UniProtKB - P14842 (5HT2A_RAT)

BLAST

>sp|P14842|5HT2A_RAT 5-hydroxytryptamine receptor 2A OS=Rattus norvegicus OX=10116 GN=Htr2a PE=1 SV=1
MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV

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History
Entry version 156 (07 Nov 2018)
Sequence version 1 (01 Apr 1990)
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Protein

5-hydroxytryptamine receptor 2A

Gene

Htr2a

Organism

Rattus norvegicus (Rat)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca²⁺ ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	229	Hydrophobic barrier that decreases the speed of ligand binding and dissociationBy similarity		1

GO - Molecular functionⁱ

1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding Source: Ensembl
G-protein alpha-subunit binding
Source: RGD
Inferred from mutant phenotypeⁱ
- 19016481
G protein-coupled receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled serotonin receptor activity
Source: RGD
Inferred from direct assayⁱ
- 19016481
neurotransmitter receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein-containing complex binding
Source: RGD
Inferred from physical interactionⁱ
- 16527989
serotonin binding
Source: RGD
Inferred from direct assayⁱ
- 19016481

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of phospholipase C activity Source: Ensembl
aging
Source: RGD
Inferred from expression patternⁱ
- 17374516
artery smooth muscle contraction
Source: RGD
Inferred from mutant phenotypeⁱ
- 14752059
behavioral response to cocaine
Source: RGD
Inferred from direct assayⁱ
- 23390419
cell death
Source: RGD
Inferred from mutant phenotypeⁱ
- 16504407
chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
detection of mechanical stimulus involved in sensory perception of pain
Source: RGD
Inferred from mutant phenotypeⁱ
- 20531396
detection of temperature stimulus involved in sensory perception of pain
Source: RGD
Inferred from mutant phenotypeⁱ
- 20531396
G protein-coupled receptor signaling pathway
Source: RGD
Inferred from direct assayⁱ
- 19016481
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
memory
Source: RGD
Inferred from mutant phenotypeⁱ
- 16149040
negative regulation of potassium ion transport
Source: RGD
Inferred from mutant phenotypeⁱ
- 16527989
negative regulation of synaptic transmission, glutamatergic
Source: RGD
Inferred from mutant phenotypeⁱ
- 17016851
phosphatidylinositol 3-kinase signaling Source: Ensembl
phospholipase C-activating G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phospholipase C-activating serotonin receptor signaling pathway
Source: RGD
Inferred from direct assayⁱ
- 17010161
positive regulation of cell proliferation
Source: RGD
Inferred from mutant phenotypeⁱ
- 15087293
positive regulation of cytosolic calcium ion concentration
Source: RGD
Inferred from mutant phenotypeⁱ
- 20531396
positive regulation of ERK1 and ERK2 cascade Source: Ensembl
positive regulation of fat cell differentiation Source: Ensembl
positive regulation of glycolytic process Source: Ensembl
positive regulation of MAP kinase activity
Source: RGD
Inferred from mutant phenotypeⁱ
- 15087293
positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
positive regulation of phosphatidylinositol biosynthetic process Source: Ensembl
positive regulation of vasoconstriction
Source: RGD
Inferred from mutant phenotypeⁱ
- 16527989
protein localization to cytoskeleton Source: Ensembl
regulation of dopamine secretion
Source: RGD
Inferred from mutant phenotypeⁱ
- 15999145
regulation of synaptic vesicle exocytosis
Source: SynGO
Inferred from direct assayⁱ
- 12196574
release of sequestered calcium ion into cytosol
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to drug
Source: RGD
Inferred from mutant phenotypeⁱ
- 17077317
sensory perception of pain
Source: RGD
Inferred from mutant phenotypeⁱ
- 16527395
sleep
Source: RGD
Inferred from mutant phenotypeⁱ
- 17059817
temperature homeostasis
Source: RGD
Inferred from mutant phenotypeⁱ
- 17067560
urinary bladder smooth muscle contraction
Source: RGD
Inferred from mutant phenotypeⁱ
- 23274492

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Behavior

Enzyme and pathway databases

Reactomeⁱ	R-RNO-390666 Serotonin receptors R-RNO-416476 G alpha (q) signalling events

Reactomeⁱ

R-RNO-390666 Serotonin receptors
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 5-hydroxytryptamine receptor 2A Short name: 5-HT-2 Short name: 5-HT-2A Alternative name(s): Serotonin receptor 2A
Gene namesⁱ	Name:Htr2a Synonyms:Htr2
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 15

Organism-specific databases

Rat genome database More...RGDⁱ	61800 Htr2a

RGDⁱ

61800 Htr2a

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 75	ExtracellularBy similarityAdd BLAST	75
Transmembraneⁱ	76 – 99	Helical; Name=1By similarityAdd BLAST	24
Topological domainⁱ	100 – 110	CytoplasmicBy similarityAdd BLAST	11
Transmembraneⁱ	111 – 132	Helical; Name=2By similarityAdd BLAST	22
Topological domainⁱ	133 – 148	ExtracellularBy similarityAdd BLAST	16
Transmembraneⁱ	149 – 171	Helical; Name=3By similarityAdd BLAST	23
Topological domainⁱ	172 – 191	CytoplasmicBy similarityAdd BLAST	20
Transmembraneⁱ	192 – 215	Helical; Name=4By similarityAdd BLAST	24
Topological domainⁱ	216 – 233	ExtracellularBy similarityAdd BLAST	18
Transmembraneⁱ	234 – 254	Helical; Name=5By similarityAdd BLAST	21
Topological domainⁱ	255 – 324	CytoplasmicBy similarityAdd BLAST	70
Transmembraneⁱ	325 – 346	Helical; Name=6By similarityAdd BLAST	22
Topological domainⁱ	347 – 362	ExtracellularBy similarityAdd BLAST	16
Transmembraneⁱ	363 – 384	Helical; Name=7By similarityAdd BLAST	22
Topological domainⁱ	385 – 471	CytoplasmicBy similarityAdd BLAST	87

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL322
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	6

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000068951	1 – 471	5-hydroxytryptamine receptor 2AAdd BLAST		471

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	8	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	38	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	44	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	51	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	54	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	148 ↔ 227	PROSITE-ProRule annotation
Modified residueⁱ	280	PhosphoserineBy similarity	1
Disulfide bondⁱ	349 ↔ 353	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	P14842
PRIDEⁱ	P14842

PTM databases

iPTMnetⁱ	P14842
PhosphoSitePlusⁱ	P14842

Expressionⁱ

Tissue specificityⁱ

Detected in adult intestine, especially in mucosal epithelium, longitudinal and circular layers of muscularis externa and myenteric plexuses. Highly expressed in Paneth cells, and detected at lower levels in enterocytes (at protein level). Detected in brain cortex.2 Publications

Gene expression databases

Bgeeⁱ	ENSRNOG00000010063 Expressed in 7 organ(s), highest expression level in brain
Genevisibleⁱ	P14842 RN

Interactionⁱ

Subunit structureⁱ

Interacts (via C-terminus) with MPDZ and PATJ. May interact (via C-terminus) with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2. Interacts with GRM2 and DRD2; this may affect signaling.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Grm2	P31421	3	EBI-7090176,EBI-7090147

With

Entry

#Exp.

IntAct

Notes

Grm2

P31421

EBI-7090176,EBI-7090147

GO - Molecular functionⁱ

G-protein alpha-subunit binding
Source: RGD
Inferred from mutant phenotypeⁱ
- 19016481

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	248227, 1 interactor
Database of interacting proteins More...DIPⁱ	DIP-57661N
IntActⁱ	P14842, 2 interactors
Molecular INTeraction database More...MINTⁱ	P14842
STRINGⁱ	10116.ENSRNOP00000013408

Chemistry databases

BindingDBⁱ

P14842

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Beta strandⁱ	469 – 471	Combined sources		3

Show more details

3D structure databases

ProteinModelPortalⁱ	P14842
SMRⁱ	P14842
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	155 – 160	Agonist bindingBy similarity		6
Regionⁱ	336 – 340	Agonist bindingBy similarity		5

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	172 – 174	DRY motif; important for ligand-induced conformation changesBy similarity	3
Motifⁱ	376 – 380	NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity	5
Motifⁱ	469 – 471	PDZ-bindingBy similarity	3

Domainⁱ

The PDZ domain-binding motif is involved in the interaction with PATJ, CASK, APBA1, DLG1 and DLG4.By similarity

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139331
HOGENOMⁱ	HOG000240378
HOVERGENⁱ	HBG107487
InParanoidⁱ	P14842
KEGG Orthology (KO) More...KOⁱ	K04157
OMAⁱ	AGRRTMQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P14842
TreeFamⁱ	TF316350

Family and domain databases

InterProⁱ	View protein in InterPro IPR000455 5HT2A_rcpt IPR002231 5HT_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24247:SF30 PTHR24247:SF30, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00516 5HT2ARECEPTR PR01101 5HTRECEPTOR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P14842-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEILCEDNIS LSSIPNSLMQ LGDGPRLYHN DFNSRDANTS EASNWTIDAE 
        60         70         80         90        100
NRTNLSCEGY LPPTCLSILH LQEKNWSALL TTVVIILTIA GNILVIMAVS 
       110        120        130        140        150
LEKKLQNATN YFLMSLAIAD MLLGFLVMPV SMLTILYGYR WPLPSKLCAI 
       160        170        180        190        200
WIYLDVLFST ASIMHLCAIS LDRYVAIQNP IHHSRFNSRT KAFLKIIAVW 
       210        220        230        240        250
TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF VAFFIPLTIM 
       260        270        280        290        300
VITYFLTIKS LQKEATLCVS DLSTRAKLAS FSFLPQSSLS SEKLFQRSIH 
       310        320        330        340        350
REPGSYAGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK 
       360        370        380        390        400
ESCNENVIGA LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK 
       410        420        430        440        450
ENRKPLQLIL VNTIPALAYK SSQLQVGQKK NSQEDAEQTV DDCSMVTLGK 
       460        470 
QQSEENCTDN IETVNEKVSC V

Length:471

Mass (Da):52,850

Last modified:April 1, 1990 - v1

Checksum:ⁱ3626DACE5F6C7FF4

Sequence cautionⁱ

The sequence CAA32150 differs from that shown. Reason: Frameshift at position 37.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M30705 mRNA Translation: AAA42178.1 X13971 mRNA Translation: CAA32150.1 Frameshift. M64867 mRNA No translation available.
PIRⁱ	A34863 S02011
NCBI Reference Sequences More...RefSeqⁱ	NP_058950.1, NM_017254.1
UniGeneⁱ	Rn.10294 Rn.146756

Genome annotation databases

Ensemblⁱ	ENSRNOT00000013408; ENSRNOP00000013408; ENSRNOG00000010063
GeneIDⁱ	29595
KEGGⁱ	rno:29595
UCSC genome browser More...UCSCⁱ	RGD:61800 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P14842	5-hydroxytryptamine receptor 2A		CRIGR		471	UniRef90_P14842
5-hydroxytryptamine receptor 2A		MOUSE		471
5-hydroxytryptamine receptor 2A		MESAU		471
Uncharacterized protein (Fragment)		NEOLE		425
5-hydroxytryptamine (Serotonin) receptor 2A (Fragment)		HUMAN		66
+13

Protein	Similar proteins		Species	Score	Length	Source
P14842	5-hydroxytryptamine receptor 2A		HUMAN		471	UniRef50_P28223
5-hydroxytryptamine receptor 2A		PONPY		471
5-hydroxytryptamine receptor 2A		MACMU		471
5-hydroxytryptamine receptor 2A		CANLF		470
5-hydroxytryptamine receptor 2A		BOVIN		470
+369

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M30705 mRNA Translation: AAA42178.1 X13971 mRNA Translation: CAA32150.1 Frameshift. M64867 mRNA No translation available.
PIRⁱ	A34863 S02011
RefSeqⁱ	NP_058950.1, NM_017254.1
UniGeneⁱ	Rn.10294 Rn.146756

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4OAJ	X-ray	2.30	B	465-471	[»]
ProteinModelPortalⁱ	P14842
SMRⁱ	P14842
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	248227, 1 interactor
DIPⁱ	DIP-57661N
IntActⁱ	P14842, 2 interactors
MINTⁱ	P14842
STRINGⁱ	10116.ENSRNOP00000013408

Chemistry databases

BindingDBⁱ	P14842
ChEMBLⁱ	CHEMBL322
GuidetoPHARMACOLOGYⁱ	6

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P14842
PhosphoSitePlusⁱ	P14842

Proteomic databases

PaxDbⁱ	P14842
PRIDEⁱ	P14842

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000013408; ENSRNOP00000013408; ENSRNOG00000010063
GeneIDⁱ	29595
KEGGⁱ	rno:29595
UCSCⁱ	RGD:61800 rat

Organism-specific databases

CTDⁱ	3356
RGDⁱ	61800 Htr2a

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00890000139331
HOGENOMⁱ	HOG000240378
HOVERGENⁱ	HBG107487
InParanoidⁱ	P14842
KOⁱ	K04157
OMAⁱ	AGRRTMQ
OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P14842
TreeFamⁱ	TF316350

Enzyme and pathway databases

Reactomeⁱ	R-RNO-390666 Serotonin receptors R-RNO-416476 G alpha (q) signalling events

Reactomeⁱ

R-RNO-390666 Serotonin receptors
R-RNO-416476 G alpha (q) signalling events

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P14842

PROⁱ

PR:P14842

Gene expression databases

Bgeeⁱ	ENSRNOG00000010063 Expressed in 7 organ(s), highest expression level in brain
Genevisibleⁱ	P14842 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR000455 5HT2A_rcpt IPR002231 5HT_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24247:SF30 PTHR24247:SF30, 1 hit
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00516 5HT2ARECEPTR PR01101 5HTRECEPTOR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	5HT2A_RAT
Accessionⁱ	P14842Primary (citable) accession number: P14842
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	April 1, 1990
	Last modified:	November 7, 2018
	This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

UniProtKB

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Help

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Annotation systems

Supporting data

UniProtKB - P14842 (5HT2A_RAT)

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5-hydroxytryptamine receptor 2A

Htr2a

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Cytosol

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ