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Entry version 192 (08 May 2019)
Sequence version 3 (01 Nov 1997)
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Protein

Platelet glycoprotein IX

Gene

GP9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.

Miscellaneous

Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBlood coagulation, Cell adhesion, Hemostasis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-430116 GP1b-IX-V activation signalling
R-HSA-75892 Platelet Adhesion to exposed collagen
R-HSA-76009 Platelet Aggregation (Plug Formation)

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P14770

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Platelet glycoprotein IX
Short name:
GP-IX
Short name:
GPIX
Alternative name(s):
Glycoprotein 9
CD_antigen: CD42a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GP9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4444 GP9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
173515 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P14770

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini17 – 147ExtracellularSequence analysisAdd BLAST131
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Topological domaini169 – 177CytoplasmicSequence analysis9

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Bernard-Soulier syndrome (BSS)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA coagulation disorder characterized by a prolonged bleeding time, unusually large platelets, thrombocytopenia, and impaired prothrombin consumption.
See also OMIM:231200
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0249967L → P in BSS. 1 PublicationCorresponds to variant dbSNP:rs121918038EnsemblClinVar.1
Natural variantiVAR_02499724C → R in BSS. 1 PublicationCorresponds to variant dbSNP:rs28933378EnsemblClinVar.1
Natural variantiVAR_00526337D → G in BSS. 1 PublicationCorresponds to variant dbSNP:rs121918036EnsemblClinVar.1
Natural variantiVAR_02499856L → P in BSS. 1 PublicationCorresponds to variant dbSNP:rs28933377EnsemblClinVar.1
Natural variantiVAR_00526461N → S in BSS. 1 PublicationCorresponds to variant dbSNP:rs5030764EnsemblClinVar.1
Natural variantiVAR_02499971F → S in BSS. 1 PublicationCorresponds to variant dbSNP:rs121918037EnsemblClinVar.1
Natural variantiVAR_025008113C → Y in BSS. 1 Publication1

Keywords - Diseasei

Bernard Soulier syndrome, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
2815

MalaCards human disease database

More...
MalaCardsi
GP9
MIMi231200 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000169704

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
274 Bernard-Soulier syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28825

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00468 Quinine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GP9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2822110

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 164 PublicationsAdd BLAST16
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002136017 – 177Platelet glycoprotein IXAdd BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P14770

PeptideAtlas

More...
PeptideAtlasi
P14770

PRoteomics IDEntifications database

More...
PRIDEi
P14770

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53080

2D gel databases

USC-OGP 2-DE database

More...
OGPi
P14770

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P14770

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P14770

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169704 Expressed in 49 organ(s), highest expression level in blood

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P14770 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA063182

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109077, 20 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-114 Glycoprotein Ib-IX-V complex
CPX-117 Glycoprotein Ib-IX-V-Filamin-A complex

Protein interaction database and analysis system

More...
IntActi
P14770, 8 interactors

Molecular INTeraction database

More...
MINTi
P14770

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000303942

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1177
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3REZX-ray2.35A/B/C/D45-52[»]
A/B/C/D65-76[»]
A/B/C/D92-102[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P14770

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 51LRRNTAdd BLAST35
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati60 – 83LRRAdd BLAST24
Domaini85 – 137LRRCTAdd BLAST53

Keywords - Domaini

Leucine-rich repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064244

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000089943

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P14770

KEGG Orthology (KO)

More...
KOi
K06263

Identification of Orthologs from Complete Genome Data

More...
OMAi
ILYLKLW

Database of Orthologous Groups

More...
OrthoDBi
1366218at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P14770

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR000372 LRRNT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 1 hit
PF01462 LRRNT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P14770-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAWGALFLL WATAEATKDC PSPCTCRALE TMGLWVDCRG HGLTALPALP
60 70 80 90 100
ARTRHLLLAN NSLQSVPPGA FDHLPQLQTL DVTQNPWHCD CSLTYLRLWL
110 120 130 140 150
EDRTPEALLQ VRCASPSLAA HGPLGRLTGY QLGSCGWQLQ ASWVRPGVLW
160 170
DVALVAVAAL GLALLAGLLC ATTEALD
Length:177
Mass (Da):19,046
Last modified:November 1, 1997 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A023B96C7854D59
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24 – 26CTC → LTT AA sequence (PubMed:3056407).Curated3
Sequence conflicti125Missing in AAA36809 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0249967L → P in BSS. 1 PublicationCorresponds to variant dbSNP:rs121918038EnsemblClinVar.1
Natural variantiVAR_02499724C → R in BSS. 1 PublicationCorresponds to variant dbSNP:rs28933378EnsemblClinVar.1
Natural variantiVAR_00526337D → G in BSS. 1 PublicationCorresponds to variant dbSNP:rs121918036EnsemblClinVar.1
Natural variantiVAR_02499856L → P in BSS. 1 PublicationCorresponds to variant dbSNP:rs28933377EnsemblClinVar.1
Natural variantiVAR_00526461N → S in BSS. 1 PublicationCorresponds to variant dbSNP:rs5030764EnsemblClinVar.1
Natural variantiVAR_02499971F → S in BSS. 1 PublicationCorresponds to variant dbSNP:rs121918037EnsemblClinVar.1
Natural variantiVAR_025008113C → Y in BSS. 1 Publication1
Natural variantiVAR_025009156A → T2 PublicationsCorresponds to variant dbSNP:rs3796130EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X52997 mRNA Translation: CAA37186.1
M80478 Genomic DNA Translation: AAB40042.1
M25827 mRNA Translation: AAA36809.1
BC030229 mRNA Translation: AAH30229.1
D88290 Genomic DNA Translation: BAA13580.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3055.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A46606

NCBI Reference Sequences

More...
RefSeqi
NP_000165.1, NM_000174.4
XP_005247431.1, XM_005247374.3
XP_011511003.1, XM_011512701.1
XP_011511004.1, XM_011512702.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000307395; ENSP00000303942; ENSG00000169704

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2815

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2815

UCSC genome browser

More...
UCSCi
uc003elm.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52997 mRNA Translation: CAA37186.1
M80478 Genomic DNA Translation: AAB40042.1
M25827 mRNA Translation: AAA36809.1
BC030229 mRNA Translation: AAH30229.1
D88290 Genomic DNA Translation: BAA13580.1
CCDSiCCDS3055.1
PIRiA46606
RefSeqiNP_000165.1, NM_000174.4
XP_005247431.1, XM_005247374.3
XP_011511003.1, XM_011512701.1
XP_011511004.1, XM_011512702.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3REZX-ray2.35A/B/C/D45-52[»]
A/B/C/D65-76[»]
A/B/C/D92-102[»]
SMRiP14770
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109077, 20 interactors
ComplexPortaliCPX-114 Glycoprotein Ib-IX-V complex
CPX-117 Glycoprotein Ib-IX-V-Filamin-A complex
IntActiP14770, 8 interactors
MINTiP14770
STRINGi9606.ENSP00000303942

Chemistry databases

DrugBankiDB00468 Quinine

PTM databases

iPTMnetiP14770
PhosphoSitePlusiP14770

Polymorphism and mutation databases

BioMutaiGP9
DMDMi2822110

2D gel databases

OGPiP14770

Proteomic databases

PaxDbiP14770
PeptideAtlasiP14770
PRIDEiP14770
ProteomicsDBi53080

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2815
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307395; ENSP00000303942; ENSG00000169704
GeneIDi2815
KEGGihsa:2815
UCSCiuc003elm.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2815
DisGeNETi2815

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GP9
HGNCiHGNC:4444 GP9
HPAiHPA063182
MalaCardsiGP9
MIMi173515 gene
231200 phenotype
neXtProtiNX_P14770
OpenTargetsiENSG00000169704
Orphaneti274 Bernard-Soulier syndrome
PharmGKBiPA28825

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00530000064244
HOGENOMiHOG000089943
InParanoidiP14770
KOiK06263
OMAiILYLKLW
OrthoDBi1366218at2759
PhylomeDBiP14770

Enzyme and pathway databases

ReactomeiR-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-430116 GP1b-IX-V activation signalling
R-HSA-75892 Platelet Adhesion to exposed collagen
R-HSA-76009 Platelet Aggregation (Plug Formation)
SIGNORiP14770

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Glycoprotein_IX

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2815

Protein Ontology

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PROi
PR:P14770

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000169704 Expressed in 49 organ(s), highest expression level in blood
GenevisibleiP14770 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGPIX_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14770
Secondary accession number(s): Q14445, Q8N1D1, Q92525
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 1, 1997
Last modified: May 8, 2019
This is version 192 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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