IL1R1

Functionⁱ

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).2 Publications

GO - Molecular functionⁱ

interleukin-1, type I, activating receptor activity
Source: ProtInc
Traceable author statementⁱ
- 9120302
interleukin-1 binding Source: Ensembl
interleukin-1 receptor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 10383454
platelet-derived growth factor receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16477012
protease binding Source: Ensembl
transmembrane signaling receptor activity
Source: ProtInc
Traceable author statementⁱ
- 2530587

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell surface receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 1833184
cytokine-mediated signaling pathway Source: Reactome
immune response
Source: ProtInc
Traceable author statementⁱ
- 9120302
inflammatory response Source: UniProtKB-KW
interleukin-1-mediated signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 10383454
positive regulation of interferon-gamma production
Source: UniProtKB
Inferred from direct assayⁱ
- 10653850
positive regulation of interleukin-1-mediated signaling pathway Source: Ensembl
positive regulation of neutrophil extravasation Source: Ensembl
positive regulation of T-helper 1 cell cytokine production
Source: UniProtKB
Inferred from direct assayⁱ
- 10653850
regulation of inflammatory response Source: Ensembl
response to interleukin-1
Source: BHF-UCL
Inferred from direct assayⁱ
- 10383454

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Inflammatory response

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6783783 Interleukin-10 signaling R-HSA-9020702 Interleukin-1 signaling
SignaLinkⁱ	P14778
SIGNORⁱ	P14778

Protein family/group databases

TCDBⁱ	8.A.23.1.11 the basigin (basigin) family

TCDBⁱ

8.A.23.1.11 the basigin (basigin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-1 receptor type 1 Short name: IL-1R-1 Short name: IL-1RT-1 Short name: IL-1RT1 Alternative name(s): CD121 antigen-like family member A Interleukin-1 receptor alpha Short name: IL-1R-alpha Interleukin-1 receptor type I p80 CD_antigen: CD121a Cleaved into the following 2 chains: Interleukin-1 receptor type 1, membrane form Short name: mIL-1R1 Short name: mIL-1RI Interleukin-1 receptor type 1, soluble form Short name: sIL-1R1 Short name: sIL-1RI
Gene namesⁱ	Name:IL1R1 Synonyms:IL1R, IL1RA, IL1RT1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000115594.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5993 IL1R1
MIMⁱ	147810 gene
neXtProtⁱ	NX_P14778

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	18 – 336	ExtracellularSequence analysisAdd BLAST	319
Transmembraneⁱ	337 – 356	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	357 – 569	CytoplasmicSequence analysisAdd BLAST	213

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	369	D → A: Reduces NF-kappa-B activation. 1 Publication		1
Mutagenesisⁱ	428	R → A: Reduces NF-kappa-B activation and receptor-associated kinase activation. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3554
Open Targets More...OpenTargetsⁱ	ENSG00000115594
PharmGKBⁱ	PA29809

Chemistry databases

ChEMBLⁱ	CHEMBL1959
Drug and drug target database More...DrugBankⁱ	DB00026 Anakinra DB05303 OMS-103HP DB05207 SD118
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1734

Polymorphism and mutation databases

BioMutaⁱ	IL1R1
DMDMⁱ	124308

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 17	Add BLAST	17
ChainⁱPRO_0000015435	18 – 569	Interleukin-1 receptor type 1, membrane formAdd BLAST	552
ChainⁱPRO_0000415344	18 – ?	Interleukin-1 receptor type 1, soluble form

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	23 ↔ 104
Disulfide bondⁱ	44 ↔ 96
Glycosylationⁱ	100	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	121 ↔ 164
Disulfide bondⁱ	142 ↔ 196
Glycosylationⁱ	193	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	233	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	248 ↔ 312
Glycosylationⁱ	249	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	263	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	297	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	496	Phosphotyrosine1 Publication	1

Post-translational modificationⁱ

A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).1 Publication

Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P14778
PaxDbⁱ	P14778
PeptideAtlas More...PeptideAtlasⁱ	P14778
PRIDEⁱ	P14778
ProteomicsDBⁱ	53081

PTM databases

iPTMnetⁱ	P14778
PhosphoSitePlusⁱ	P14778

Expressionⁱ

Tissue specificityⁱ

Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000115594 Expressed in 228 organ(s), highest expression level in palpebral conjunctiva
CleanExⁱ	HS_IL1R1
ExpressionAtlasⁱ	P14778 baseline and differential
Genevisibleⁱ	P14778 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB007779 HPA005823 HPA029560

HPAⁱ

CAB007779
HPA005823
HPA029560

Interactionⁱ

Subunit structureⁱ

The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1.5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PDGFRB	P09619	2	EBI-525905,EBI-641237
TRAF6	Q9Y4K3	2	EBI-525905,EBI-359276

GO - Molecular functionⁱ

interleukin-1 binding Source: Ensembl
platelet-derived growth factor receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16477012
protease binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109770, 23 interactors
Database of interacting proteins More...DIPⁱ	DIP-93N
IntActⁱ	P14778, 7 interactors
STRINGⁱ	9606.ENSP00000233946

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	24 – 27	Combined sources	4
Beta strandⁱ	32 – 35	Combined sources	4
Beta strandⁱ	40 – 43	Combined sources	4
Helixⁱ	48 – 50	Combined sources	3
Beta strandⁱ	56 – 59	Combined sources	4
Beta strandⁱ	72 – 77	Combined sources	6
Beta strandⁱ	80 – 83	Combined sources	4
Helixⁱ	88 – 90	Combined sources	3
Beta strandⁱ	92 – 97	Combined sources	6
Beta strandⁱ	100 – 102	Combined sources	3
Beta strandⁱ	105 – 114	Combined sources	10
Beta strandⁱ	120 – 122	Combined sources	3
Helixⁱ	124 – 126	Combined sources	3
Beta strandⁱ	127 – 133	Combined sources	7
Beta strandⁱ	135 – 137	Combined sources	3
Beta strandⁱ	138 – 141	Combined sources	4
Helixⁱ	146 – 148	Combined sources	3
Turnⁱ	151 – 153	Combined sources	3
Beta strandⁱ	159 – 162	Combined sources	4
Beta strandⁱ	171 – 177	Combined sources	7
Beta strandⁱ	180 – 183	Combined sources	4
Helixⁱ	188 – 190	Combined sources	3
Beta strandⁱ	192 – 202	Combined sources	11
Beta strandⁱ	205 – 218	Combined sources	14
Beta strandⁱ	227 – 230	Combined sources	4
Beta strandⁱ	233 – 237	Combined sources	5
Beta strandⁱ	240 – 242	Combined sources	3
Beta strandⁱ	244 – 252	Combined sources	9
Beta strandⁱ	256 – 262	Combined sources	7
Beta strandⁱ	272 – 281	Combined sources	10
Helixⁱ	287 – 289	Combined sources	3
Beta strandⁱ	290 – 300	Combined sources	11
Helixⁱ	303 – 306	Combined sources	4
Beta strandⁱ	310 – 316	Combined sources	7
Beta strandⁱ	319 – 328	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	P14778
SMRⁱ	P14778
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P14778

EvolutionaryTraceⁱ

P14778

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	23 – 110	Ig-like C2-type 1Add BLAST	88
Domainⁱ	118 – 210	Ig-like C2-type 2Add BLAST	93
Domainⁱ	226 – 328	Ig-like C2-type 3Add BLAST	103
Domainⁱ	383 – 541	TIRPROSITE-ProRule annotationAdd BLAST	159

Sequence similaritiesⁱ

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IQBC Eukaryota ENOG410Z3W1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119071
HOGENOMⁱ	HOG000253916
HOVERGENⁱ	HBG052103
InParanoidⁱ	P14778
KEGG Orthology (KO) More...KOⁱ	K04386
OMAⁱ	AYIQLIH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03IT
PhylomeDBⁱ	P14778
TreeFamⁱ	TF325519

Family and domain databases

Gene3Dⁱ	2.60.40.10, 3 hits 3.40.50.10140, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR015621 IL-1_rcpt_fam IPR004076 IL-1_rcpt_I-typ IPR004074 IL-1_rcpt_I/II-typ IPR000157 TIR_dom IPR035897 Toll_tir_struct_dom_sf
PANTHERⁱ	PTHR11890 PTHR11890, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07679 I-set, 1 hit PF13895 Ig_2, 1 hit PF01582 TIR, 1 hit
PRINTSⁱ	PR01538 INTRLEUKN1R1 PR01536 INTRLKN1R12F
SMARTⁱ	View protein in SMART SM00409 IG, 3 hits SM00255 TIR, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 3 hits SSF52200 SSF52200, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 3 hits PS50104 TIR, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show all Align All

P14778-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKVLLRLICF IALLISSLEA DKCKEREEKI ILVSSANEID VRPCPLNPNE 
        60         70         80         90        100
HKGTITWYKD DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN 
       110        120        130        140        150
SSYCLRIKIS AKFVENEPNL CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN 
       160        170        180        190        200
ENNELPKLQW YKDCKPLLLD NIHFSGVKDR LIVMNVAEKH RGNYTCHASY 
       210        220        230        240        250
TYLGKQYPIT RVIEFITLEE NKPTRPVIVS PANETMEVDL GSQIQLICNV 
       260        270        280        290        300
TGQLSDIAYW KWNGSVIDED DPVLGEDYYS VENPANKRRS TLITVLNISE 
       310        320        330        340        350
IESRFYKHPF TCFAKNTHGI DAAYIQLIYP VTNFQKHMIG ICVTLTVIIV 
       360        370        380        390        400
CSVFIYKIFK IDIVLWYRDS CYDFLPIKAS DGKTYDAYIL YPKTVGEGST 
       410        420        430        440        450
SDCDIFVFKV LPEVLEKQCG YKLFIYGRDD YVGEDIVEVI NENVKKSRRL 
       460        470        480        490        500
IIILVRETSG FSWLGGSSEE QIAMYNALVQ DGIKVVLLEL EKIQDYEKMP 
       510        520        530        540        550
ESIKFIKQKH GAIRWSGDFT QGPQSAKTRF WKNVRYHMPV QRRSPSSKHQ 
       560 
LLSPATKEKL QREAHVPLG

Length:569

Mass (Da):65,402

Last modified:April 1, 1990 - v1

Checksum:ⁱ5BAA83F8F0225C25

GO

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B8ZZW4	B8ZZW4_HUMAN	Interleukin-1 receptor type 1 Interleukin-1 receptor type 1	IL1R1	538	Annotation score:
B8ZZ73	B8ZZ73_HUMAN	Interleukin-1 receptor type 1 Interleukin-1 receptor type 1	IL1R1	447	Annotation score:
C9J3W8	C9J3W8_HUMAN	Interleukin-1 receptor type 1 Interleukin-1 receptor type 1	IL1R1	298	Annotation score:
H7BZM5	H7BZM5_HUMAN	Interleukin-1 receptor type 1 Interleukin-1 receptor type 1	IL1R1	124	Annotation score:
C9JQ36	C9JQ36_HUMAN	Interleukin-1 receptor type 1 Interleukin-1 receptor type 1	IL1R1	182	Annotation score:
B9A040	B9A040_HUMAN	Interleukin-1 receptor type 1 Interleukin-1 receptor type 1	IL1R1	173	Annotation score:
C9JWB2	C9JWB2_HUMAN	Interleukin-1 receptor type 1 Interleukin-1 receptor type 1	IL1R1	114	Annotation score:
C9J686	C9J686_HUMAN	Interleukin-1 receptor type 1 Interleukin-1 receptor type 1	IL1R1	106	Annotation score:
F8WF92	F8WF92_HUMAN	Interleukin-1 receptor type 1 Interleukin-1 receptor type 1	IL1R1	119	Annotation score:
C9JW84	C9JW84_HUMAN	Interleukin-1 receptor type 1 Interleukin-1 receptor type 1	IL1R1	80	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_019131	124	A → G1 PublicationCorresponds to variant dbSNP:rs2228139Ensembl.		1
Natural variantⁱVAR_029189	344	T → M. Corresponds to variant dbSNP:rs28362304Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X16896 mRNA Translation: CAA34773.1 M27492 mRNA Translation: AAA59137.1 AF531102 Genomic DNA Translation: AAM88423.1 AC007271 Genomic DNA Translation: AAX81988.1 CH471127 Genomic DNA Translation: EAX01799.1 BC067506 mRNA Translation: AAH67506.1 BC075062 mRNA Translation: AAH75062.1 BC075063 mRNA Translation: AAH75063.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2055.1
PIRⁱ	A36187
NCBI Reference Sequences More...RefSeqⁱ	NP_000868.1, NM_000877.3 NP_001275635.1, NM_001288706.1 NP_001307907.1, NM_001320978.1 NP_001307909.1, NM_001320980.1 NP_001307910.1, NM_001320981.1 NP_001307911.1, NM_001320982.1 NP_001307912.1, NM_001320983.1 NP_001307913.1, NM_001320984.1 NP_001307914.1, NM_001320985.1 XP_005263987.1, XM_005263930.4 XP_005263991.1, XM_005263934.4 XP_011509417.1, XM_011511115.2 XP_011509418.1, XM_011511116.1 XP_011509419.1, XM_011511117.1 XP_011509420.1, XM_011511118.2 XP_016859478.1, XM_017003989.1
UniGeneⁱ	Hs.701982

Genome annotation databases

Ensemblⁱ	ENST00000410023; ENSP00000386380; ENSG00000115594
GeneIDⁱ	3554
KEGGⁱ	hsa:3554
UCSC genome browser More...UCSCⁱ	uc002tbq.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P14778	Interleukin-1 receptor type 1 (Fragment)		HUMAN		298	UniRef100_P14778
IL1R1 isoform 6 (Fragment)		PANTR		106
Interleukin-1 receptor type 1 (Fragment)		HUMAN		106
Interleukin-1 receptor type 1 (Fragment)		HUMAN		182
Interleukin-1 receptor type 1 (Fragment)		HUMAN		80
+7

Protein	Similar proteins		Species	Score	Length	Source
P14778	Interleukin-1 receptor type 1 (Fragment)		HUMAN		298	UniRef90_P14778
IL1R1 isoform 6 (Fragment)		PANTR		106
Uncharacterized protein		PAPAN		569
Interleukin-1 receptor type 1		CALJA		569
Interleukin 1 receptor type 1		SAIBB		569
+47

Protein	Similar proteins		Species	Score	Length	Source
P14778	Interleukin-1 receptor type 1 (Fragment)		HUMAN		298	UniRef50_P14778
IL1R1 isoform 6 (Fragment)		PANTR		106
Interleukin-1 receptor type 1		CALJA		569
Uncharacterized protein		MACMU		569
Uncharacterized protein		MACFA		569
+107

Cross-referencesⁱ

Web resourcesⁱ

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X16896 mRNA Translation: CAA34773.1 M27492 mRNA Translation: AAA59137.1 AF531102 Genomic DNA Translation: AAM88423.1 AC007271 Genomic DNA Translation: AAX81988.1 CH471127 Genomic DNA Translation: EAX01799.1 BC067506 mRNA Translation: AAH67506.1 BC075062 mRNA Translation: AAH75062.1 BC075063 mRNA Translation: AAH75063.1
CCDSⁱ	CCDS2055.1
PIRⁱ	A36187
RefSeqⁱ	NP_000868.1, NM_000877.3 NP_001275635.1, NM_001288706.1 NP_001307907.1, NM_001320978.1 NP_001307909.1, NM_001320980.1 NP_001307910.1, NM_001320981.1 NP_001307911.1, NM_001320982.1 NP_001307912.1, NM_001320983.1 NP_001307913.1, NM_001320984.1 NP_001307914.1, NM_001320985.1 XP_005263987.1, XM_005263930.4 XP_005263991.1, XM_005263934.4 XP_011509417.1, XM_011511115.2 XP_011509418.1, XM_011511116.1 XP_011509419.1, XM_011511117.1 XP_011509420.1, XM_011511118.2 XP_016859478.1, XM_017003989.1
UniGeneⁱ	Hs.701982

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1G0Y	X-ray	3.00	R	21-332	[»]
	1IRA	X-ray	2.70	Y	18-336	[»]
	1ITB	X-ray	2.50	B	18-332	[»]
	4DEP	X-ray	3.10	B/E	18-336	[»]
	4GAF	X-ray	2.15	B	18-336	[»]
ProteinModelPortalⁱ	P14778
SMRⁱ	P14778
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109770, 23 interactors
DIPⁱ	DIP-93N
IntActⁱ	P14778, 7 interactors
STRINGⁱ	9606.ENSP00000233946

Chemistry databases

ChEMBLⁱ	CHEMBL1959
DrugBankⁱ	DB00026 Anakinra DB05303 OMS-103HP DB05207 SD118
GuidetoPHARMACOLOGYⁱ	1734

Protein family/group databases

TCDBⁱ	8.A.23.1.11 the basigin (basigin) family

TCDBⁱ

8.A.23.1.11 the basigin (basigin) family

PTM databases

iPTMnetⁱ	P14778
PhosphoSitePlusⁱ	P14778

Polymorphism and mutation databases

BioMutaⁱ	IL1R1
DMDMⁱ	124308

Proteomic databases

MaxQBⁱ	P14778
PaxDbⁱ	P14778
PeptideAtlasⁱ	P14778
PRIDEⁱ	P14778
ProteomicsDBⁱ	53081

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000410023; ENSP00000386380; ENSG00000115594
GeneIDⁱ	3554
KEGGⁱ	hsa:3554
UCSCⁱ	uc002tbq.5 human

Organism-specific databases

CTDⁱ	3554
DisGeNETⁱ	3554
EuPathDBⁱ	HostDB:ENSG00000115594.11
GeneCardsⁱ	IL1R1
HGNCⁱ	HGNC:5993 IL1R1
HPAⁱ	CAB007779 HPA005823 HPA029560
MIMⁱ	147810 gene
neXtProtⁱ	NX_P14778
OpenTargetsⁱ	ENSG00000115594
PharmGKBⁱ	PA29809
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IQBC Eukaryota ENOG410Z3W1 LUCA
GeneTreeⁱ	ENSGT00760000119071
HOGENOMⁱ	HOG000253916
HOVERGENⁱ	HBG052103
InParanoidⁱ	P14778
KOⁱ	K04386
OMAⁱ	AYIQLIH
OrthoDBⁱ	EOG091G03IT
PhylomeDBⁱ	P14778
TreeFamⁱ	TF325519

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6783783 Interleukin-10 signaling R-HSA-9020702 Interleukin-1 signaling
SignaLinkⁱ	P14778
SIGNORⁱ	P14778

Miscellaneous databases

ChiTaRSⁱ	IL1R1 human
EvolutionaryTraceⁱ	P14778
GeneWikiⁱ	Interleukin_1_receptor,_type_I
GenomeRNAiⁱ	3554
Protein Ontology More...PROⁱ	PR:P14778
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000115594 Expressed in 228 organ(s), highest expression level in palpebral conjunctiva
CleanExⁱ	HS_IL1R1
ExpressionAtlasⁱ	P14778 baseline and differential
Genevisibleⁱ	P14778 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 3 hits 3.40.50.10140, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR015621 IL-1_rcpt_fam IPR004076 IL-1_rcpt_I-typ IPR004074 IL-1_rcpt_I/II-typ IPR000157 TIR_dom IPR035897 Toll_tir_struct_dom_sf
PANTHERⁱ	PTHR11890 PTHR11890, 1 hit
Pfamⁱ	View protein in Pfam PF07679 I-set, 1 hit PF13895 Ig_2, 1 hit PF01582 TIR, 1 hit
PRINTSⁱ	PR01538 INTRLEUKN1R1 PR01536 INTRLKN1R12F
SMARTⁱ	View protein in SMART SM00409 IG, 3 hits SM00255 TIR, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 3 hits SSF52200 SSF52200, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 3 hits PS50104 TIR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IL1R1_HUMAN
Accessionⁱ	P14778Primary (citable) accession number: P14778 Secondary accession number(s): Q587I7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	April 1, 1990
	Last modified:	November 7, 2018
	This is version 211 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniProtKB - P14778 (IL1R1_HUMAN)

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Interleukin-1 receptor type 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Plasma membrane

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ