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Entry version 199 (13 Feb 2019)
Sequence version 2 (16 Apr 2002)
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Protein

Aspartate--tRNA ligase, cytoplasmic

Gene

DARS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei229AspartateBy similarity1
Binding sitei273AspartateBy similarity1
Binding sitei424ATPBy similarity1
Binding sitei427AspartateBy similarity1
Binding sitei431AspartateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi273 – 275ATPBy similarity3
Nucleotide bindingi281 – 283ATPBy similarity3
Nucleotide bindingi472 – 475ATPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • aminoacylase activity Source: ProtInc
  • aspartate-tRNA ligase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
6.1.1.12 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2408517 SeMet incorporation into proteins
R-HSA-379716 Cytosolic tRNA aminoacylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aspartate--tRNA ligase, cytoplasmic (EC:6.1.1.12By similarity)
Alternative name(s):
Aspartyl-tRNA synthetase
Short name:
AspRS
Cell proliferation-inducing gene 40 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DARS
ORF Names:PIG40
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000115866.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2678 DARS

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603084 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P14868

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive leukoencephalopathy characterized by onset in the first year of life of severe spasticity, mainly affecting the lower limbs and resulting in an inability to achieve independent ambulation. Affected individuals show delayed motor development and nystagmus; some may have mild mental retardation. Brain MRI shows hypomyelination and white matter lesions in the cerebrum, brainstem, cerebellum, and spinal cord.
See also OMIM:615281
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070038256M → L in HBSL. 1 PublicationCorresponds to variant dbSNP:rs886037635EnsemblClinVar.1
Natural variantiVAR_070039274A → V in HBSL. 1 PublicationCorresponds to variant dbSNP:rs369152939EnsemblClinVar.1
Natural variantiVAR_070040367D → Y in HBSL. 1 PublicationCorresponds to variant dbSNP:rs370064817EnsemblClinVar.1
Natural variantiVAR_070041460R → H in HBSL. 1 PublicationCorresponds to variant dbSNP:rs587776985EnsemblClinVar.1
Natural variantiVAR_070042464P → L in HBSL. 1 PublicationCorresponds to variant dbSNP:rs148806569Ensembl.1
Natural variantiVAR_070043487R → C in HBSL. 1 PublicationCorresponds to variant dbSNP:rs587776984EnsemblClinVar.1
Natural variantiVAR_070044494R → C in HBSL. 1 PublicationCorresponds to variant dbSNP:rs147077598EnsemblClinVar.1
Natural variantiVAR_070045494R → G in HBSL. 1 PublicationCorresponds to variant dbSNP:rs147077598EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
1615

MalaCards human disease database

More...
MalaCardsi
DARS
MIMi615281 phenotype

Open Targets

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OpenTargetsi
ENSG00000115866

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
363412 Hypomyelination with brain stem and spinal cord involvement and leg spasticity

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27146

Chemistry databases

Drug and drug target database

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DrugBanki
DB00128 L-Aspartic Acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DARS

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20178330

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001110101 – 501Aspartate--tRNA ligase, cytoplasmicAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei52PhosphothreonineCombined sources1
Modified residuei74N6-acetyllysineCombined sources1
Modified residuei249PhosphoserineCombined sources1
Modified residuei374N6-acetyllysineCombined sources1
Modified residuei500Phosphothreonine; by PKASequence analysis1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P14868

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P14868

MaxQB - The MaxQuant DataBase

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MaxQBi
P14868

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P14868

PeptideAtlas

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PeptideAtlasi
P14868

PRoteomics IDEntifications database

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PRIDEi
P14868

ProteomicsDB human proteome resource

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ProteomicsDBi
53092

2D gel databases

USC-OGP 2-DE database

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OGPi
P14868

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00216951

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P14868

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P14868

SwissPalm database of S-palmitoylation events

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SwissPalmi
P14868

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression in the developing and adult brain shows similar patterns. Highly expressed in the ventricular and subventricular zones, including hippocampal subfields, the midlateral temporaal cortex and the frontal polar cortex. The cerebellum, cereral cortex, hippocampus, and lateral ventricle show preferential neuronal expression. Expression in the peripheral neurons is evident in the colon.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000115866 Expressed in 242 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P14868 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P14868 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020451
HPA029804
HPA029805

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:23609930). Part of a multisubunit complex that groups tRNA ligases for Arg (RARS), Asp (DARS), Gln (QARS), Ile (IARS), Leu (LARS), Lys (KARS), Met (MARS) the bifunctional ligase for Glu and Pro (EPRS) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:19131329, PubMed:19289464).3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107984, 189 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P14868

Protein interaction database and analysis system

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IntActi
P14868, 34 interactors

Molecular INTeraction database

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MINTi
P14868

STRING: functional protein association networks

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STRINGi
9606.ENSP00000264161

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1501
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4J15X-ray2.24A/B1-501[»]
5Y6LX-ray2.90E1-501[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P14868

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P14868

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni251 – 254AspartateBy similarity4
Regioni411 – 415Binding site for the 3'-end of tRNASequence analysis5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0556 Eukaryota
COG0017 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153562

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG001028

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P14868

KEGG Orthology (KO)

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KOi
K22503

Identification of Orthologs from Complete Genome Data

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OMAi
WVHEIRD

Database of Orthologous Groups

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OrthoDBi
677307at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P14868

TreeFam database of animal gene trees

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TreeFami
TF105676

Family and domain databases

HAMAP database of protein families

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HAMAPi
MF_02075 Asp_tRNA_synth_type2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR004523 Asp-tRNA_synthase_2
IPR002312 Asp/Asn-tRNA-synth_IIb
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA

The PANTHER Classification System

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PANTHERi
PTHR43450 PTHR43450, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01042 TRNASYNTHASP

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50249 SSF50249, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00458 aspS_nondisc, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P14868-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSASASRKS QEKPREIMDA AEDYAKERYG ISSMIQSQEK PDRVLVRVRD
60 70 80 90 100
LTIQKADEVV WVRARVHTSR AKGKQCFLVL RQQQFNVQAL VAVGDHASKQ
110 120 130 140 150
MVKFAANINK ESIVDVEGVV RKVNQKIGSC TQQDVELHVQ KIYVISLAEP
160 170 180 190 200
RLPLQLDDAV RPEAEGEEEG RATVNQDTRL DNRVIDLRTS TSQAVFRLQS
210 220 230 240 250
GICHLFRETL INKGFVEIQT PKIISAASEG GANVFTVSYF KNNAYLAQSP
260 270 280 290 300
QLYKQMCICA DFEKVFSIGP VFRAEDSNTH RHLTEFVGLD IEMAFNYHYH
310 320 330 340 350
EVMEEIADTM VQIFKGLQER FQTEIQTVNK QFPCEPFKFL EPTLRLEYCE
360 370 380 390 400
ALAMLREAGV EMGDEDDLST PNEKLLGHLV KEKYDTDFYI LDKYPLAVRP
410 420 430 440 450
FYTMPDPRNP KQSNSYDMFM RGEEILSGAQ RIHDPQLLTE RALHHGIDLE
460 470 480 490 500
KIKAYIDSFR FGAPPHAGGG IGLERVTMLF LGLHNVRQTS MFPRDPKRLT

P
Length:501
Mass (Da):57,136
Last modified:April 16, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB181572DF0AF5F94
GO
Isoform 2 (identifier: P14868-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.

Note: No experimental confirmation available.
Show »
Length:401
Mass (Da):45,771
Checksum:i0383EB6177DD0739
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JLC1C9JLC1_HUMAN
Aspartate--tRNA ligase, cytoplasmic
DARS
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C278H7C278_HUMAN
Aspartate--tRNA ligase, cytoplasmic
DARS
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQM9C9JQM9_HUMAN
Aspartate--tRNA ligase, cytoplasmic
DARS
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J7S3C9J7S3_HUMAN
Aspartate--tRNA ligase, cytoplasmic
DARS
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ35H7BZ35_HUMAN
Aspartate--tRNA ligase, cytoplasmic
DARS
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5 – 7SAS → TQ in AAA35567 (PubMed:2674137).Curated3
Sequence conflicti31I → T in AAI07750 (PubMed:15489334).Curated1
Sequence conflicti38Q → H in BAD96196 (Ref. 5) Curated1
Sequence conflicti164A → Q in AAA35567 (PubMed:2674137).Curated1
Sequence conflicti312Q → H in AAX07827 (Ref. 2) Curated1
Sequence conflicti414N → K in AAA35567 (PubMed:2674137).Curated1
Sequence conflicti447I → N in AAA35567 (PubMed:2674137).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070038256M → L in HBSL. 1 PublicationCorresponds to variant dbSNP:rs886037635EnsemblClinVar.1
Natural variantiVAR_070039274A → V in HBSL. 1 PublicationCorresponds to variant dbSNP:rs369152939EnsemblClinVar.1
Natural variantiVAR_070040367D → Y in HBSL. 1 PublicationCorresponds to variant dbSNP:rs370064817EnsemblClinVar.1
Natural variantiVAR_027611426L → F. Corresponds to variant dbSNP:rs1803165Ensembl.1
Natural variantiVAR_070041460R → H in HBSL. 1 PublicationCorresponds to variant dbSNP:rs587776985EnsemblClinVar.1
Natural variantiVAR_070042464P → L in HBSL. 1 PublicationCorresponds to variant dbSNP:rs148806569Ensembl.1
Natural variantiVAR_070043487R → C in HBSL. 1 PublicationCorresponds to variant dbSNP:rs587776984EnsemblClinVar.1
Natural variantiVAR_070044494R → C in HBSL. 1 PublicationCorresponds to variant dbSNP:rs147077598EnsemblClinVar.1
Natural variantiVAR_070045494R → G in HBSL. 1 PublicationCorresponds to variant dbSNP:rs147077598EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0561921 – 100Missing in isoform 2. 1 PublicationAdd BLAST100

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
J05032 mRNA Translation: AAA35567.1
AY762100 mRNA Translation: AAX07827.1
BT006710 mRNA Translation: AAP35356.1
AK290607 mRNA Translation: BAF83296.1
AK222476 mRNA Translation: BAD96196.1
CR749809 mRNA Translation: CAH18669.1
AC011999 Genomic DNA No translation available.
AC093391 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11617.1
CH471058 Genomic DNA Translation: EAX11620.1
BC000629 mRNA Translation: AAH00629.1
BC107749 mRNA Translation: AAI07750.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2180.1 [P14868-1]

Protein sequence database of the Protein Information Resource

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PIRi
A34393 SYHUDT

NCBI Reference Sequences

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RefSeqi
NP_001280241.1, NM_001293312.1 [P14868-2]
NP_001340.2, NM_001349.3 [P14868-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.503787
Hs.595819

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000264161; ENSP00000264161; ENSG00000115866 [P14868-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1615

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1615

UCSC genome browser

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UCSCi
uc002tux.2 human [P14868-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05032 mRNA Translation: AAA35567.1
AY762100 mRNA Translation: AAX07827.1
BT006710 mRNA Translation: AAP35356.1
AK290607 mRNA Translation: BAF83296.1
AK222476 mRNA Translation: BAD96196.1
CR749809 mRNA Translation: CAH18669.1
AC011999 Genomic DNA No translation available.
AC093391 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11617.1
CH471058 Genomic DNA Translation: EAX11620.1
BC000629 mRNA Translation: AAH00629.1
BC107749 mRNA Translation: AAI07750.1
CCDSiCCDS2180.1 [P14868-1]
PIRiA34393 SYHUDT
RefSeqiNP_001280241.1, NM_001293312.1 [P14868-2]
NP_001340.2, NM_001349.3 [P14868-1]
UniGeneiHs.503787
Hs.595819

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4J15X-ray2.24A/B1-501[»]
5Y6LX-ray2.90E1-501[»]
ProteinModelPortaliP14868
SMRiP14868
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107984, 189 interactors
CORUMiP14868
IntActiP14868, 34 interactors
MINTiP14868
STRINGi9606.ENSP00000264161

Chemistry databases

DrugBankiDB00128 L-Aspartic Acid

PTM databases

iPTMnetiP14868
PhosphoSitePlusiP14868
SwissPalmiP14868

Polymorphism and mutation databases

BioMutaiDARS
DMDMi20178330

2D gel databases

OGPiP14868
REPRODUCTION-2DPAGEiIPI00216951

Proteomic databases

EPDiP14868
jPOSTiP14868
MaxQBiP14868
PaxDbiP14868
PeptideAtlasiP14868
PRIDEiP14868
ProteomicsDBi53092

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1615
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264161; ENSP00000264161; ENSG00000115866 [P14868-1]
GeneIDi1615
KEGGihsa:1615
UCSCiuc002tux.2 human [P14868-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1615
DisGeNETi1615
EuPathDBiHostDB:ENSG00000115866.10

GeneCards: human genes, protein and diseases

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GeneCardsi
DARS
HGNCiHGNC:2678 DARS
HPAiHPA020451
HPA029804
HPA029805
MalaCardsiDARS
MIMi603084 gene
615281 phenotype
neXtProtiNX_P14868
OpenTargetsiENSG00000115866
Orphaneti363412 Hypomyelination with brain stem and spinal cord involvement and leg spasticity
PharmGKBiPA27146

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0556 Eukaryota
COG0017 LUCA
GeneTreeiENSGT00940000153562
HOVERGENiHBG001028
InParanoidiP14868
KOiK22503
OMAiWVHEIRD
OrthoDBi677307at2759
PhylomeDBiP14868
TreeFamiTF105676

Enzyme and pathway databases

BRENDAi6.1.1.12 2681
ReactomeiR-HSA-2408517 SeMet incorporation into proteins
R-HSA-379716 Cytosolic tRNA aminoacylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DARS human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DARS_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1615

Protein Ontology

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PROi
PR:P14868

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115866 Expressed in 242 organ(s), highest expression level in oocyte
ExpressionAtlasiP14868 baseline and differential
GenevisibleiP14868 HS

Family and domain databases

HAMAPiMF_02075 Asp_tRNA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR004523 Asp-tRNA_synthase_2
IPR002312 Asp/Asn-tRNA-synth_IIb
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PANTHERiPTHR43450 PTHR43450, 1 hit
PfamiView protein in Pfam
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
PRINTSiPR01042 TRNASYNTHASP
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00458 aspS_nondisc, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYDC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14868
Secondary accession number(s): A8K3J2
, D3DP77, Q2TNI3, Q32Q69, Q53HV4, Q53YC5, Q68CR9, Q9BW52
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 16, 2002
Last modified: February 13, 2019
This is version 199 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
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