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UniProtKB - P14859 (PO2F1_HUMAN)

Entry version 234 (02 Dec 2020)
Sequence version 2 (01 Feb 2003)
Previous versions | rss
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Protein

POU domain, class 2, transcription factor 1

Gene

POU2F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.3 Publications
(Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi379 – 438HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P14859

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
R-HSA-6807505, RNA polymerase II transcribes snRNA genes
R-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76071, RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-HSA-9018519, Estrogen-dependent gene expression

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P14859

SIGNOR Signaling Network Open Resource

More...SIGNORi		P14859

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
POU domain, class 2, transcription factor 1
Alternative name(s):
NF-A1
Octamer-binding protein 1
Short name:
Oct-1
Octamer-binding transcription factor 1
Short name:
OTF-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POU2F1
Synonyms:OCT1, OTF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000143190.21

Human Gene Nomenclature Database

More...HGNCi		HGNC:9212, POU2F1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		164175, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P14859

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi385S → A: Loss of inhibition of DNA binding. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		5451

Open Targets

More...OpenTargetsi		ENSG00000143190

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33536

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P14859, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3509601

Drug and drug target database

More...DrugBanki		DB01203, Nadolol

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		POU2F1

Domain mapping of disease mutations (DMDM)

More...DMDMi		28202257

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001007071 – 743POU domain, class 2, transcription factor 1Add BLAST743

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei270PhosphothreonineCombined sources1
Modified residuei276PhosphothreonineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei385Phosphoserine1 Publication1
Modified residuei448PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PRKDC.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P14859

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P14859

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P14859

MaxQB - The MaxQuant DataBase

More...MaxQBi		P14859

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P14859

PeptideAtlas

More...PeptideAtlasi		P14859

PRoteomics IDEntifications database

More...PRIDEi		P14859

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53085 [P14859-1]
53086 [P14859-2]
53087 [P14859-3]
53088 [P14859-4]
53089 [P14859-5]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P14859, 2 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P14859

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P14859

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Isoform 2 is lymphocyte-specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143190, Expressed in buccal mucosa cell and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P14859, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P14859, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143190, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with POU2AF1; the interaction increases POU2F1 transactivation activity (PubMed:7859290).

Interacts with NR3C1, AR, PGR and HCFC1.

3 Publications

(Microbial infection) Associates with the herpes simplex virus VP16-induced complex; binding to HCFC1 activates the viral transcriptional activator VP16 for association with POU2F1, to form a multiprotein-DNA complex responsible for activating transcription of the viral immediate early genes.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111447, 89 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P14859

Database of interacting proteins

More...DIPi		DIP-226N

Protein interaction database and analysis system

More...IntActi		P14859, 29 interactors

Molecular INTeraction database

More...MINTi		P14859

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356840

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P14859

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P14859, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1743
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P14859

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P14859

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini280 – 354POU-specificPROSITE-ProRule annotationAdd BLAST75

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the POU transcription factor family. Class-2 subfamily.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3802, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157831

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013065_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P14859

Identification of Orthologs from Complete Genome Data

More...OMAi		IKAIFPC

Database of Orthologous Groups

More...OrthoDBi		873012at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P14859

TreeFam database of animal gene trees

More...TreeFami		TF316413

Family and domain databases

Conserved Domains Database

More...CDDi		cd00086, homeodomain, 1 hit

Database of protein disorder

More...DisProti		DP00231

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.260.40, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00144

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR010982, Lambda_DNA-bd_dom_sf
IPR013847, POU
IPR000327, POU_dom
IPR000972, TF_octamer

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00046, Homeodomain, 1 hit
PF00157, Pou, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00029, OCTAMER
PR00028, POUDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00389, HOX, 1 hit
SM00352, POU, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit
SSF47413, SSF47413, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit
PS00035, POU_1, 1 hit
PS00465, POU_2, 1 hit
PS51179, POU_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P14859-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNNPSETSKP SMESGDGNTG TQTNGLDFQK QPVPVGGAIS TAQAQAFLGH 
        60         70         80         90        100
LHQVQLAGTS LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT 
       110        120        130        140        150
QLMLAGGQIT GLTLTPAQQQ LLLQQAQAQA QLLAAAVQQH SASQQHSAAG 
       160        170        180        190        200
ATISASAATP MTQIPLSQPI QIAQDLQQLQ QLQQQNLNLQ QFVLVHPTTN 
       210        220        230        240        250
LQPAQFIISQ TPQGQQGLLQ AQNLLTQLPQ QSQANLLQSQ PSITLTSQPA 
       260        270        280        290        300
TPTRTIAATP IQTLPQSQST PKRIDTPSLE EPSDLEELEQ FAKTFKQRRI 
       310        320        330        340        350
KLGFTQGDVG LAMGKLYGND FSQTTISRFE ALNLSFKNMC KLKPLLEKWL 
       360        370        380        390        400
NDAENLSSDS SLSSPSALNS PGIEGLSRRR KKRTSIETNI RVALEKSFLE 
       410        420        430        440        450
NQKPTSEEIT MIADQLNMEK EVIRVWFCNR RQKEKRINPP SSGGTSSSPI 
       460        470        480        490        500
KAIFPSPTSL VATTPSLVTS SAATTLTVSP VLPLTSAAVT NLSVTGTSDT 
       510        520        530        540        550
TSNNTATVIS TAPPASSAVT SPSLSPSPSA SASTSEASSA SETSTTQTTS 
       560        570        580        590        600
TPLSSPLGTS QVMVTASGLQ TAAAAALQGA AQLPANASLA AMAAAAGLNP 
       610        620        630        640        650
SLMAPSQFAA GGALLSLNPG TLSGALSPAL MSNSTLATIQ ALASGGSLPI 
       660        670        680        690        700
TSLDATGNLV FANAGGAPNI VTAPLFLNPQ NLSLLTSNPV SLVSAAAASA 
       710        720        730        740 
GNSAPVASLH ATSTSAESIQ NSLFTVASAS GAASTTTTAS KAQ
Length:743
Mass (Da):76,472
Last modified:February 1, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFAB27FFC79CF2276
GO
Isoform 2 (identifier: P14859-2) [UniParc]FASTAAdd to basket
Also known as: Oct-1L, lymphocyte-specific

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLDCSDYVLDSRM

Show »
Length:755
Mass (Da):77,870
Checksum:i084E222919B616AA
GO
Isoform 3 (identifier: P14859-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MNNPSETSKPSMESGDGNTG → MKTRMKIFVMIHFHLMNS

Show »
Length:741
Mass (Da):76,696
Checksum:i28E72DF211628CE3
GO
Isoform 6 (identifier: P14859-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MADGGAASQDESSAAAAAAADSRM

Show »
Length:766
Mass (Da):78,535
Checksum:i54C541CD1D6BA426
GO
Isoform 4 (identifier: P14859-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     641-653: ALASGGSLPITSL → GLLHGLENFLTKN
     654-743: Missing.

Show »
Length:653
Mass (Da):68,143
Checksum:i1C82E7818D70A368
GO
Isoform 5 (identifier: P14859-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MADGGAASQDESSAAAAAAADSRM
     112-174: Missing.

Show »
Length:703
Mass (Da):72,082
Checksum:i1E6037CDCF41F528
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DG88A0A0C4DG88_HUMAN
POU domain protein
POU2F1
561Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MT46A0A0A0MT46_HUMAN
POU domain protein
POU2F1
594Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q16075Q16075_HUMAN
Oct-1B
POU2F1 oct-1B
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSV5A0A0A0MSV5_HUMAN
POU domain, class 2, transcription ...
POU2F1
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti225L → Q in CAA31767 (PubMed:2905684).Curated1
Sequence conflicti546T → I in AAM77920 (PubMed:12663137).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03581688S → F in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0134211 – 20MNNPS…DGNTG → MKTRMKIFVMIHFHLMNS in isoform 3. CuratedAdd BLAST20
Alternative sequenceiVSP_0023201M → MLDCSDYVLDSRM in isoform 2. 1 Publication1
Alternative sequenceiVSP_0431951M → MADGGAASQDESSAAAAAAA DSRM in isoform 5 and isoform 6. 1 Publication1
Alternative sequenceiVSP_043196112 – 174Missing in isoform 5. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_013422641 – 653ALASG…PITSL → GLLHGLENFLTKN in isoform 4. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_013423654 – 743Missing in isoform 4. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X13403 mRNA Translation: CAA31767.1
AY113189 mRNA Translation: AAM77920.1
AK303201 mRNA Translation: BAG64291.1
AL136984 Genomic DNA No translation available.
AL359962 Genomic DNA No translation available.
AL451050 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90786.1
CH471067 Genomic DNA Translation: EAW90788.1
BC001664 mRNA Translation: AAH01664.1
BC003571 mRNA Translation: AAH03571.1
BC007388 mRNA Translation: AAH07388.1
BC052274 mRNA Translation: AAH52274.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1259.2 [P14859-6]
CCDS55655.1 [P14859-5]
CCDS55656.1 [P14859-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A47001

NCBI Reference Sequences

More...RefSeqi		NP_001185712.1, NM_001198783.1 [P14859-2]
NP_001185715.1, NM_001198786.1 [P14859-5]
NP_002688.3, NM_002697.3 [P14859-6]
XP_011507956.1, XM_011509654.2 [P14859-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000367862; ENSP00000356836; ENSG00000143190 [P14859-2]
ENST00000367866; ENSP00000356840; ENSG00000143190 [P14859-6]
ENST00000429375; ENSP00000401217; ENSG00000143190 [P14859-5]
ENST00000541643; ENSP00000441285; ENSG00000143190 [P14859-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5451

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5451

UCSC genome browser

More...UCSCi		uc001gec.4, human [P14859-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13403 mRNA Translation: CAA31767.1
AY113189 mRNA Translation: AAM77920.1
AK303201 mRNA Translation: BAG64291.1
AL136984 Genomic DNA No translation available.
AL359962 Genomic DNA No translation available.
AL451050 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90786.1
CH471067 Genomic DNA Translation: EAW90788.1
BC001664 mRNA Translation: AAH01664.1
BC003571 mRNA Translation: AAH03571.1
BC007388 mRNA Translation: AAH07388.1
BC052274 mRNA Translation: AAH52274.1
CCDSiCCDS1259.2 [P14859-6]
CCDS55655.1 [P14859-5]
CCDS55656.1 [P14859-2]
PIRiA47001
RefSeqiNP_001185712.1, NM_001198783.1 [P14859-2]
NP_001185715.1, NM_001198786.1 [P14859-5]
NP_002688.3, NM_002697.3 [P14859-6]
XP_011507956.1, XM_011509654.2 [P14859-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CQTX-ray3.20A/B278-439[»]
1E3OX-ray1.90C280-438[»]
1GT0X-ray2.60C280-438[»]
1HF0X-ray2.70A/B280-438[»]
1O4XNMR-A280-442[»]
1OCTX-ray3.00C284-439[»]
1POGNMR-A378-437[»]
1POUNMR-A284-354[»]
SMRiP14859
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111447, 89 interactors
CORUMiP14859
DIPiDIP-226N
IntActiP14859, 29 interactors
MINTiP14859
STRINGi9606.ENSP00000356840

Chemistry databases

BindingDBiP14859
ChEMBLiCHEMBL3509601
DrugBankiDB01203, Nadolol

PTM databases

GlyGeniP14859, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetiP14859
PhosphoSitePlusiP14859

Polymorphism and mutation databases

BioMutaiPOU2F1
DMDMi28202257

Proteomic databases

EPDiP14859
jPOSTiP14859
MassIVEiP14859
MaxQBiP14859
PaxDbiP14859
PeptideAtlasiP14859
PRIDEiP14859
ProteomicsDBi53085 [P14859-1]
53086 [P14859-2]
53087 [P14859-3]
53088 [P14859-4]
53089 [P14859-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3616, 621 antibodies

The DNASU plasmid repository

More...DNASUi		5451

Genome annotation databases

EnsembliENST00000367862; ENSP00000356836; ENSG00000143190 [P14859-2]
ENST00000367866; ENSP00000356840; ENSG00000143190 [P14859-6]
ENST00000429375; ENSP00000401217; ENSG00000143190 [P14859-5]
ENST00000541643; ENSP00000441285; ENSG00000143190 [P14859-1]
GeneIDi5451
KEGGihsa:5451
UCSCiuc001gec.4, human [P14859-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5451
DisGeNETi5451
EuPathDBiHostDB:ENSG00000143190.21

GeneCards: human genes, protein and diseases

More...GeneCardsi		POU2F1
HGNCiHGNC:9212, POU2F1
HPAiENSG00000143190, Tissue enhanced (brain)
MIMi164175, gene
neXtProtiNX_P14859
OpenTargetsiENSG00000143190
PharmGKBiPA33536

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3802, Eukaryota
GeneTreeiENSGT00940000157831
HOGENOMiCLU_013065_4_0_1
InParanoidiP14859
OMAiIKAIFPC
OrthoDBi873012at2759
PhylomeDBiP14859
TreeFamiTF316413

Enzyme and pathway databases

PathwayCommonsiP14859
ReactomeiR-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
R-HSA-6807505, RNA polymerase II transcribes snRNA genes
R-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76071, RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-HSA-9018519, Estrogen-dependent gene expression
SignaLinkiP14859
SIGNORiP14859

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5451, 53 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		POU2F1, human
EvolutionaryTraceiP14859

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		POU2F1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5451
PharosiP14859, Tbio

Protein Ontology

More...PROi		PR:P14859
RNActiP14859, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143190, Expressed in buccal mucosa cell and 230 other tissues
ExpressionAtlasiP14859, baseline and differential
GenevisibleiP14859, HS

Family and domain databases

CDDicd00086, homeodomain, 1 hit
DisProtiDP00231
Gene3Di1.10.260.40, 1 hit
IDEALiIID00144
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR010982, Lambda_DNA-bd_dom_sf
IPR013847, POU
IPR000327, POU_dom
IPR000972, TF_octamer
PfamiView protein in Pfam
PF00046, Homeodomain, 1 hit
PF00157, Pou, 1 hit
PRINTSiPR00029, OCTAMER
PR00028, POUDOMAIN
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SM00352, POU, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
SSF47413, SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit
PS00035, POU_1, 1 hit
PS00465, POU_2, 1 hit
PS51179, POU_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPO2F1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14859
Secondary accession number(s): B1AL91
, B1AL93, B4E029, J3KP77, Q5TBT7, Q6PK46, Q8NEU9, Q9BPV1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: February 1, 2003
Last modified: December 2, 2020
This is version 234 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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