POU2F1

Functionⁱ

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.By similarity1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	379 – 438	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA binding
Source: CAFA
Inferred from direct assayⁱ
- 9199328
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
RNA polymerase II core promoter sequence-specific DNA binding
Source: CAFA
Inferred from mutant phenotypeⁱ
- 10541551
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: CAFA
Inferred from mutant phenotypeⁱ
sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11997177
transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding
Source: CAFA
Inferred from mutant phenotypeⁱ
- 11380252

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cytokine-mediated signaling pathway Source: Reactome
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 11997177
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 15252056
snRNA transcription by RNA polymerase II Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-6807505 RNA polymerase II transcribes snRNA genes R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkⁱ	P14859
SIGNORⁱ	P14859

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: POU domain, class 2, transcription factor 1 Alternative name(s): NF-A1 Octamer-binding protein 1 Short name: Oct-1 Octamer-binding transcription factor 1 Short name: OTF-1
Gene namesⁱ	Name:POU2F1 Synonyms:OCT1, OTF1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000143190.21
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9212 POU2F1
MIMⁱ	164175 gene
neXtProtⁱ	NX_P14859

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	385	S → A: Loss of inhibition of DNA binding. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5451
Open Targets More...OpenTargetsⁱ	ENSG00000143190
PharmGKBⁱ	PA33536

Chemistry databases

ChEMBLⁱ	CHEMBL3509601

ChEMBLⁱ

CHEMBL3509601

Polymorphism and mutation databases

BioMutaⁱ	POU2F1
DMDMⁱ	28202257

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000100707	1 – 743	POU domain, class 2, transcription factor 1Add BLAST		743

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	270	PhosphothreonineCombined sources	1
Modified residueⁱ	276	PhosphothreonineCombined sources	1
Modified residueⁱ	283	PhosphoserineCombined sources	1
Modified residueⁱ	385	Phosphoserine1 Publication	1
Modified residueⁱ	448	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by PRKDC.2 Publications

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P14859
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P14859
PaxDbⁱ	P14859
PeptideAtlas More...PeptideAtlasⁱ	P14859
PRIDEⁱ	P14859
ProteomicsDBⁱ	53085 53086 [P14859-2] 53087 [P14859-3] 53088 [P14859-4] 53089 [P14859-5]

PTM databases

iPTMnetⁱ	P14859
PhosphoSitePlusⁱ	P14859

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Isoform 2 is lymphocyte-specific.

Gene expression databases

Bgeeⁱ	ENSG00000143190 Expressed in 219 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_POU2F1
ExpressionAtlasⁱ	P14859 baseline and differential
Genevisibleⁱ	P14859 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002608 HPA058559 HPA064323

HPAⁱ

CAB002608
HPA058559
HPA064323

Interactionⁱ

Subunit structureⁱ

Interacts with NR3C1, AR, PGR and HCFC1. Associates with the herpes simplex virus VP16-induced complex; binding to HCFC1 activates the viral transcriptional activator VP16 for association with POU2F1, to form a multiprotein-DNA complex responsible for activating transcription of the viral immediate early genes.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
PLK3	Q9H4B4	3	EBI-624770,EBI-751877
POGZ	Q7Z3K3	3	EBI-624770,EBI-1389308
POU6F2	P78424	4	EBI-11526590,EBI-12029004
PRR20D	P86480	4	EBI-11526590,EBI-12754095
SP1	P08047	7	EBI-624770,EBI-298336
SP4	Q02446	5	EBI-624770,EBI-10198587

Protein-protein interaction databases

BioGridⁱ	111447, 65 interactors
CORUMⁱ	P14859
Database of interacting proteins More...DIPⁱ	DIP-226N
IntActⁱ	P14859, 30 interactors
Molecular INTeraction database More...MINTⁱ	P14859
STRINGⁱ	9606.ENSP00000356840

Chemistry databases

BindingDBⁱ

P14859

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	285 – 301	Combined sources	17
Helixⁱ	306 – 317	Combined sources	12
Helixⁱ	323 – 331	Combined sources	9
Helixⁱ	336 – 353	Combined sources	18
Helixⁱ	388 – 400	Combined sources	13
Helixⁱ	406 – 416	Combined sources	11
Helixⁱ	420 – 434	Combined sources	15

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00231
ProteinModelPortalⁱ	P14859
SMRⁱ	P14859
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P14859

EvolutionaryTraceⁱ

P14859

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	280 – 354	POU-specificPROSITE-ProRule annotationAdd BLAST		75

Sequence similaritiesⁱ

Belongs to the POU transcription factor family. Class-2 subfamily.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG3802 Eukaryota ENOG410XQ7X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118935
HOGENOMⁱ	HOG000220842
HOVERGENⁱ	HBG057016
InParanoidⁱ	P14859
KEGG Orthology (KO) More...KOⁱ	K09364
OMAⁱ	IKAIFPC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0U0S
PhylomeDBⁱ	P14859
TreeFamⁱ	TF316413

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR010982 Lambda_DNA-bd_dom_sf IPR013847 POU IPR000327 POU_dom IPR000972 TF_octamer
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF00157 Pou, 1 hit
PRINTSⁱ	PR00029 OCTAMER PR00028 POUDOMAIN
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit SM00352 POU, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF47413 SSF47413, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit PS00035 POU_1, 1 hit PS00465 POU_2, 1 hit PS51179 POU_3, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P14859-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MNNPSETSKP SMESGDGNTG TQTNGLDFQK QPVPVGGAIS TAQAQAFLGH 
        60         70         80         90        100
LHQVQLAGTS LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT 
       110        120        130        140        150
QLMLAGGQIT GLTLTPAQQQ LLLQQAQAQA QLLAAAVQQH SASQQHSAAG 
       160        170        180        190        200
ATISASAATP MTQIPLSQPI QIAQDLQQLQ QLQQQNLNLQ QFVLVHPTTN 
       210        220        230        240        250
LQPAQFIISQ TPQGQQGLLQ AQNLLTQLPQ QSQANLLQSQ PSITLTSQPA 
       260        270        280        290        300
TPTRTIAATP IQTLPQSQST PKRIDTPSLE EPSDLEELEQ FAKTFKQRRI 
       310        320        330        340        350
KLGFTQGDVG LAMGKLYGND FSQTTISRFE ALNLSFKNMC KLKPLLEKWL 
       360        370        380        390        400
NDAENLSSDS SLSSPSALNS PGIEGLSRRR KKRTSIETNI RVALEKSFLE 
       410        420        430        440        450
NQKPTSEEIT MIADQLNMEK EVIRVWFCNR RQKEKRINPP SSGGTSSSPI 
       460        470        480        490        500
KAIFPSPTSL VATTPSLVTS SAATTLTVSP VLPLTSAAVT NLSVTGTSDT 
       510        520        530        540        550
TSNNTATVIS TAPPASSAVT SPSLSPSPSA SASTSEASSA SETSTTQTTS 
       560        570        580        590        600
TPLSSPLGTS QVMVTASGLQ TAAAAALQGA AQLPANASLA AMAAAAGLNP 
       610        620        630        640        650
SLMAPSQFAA GGALLSLNPG TLSGALSPAL MSNSTLATIQ ALASGGSLPI 
       660        670        680        690        700
TSLDATGNLV FANAGGAPNI VTAPLFLNPQ NLSLLTSNPV SLVSAAAASA 
       710        720        730        740 
GNSAPVASLH ATSTSAESIQ NSLFTVASAS GAASTTTTAS KAQ

Length:743

Mass (Da):76,472

Last modified:February 1, 2003 - v2

Checksum:ⁱFAB27FFC79CF2276

GO

Isoform 2 (identifier: P14859-2) [UniParc]FASTA Add to basket

Also known as: Oct-1L, lymphocyte-specific

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MLDCSDYVLDSRM

« Hide

        10         20         30         40         50
MLDCSDYVLD SRMNNPSETS KPSMESGDGN TGTQTNGLDF QKQPVPVGGA 
        60         70         80         90        100
ISTAQAQAFL GHLHQVQLAG TSLQAAAQSL NVQSKSNEES GDSQQPSQPS 
       110        120        130        140        150
QQPSVQAAIP QTQLMLAGGQ ITGLTLTPAQ QQLLLQQAQA QAQLLAAAVQ 
       160        170        180        190        200
QHSASQQHSA AGATISASAA TPMTQIPLSQ PIQIAQDLQQ LQQLQQQNLN 
       210        220        230        240        250
LQQFVLVHPT TNLQPAQFII SQTPQGQQGL LQAQNLLTQL PQQSQANLLQ 
       260        270        280        290        300
SQPSITLTSQ PATPTRTIAA TPIQTLPQSQ STPKRIDTPS LEEPSDLEEL 
       310        320        330        340        350
EQFAKTFKQR RIKLGFTQGD VGLAMGKLYG NDFSQTTISR FEALNLSFKN 
       360        370        380        390        400
MCKLKPLLEK WLNDAENLSS DSSLSSPSAL NSPGIEGLSR RRKKRTSIET 
       410        420        430        440        450
NIRVALEKSF LENQKPTSEE ITMIADQLNM EKEVIRVWFC NRRQKEKRIN 
       460        470        480        490        500
PPSSGGTSSS PIKAIFPSPT SLVATTPSLV TSSAATTLTV SPVLPLTSAA 
       510        520        530        540        550
VTNLSVTGTS DTTSNNTATV ISTAPPASSA VTSPSLSPSP SASASTSEAS 
       560        570        580        590        600
SASETSTTQT TSTPLSSPLG TSQVMVTASG LQTAAAAALQ GAAQLPANAS 
       610        620        630        640        650
LAAMAAAAGL NPSLMAPSQF AAGGALLSLN PGTLSGALSP ALMSNSTLAT 
       660        670        680        690        700
IQALASGGSL PITSLDATGN LVFANAGGAP NIVTAPLFLN PQNLSLLTSN 
       710        720        730        740        750
PVSLVSAAAA SAGNSAPVAS LHATSTSAES IQNSLFTVAS ASGAASTTTT 

ASKAQ

Show »

Length:755

Mass (Da):77,870

Checksum:ⁱ084E222919B616AA

GO

Isoform 3 (identifier: P14859-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-20: MNNPSETSKPSMESGDGNTG → MKTRMKIFVMIHFHLMNS

« Hide

        10         20         30         40         50
MKTRMKIFVM IHFHLMNSTQ TNGLDFQKQP VPVGGAISTA QAQAFLGHLH 
        60         70         80         90        100
QVQLAGTSLQ AAAQSLNVQS KSNEESGDSQ QPSQPSQQPS VQAAIPQTQL 
       110        120        130        140        150
MLAGGQITGL TLTPAQQQLL LQQAQAQAQL LAAAVQQHSA SQQHSAAGAT 
       160        170        180        190        200
ISASAATPMT QIPLSQPIQI AQDLQQLQQL QQQNLNLQQF VLVHPTTNLQ 
       210        220        230        240        250
PAQFIISQTP QGQQGLLQAQ NLLTQLPQQS QANLLQSQPS ITLTSQPATP 
       260        270        280        290        300
TRTIAATPIQ TLPQSQSTPK RIDTPSLEEP SDLEELEQFA KTFKQRRIKL 
       310        320        330        340        350
GFTQGDVGLA MGKLYGNDFS QTTISRFEAL NLSFKNMCKL KPLLEKWLND 
       360        370        380        390        400
AENLSSDSSL SSPSALNSPG IEGLSRRRKK RTSIETNIRV ALEKSFLENQ 
       410        420        430        440        450
KPTSEEITMI ADQLNMEKEV IRVWFCNRRQ KEKRINPPSS GGTSSSPIKA 
       460        470        480        490        500
IFPSPTSLVA TTPSLVTSSA ATTLTVSPVL PLTSAAVTNL SVTGTSDTTS 
       510        520        530        540        550
NNTATVISTA PPASSAVTSP SLSPSPSASA STSEASSASE TSTTQTTSTP 
       560        570        580        590        600
LSSPLGTSQV MVTASGLQTA AAAALQGAAQ LPANASLAAM AAAAGLNPSL 
       610        620        630        640        650
MAPSQFAAGG ALLSLNPGTL SGALSPALMS NSTLATIQAL ASGGSLPITS 
       660        670        680        690        700
LDATGNLVFA NAGGAPNIVT APLFLNPQNL SLLTSNPVSL VSAAAASAGN 
       710        720        730        740 
SAPVASLHAT STSAESIQNS LFTVASASGA ASTTTTASKA Q

Note: No experimental confirmation available.

Show »

Length:741

Mass (Da):76,696

Checksum:ⁱ28E72DF211628CE3

GO

Isoform 6 (identifier: P14859-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MADGGAASQDESSAAAAAAADSRM

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        10         20         30         40         50
MADGGAASQD ESSAAAAAAA DSRMNNPSET SKPSMESGDG NTGTQTNGLD 
        60         70         80         90        100
FQKQPVPVGG AISTAQAQAF LGHLHQVQLA GTSLQAAAQS LNVQSKSNEE 
       110        120        130        140        150
SGDSQQPSQP SQQPSVQAAI PQTQLMLAGG QITGLTLTPA QQQLLLQQAQ 
       160        170        180        190        200
AQAQLLAAAV QQHSASQQHS AAGATISASA ATPMTQIPLS QPIQIAQDLQ 
       210        220        230        240        250
QLQQLQQQNL NLQQFVLVHP TTNLQPAQFI ISQTPQGQQG LLQAQNLLTQ 
       260        270        280        290        300
LPQQSQANLL QSQPSITLTS QPATPTRTIA ATPIQTLPQS QSTPKRIDTP 
       310        320        330        340        350
SLEEPSDLEE LEQFAKTFKQ RRIKLGFTQG DVGLAMGKLY GNDFSQTTIS 
       360        370        380        390        400
RFEALNLSFK NMCKLKPLLE KWLNDAENLS SDSSLSSPSA LNSPGIEGLS 
       410        420        430        440        450
RRRKKRTSIE TNIRVALEKS FLENQKPTSE EITMIADQLN MEKEVIRVWF 
       460        470        480        490        500
CNRRQKEKRI NPPSSGGTSS SPIKAIFPSP TSLVATTPSL VTSSAATTLT 
       510        520        530        540        550
VSPVLPLTSA AVTNLSVTGT SDTTSNNTAT VISTAPPASS AVTSPSLSPS 
       560        570        580        590        600
PSASASTSEA SSASETSTTQ TTSTPLSSPL GTSQVMVTAS GLQTAAAAAL 
       610        620        630        640        650
QGAAQLPANA SLAAMAAAAG LNPSLMAPSQ FAAGGALLSL NPGTLSGALS 
       660        670        680        690        700
PALMSNSTLA TIQALASGGS LPITSLDATG NLVFANAGGA PNIVTAPLFL 
       710        720        730        740        750
NPQNLSLLTS NPVSLVSAAA ASAGNSAPVA SLHATSTSAE SIQNSLFTVA 
       760 
SASGAASTTT TASKAQ

Note: No experimental confirmation available.

Show »

Length:766

Mass (Da):78,535

Checksum:ⁱ54C541CD1D6BA426

GO

Isoform 4 (identifier: P14859-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
641-653: ALASGGSLPITSL → GLLHGLENFLTKN
654-743: Missing.

« Hide

        10         20         30         40         50
MNNPSETSKP SMESGDGNTG TQTNGLDFQK QPVPVGGAIS TAQAQAFLGH 
        60         70         80         90        100
LHQVQLAGTS LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT 
       110        120        130        140        150
QLMLAGGQIT GLTLTPAQQQ LLLQQAQAQA QLLAAAVQQH SASQQHSAAG 
       160        170        180        190        200
ATISASAATP MTQIPLSQPI QIAQDLQQLQ QLQQQNLNLQ QFVLVHPTTN 
       210        220        230        240        250
LQPAQFIISQ TPQGQQGLLQ AQNLLTQLPQ QSQANLLQSQ PSITLTSQPA 
       260        270        280        290        300
TPTRTIAATP IQTLPQSQST PKRIDTPSLE EPSDLEELEQ FAKTFKQRRI 
       310        320        330        340        350
KLGFTQGDVG LAMGKLYGND FSQTTISRFE ALNLSFKNMC KLKPLLEKWL 
       360        370        380        390        400
NDAENLSSDS SLSSPSALNS PGIEGLSRRR KKRTSIETNI RVALEKSFLE 
       410        420        430        440        450
NQKPTSEEIT MIADQLNMEK EVIRVWFCNR RQKEKRINPP SSGGTSSSPI 
       460        470        480        490        500
KAIFPSPTSL VATTPSLVTS SAATTLTVSP VLPLTSAAVT NLSVTGTSDT 
       510        520        530        540        550
TSNNTATVIS TAPPASSAVT SPSLSPSPSA SASTSEASSA SETSTTQTTS 
       560        570        580        590        600
TPLSSPLGTS QVMVTASGLQ TAAAAALQGA AQLPANASLA AMAAAAGLNP 
       610        620        630        640        650
SLMAPSQFAA GGALLSLNPG TLSGALSPAL MSNSTLATIQ GLLHGLENFL 

TKN

Note: No experimental confirmation available.

Show »

Length:653

Mass (Da):68,143

Checksum:ⁱ1C82E7818D70A368

GO

Isoform 5 (identifier: P14859-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MADGGAASQDESSAAAAAAADSRM
112-174: Missing.

« Hide

        10         20         30         40         50
MADGGAASQD ESSAAAAAAA DSRMNNPSET SKPSMESGDG NTGTQTNGLD 
        60         70         80         90        100
FQKQPVPVGG AISTAQAQAF LGHLHQVQLA GTSLQAAAQS LNVQSKSNEE 
       110        120        130        140        150
SGDSQQPSQP SQQPSVQAAI PQTQLMLAGG QITGDLQQLQ QLQQQNLNLQ 
       160        170        180        190        200
QFVLVHPTTN LQPAQFIISQ TPQGQQGLLQ AQNLLTQLPQ QSQANLLQSQ 
       210        220        230        240        250
PSITLTSQPA TPTRTIAATP IQTLPQSQST PKRIDTPSLE EPSDLEELEQ 
       260        270        280        290        300
FAKTFKQRRI KLGFTQGDVG LAMGKLYGND FSQTTISRFE ALNLSFKNMC 
       310        320        330        340        350
KLKPLLEKWL NDAENLSSDS SLSSPSALNS PGIEGLSRRR KKRTSIETNI 
       360        370        380        390        400
RVALEKSFLE NQKPTSEEIT MIADQLNMEK EVIRVWFCNR RQKEKRINPP 
       410        420        430        440        450
SSGGTSSSPI KAIFPSPTSL VATTPSLVTS SAATTLTVSP VLPLTSAAVT 
       460        470        480        490        500
NLSVTGTSDT TSNNTATVIS TAPPASSAVT SPSLSPSPSA SASTSEASSA 
       510        520        530        540        550
SETSTTQTTS TPLSSPLGTS QVMVTASGLQ TAAAAALQGA AQLPANASLA 
       560        570        580        590        600
AMAAAAGLNP SLMAPSQFAA GGALLSLNPG TLSGALSPAL MSNSTLATIQ 
       610        620        630        640        650
ALASGGSLPI TSLDATGNLV FANAGGAPNI VTAPLFLNPQ NLSLLTSNPV 
       660        670        680        690        700
SLVSAAAASA GNSAPVASLH ATSTSAESIQ NSLFTVASAS GAASTTTTAS 

KAQ

Note: No experimental confirmation available.

Show »

Length:703

Mass (Da):72,082

Checksum:ⁱ1E6037CDCF41F528

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0C4DG88	A0A0C4DG88_HUMAN	POU domain protein POU domain protein	POU2F1	561	Annotation score:
A0A0A0MT46	A0A0A0MT46_HUMAN	POU domain protein POU domain protein	POU2F1	594	Annotation score:
Q16075	Q16075_HUMAN	Oct-1B Oct-1B (POU domain, class 2, transcription factor 1)	POU2F1 oct-1B	57	Annotation score:
A0A0A0MSV5	A0A0A0MSV5_HUMAN	POU domain, class 2, transcription ... POU domain, class 2, transcription factor 1	POU2F1	60	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	225	L → Q in CAA31767 (PubMed:2905684).Curated		1
Sequence conflictⁱ	546	T → I in AAM77920 (PubMed:12663137).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035816	88	S → F in a breast cancer sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_013421	1 – 20	MNNPS…DGNTG → MKTRMKIFVMIHFHLMNS in isoform 3. CuratedAdd BLAST	20
Alternative sequenceⁱVSP_002320	1	M → MLDCSDYVLDSRM in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_043195	1	M → MADGGAASQDESSAAAAAAA DSRM in isoform 5 and isoform 6. 1 Publication	1
Alternative sequenceⁱVSP_043196	112 – 174	Missing in isoform 5. 1 PublicationAdd BLAST	63
Alternative sequenceⁱVSP_013422	641 – 653	ALASG…PITSL → GLLHGLENFLTKN in isoform 4. 1 PublicationAdd BLAST	13
Alternative sequenceⁱVSP_013423	654 – 743	Missing in isoform 4. 1 PublicationAdd BLAST	90

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X13403 mRNA Translation: CAA31767.1 AY113189 mRNA Translation: AAM77920.1 AK303201 mRNA Translation: BAG64291.1 AL136984 Genomic DNA No translation available. AL359962 Genomic DNA No translation available. AL451050 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90786.1 CH471067 Genomic DNA Translation: EAW90788.1 BC001664 mRNA Translation: AAH01664.1 BC003571 mRNA Translation: AAH03571.1 BC007388 mRNA Translation: AAH07388.1 BC052274 mRNA Translation: AAH52274.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1259.2 [P14859-6] CCDS55655.1 [P14859-5] CCDS55656.1 [P14859-2]
PIRⁱ	A47001
NCBI Reference Sequences More...RefSeqⁱ	NP_001185712.1, NM_001198783.1 [P14859-2] NP_001185715.1, NM_001198786.1 [P14859-5] NP_002688.3, NM_002697.3 [P14859-6] XP_011507956.1, XM_011509654.2 [P14859-1]
UniGeneⁱ	Hs.283402

Genome annotation databases

Ensemblⁱ	ENST00000367862; ENSP00000356836; ENSG00000143190 [P14859-2] ENST00000367866; ENSP00000356840; ENSG00000143190 [P14859-6] ENST00000429375; ENSP00000401217; ENSG00000143190 [P14859-5] ENST00000541643; ENSP00000441285; ENSG00000143190 [P14859-1]
GeneIDⁱ	5451
KEGGⁱ	hsa:5451
UCSC genome browser More...UCSCⁱ	uc001gec.4 human [P14859-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P14859	POU domain protein		HUMAN		743	UniRef100_P14859
POU domain protein		PONAB		743
UPI0005CFF752		HUMAN		769
P14859-2	POU domain protein		PONAB		755	UniRef100_H2N4V6
POU domain protein		NOMLE		755
POU domain protein		GORGO		755
P14859-6	POU domain protein		PONAB		766	UniRef100_A0A2J8SAM8
POU domain protein		GORGO		766
P14859-4	POU domain protein (Fragment)		HUMAN		561	UniRef100_P14859-4
POU domain protein (Fragment)		PONAB		561
P14859-5	POU domain protein		PONAB		703	UniRef100_A0A2J8SAQ0
POU domain protein		GORGO		703
POU domain protein		NOMLE		682

Protein	Similar proteins		Species	Score	Length	Source
P14859	POU domain, class 2, transcription factor 1		PIG		745	UniRef90_P14859
POU domain, class 2, transcription factor 1		CHICK		739
POU domain, class 2, transcription factor 1 (Fragment)		RAT		632
POU domain protein		HUMAN		743
POU domain protein		PONAB		743
+395
P14859-4	POU domain protein (Fragment)		HUMAN		561	UniRef90_P14859-4
POU domain protein (Fragment)		PONAB		561
POU domain protein (Fragment)		PELCR		589
UPI000E778C6C		Three-toed box turtle		762
UPI0005323125		East African grey crowned-crane		641
+3
P14859-5	POU domain protein		PANTR		703	UniRef90_A0A2I3SHX9
POU domain protein		PANPA		703
POU domain protein		CAVPO		705
POU domain protein		ODORO		704
POU domain protein		ERIEU		704
+48

Protein	Similar proteins		Species	Score	Length	Source
P14859	POU domain, class 2, transcription factor 1		PIG		745	UniRef50_P14859
POU domain, class 2, transcription factor 1		CHICK		739
POU domain, class 2, transcription factor 1 (Fragment)		RAT		632
POU domain, class 2, transcription factor 1		MOUSE		770
POU domain protein		HUMAN		743
+543
P14859-4	POU domain, class 2, transcription factor 1		XENLA		758	UniRef50_P14859-4
POU domain, class 2, transcription factor 1		XENTR		757
POU domain protein (Fragment)		HUMAN		561
POU domain protein (Fragment)		PONAB		561
POU domain protein (Fragment)		PELCR		589
+628
P14859-5	Isoform 4 of POU domain, class 2, transcription factor 1		HUMAN		653	UniRef50_P14859-4
POU domain, class 2, transcription factor 1		XENLA		758
POU domain, class 2, transcription factor 1		XENTR		757
POU domain protein (Fragment)		PONAB		561
POU domain protein (Fragment)		PELCR		589
+628

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X13403 mRNA Translation: CAA31767.1 AY113189 mRNA Translation: AAM77920.1 AK303201 mRNA Translation: BAG64291.1 AL136984 Genomic DNA No translation available. AL359962 Genomic DNA No translation available. AL451050 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90786.1 CH471067 Genomic DNA Translation: EAW90788.1 BC001664 mRNA Translation: AAH01664.1 BC003571 mRNA Translation: AAH03571.1 BC007388 mRNA Translation: AAH07388.1 BC052274 mRNA Translation: AAH52274.1
CCDSⁱ	CCDS1259.2 [P14859-6] CCDS55655.1 [P14859-5] CCDS55656.1 [P14859-2]
PIRⁱ	A47001
RefSeqⁱ	NP_001185712.1, NM_001198783.1 [P14859-2] NP_001185715.1, NM_001198786.1 [P14859-5] NP_002688.3, NM_002697.3 [P14859-6] XP_011507956.1, XM_011509654.2 [P14859-1]
UniGeneⁱ	Hs.283402

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1CQT	X-ray	3.20	A/B	278-439	[»]
	1E3O	X-ray	1.90	C	280-438	[»]
	1GT0	X-ray	2.60	C	280-438	[»]
	1HF0	X-ray	2.70	A/B	280-438	[»]
	1O4X	NMR	-	A	280-442	[»]
	1OCT	X-ray	3.00	C	284-439	[»]
	1POG	NMR	-	A	378-437	[»]
	1POU	NMR	-	A	284-354	[»]
DisProtⁱ	DP00231
ProteinModelPortalⁱ	P14859
SMRⁱ	P14859
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111447, 65 interactors
CORUMⁱ	P14859
DIPⁱ	DIP-226N
IntActⁱ	P14859, 30 interactors
MINTⁱ	P14859
STRINGⁱ	9606.ENSP00000356840

Chemistry databases

BindingDBⁱ	P14859
ChEMBLⁱ	CHEMBL3509601

PTM databases

iPTMnetⁱ	P14859
PhosphoSitePlusⁱ	P14859

Polymorphism and mutation databases

BioMutaⁱ	POU2F1
DMDMⁱ	28202257

Proteomic databases

EPDⁱ	P14859
MaxQBⁱ	P14859
PaxDbⁱ	P14859
PeptideAtlasⁱ	P14859
PRIDEⁱ	P14859
ProteomicsDBⁱ	53085 53086 [P14859-2] 53087 [P14859-3] 53088 [P14859-4] 53089 [P14859-5]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5451
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000367862; ENSP00000356836; ENSG00000143190 [P14859-2] ENST00000367866; ENSP00000356840; ENSG00000143190 [P14859-6] ENST00000429375; ENSP00000401217; ENSG00000143190 [P14859-5] ENST00000541643; ENSP00000441285; ENSG00000143190 [P14859-1]
GeneIDⁱ	5451
KEGGⁱ	hsa:5451
UCSCⁱ	uc001gec.4 human [P14859-1]

Organism-specific databases

CTDⁱ	5451
DisGeNETⁱ	5451
EuPathDBⁱ	HostDB:ENSG00000143190.21
GeneCardsⁱ	POU2F1
H-InvDBⁱ	HIX0018279
HGNCⁱ	HGNC:9212 POU2F1
HPAⁱ	CAB002608 HPA058559 HPA064323
MIMⁱ	164175 gene
neXtProtⁱ	NX_P14859
OpenTargetsⁱ	ENSG00000143190
PharmGKBⁱ	PA33536
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3802 Eukaryota ENOG410XQ7X LUCA
GeneTreeⁱ	ENSGT00760000118935
HOGENOMⁱ	HOG000220842
HOVERGENⁱ	HBG057016
InParanoidⁱ	P14859
KOⁱ	K09364
OMAⁱ	IKAIFPC
OrthoDBⁱ	EOG091G0U0S
PhylomeDBⁱ	P14859
TreeFamⁱ	TF316413

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-6807505 RNA polymerase II transcribes snRNA genes R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkⁱ	P14859
SIGNORⁱ	P14859

Miscellaneous databases

ChiTaRSⁱ	POU2F1 human
EvolutionaryTraceⁱ	P14859
GeneWikiⁱ	POU2F1
GenomeRNAiⁱ	5451
Protein Ontology More...PROⁱ	PR:P14859
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000143190 Expressed in 219 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_POU2F1
ExpressionAtlasⁱ	P14859 baseline and differential
Genevisibleⁱ	P14859 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR010982 Lambda_DNA-bd_dom_sf IPR013847 POU IPR000327 POU_dom IPR000972 TF_octamer
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF00157 Pou, 1 hit
PRINTSⁱ	PR00029 OCTAMER PR00028 POUDOMAIN
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit SM00352 POU, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF47413 SSF47413, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit PS00035 POU_1, 1 hit PS00465 POU_2, 1 hit PS51179 POU_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PO2F1_HUMAN
Accessionⁱ	P14859Primary (citable) accession number: P14859 Secondary accession number(s): B1AL91 Q9BPV1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	February 1, 2003
	Last modified:	November 7, 2018
	This is version 219 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P14859 (PO2F1_HUMAN)

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POU domain, class 2, transcription factor 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Experimental Info

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Alternative sequence

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Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

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Chemistry databases

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Proteomic databases

Protocols and materials databases

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Miscellaneous databases

Gene expression databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ