5-hydroxytryptamine receptor 2A

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding Source: RGD
• G protein-coupled serotonin receptor activity Source: RGD
• Gq/11-coupled serotonin receptor activity Source: RGD
• identical protein binding Source: RGD
• neurotransmitter receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization."
    Cogolludo A., Moreno L., Lodi F., Frazziano G., Cobeno L., Tamargo J., Perez-Vizcaino F.
    Circ Res 98:931-938(2006) [PubMed] [Europe PMC] [Abstract]
• serotonin binding Source: RGD

GO - Biological processⁱ

• activation of phospholipase C activity Source: RGD
• aging Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Age-related changes in the serotonin 2A receptor in the hypoglossal nucleus of male and female rats."
    Seebart B.R., Stoffel R.T., Behan M.
    Respir Physiol Neurobiol 158:14-21(2007) [PubMed] [Europe PMC] [Abstract]
• artery smooth muscle contraction Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The fenfluramine metabolite (+)-norfenfluramine is vasoactive."
    Ni W., Li M.W., Thakali K., Fink G.D., Watts S.W.
    J Pharmacol Exp Ther 309:845-852(2004) [PubMed] [Europe PMC] [Abstract]
• behavioral response to cocaine Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Elevated Expression of Serotonin 5-HT(2A) Receptors in the Rat Ventral Tegmental Area Enhances Vulnerability to the Behavioral Effects of Cocaine."
    Herin D.V., Bubar M.J., Seitz P.K., Thomas M.L., Hillman G.R., Tarasenko Y.I., Wu P., Cunningham K.A.
    Front Psychiatry 4:2-2(2013) [PubMed] [Europe PMC] [Abstract]
• cell death Source: RGDInferred from mutant phenotypeⁱ
  • "Ecstasy-induced cell death in cortical neuronal cultures is serotonin 2A-receptor-dependent and potentiated under hyperthermia."
    Capela J.P., Ruscher K., Lautenschlager M., Freyer D., Dirnagl U., Gaio A.R., Bastos M.L., Meisel A., Carvalho F.
    Neuroscience 139:1069-1081(2006) [PubMed] [Europe PMC] [Abstract]
• cellular calcium ion homeostasis Source: RGD
• chemical synaptic transmission Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• detection of mechanical stimulus involved in sensory perception of pain Source: RGDInferred from mutant phenotypeⁱ
  • "Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain."
    Pichon X., Wattiez A.S., Becamel C., Ehrlich I., Bockaert J., Eschalier A., Marin P., Courteix C.
    Mol Ther 18:1462-1470(2010) [PubMed] [Europe PMC] [Abstract]
• detection of temperature stimulus involved in sensory perception of pain Source: RGDInferred from mutant phenotypeⁱ
  • "Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain."
    Pichon X., Wattiez A.S., Becamel C., Ehrlich I., Bockaert J., Eschalier A., Marin P., Courteix C.
    Mol Ther 18:1462-1470(2010) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled serotonin receptor signaling pathway Source: RGD
• memory Source: RGDInferred from mutant phenotypeⁱ
  • "Anxiolytic effect and memory improvement in rats by antisense oligodeoxynucleotide to 5-hydroxytryptamine-2A precursor protein."
    Cohen H.
    Depress Anxiety 22:84-93(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of potassium ion transport Source: RGDInferred from mutant phenotypeⁱ
  • "Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization."
    Cogolludo A., Moreno L., Lodi F., Frazziano G., Cobeno L., Tamargo J., Perez-Vizcaino F.
    Circ Res 98:931-938(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of synaptic transmission, glutamatergic Source: RGDInferred from mutant phenotypeⁱ
  • "Unexpected inhibitory regulation of glutamate release from rat cerebrocortical nerve terminals by presynaptic 5-hydroxytryptamine-2A receptors."
    Wang S.J., Wang K.Y., Wang W.C., Sihra T.S.
    J Neurosci Res 84:1528-1542(2006) [PubMed] [Europe PMC] [Abstract]
• phosphatidylinositol 3-kinase signaling Source: RGD
• phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• phospholipase C-activating serotonin receptor signaling pathway Source: RGDInferred from direct assayⁱ
  • "Serotonin 5-HT(2A) receptor activation induces 2-arachidonoylglycerol release through a phospholipase c-dependent mechanism."
    Parrish J.C., Nichols D.E.
    J Neurochem 99:1164-1175(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "Proliferation and signaling in fibroblasts: role of 5-hydroxytryptamine2A receptor and transporter."
    Welsh D.J., Harnett M., MacLean M., Peacock A.J.
    Am J Respir Crit Care Med 170:252-259(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytosolic calcium ion concentration Source: RGDInferred from mutant phenotypeⁱ
  • "Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain."
    Pichon X., Wattiez A.S., Becamel C., Ehrlich I., Bockaert J., Eschalier A., Marin P., Courteix C.
    Mol Ther 18:1462-1470(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of ERK1 and ERK2 cascade Source: RGD
• positive regulation of fat cell differentiation Source: RGD
• positive regulation of glycolytic process Source: RGD
• positive regulation of kinase activity Source: RGD
• positive regulation of MAP kinase activity Source: RGDInferred from mutant phenotypeⁱ
  • "Proliferation and signaling in fibroblasts: role of 5-hydroxytryptamine2A receptor and transporter."
    Welsh D.J., Harnett M., MacLean M., Peacock A.J.
    Am J Respir Crit Care Med 170:252-259(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of peptidyl-tyrosine phosphorylation Source: RGD
• positive regulation of phosphatidylinositol biosynthetic process Source: RGD
• positive regulation of vasoconstriction Source: RGDInferred from mutant phenotypeⁱ
  • "Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization."
    Cogolludo A., Moreno L., Lodi F., Frazziano G., Cobeno L., Tamargo J., Perez-Vizcaino F.
    Circ Res 98:931-938(2006) [PubMed] [Europe PMC] [Abstract]
• protein localization to cytoskeleton Source: RGD
• regulation of dopamine secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex."
    Pehek E.A., Nocjar C., Roth B.L., Byrd T.A., Mabrouk O.S.
    Neuropsychopharmacology 31:265-277(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of synaptic vesicle exocytosis Source: SynGOInferred from direct assayⁱ
  • "Activation of presynaptic 5-hydroxytryptamine 2A receptors facilitates excitatory synaptic transmission via protein kinase C in the dorsolateral septal nucleus."
    Hasuo H., Matsuoka T., Akasu T.
    J Neurosci 22:7509-7517(2002) [PubMed] [Europe PMC] [Abstract]
• release of sequestered calcium ion into cytosol Source: RGD
• response to xenobiotic stimulus Source: RGDInferred from mutant phenotypeⁱ
  • "5-Hydroxytryptamine (serotonin)2A receptors in rat anterior cingulate cortex mediate the discriminative stimulus properties of d-lysergic acid diethylamide."
    Gresch P.J., Barrett R.J., Sanders-Bush E., Smith R.L.
    J Pharmacol Exp Ther 320:662-669(2007) [PubMed] [Europe PMC] [Abstract]
• sensory perception of pain Source: RGDInferred from mutant phenotypeⁱ
  • "Peripheral 5-HT2A receptor antagonism attenuates primary thermal hyperalgesia and secondary mechanical allodynia after thermal injury in rats."
    Sasaki M., Obata H., Kawahara K., Saito S., Goto F.
    Pain 122:130-136(2006) [PubMed] [Europe PMC] [Abstract]
• sleep Source: RGDInferred from mutant phenotypeⁱ
  • "Effects of the serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213, respectively, on sleep and waking in the rat."
    Monti J.M., Jantos H.
    Eur J Pharmacol 553:163-170(2006) [PubMed] [Europe PMC] [Abstract]
• temperature homeostasis Source: RGDInferred from mutant phenotypeⁱ
  • "Effects of the 5-HT2A antagonist mirtazapine in rat models of thermoregulation."
    Pawlyk A.C., Cosmi S., Alfinito P.D., Maswood N., Deecher D.C.
    Brain Res 1123:135-144(2006) [PubMed] [Europe PMC] [Abstract]
• urinary bladder smooth muscle contraction Source: RGDInferred from mutant phenotypeⁱ
  • "Naftopidil inhibits 5-hydroxytryptamine-induced bladder contraction in rats."
    Sakai T., Kasahara K., Tomita K., Ikegaki I., Kuriyama H.
    Eur J Pharmacol 700:194-200(2013) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: RGD

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Motif

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEILCEDNIS LSSIPNSLMQ LGDGPRLYHN DFNSRDANTS EASNWTIDAE 
        60         70         80         90        100
NRTNLSCEGY LPPTCLSILH LQEKNWSALL TTVVIILTIA GNILVIMAVS 
       110        120        130        140        150
LEKKLQNATN YFLMSLAIAD MLLGFLVMPV SMLTILYGYR WPLPSKLCAI 
       160        170        180        190        200
WIYLDVLFST ASIMHLCAIS LDRYVAIQNP IHHSRFNSRT KAFLKIIAVW 
       210        220        230        240        250
TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF VAFFIPLTIM 
       260        270        280        290        300
VITYFLTIKS LQKEATLCVS DLSTRAKLAS FSFLPQSSLS SEKLFQRSIH 
       310        320        330        340        350
REPGSYAGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK 
       360        370        380        390        400
ESCNENVIGA LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK 
       410        420        430        440        450
ENRKPLQLIL VNTIPALAYK SSQLQVGQKK NSQEDAEQTV DDCSMVTLGK 
       460        470 
QQSEENCTDN IETVNEKVSC V                                

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families