 – 2464Microtubule-associated protein 1BAdd BLAST2463
ChainiPRO_00004183802 – 2202MAP1B heavy chainAdd BLAST2201
ChainiPRO_00000186072203 – 2464MAP1 light chain LC1Add BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei336PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei341PhosphoserineBy similarity1
Modified residuei343PhosphoserineCombined sources1
Modified residuei527PhosphothreonineBy similarity1
Modified residuei541PhosphoserineCombined sources1
Modified residuei544PhosphoserineCombined sources1
Modified residuei561PhosphoserineCombined sources1
Modified residuei614PhosphoserineCombined sources1
Modified residuei825PhosphoserineCombined sources1
Modified residuei828PhosphoserineCombined sources1
Modified residuei829PhosphoserineCombined sources1
Modified residuei885PhosphoserineCombined sources1
Modified residuei888PhosphoserineCombined sources1
Modified residuei896PhosphothreonineCombined sources1
Modified residuei905PhosphothreonineCombined sources1
Modified residuei933PhosphoserineBy similarity1
Modified residuei934PhosphoserineBy similarity1
Modified residuei945PhosphothreonineCombined sources1
Modified residuei960PhosphoserineBy similarity1
Modified residuei967PhosphoserineCombined sources1
Modified residuei974PhosphoserineCombined sources1
Modified residuei989PhosphoserineCombined sources1
Modified residuei992PhosphoserineCombined sources1
Modified residuei1013PhosphoserineCombined sources1
Modified residuei1141PhosphoserineCombined sources1
Modified residuei1151PhosphoserineCombined sources1
Modified residuei1153PhosphoserineCombined sources1
Modified residuei1183PhosphoserineBy similarity1
Modified residuei1186PhosphoserineBy similarity1
Modified residuei1204PhosphoserineCombined sources1
Modified residuei1207PhosphoserineCombined sources1
Modified residuei1208PhosphoserineCombined sources1
Modified residuei1225PhosphoserineCombined sources1
Modified residuei1242PhosphoserineCombined sources1
Modified residuei1247PhosphoserineCombined sources1
Modified residuei1251PhosphoserineCombined sources1
Modified residuei1253PhosphoserineCombined sources1
Modified residuei1255PhosphoserineCombined sources1
Modified residuei1257PhosphoserineCombined sources1
Modified residuei1260PhosphoserineCombined sources1
Modified residuei1271PhosphoserineBy similarity1
Modified residuei1275PhosphoserineBy similarity1
Modified residuei1277PhosphothreonineBy similarity1
Modified residuei1293PhosphoserineBy similarity1
Modified residuei1307PhosphoserineCombined sources1
Modified residuei1317PhosphoserineCombined sources1
Modified residuei1319PhosphoserineCombined sources1
Modified residuei1321PhosphoserineCombined sources1
Modified residuei1323PhosphothreonineCombined sources1
Modified residuei1325PhosphoserineCombined sources1
Modified residuei1334PhosphoserineCombined sources1
Modified residuei1371PhosphoserineCombined sources1
Modified residuei1373PhosphoserineCombined sources1
Modified residuei1382PhosphoserineCombined sources1
Modified residuei1384PhosphoserineCombined sources1
Modified residuei1391PhosphoserineCombined sources1
Modified residuei1395PhosphoserineCombined sources1
Modified residuei1403PhosphoserineCombined sources1
Modified residuei1405PhosphotyrosineCombined sources1
Modified residuei1422PhosphoserineBy similarity1
Modified residuei1438PhosphoserineCombined sources1
Modified residuei1497PhosphoserineCombined sources1
Modified residuei1508PhosphoserineCombined sources1
Modified residuei1516PhosphoserineBy similarity1
Modified residuei1518PhosphoserineBy similarity1
Modified residuei1521PhosphothreonineBy similarity1
Modified residuei1523PhosphoserineCombined sources1
Modified residuei1614PhosphoserineBy similarity1
Modified residuei1616PhosphoserineCombined sources1
Modified residuei1621PhosphoserineCombined sources1
Modified residuei1649PhosphoserineBy similarity1
Modified residuei1659PhosphoserineBy similarity1
Modified residuei1662PhosphoserineCombined sources1
Modified residuei1686PhosphoserineCombined sources1
Modified residuei1768PhosphoserineCombined sources1
Modified residuei1775PhosphoserineCombined sources1
Modified residuei1778PhosphoserineCombined sources1
Modified residuei1781PhosphoserineCombined sources1
Modified residuei1784PhosphothreonineCombined sources1
Modified residuei1788PhosphoserineCombined sources1
Modified residuei1789PhosphoserineCombined sources1
Modified residuei1792PhosphotyrosineCombined sources1
Modified residuei1793PhosphoserineCombined sources1
Modified residuei1797PhosphoserineCombined sources1
Modified residuei1815PhosphoserineBy similarity1
Modified residuei1877PhosphoserineCombined sources1
Modified residuei1911PhosphoserineCombined sources1
Modified residuei1915PhosphoserineBy similarity1
Modified residuei1928PhosphothreonineCombined sources1
Modified residuei1945PhosphothreonineCombined sources1
Modified residuei2030PhosphoserineCombined sources1
Modified residuei2060Omega-N-methylarginineCombined sources1
Modified residuei2205PhosphoserineBy similarity1
Modified residuei2267PhosphoserineBy similarity1
Modified residuei2285PhosphoserineBy similarity1
Modified residuei2301PhosphothreonineBy similarity1
Modified residuei2410PhosphoserineCombined sources1
Modified residuei2460S-nitrosocysteine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

LC1 is coexpressed with MAP1B. It is a polypeptide generated from MAP1B by proteolytic processing. It is free to associate with both MAP1A and MAP1B. It interacts with the N-terminal region of MAP1B.
S-nitrosylation at Cys-2460 enhances interaction with microtubules, and may act as an effector modification for neuronal nitric oxide synthase control of growth-cone size, growth-cone collapse and axon retraction.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein, S-nitrosylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P14873

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P14873

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P14873

PeptideAtlas

More...
PeptideAtlasi
P14873

PRoteomics IDEntifications database

More...
PRIDEi
P14873

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P14873

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P14873

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P14873

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000052727 Expressed in 263 organ(s), highest expression level in dorsal root ganglion

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P14873 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P14873 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. LC1 interacts with the amino-terminal region of MAP1B.

Interacts with ANP32A and TIAM2 (PubMed:12807913, PubMed:17320046).

Interacts with the tubulin tyrosine TTL (PubMed:18075266).

Interacts (via C-terminus) with GAN (via Kelch domains) (PubMed:12147674).

Interacts (via N-terminus) with DAPK1 (By similarity).

Interacts with TMEM185A (By similarity).

Interacts with MAP1LC3B (By similarity).

Interacts with KIRREL3 (By similarity). MAP1 light chain LC1 (via C-terminus):

Interacts with ELAVL4; the interaction contributes to the association of ELAVL4 with microtubules (PubMed:21288476). MAP1 light chain LC1:

Interacts with ELAVL2 and ELAVL3 (PubMed:21288476).

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
201584, 18 interactors

Protein interaction database and analysis system

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IntActi
P14873, 12 interactors

Molecular INTeraction database

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MINTi
P14873

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000068374

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1874 – 1890MAP1B 1Add BLAST17
Repeati1891 – 1907MAP1B 2Add BLAST17
Repeati1908 – 1924MAP1B 3Add BLAST17
Repeati1925 – 1941MAP1B 4Add BLAST17
Repeati1942 – 1958MAP1B 5Add BLAST17
Repeati1959 – 1975MAP1B 6Add BLAST17
Repeati1993 – 2009MAP1B 7Add BLAST17
Repeati2010 – 2026MAP1B 8Add BLAST17
Repeati2027 – 2043MAP1B 9Add BLAST17
Repeati2044 – 2060MAP1B 10Add BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2290 – 2464Mediates interaction with TMEM185ABy similarityAdd BLAST175

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi589 – 787Lys-rich (highly basic, contains many KKEE and KKEI/V repeats)Add BLAST199

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Has a highly basic region with many copies of the sequence KKEE and KKEI/V, repeated but not at fixed intervals, which is responsible for the binding of MAP1B to microtubules.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAP1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3592 Eukaryota
ENOG410XRYM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155897

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000063256

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P14873

KEGG Orthology (KO)

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KOi
K10429

Identification of Orthologs from Complete Genome Data

More...
OMAi
YETSDQC

Database of Orthologous Groups

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OrthoDBi
86642at2759

TreeFam database of animal gene trees

More...
TreeFami
TF350229

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026074 MAP1
IPR027321 MAP1B
IPR000102 MAP1B_neuraxin

The PANTHER Classification System

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PANTHERi
PTHR13843 PTHR13843, 1 hit
PTHR13843:SF5 PTHR13843:SF5, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00414 MAP1B_neuraxin, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00230 MAP1B_NEURAXIN, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P14873-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATVVVEATE PEPSGSIGNP AASTSPSLSH RFLDSKFYLL VVVGETVTEE
60 70 80 90 100
HLRRAIGNIE LGIRSWDTNL IECNLDQELK LFVSRHSARF SPEVPGQKIL
110 120 130 140 150
HHRSDVLETV VLINPSDEAV STEVRLMITD AARHKLLVLT GQCFENTGEL
160 170 180 190 200
ILQSGSFSFQ NFIEIFTDQE IGELLSTTHP ANKASLTLFC PEEGDWKNSN
210 220 230 240 250
LDRHNLQDFI NIKLNSASIL PEMEGLSEFT EYLSESVEVP SPFDILEPPT
260 270 280 290 300
SGGFLKLSKP CCYIFPGGRG DSALFAVNGF NMLINGGSER KSCFWKLIRH
310 320 330 340 350
LDRVDSILLT HIGDDNLPGI NSMLQRKIAE LEEERSQGST SNSDWMKNLI
360 370 380 390 400
SPDLGVVFLN VPENLKDPEP NIKMKRSIEE ACFTLQYLNK LSMKPEPLFR
410 420 430 440 450
SVGNTIEPVI LFQKMGVGKL EMYVLNPVKS SKEMQYFMQQ WTGTNKDKAE
460 470 480 490 500
LILPNGQEVD IPISYLTSVS SLIVWHPANP AEKIIRVLFP GNSTQYNILE
510 520 530 540 550
GLEKLKHLDF LKQPLATQKD LTGQVPTPPV KQVKLKQRAD SRESLKPATK
560 570 580 590 600
PVASKSVRKE SKEETPEVTK TSQVEKTPKV ESKEKVLVKK DKPVKTESKP
610 620 630 640 650
SVTEKEVSSK EEQSPVKAEV AEKQATESKP KVTKDKVVKK EIKTKLEEKK
660 670 680 690 700
EEKPKKEVVK KEDKTPLKKD EKPRKEEVKK EIKKEIKKEE RKELKKEVKK
710 720 730 740 750
ETPLKDAKKE VKKEEKKEVK KEEKEPKKEI KKISKDIKKS TPLSDTKKPS
760 770 780 790 800
ALKPKVAKKE ESTKKEPLAA GKLKDKGKVK VIKKEGKTTE AAATAVGTAA
810 820 830 840 850
TTAAVVAAAG IAASGPVKEL EAERSLMSSP EDLTKDFEEL KAEEIDVAKD
860 870 880 890 900
IKPQLELIED EEKLKETQPG EAYVIQKETE VSKGSAESPD EGITTTEGEG
910 920 930 940 950
ECEQTPEELE PVEKQGVDDI EKFEDEGAGF EESSETGDYE EKAETEEAEE
960 970 980 990 1000
PEEDGEDNAS GSASKHSPTE DDESAKAEAD VHLKEKRESV VSGDDRAEED
1010 1020 1030 1040 1050
MDDVLEKGEA EQSEEEGEEE DKAEDAREEG YEPDKTEAED YVMAVADKAA
1060 1070 1080 1090 1100
EAGVTEEQYG YLGTSAKQPG IQSPSREPAS SIHDETLPGG SESEATASDE
1110 1120 1130 1140 1150
ENREDQPEEF TATSGYTQST IEISSEPTPM DEMSTPRDVM SDETNNEETE
1160 1170 1180 1190 1200
SPSQEFVNIT KYESSLYSQE YSKPAVASFN GLSEGSKTDA TDGKDYNASA
1210 1220 1230 1240 1250
STISPPSSME EDKFSKSALR DAYCSEEKEL KASAELDIKD VSDERLSPAK
1260 1270 1280 1290 1300
SPSLSPSPPS PIEKTPLGER SVNFSLTPNE IKVSAEGEAR SVSPGVTQAV
1310 1320 1330 1340 1350
VEEHCASPEE KTLEVVSPSQ SVTGSAGHTP YYQSPTDEKS SHLPTEVTEK
1360 1370 1380 1390 1400
PQAVPVSFEF SEAKDENERA SLSPMDEPVP DSESPVEKVL SPLRSPPLLG
1410 1420 1430 1440 1450
SESPYEDFLS ADSKVLGRRS ESPFEGKNGK QGFPDRESPV SDLTSTGLYQ
1460 1470 1480 1490 1500
DKQEEKSTGF IPIKEDFGPE KKTSDVETMS SQSALALDER KLGGDVSPTQ
1510 1520 1530 1540 1550
IDVSQFGSFK EDTKMSISEG TVSDKSATPV DEGVAEDTYS HMEGVASVST
1560 1570 1580 1590 1600
ASVATSSFPE PTTDDVSPSL HAEVGSPHST EVDDSLSVSV VQTPTTFQET
1610 1620 1630 1640 1650
EMSPSKEECP RPMSISPPDF SPKTAKSRTP VQDHRSEQSS MSIEFGQESP
1660 1670 1680 1690 1700
EHSLAMDFSR QSPDHPTLGA SVLHITENGP TEVDYSPSDI QDSSLSHKIP
1710 1720 1730 1740 1750
PTEEPSYTQD NDLSELISVS QVEASPSTSS AHTPSQIASP LQEDTLSDVV
1760 1770 1780 1790 1800
PPREMSLYAS LASEKVQSLE GEKLSPKSDI SPLTPRESSP LYSPGFSDST
1810 1820 1830 1840 1850
SAAKETAAAH QASSSPPIDA ATAEPYGFRS SMLFDTMQHH LALNRDLTTS
1860 1870 1880 1890 1900
SVEKDSGGKT PGDFNYAYQK PENAAGSPDE EDYDYESQEK TIRTHDVGGY
1910 1920 1930 1940 1950
YYEKTERTIK SPCDSGYSYE TIEKTIKTPE DGGYTCEITE KTTRTPEEGG
1960 1970 1980 1990 2000
YSYEISEKTT RTPEVSGYTY EKTERSRRLL DDISNGYDDT EDGGHTLGDC
2010 2020 2030 2040 2050
SYSYETTEKI TSFPESESYS YETSTKTTRS PDTSAYCYET MEKITKTPQA
2060 2070 2080 2090 2100
STYSYETSDR CYTTEKKSPS EARQDVDLCL VSSCEFKHPK TELSPSFINP
2110 2120 2130 2140 2150
NPLEWFAGEE PTEESEKPLT QSGGAPPPSG GKQQGRQCDE TPPTSVSESA
2160 2170 2180 2190 2200
PSQTDSDVPP ETEECPSITA DANIDSEDES ETIPTDKTVT YKHMDPPPAP
2210 2220 2230 2240 2250
MQDRSPSPRH PDVSMVDPDA LAVDQNLGKA LKKDLKEKTK TKKPGTKTKS
2260 2270 2280 2290 2300
SSPVKKGDGK SKPLAASPKP GALKESSDKV SRVASPKKKE SVEKATKTTT
2310 2320 2330 2340 2350
TPEVKATRGE EKDKETKNAA NASASKSAKT ATAGPGTTKT AKSSTVPPGL
2360 2370 2380 2390 2400
PVYLDLCYIP NHSNSKNVDV EFFKRVRSSY YVVSGNDPAA EEPSRAVLDA
2410 2420 2430 2440 2450
LLEGKAQWGS NMQVTLIPTH DSEVMREWYQ ETHEKQQDLN IMVLASSSTV
2460
VMQDESFPAC KIEL
Length:2,464
Mass (Da):270,255
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2835101531B0694A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YDV1A0A286YDV1_MOUSE
Microtubule-associated protein 1B
Map1b
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti743L → Q in CAA35761 (PubMed:2480963).Curated1
Sequence conflicti1348 – 1351TEKP → SENA in CAA35761 (PubMed:2480963).Curated4
Sequence conflicti1654L → F in CAA35761 (PubMed:2480963).Curated1
Sequence conflicti1688S → C in CAA35761 (PubMed:2480963).Curated1
Sequence conflicti1898 – 1899GG → VR in CAA35761 (PubMed:2480963).Curated2
Sequence conflicti1926I → T in CAA35761 (PubMed:2480963).Curated1
Sequence conflicti2231L → V in CAA35761 (PubMed:2480963).Curated1
Sequence conflicti2333A → T in CAA35761 (PubMed:2480963).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X51396 mRNA Translation: CAA35761.1
AC170188 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS26723.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S07549 QRMSP1

NCBI Reference Sequences

More...
RefSeqi
NP_032660.2, NM_008634.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000064762; ENSMUSP00000068374; ENSMUSG00000052727

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
17755

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:17755

UCSC genome browser

More...
UCSCi
uc007rpr.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51396 mRNA Translation: CAA35761.1
AC170188 Genomic DNA No translation available.
CCDSiCCDS26723.1
PIRiS07549 QRMSP1
RefSeqiNP_032660.2, NM_008634.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi201584, 18 interactors
IntActiP14873, 12 interactors
MINTiP14873
STRINGi10090.ENSMUSP00000068374

PTM databases

iPTMnetiP14873
PhosphoSitePlusiP14873
SwissPalmiP14873

Proteomic databases

jPOSTiP14873
MaxQBiP14873
PaxDbiP14873
PeptideAtlasiP14873
PRIDEiP14873

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064762; ENSMUSP00000068374; ENSMUSG00000052727
GeneIDi17755
KEGGimmu:17755
UCSCiuc007rpr.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4131
MGIiMGI:1306778 Map1b

Phylogenomic databases

eggNOGiKOG3592 Eukaryota
ENOG410XRYM LUCA
GeneTreeiENSGT00940000155897
HOGENOMiHOG000063256
InParanoidiP14873
KOiK10429
OMAiYETSDQC
OrthoDBi86642at2759
TreeFamiTF350229

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Map1b mouse

Protein Ontology

More...
PROi
PR:P14873

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000052727 Expressed in 263 organ(s), highest expression level in dorsal root ganglion
ExpressionAtlasiP14873 baseline and differential
GenevisibleiP14873 MM

Family and domain databases

InterProiView protein in InterPro
IPR026074 MAP1
IPR027321 MAP1B
IPR000102 MAP1B_neuraxin
PANTHERiPTHR13843 PTHR13843, 1 hit
PTHR13843:SF5 PTHR13843:SF5, 1 hit
PfamiView protein in Pfam
PF00414 MAP1B_neuraxin, 6 hits
PROSITEiView protein in PROSITE
PS00230 MAP1B_NEURAXIN, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAP1B_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14873
Secondary accession number(s): E9QM11
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 27, 2011
Last modified: September 18, 2019
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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