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UniProtKB - P14775 (DHM2_METEA)
Protein
Methanol dehydrogenase [cytochrome c] subunit 2
Gene
moxI
Organism
Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (Methylobacterium extorquens)
Status
Functioni
Catalyzes the oxidation of primary alcohols including methanol.
Catalytic activityi
- a primary alcohol + 2 Fe(III)-[cytochrome cL] = an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H+1 PublicationEC:1.1.2.71 Publication
GO - Molecular functioni
- alcohol dehydrogenase (cytochrome c(L)) activity Source: UniProtKB-EC
- alcohol dehydrogenase (NAD+) activity Source: InterPro
GO - Biological processi
- methanol oxidation Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Methanol utilization |
Enzyme and pathway databases
BRENDAi | 1.1.2.7, 3296 |
Names & Taxonomyi
Protein namesi | Recommended name: Methanol dehydrogenase [cytochrome c] subunit 2 (EC:1.1.2.7)Alternative name(s): MDH small subunit beta MDH-associated peptide MEDH |
Gene namesi | Name:moxI Synonyms:mxaI Ordered Locus Names:MexAM1_META1p4535 |
Organismi | Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (Methylobacterium extorquens) |
Taxonomic identifieri | 272630 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Alphaproteobacteria › Hyphomicrobiales › Methylobacteriaceae › Methylorubrum › |
Proteomesi |
|
Subcellular locationi
Other locations
Other locations
- periplasmic space Source: UniProtKB-SubCell
Keywords - Cellular componenti
PeriplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Add BLAST | 22 | |
ChainiPRO_0000025569 | 23 – 96 | Methanol dehydrogenase [cytochrome c] subunit 2Add BLAST | 74 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 28 ↔ 34 | 1 Publication |
Keywords - PTMi
Disulfide bondInteractioni
Subunit structurei
Heterotetramer composed of 2 alpha and 2 beta subunits.
Protein-protein interaction databases
STRINGi | 272630.MexAM1_META1p4535 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P14775 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P14775 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 45 – 75 | DisorderedSequence analysisAdd BLAST | 31 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 47 – 75 | Basic and acidic residuesSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the methanol dehydrogenase subunit 2 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG5032TB9, Bacteria |
HOGENOMi | CLU_2356482_0_0_5 |
OMAi | PGNCWEP |
OrthoDBi | 2000979at2 |
Family and domain databases
Gene3Di | 4.10.160.10, 1 hit |
InterProi | View protein in InterPro IPR003420, Meth_DH_bsu IPR036557, Meth_DH_bsu_sf |
Pfami | View protein in Pfam PF02315, MDH, 1 hit |
PIRSFi | PIRSF029163, Meth_DH_beta, 1 hit |
SUPFAMi | SSF48666, SSF48666, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P14775-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKTTLIAAAI VALSGLAAPA LAYDGTKCKA AGNCWEPKPG FPEKIAGSKY
60 70 80 90
DPKHDPKELN KQADSIKQME ERNKKRVENF KKTGKFEYDV AKISAN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15792 Genomic DNA Translation: CAA33796.1 X07856 Genomic DNA Translation: CAA30705.1 CP001510 Genomic DNA Translation: ACS42166.1 |
RefSeqi | WP_003599120.1, NC_012808.1 |
Genome annotation databases
EnsemblBacteriai | ACS42166; ACS42166; MexAM1_META1p4535 |
KEGGi | mea:Mex_1p4535 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15792 Genomic DNA Translation: CAA33796.1 X07856 Genomic DNA Translation: CAA30705.1 CP001510 Genomic DNA Translation: ACS42166.1 |
RefSeqi | WP_003599120.1, NC_012808.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1H4I | X-ray | 1.94 | B/D | 23-96 | [»] | |
1H4J | X-ray | 3.00 | B/D/F/H | 23-96 | [»] | |
1W6S | X-ray | 1.20 | B/D | 23-96 | [»] | |
SMRi | P14775 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 272630.MexAM1_META1p4535 |
Genome annotation databases
EnsemblBacteriai | ACS42166; ACS42166; MexAM1_META1p4535 |
KEGGi | mea:Mex_1p4535 |
Phylogenomic databases
eggNOGi | ENOG5032TB9, Bacteria |
HOGENOMi | CLU_2356482_0_0_5 |
OMAi | PGNCWEP |
OrthoDBi | 2000979at2 |
Enzyme and pathway databases
BRENDAi | 1.1.2.7, 3296 |
Miscellaneous databases
EvolutionaryTracei | P14775 |
Family and domain databases
Gene3Di | 4.10.160.10, 1 hit |
InterProi | View protein in InterPro IPR003420, Meth_DH_bsu IPR036557, Meth_DH_bsu_sf |
Pfami | View protein in Pfam PF02315, MDH, 1 hit |
PIRSFi | PIRSF029163, Meth_DH_beta, 1 hit |
SUPFAMi | SSF48666, SSF48666, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DHM2_METEA | |
Accessioni | P14775Primary (citable) accession number: P14775 Secondary accession number(s): C5AQA6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families