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Protein

Interleukin-1 receptor type 1

Gene

IL1R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).2 Publications

GO - Molecular functioni

  • interleukin-1, Type I, activating receptor activity Source: ProtInc
  • interleukin-1 binding Source: Ensembl
  • interleukin-1 receptor activity Source: BHF-UCL
  • platelet-derived growth factor receptor binding Source: BHF-UCL
  • protease binding Source: Ensembl
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • cell surface receptor signaling pathway Source: ProtInc
  • cytokine-mediated signaling pathway Source: Reactome
  • immune response Source: ProtInc
  • interleukin-1-mediated signaling pathway Source: BHF-UCL
  • positive regulation of interleukin-1-mediated signaling pathway Source: Ensembl
  • positive regulation of neutrophil extravasation Source: Ensembl
  • regulation of inflammatory response Source: Ensembl
  • response to interleukin-1 Source: BHF-UCL

Keywordsi

Molecular functionReceptor
Biological processInflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-6783783 Interleukin-10 signaling
R-HSA-9020702 Interleukin-1 signaling
SignaLinkiP14778
SIGNORiP14778

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor type 1
Short name:
IL-1R-1
Short name:
IL-1RT-1
Short name:
IL-1RT1
Alternative name(s):
CD121 antigen-like family member A
Interleukin-1 receptor alpha
Short name:
IL-1R-alpha
Interleukin-1 receptor type I
p80
CD_antigen: CD121a
Cleaved into the following 2 chains:
Interleukin-1 receptor type 1, membrane form
Short name:
mIL-1R1
Short name:
mIL-1RI
Interleukin-1 receptor type 1, soluble form
Short name:
sIL-1R1
Short name:
sIL-1RI
Gene namesi
Name:IL1R1
Synonyms:IL1R, IL1RA, IL1RT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115594.11
HGNCiHGNC:5993 IL1R1
MIMi147810 gene
neXtProtiNX_P14778

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 336ExtracellularSequence analysisAdd BLAST319
Transmembranei337 – 356HelicalSequence analysisAdd BLAST20
Topological domaini357 – 569CytoplasmicSequence analysisAdd BLAST213

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi369D → A: Reduces NF-kappa-B activation. 1 Publication1
Mutagenesisi428R → A: Reduces NF-kappa-B activation and receptor-associated kinase activation. 1 Publication1

Organism-specific databases

DisGeNETi3554
OpenTargetsiENSG00000115594
PharmGKBiPA29809

Chemistry databases

ChEMBLiCHEMBL1959
DrugBankiDB00026 Anakinra
DB05303 OMS-103HP
DB05207 SD118
GuidetoPHARMACOLOGYi1734

Polymorphism and mutation databases

BioMutaiIL1R1
DMDMi124308

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Add BLAST17
ChainiPRO_000001543518 – 569Interleukin-1 receptor type 1, membrane formAdd BLAST552
ChainiPRO_000041534418 – ?Interleukin-1 receptor type 1, soluble form

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 104
Disulfide bondi44 ↔ 96
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi121 ↔ 164
Disulfide bondi142 ↔ 196
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi248 ↔ 312
Glycosylationi249N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi263N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei496Phosphotyrosine1 Publication1

Post-translational modificationi

A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).1 Publication
Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP14778
PaxDbiP14778
PeptideAtlasiP14778
PRIDEiP14778
ProteomicsDBi53081

PTM databases

iPTMnetiP14778
PhosphoSitePlusiP14778

Expressioni

Tissue specificityi

Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells.1 Publication

Gene expression databases

BgeeiENSG00000115594
CleanExiHS_IL1R1
ExpressionAtlasiP14778 baseline and differential
GenevisibleiP14778 HS

Organism-specific databases

HPAiCAB007779
HPA005823
HPA029560

Interactioni

Subunit structurei

The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1.5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109770, 23 interactors
DIPiDIP-93N
IntActiP14778, 7 interactors
STRINGi9606.ENSP00000233946

Structurei

Secondary structure

1569
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 27Combined sources4
Beta strandi32 – 35Combined sources4
Beta strandi40 – 43Combined sources4
Helixi48 – 50Combined sources3
Beta strandi56 – 59Combined sources4
Beta strandi72 – 77Combined sources6
Beta strandi80 – 83Combined sources4
Helixi88 – 90Combined sources3
Beta strandi92 – 97Combined sources6
Beta strandi100 – 102Combined sources3
Beta strandi105 – 114Combined sources10
Beta strandi120 – 122Combined sources3
Helixi124 – 126Combined sources3
Beta strandi127 – 133Combined sources7
Beta strandi135 – 137Combined sources3
Beta strandi138 – 141Combined sources4
Helixi146 – 148Combined sources3
Turni151 – 153Combined sources3
Beta strandi159 – 162Combined sources4
Beta strandi171 – 177Combined sources7
Beta strandi180 – 183Combined sources4
Helixi188 – 190Combined sources3
Beta strandi192 – 202Combined sources11
Beta strandi205 – 218Combined sources14
Beta strandi227 – 230Combined sources4
Beta strandi233 – 237Combined sources5
Beta strandi240 – 242Combined sources3
Beta strandi244 – 252Combined sources9
Beta strandi256 – 262Combined sources7
Beta strandi272 – 281Combined sources10
Helixi287 – 289Combined sources3
Beta strandi290 – 300Combined sources11
Helixi303 – 306Combined sources4
Beta strandi310 – 316Combined sources7
Beta strandi319 – 328Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G0YX-ray3.00R21-332[»]
1IRAX-ray2.70Y18-336[»]
1ITBX-ray2.50B18-332[»]
4DEPX-ray3.10B/E18-336[»]
4GAFX-ray2.15B18-336[»]
ProteinModelPortaliP14778
SMRiP14778
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14778

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 110Ig-like C2-type 1Add BLAST88
Domaini118 – 210Ig-like C2-type 2Add BLAST93
Domaini226 – 328Ig-like C2-type 3Add BLAST103
Domaini383 – 541TIRPROSITE-ProRule annotationAdd BLAST159

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQBC Eukaryota
ENOG410Z3W1 LUCA
GeneTreeiENSGT00760000119071
HOGENOMiHOG000253916
HOVERGENiHBG052103
InParanoidiP14778
KOiK04386
OMAiIQDYEKM
OrthoDBiEOG091G03IT
PhylomeDBiP14778
TreeFamiTF325519

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR015621 IL-1_rcpt_fam
IPR004076 IL-1_rcpt_I-typ
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13895 Ig_2, 1 hit
PF01582 TIR, 1 hit
PRINTSiPR01538 INTRLEUKN1R1
PR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLLRLICF IALLISSLEA DKCKEREEKI ILVSSANEID VRPCPLNPNE
60 70 80 90 100
HKGTITWYKD DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN
110 120 130 140 150
SSYCLRIKIS AKFVENEPNL CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN
160 170 180 190 200
ENNELPKLQW YKDCKPLLLD NIHFSGVKDR LIVMNVAEKH RGNYTCHASY
210 220 230 240 250
TYLGKQYPIT RVIEFITLEE NKPTRPVIVS PANETMEVDL GSQIQLICNV
260 270 280 290 300
TGQLSDIAYW KWNGSVIDED DPVLGEDYYS VENPANKRRS TLITVLNISE
310 320 330 340 350
IESRFYKHPF TCFAKNTHGI DAAYIQLIYP VTNFQKHMIG ICVTLTVIIV
360 370 380 390 400
CSVFIYKIFK IDIVLWYRDS CYDFLPIKAS DGKTYDAYIL YPKTVGEGST
410 420 430 440 450
SDCDIFVFKV LPEVLEKQCG YKLFIYGRDD YVGEDIVEVI NENVKKSRRL
460 470 480 490 500
IIILVRETSG FSWLGGSSEE QIAMYNALVQ DGIKVVLLEL EKIQDYEKMP
510 520 530 540 550
ESIKFIKQKH GAIRWSGDFT QGPQSAKTRF WKNVRYHMPV QRRSPSSKHQ
560
LLSPATKEKL QREAHVPLG
Length:569
Mass (Da):65,402
Last modified:April 1, 1990 - v1
Checksum:i5BAA83F8F0225C25
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019131124A → G1 PublicationCorresponds to variant dbSNP:rs2228139Ensembl.1
Natural variantiVAR_029189344T → M. Corresponds to variant dbSNP:rs28362304Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16896 mRNA Translation: CAA34773.1
M27492 mRNA Translation: AAA59137.1
AF531102 Genomic DNA Translation: AAM88423.1
AC007271 Genomic DNA Translation: AAX81988.1
CH471127 Genomic DNA Translation: EAX01799.1
BC067506 mRNA Translation: AAH67506.1
BC075062 mRNA Translation: AAH75062.1
BC075063 mRNA Translation: AAH75063.1
CCDSiCCDS2055.1
PIRiA36187
RefSeqiNP_000868.1, NM_000877.3
NP_001275635.1, NM_001288706.1
NP_001307907.1, NM_001320978.1
NP_001307909.1, NM_001320980.1
NP_001307910.1, NM_001320981.1
NP_001307911.1, NM_001320982.1
NP_001307912.1, NM_001320983.1
NP_001307913.1, NM_001320984.1
NP_001307914.1, NM_001320985.1
XP_005263987.1, XM_005263930.4
XP_005263991.1, XM_005263934.4
XP_011509417.1, XM_011511115.2
XP_011509418.1, XM_011511116.1
XP_011509419.1, XM_011511117.1
XP_011509420.1, XM_011511118.2
XP_016859478.1, XM_017003989.1
UniGeneiHs.701982

Genome annotation databases

EnsembliENST00000410023; ENSP00000386380; ENSG00000115594
GeneIDi3554
KEGGihsa:3554
UCSCiuc002tbq.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIL1R1_HUMAN
AccessioniPrimary (citable) accession number: P14778
Secondary accession number(s): Q587I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 20, 2018
This is version 208 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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