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UniProtKB - P14778 (IL1R1_HUMAN)

Entry version 227 (10 Feb 2021)
Sequence version 1 (01 Apr 1990)
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Protein

Interleukin-1 receptor type 1

Gene

IL1R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei470PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Receptor
Biological processInflammatory response
LigandNAD

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P14778

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6783783, Interleukin-10 signaling
R-HSA-9020702, Interleukin-1 signaling
R-HSA-9679191, Potential therapeutics for SARS

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P14778

SIGNOR Signaling Network Open Resource

More...SIGNORi		P14778

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.23.1.11, the basigin (basigin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-1 receptor type 1 (EC:3.2.2.6PROSITE-ProRule annotation)
Short name:
IL-1R-1
Short name:
IL-1RT-1
Short name:
IL-1RT1
Alternative name(s):
CD121 antigen-like family member A
Interleukin-1 receptor alpha
Short name:
IL-1R-alpha
Interleukin-1 receptor type I
p80
CD_antigen: CD121a
Cleaved into the following 2 chains:
Interleukin-1 receptor type 1, membrane form
Short name:
mIL-1R1
Short name:
mIL-1RI
Interleukin-1 receptor type 1, soluble form
Short name:
sIL-1R1
Short name:
sIL-1RI
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL1R1
Synonyms:IL1R, IL1RA, IL1RT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5993, IL1R1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		147810, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P14778

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000115594.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini18 – 336ExtracellularSequence analysisAdd BLAST319
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei337 – 356HelicalSequence analysisAdd BLAST20
Topological domaini357 – 569CytoplasmicSequence analysisAdd BLAST213

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi369D → A: Reduces NF-kappa-B activation. 1 Publication1
Mutagenesisi428R → A: Reduces NF-kappa-B activation and receptor-associated kinase activation. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		3554

Open Targets

More...OpenTargetsi		ENSG00000115594

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29809

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P14778, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1959

Drug and drug target database

More...DrugBanki		DB00026, Anakinra
DB10770, Foreskin fibroblast (neonatal)
DB05303, OMS-103HP
DB05207, SD118

DrugCentral

More...DrugCentrali		P14778

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1734

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IL1R1

Domain mapping of disease mutations (DMDM)

More...DMDMi		124308

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Add BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001543518 – 569Interleukin-1 receptor type 1, membrane formAdd BLAST552
ChainiPRO_000041534418 – ?Interleukin-1 receptor type 1, soluble form

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi23 ↔ 104
Disulfide bondi44 ↔ 96
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi121 ↔ 164
Disulfide bondi142 ↔ 196
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi248 ↔ 312
Glycosylationi249N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi263N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei496Phosphotyrosine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).1 Publication
Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P14778

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P14778

MaxQB - The MaxQuant DataBase

More...MaxQBi		P14778

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P14778

PeptideAtlas

More...PeptideAtlasi		P14778

PRoteomics IDEntifications database

More...PRIDEi		P14778

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53081

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P14778, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P14778

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P14778

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000115594, Expressed in palpebral conjunctiva and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P14778, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P14778, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000115594, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP.

Interacts with PIK3R1.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109770, 29 interactors

Database of interacting proteins

More...DIPi		DIP-93N

Protein interaction database and analysis system

More...IntActi		P14778, 15 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000386380

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P14778

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P14778, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1569
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Small Angle Scattering Biological Data Bank

More...SASBDBi		P14778

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P14778

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P14778

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 110Ig-like C2-type 1Add BLAST88
Domaini118 – 210Ig-like C2-type 2Add BLAST93
Domaini226 – 328Ig-like C2-type 3Add BLAST103
Domaini383 – 538TIRPROSITE-ProRule annotationAdd BLAST156

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The TIR domain mediates NAD+ hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.PROSITE-ProRule annotation

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QWEU, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214361

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_025552_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P14778

Identification of Orthologs from Complete Genome Data

More...OMAi		EISGFSW

Database of Orthologous Groups

More...OrthoDBi		1109920at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P14778

TreeFam database of animal gene trees

More...TreeFami		TF325519

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 3 hits
3.40.50.10140, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR015621, IL-1_rcpt_fam
IPR004076, IL-1_rcpt_I-typ
IPR004074, IL-1_rcpt_I/II-typ
IPR041416, IL-1RAcP-like_ig
IPR000157, TIR_dom
IPR035897, Toll_tir_struct_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR11890, PTHR11890, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13895, Ig_2, 1 hit
PF18452, Ig_6, 1 hit
PF01582, TIR, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01538, INTRLEUKN1R1
PR01536, INTRLKN1R12F

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 3 hits
SM00255, TIR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 3 hits
SSF52200, SSF52200, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 3 hits
PS50104, TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

P14778-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVLLRLICF IALLISSLEA DKCKEREEKI ILVSSANEID VRPCPLNPNE 
        60         70         80         90        100
HKGTITWYKD DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN 
       110        120        130        140        150
SSYCLRIKIS AKFVENEPNL CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN 
       160        170        180        190        200
ENNELPKLQW YKDCKPLLLD NIHFSGVKDR LIVMNVAEKH RGNYTCHASY 
       210        220        230        240        250
TYLGKQYPIT RVIEFITLEE NKPTRPVIVS PANETMEVDL GSQIQLICNV 
       260        270        280        290        300
TGQLSDIAYW KWNGSVIDED DPVLGEDYYS VENPANKRRS TLITVLNISE 
       310        320        330        340        350
IESRFYKHPF TCFAKNTHGI DAAYIQLIYP VTNFQKHMIG ICVTLTVIIV 
       360        370        380        390        400
CSVFIYKIFK IDIVLWYRDS CYDFLPIKAS DGKTYDAYIL YPKTVGEGST 
       410        420        430        440        450
SDCDIFVFKV LPEVLEKQCG YKLFIYGRDD YVGEDIVEVI NENVKKSRRL 
       460        470        480        490        500
IIILVRETSG FSWLGGSSEE QIAMYNALVQ DGIKVVLLEL EKIQDYEKMP 
       510        520        530        540        550
ESIKFIKQKH GAIRWSGDFT QGPQSAKTRF WKNVRYHMPV QRRSPSSKHQ 
       560 
LLSPATKEKL QREAHVPLG
Length:569
Mass (Da):65,402
Last modified:April 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BAA83F8F0225C25
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZW4B8ZZW4_HUMAN
Interleukin-1 receptor type 1
IL1R1
538Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B8ZZ73B8ZZ73_HUMAN
Interleukin-1 receptor type 1
IL1R1
447Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3W8C9J3W8_HUMAN
Interleukin-1 receptor type 1
IL1R1
298Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B9A040B9A040_HUMAN
Interleukin-1 receptor type 1
IL1R1
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQ36C9JQ36_HUMAN
Interleukin-1 receptor type 1
IL1R1
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J686C9J686_HUMAN
Interleukin-1 receptor type 1
IL1R1
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWB2C9JWB2_HUMAN
Interleukin-1 receptor type 1
IL1R1
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF92F8WF92_HUMAN
Interleukin-1 receptor type 1
IL1R1
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZM5H7BZM5_HUMAN
Interleukin-1 receptor type 1
IL1R1
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JW84C9JW84_HUMAN
Interleukin-1 receptor type 1
IL1R1
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019131124A → G1 PublicationCorresponds to variant dbSNP:rs2228139Ensembl.1
Natural variantiVAR_029189344T → M. Corresponds to variant dbSNP:rs28362304Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X16896 mRNA Translation: CAA34773.1
M27492 mRNA Translation: AAA59137.1
AF531102 Genomic DNA Translation: AAM88423.1
AC007271 Genomic DNA Translation: AAX81988.1
CH471127 Genomic DNA Translation: EAX01799.1
BC067506 mRNA Translation: AAH67506.1
BC075062 mRNA Translation: AAH75062.1
BC075063 mRNA Translation: AAH75063.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2055.1

Protein sequence database of the Protein Information Resource

More...PIRi		A36187

NCBI Reference Sequences

More...RefSeqi		NP_000868.1, NM_000877.3
NP_001275635.1, NM_001288706.1
NP_001307907.1, NM_001320978.1
NP_001307909.1, NM_001320980.1
NP_001307910.1, NM_001320981.1
NP_001307911.1, NM_001320982.1
NP_001307912.1, NM_001320983.1
NP_001307913.1, NM_001320984.1
NP_001307914.1, NM_001320985.1
XP_005263987.1, XM_005263930.4
XP_005263991.1, XM_005263934.4
XP_011509417.1, XM_011511115.2
XP_011509418.1, XM_011511116.1
XP_011509419.1, XM_011511117.1
XP_011509420.1, XM_011511118.2
XP_016859478.1, XM_017003989.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000410023; ENSP00000386380; ENSG00000115594

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3554

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3554

UCSC genome browser

More...UCSCi		uc002tbq.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16896 mRNA Translation: CAA34773.1
M27492 mRNA Translation: AAA59137.1
AF531102 Genomic DNA Translation: AAM88423.1
AC007271 Genomic DNA Translation: AAX81988.1
CH471127 Genomic DNA Translation: EAX01799.1
BC067506 mRNA Translation: AAH67506.1
BC075062 mRNA Translation: AAH75062.1
BC075063 mRNA Translation: AAH75063.1
CCDSiCCDS2055.1
PIRiA36187
RefSeqiNP_000868.1, NM_000877.3
NP_001275635.1, NM_001288706.1
NP_001307907.1, NM_001320978.1
NP_001307909.1, NM_001320980.1
NP_001307910.1, NM_001320981.1
NP_001307911.1, NM_001320982.1
NP_001307912.1, NM_001320983.1
NP_001307913.1, NM_001320984.1
NP_001307914.1, NM_001320985.1
XP_005263987.1, XM_005263930.4
XP_005263991.1, XM_005263934.4
XP_011509417.1, XM_011511115.2
XP_011509418.1, XM_011511116.1
XP_011509419.1, XM_011511117.1
XP_011509420.1, XM_011511118.2
XP_016859478.1, XM_017003989.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G0YX-ray3.00R21-332[»]
1IRAX-ray2.70Y18-336[»]
1ITBX-ray2.50B18-332[»]
4DEPX-ray3.10B/E18-336[»]
4GAFX-ray2.15B18-336[»]
SASBDBiP14778
SMRiP14778
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109770, 29 interactors
DIPiDIP-93N
IntActiP14778, 15 interactors
STRINGi9606.ENSP00000386380

Chemistry databases

BindingDBiP14778
ChEMBLiCHEMBL1959
DrugBankiDB00026, Anakinra
DB10770, Foreskin fibroblast (neonatal)
DB05303, OMS-103HP
DB05207, SD118
DrugCentraliP14778
GuidetoPHARMACOLOGYi1734

Protein family/group databases

TCDBi8.A.23.1.11, the basigin (basigin) family

PTM databases

GlyGeniP14778, 6 sites
iPTMnetiP14778
PhosphoSitePlusiP14778

Genetic variation databases

BioMutaiIL1R1
DMDMi124308

Proteomic databases

jPOSTiP14778
MassIVEiP14778
MaxQBiP14778
PaxDbiP14778
PeptideAtlasiP14778
PRIDEiP14778
ProteomicsDBi53081

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P14778, 16 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3576, 960 antibodies

Genome annotation databases

EnsembliENST00000410023; ENSP00000386380; ENSG00000115594
GeneIDi3554
KEGGihsa:3554
UCSCiuc002tbq.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3554
DisGeNETi3554

GeneCards: human genes, protein and diseases

More...GeneCardsi		IL1R1
HGNCiHGNC:5993, IL1R1
HPAiENSG00000115594, Low tissue specificity
MIMi147810, gene
neXtProtiNX_P14778
OpenTargetsiENSG00000115594
PharmGKBiPA29809
VEuPathDBiHostDB:ENSG00000115594.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QWEU, Eukaryota
GeneTreeiENSGT01000000214361
HOGENOMiCLU_025552_3_1_1
InParanoidiP14778
OMAiEISGFSW
OrthoDBi1109920at2759
PhylomeDBiP14778
TreeFamiTF325519

Enzyme and pathway databases

PathwayCommonsiP14778
ReactomeiR-HSA-6783783, Interleukin-10 signaling
R-HSA-9020702, Interleukin-1 signaling
R-HSA-9679191, Potential therapeutics for SARS
SignaLinkiP14778
SIGNORiP14778

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3554, 13 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IL1R1, human
EvolutionaryTraceiP14778

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Interleukin_1_receptor,_type_I

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3554
PharosiP14778, Tclin

Protein Ontology

More...PROi		PR:P14778
RNActiP14778, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000115594, Expressed in palpebral conjunctiva and 237 other tissues
ExpressionAtlasiP14778, baseline and differential
GenevisibleiP14778, HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR015621, IL-1_rcpt_fam
IPR004076, IL-1_rcpt_I-typ
IPR004074, IL-1_rcpt_I/II-typ
IPR041416, IL-1RAcP-like_ig
IPR000157, TIR_dom
IPR035897, Toll_tir_struct_dom_sf
PANTHERiPTHR11890, PTHR11890, 1 hit
PfamiView protein in Pfam
PF13895, Ig_2, 1 hit
PF18452, Ig_6, 1 hit
PF01582, TIR, 1 hit
PRINTSiPR01538, INTRLEUKN1R1
PR01536, INTRLKN1R12F
SMARTiView protein in SMART
SM00409, IG, 3 hits
SM00255, TIR, 1 hit
SUPFAMiSSF48726, SSF48726, 3 hits
SSF52200, SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 3 hits
PS50104, TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL1R1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14778
Secondary accession number(s): Q587I7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: February 10, 2021
This is version 227 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  6. Human entries with genetic variants
    List of human entries with genetic variants
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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