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UniProtKB - P14854 (CX6B1_HUMAN)

Entry version 177 (13 Feb 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Cytochrome c oxidase subunit 6B1

Gene

COX6B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Connects the two COX monomers into the physiological dimeric form.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytochrome-c oxidase activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6B1
Alternative name(s):
Cytochrome c oxidase subunit VIb isoform 1
Short name:
COX VIb-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COX6B1
Synonyms:COX6B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000126267.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:2280 COX6B1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		124089 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P14854

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mitochondrial complex IV deficiency (MT-C4D)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal death. A subset of patients manifest Leigh syndrome.
See also OMIM:220110
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04677520R → H in MT-C4D. 1 PublicationCorresponds to variant dbSNP:rs121909602EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...DisGeNETi		1340

MalaCards human disease database

More...MalaCardsi		COX6B1
MIMi220110 phenotype

Open Targets

More...OpenTargetsi		ENSG00000126267

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		254905 Isolated cytochrome C oxidase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26797

Chemistry databases

Drug and drug target database

More...DrugBanki		DB02659 Cholic Acid
DB04464 N-Formylmethionine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		COX6B1

Domain mapping of disease mutations (DMDM)

More...DMDMi		117115

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001949122 – 86Cytochrome c oxidase subunit 6B1Add BLAST85

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi30 ↔ 65PROSITE-ProRule annotation
Disulfide bondi40 ↔ 54PROSITE-ProRule annotation

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P14854

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P14854

MaxQB - The MaxQuant DataBase

More...MaxQBi		P14854

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P14854

PeptideAtlas

More...PeptideAtlasi		P14854

PRoteomics IDEntifications database

More...PRIDEi		P14854

ProteomicsDB human proteome resource

More...ProteomicsDBi		53084

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P14854

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P14854

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P14854

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000126267 Expressed in 237 organ(s), highest expression level in apex of heart

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P14854 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P14854 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA004192

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		107733, 53 interactors

Protein interaction database and analysis system

More...IntActi		P14854, 199 interactors

Molecular INTeraction database

More...MINTi		P14854

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000246554

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P14854

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P14854

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 73CHCHPROSITE-ProRule annotationAdd BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi30 – 40Cx9C motifPROSITE-ProRule annotationAdd BLAST11
Motifi54 – 65Cx10C motifPROSITE-ProRule annotationAdd BLAST12

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 6B family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3057 Eukaryota
ENOG41121WM LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156204

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000165128

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG051090

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P14854

KEGG Orthology (KO)

More...KOi		K02267

Identification of Orthologs from Complete Genome Data

More...OMAi		APCKQFK

Database of Orthologous Groups

More...OrthoDBi		1586678at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P14854

TreeFam database of animal gene trees

More...TreeFami		TF105065

Family and domain databases

Conserved Domains Database

More...CDDi		cd00926 Cyt_c_Oxidase_VIb, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.140, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003213 Cyt_c_oxidase_su6B
IPR036549 Cyt_c_oxidase_su6B_sf

The PANTHER Classification System

More...PANTHERi		PTHR11387 PTHR11387, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02297 COX6B, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000278 Cyt_c_oxidase_6B, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47694 SSF47694, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51808 CHCH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P14854-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEDMETKIK NYKTAPFDSR FPNQNQTRNC WQNYLDFHRC QKAMTAKGGD 
        60         70         80 
ISVCEWYQRV YQSLCPTSWV TDWDEQRAEG TFPGKI
Length:86
Mass (Da):10,192
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15C8B056491FB248
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQD3K7EQD3_HUMAN
Cytochrome c oxidase subunit 6B1
COX6B1
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04677520R → H in MT-C4D. 1 PublicationCorresponds to variant dbSNP:rs121909602EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X13923 mRNA Translation: CAA32114.1
X54473 mRNA Translation: CAA38352.1
AK312140 mRNA Translation: BAG35076.1
BT006945 mRNA Translation: AAP35591.1
CR456789 mRNA Translation: CAG33070.1
CR542137 mRNA Translation: CAG46934.1
AC002115 Genomic DNA Translation: AAB57628.1
BC001015 mRNA Translation: AAH01015.1
BC002478 mRNA Translation: AAH02478.1
X58139 Genomic DNA Translation: CAA41147.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12469.1

Protein sequence database of the Protein Information Resource

More...PIRi		S03287 OGHU6B

NCBI Reference Sequences

More...RefSeqi		NP_001854.1, NM_001863.4

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.431668

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000246554; ENSP00000246554; ENSG00000126267
ENST00000392201; ENSP00000376037; ENSG00000126267
ENST00000592141; ENSP00000466818; ENSG00000126267
ENST00000649813; ENSP00000497926; ENSG00000126267

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1340

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1340

UCSC genome browser

More...UCSCi		uc002oav.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13923 mRNA Translation: CAA32114.1
X54473 mRNA Translation: CAA38352.1
AK312140 mRNA Translation: BAG35076.1
BT006945 mRNA Translation: AAP35591.1
CR456789 mRNA Translation: CAG33070.1
CR542137 mRNA Translation: CAG46934.1
AC002115 Genomic DNA Translation: AAB57628.1
BC001015 mRNA Translation: AAH01015.1
BC002478 mRNA Translation: AAH02478.1
X58139 Genomic DNA Translation: CAA41147.1
CCDSiCCDS12469.1
PIRiS03287 OGHU6B
RefSeqiNP_001854.1, NM_001863.4
UniGeneiHs.431668

3D structure databases

ProteinModelPortaliP14854
SMRiP14854
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107733, 53 interactors
IntActiP14854, 199 interactors
MINTiP14854
STRINGi9606.ENSP00000246554

Chemistry databases

DrugBankiDB02659 Cholic Acid
DB04464 N-Formylmethionine

PTM databases

iPTMnetiP14854
PhosphoSitePlusiP14854

Polymorphism and mutation databases

BioMutaiCOX6B1
DMDMi117115

Proteomic databases

EPDiP14854
jPOSTiP14854
MaxQBiP14854
PaxDbiP14854
PeptideAtlasiP14854
PRIDEiP14854
ProteomicsDBi53084
TopDownProteomicsiP14854

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		1340
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246554; ENSP00000246554; ENSG00000126267
ENST00000392201; ENSP00000376037; ENSG00000126267
ENST00000592141; ENSP00000466818; ENSG00000126267
ENST00000649813; ENSP00000497926; ENSG00000126267
GeneIDi1340
KEGGihsa:1340
UCSCiuc002oav.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1340
DisGeNETi1340
EuPathDBiHostDB:ENSG00000126267.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		COX6B1
HGNCiHGNC:2280 COX6B1
HPAiHPA004192
MalaCardsiCOX6B1
MIMi124089 gene
220110 phenotype
neXtProtiNX_P14854
OpenTargetsiENSG00000126267
Orphaneti254905 Isolated cytochrome C oxidase deficiency
PharmGKBiPA26797

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3057 Eukaryota
ENOG41121WM LUCA
GeneTreeiENSGT00940000156204
HOGENOMiHOG000165128
HOVERGENiHBG051090
InParanoidiP14854
KOiK02267
OMAiAPCKQFK
OrthoDBi1586678at2759
PhylomeDBiP14854
TreeFamiTF105065

Enzyme and pathway databases

ReactomeiR-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		COX6B1 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		COX6B1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1340

Protein Ontology

More...PROi		PR:P14854

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000126267 Expressed in 237 organ(s), highest expression level in apex of heart
ExpressionAtlasiP14854 baseline and differential
GenevisibleiP14854 HS

Family and domain databases

CDDicd00926 Cyt_c_Oxidase_VIb, 1 hit
Gene3Di1.10.10.140, 1 hit
InterProiView protein in InterPro
IPR003213 Cyt_c_oxidase_su6B
IPR036549 Cyt_c_oxidase_su6B_sf
PANTHERiPTHR11387 PTHR11387, 1 hit
PfamiView protein in Pfam
PF02297 COX6B, 1 hit
PIRSFiPIRSF000278 Cyt_c_oxidase_6B, 1 hit
SUPFAMiSSF47694 SSF47694, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCX6B1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14854
Secondary accession number(s): B2R5C9, Q6IBL4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: February 13, 2019
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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