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Protein

C-reactive protein

Gene

Crp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80Calcium 1By similarity1
Metal bindingi157Calcium 1By similarity1
Metal bindingi157Calcium 2PROSITE-ProRule annotation1
Metal bindingi158Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi159Calcium 1By similarity1
Metal bindingi159Calcium 2PROSITE-ProRule annotation1
Metal bindingi169Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAcute phase
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-173623 Classical antibody-mediated complement activation

Names & Taxonomyi

Protein namesi
Recommended name:
C-reactive protein
Gene namesi
Name:Crp
Synonyms:Ptx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88512 Crp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000002352920 – 225C-reactive proteinAdd BLAST206

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 116PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP14847
PaxDbiP14847
PRIDEiP14847

PTM databases

PhosphoSitePlusiP14847

Expressioni

Tissue specificityi

Found in plasma.

Inductioni

The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli.

Gene expression databases

BgeeiENSMUSG00000037942 Expressed in 50 organ(s), highest expression level in jejunum
CleanExiMM_CRP
GenevisibleiP14847 MM

Interactioni

Subunit structurei

Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044665

Structurei

3D structure databases

ProteinModelPortaliP14847
SMRiP14847
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 225Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST202

Sequence similaritiesi

Belongs to the pentraxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J9V0 Eukaryota
ENOG410YIJN LUCA
GeneTreeiENSGT00760000119128
HOGENOMiHOG000247043
HOVERGENiHBG005405
InParanoidiP14847
KOiK16143
OMAiNEILIFW
OrthoDBiEOG091G0H6X
TreeFamiTF330208

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14847-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKLLWCLLI MISFSRTFGH EDMFKKAFVF PKESDTSYVS LEAESKKPLN
60 70 80 90 100
TFTVCLHFYT ALSTVRSFSV FSYATKKNSN DILIFWNKDK QYTFGVGGAE
110 120 130 140 150
VRFMVSEIPE APTHICASWE SATGIVEFWI DGKPKVRKSL HKGYTVGPDA
160 170 180 190 200
SIILGQEQDS YGGDFDAKQS LVGDIGDVNM WDFVLSPEQI STVYVGGTLS
210 220
PNVLNWRALN YKAQGDVFIK PQLWS
Length:225
Mass (Da):25,360
Last modified:October 3, 2012 - v2
Checksum:i0E5FC77BEB8052D8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134P → A in CAA31928 (PubMed:3190681).Curated1
Sequence conflicti191S → N in CAA31928 (PubMed:3190681).Curated1
Sequence conflicti191S → N in CAA35531 (PubMed:2310378).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13588 Genomic DNA Translation: CAA31928.1
AC131177 Genomic DNA No translation available.
X17496 mRNA Translation: CAA35531.1
CCDSiCCDS35787.1
PIRiA31583
RefSeqiNP_031794.3, NM_007768.4
UniGeneiMm.28767

Genome annotation databases

EnsembliENSMUST00000038495; ENSMUSP00000044665; ENSMUSG00000037942
GeneIDi12944
KEGGimmu:12944
UCSCiuc011wwq.1 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13588 Genomic DNA Translation: CAA31928.1
AC131177 Genomic DNA No translation available.
X17496 mRNA Translation: CAA35531.1
CCDSiCCDS35787.1
PIRiA31583
RefSeqiNP_031794.3, NM_007768.4
UniGeneiMm.28767

3D structure databases

ProteinModelPortaliP14847
SMRiP14847
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044665

PTM databases

PhosphoSitePlusiP14847

Proteomic databases

MaxQBiP14847
PaxDbiP14847
PRIDEiP14847

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038495; ENSMUSP00000044665; ENSMUSG00000037942
GeneIDi12944
KEGGimmu:12944
UCSCiuc011wwq.1 mouse

Organism-specific databases

CTDi1401
MGIiMGI:88512 Crp

Phylogenomic databases

eggNOGiENOG410J9V0 Eukaryota
ENOG410YIJN LUCA
GeneTreeiENSGT00760000119128
HOGENOMiHOG000247043
HOVERGENiHBG005405
InParanoidiP14847
KOiK16143
OMAiNEILIFW
OrthoDBiEOG091G0H6X
TreeFamiTF330208

Enzyme and pathway databases

ReactomeiR-MMU-173623 Classical antibody-mediated complement activation

Miscellaneous databases

ChiTaRSiCrip2 mouse
PROiPR:P14847
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037942 Expressed in 50 organ(s), highest expression level in jejunum
CleanExiMM_CRP
GenevisibleiP14847 MM

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRP_MOUSE
AccessioniPrimary (citable) accession number: P14847
Secondary accession number(s): E9PZ20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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