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Protein

Interleukin-2 receptor subunit beta

Gene

IL2RB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

GO - Molecular functioni

GO - Biological processi

  • cytokine-mediated signaling pathway Source: MGI
  • interleukin-15-mediated signaling pathway Source: Reactome
  • interleukin-2-mediated signaling pathway Source: Reactome
  • MAPK cascade Source: Reactome
  • negative regulation of apoptotic process Source: MGI
  • protein-containing complex assembly Source: ProtInc
  • signal transduction Source: ProtInc
  • viral process Source: UniProtKB-KW

Keywordsi

Molecular functionReceptor
Biological processHost-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8983432 Interleukin-15 signaling
R-HSA-9020558 Interleukin-2 signaling
R-HSA-912526 Interleukin receptor SHC signaling
SignaLinkiP14784
SIGNORiP14784

Protein family/group databases

TCDBi9.B.281.1.1 the interleukin-2 receptor (il2r) family

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2 receptor subunit beta
Short name:
IL-2 receptor subunit beta
Short name:
IL-2R subunit beta
Short name:
IL-2RB
Alternative name(s):
High affinity IL-2 receptor subunit beta
Interleukin-15 receptor subunit betaImported
p70-75
Short name:
p75
CD_antigen: CD122
Gene namesi
Name:IL2RBImported
Synonyms:IL15RBImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100385.13
HGNCiHGNC:6009 IL2RB
MIMi146710 gene
neXtProtiNX_P14784

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 240ExtracellularSequence analysisAdd BLAST214
Transmembranei241 – 265HelicalSequence analysisAdd BLAST25
Topological domaini266 – 551CytoplasmicSequence analysisAdd BLAST286

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi418Y → F: Partial loss of interaction with SHB; when associated with F-536. 1 Publication1
Mutagenesisi536Y → F: Partial loss of interaction with SHB; when associated with F-418. 1 Publication1

Organism-specific databases

DisGeNETi3560
MalaCardsiIL2RB
OpenTargetsiENSG00000100385
Orphaneti85408 Juvenile rheumatoid factor-negative polyarthritis
85410 Oligoarticular juvenile arthritis
PharmGKBiPA29829

Chemistry databases

ChEMBLiCHEMBL3276
DrugBankiDB00041 Aldesleukin
DB00074 Basiliximab
DB00111 Daclizumab
DB00004 Denileukin diftitox
GuidetoPHARMACOLOGYi1696

Polymorphism and mutation databases

BioMutaiIL2RB
DMDMi124321

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000001087827 – 551Interleukin-2 receptor subunit betaAdd BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi36 ↔ 46
Glycosylationi43N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi59 ↔ 110
Glycosylationi71N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi74 ↔ 86
Glycosylationi149N-linked (GlcNAc...) asparagine2 Publications1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP14784
PeptideAtlasiP14784
PRIDEiP14784
ProteomicsDBi53083

PTM databases

iPTMnetiP14784
PhosphoSitePlusiP14784

Expressioni

Gene expression databases

BgeeiENSG00000100385
CleanExiHS_IL2RB
ExpressionAtlasiP14784 baseline and differential
GenevisibleiP14784 HS

Organism-specific databases

HPAiHPA062657

Interactioni

Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation.3 Publications
(Microbial infection) Interacts with HTLV-1 accessory protein p12I.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109775, 18 interactors
CORUMiP14784
DIPiDIP-43N
ELMiP14784
IntActiP14784, 10 interactors
MINTiP14784
STRINGi9606.ENSP00000216223

Structurei

Secondary structure

1551
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 38Combined sources6
Beta strandi40 – 49Combined sources10
Beta strandi51 – 53Combined sources3
Beta strandi59 – 65Combined sources7
Beta strandi72 – 75Combined sources4
Beta strandi77 – 80Combined sources4
Beta strandi84 – 89Combined sources6
Beta strandi104 – 110Combined sources7
Beta strandi117 – 124Combined sources8
Helixi126 – 128Combined sources3
Beta strandi136 – 143Combined sources8
Beta strandi148 – 153Combined sources6
Helixi159 – 161Combined sources3
Beta strandi165 – 172Combined sources8
Turni178 – 180Combined sources3
Beta strandi184 – 186Combined sources3
Beta strandi192 – 195Combined sources4
Beta strandi203 – 213Combined sources11
Beta strandi227 – 230Combined sources4

3D structure databases

ProteinModelPortaliP14784
SMRiP14784
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14784

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 234Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi220 – 224WSXWS motif5
Motifi278 – 286Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5H Eukaryota
ENOG410YXT9 LUCA
GeneTreeiENSGT00510000049239
HOGENOMiHOG000038003
HOVERGENiHBG052110
InParanoidiP14784
KOiK05069
OMAiACQVYFT
OrthoDBiEOG091G046N
PhylomeDBiP14784
TreeFamiTF337874

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003531 Hempt_rcpt_S_F1_CS
IPR013783 Ig-like_fold
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01355 HEMATOPO_REC_S_F1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14784-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPALSWRL PLLILLLPLA TSWASAAVNG TSQFTCFYNS RANISCVWSQ
60 70 80 90 100
DGALQDTSCQ VHAWPDRRRW NQTCELLPVS QASWACNLIL GAPDSQKLTT
110 120 130 140 150
VDIVTLRVLC REGVRWRVMA IQDFKPFENL RLMAPISLQV VHVETHRCNI
160 170 180 190 200
SWEISQASHY FERHLEFEAR TLSPGHTWEE APLLTLKQKQ EWICLETLTP
210 220 230 240 250
DTQYEFQVRV KPLQGEFTTW SPWSQPLAFR TKPAALGKDT IPWLGHLLVG
260 270 280 290 300
LSGAFGFIIL VYLLINCRNT GPWLKKVLKC NTPDPSKFFS QLSSEHGGDV
310 320 330 340 350
QKWLSSPFPS SSFSPGGLAP EISPLEVLER DKVTQLLLQQ DKVPEPASLS
360 370 380 390 400
SNHSLTSCFT NQGYFFFHLP DALEIEACQV YFTYDPYSEE DPDEGVAGAP
410 420 430 440 450
TGSSPQPLQP LSGEDDAYCT FPSRDDLLLF SPSLLGGPSP PSTAPGGSGA
460 470 480 490 500
GEERMPPSLQ ERVPRDWDPQ PLGPPTPGVP DLVDFQPPPE LVLREAGEEV
510 520 530 540 550
PDAGPREGVS FPWSRPPGQG EFRALNARLP LNTDAYLSLQ ELQGQDPTHL

V
Length:551
Mass (Da):61,117
Last modified:April 1, 1990 - v1
Checksum:i1A76FA1936BB7EE6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06118610L → V. Corresponds to variant dbSNP:rs57770674Ensembl.1
Natural variantiVAR_02199483S → F1 PublicationCorresponds to variant dbSNP:rs2228143Ensembl.1
Natural variantiVAR_019998391D → E1 PublicationCorresponds to variant dbSNP:rs228942Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26062 mRNA Translation: AAA59143.1
CR456506 mRNA Translation: CAG30392.1
AF517934 Genomic DNA Translation: AAM54040.1
AK312860 mRNA Translation: BAG35712.1
AL022314 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60144.1
BC025691 mRNA Translation: AAH25691.1
CCDSiCCDS13942.1
PIRiA30342
RefSeqiNP_000869.1, NM_000878.4
NP_001333151.1, NM_001346222.1
NP_001333152.1, NM_001346223.1
UniGeneiHs.474787

Genome annotation databases

EnsembliENST00000216223; ENSP00000216223; ENSG00000100385
GeneIDi3560
KEGGihsa:3560
UCSCiuc003aqv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIL2RB_HUMAN
AccessioniPrimary (citable) accession number: P14784
Secondary accession number(s): B2R765
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 18, 2018
This is version 206 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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