UniProtKB - P14745 (CD44_PAPHA)
CD44 antigen
CD44
Functioni
Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 41 | HyaluronanBy similarity | 1 | |
Binding sitei | 78 | HyaluronanBy similarity | 1 | |
Binding sitei | 79 | HyaluronanBy similarity | 1 | |
Binding sitei | 105 | HyaluronanBy similarity | 1 |
GO - Molecular functioni
- hyaluronic acid binding Source: InterPro
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- regulation of lamellipodium morphogenesis Source: UniProtKB
- wound healing, spreading of cells Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Biological process | Cell adhesion |
Names & Taxonomyi
Protein namesi | Recommended name: CD44 antigenAlternative name(s): Extracellular matrix receptor III Short name: ECMR-III GP90 lymphocyte homing/adhesion receptor HUTCH-I Hermes antigen Hyaluronate receptor Phagocytic glycoprotein 1 Short name: PGP-1 Phagocytic glycoprotein I Short name: PGP-I CD_antigen: CD44 |
Gene namesi | Name:CD44 |
Organismi | Papio hamadryas (Hamadryas baboon) |
Taxonomic identifieri | 9557 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Papio |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Other locations
- microvillus By similarity
Note: Colocalizes with actin in membrane protrusions at wounding edges. Co-localizes with RDX, EZR and MSN in microvilli.By similarity
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- lamellipodium membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- cell projection Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- microvillus Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 269 | ExtracellularSequence analysisAdd BLAST | 249 | |
Transmembranei | 270 – 290 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 291 – 362 | CytoplasmicSequence analysisAdd BLAST | 72 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | By similarityAdd BLAST | 20 | |
ChainiPRO_0000026690 | 21 – 362 | CD44 antigenAdd BLAST | 342 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 25 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 28 ↔ 129 | PROSITE-ProRule annotation | ||
Disulfide bondi | 53 ↔ 118 | PROSITE-ProRule annotation | ||
Glycosylationi | 57 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 77 ↔ 97 | PROSITE-ProRule annotation | ||
Glycosylationi | 100 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 110 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 120 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 256 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 292 | Phosphoserine; by PKCBy similarity | 1 | |
Modified residuei | 317 | PhosphoserineBy similarity | 1 | |
Modified residuei | 326 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, ProteoglycanInteractioni
Subunit structurei
Interacts with PKN2 (By similarity).
Interacts with TIAM1 and TIAM2 (By similarity).
Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment.
Interacts with UNC119.
Interacts with PDPN (via extracellular domain); this interaction is required for PDPN-mediated directional migration and regulation of lamellipodia extension/stabilization during cell spreading and migration (By similarity).
Interacts with RDX, EZR and MSN (By similarity).
Interacts with EGFR (By similarity).
Interacts with CD74; this complex is essential for the MIF-induced signaling cascade that results in B cell survival (By similarity).
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 120 | LinkPROSITE-ProRule annotationAdd BLAST | 89 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 160 – 186 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 201 – 261 | DisorderedSequence analysisAdd BLAST | 61 | |
Regioni | 225 – 269 | StemAdd BLAST | 45 | |
Regioni | 293 – 311 | Required for interaction with EZR, MSN and RDX and for co-localization to microvilliBy similarityAdd BLAST | 19 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 165 – 186 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 230 – 261 | Polar residuesSequence analysisAdd BLAST | 32 |
Domaini
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR001231, CD44_antigen IPR043210, CD44_antigen-like IPR016187, CTDL_fold IPR000538, Link_dom |
PANTHERi | PTHR10225, PTHR10225, 2 hits PTHR10225:SF6, PTHR10225:SF6, 2 hits |
Pfami | View protein in Pfam PF00193, Xlink, 1 hit |
PRINTSi | PR00658, CD44 PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00445, LINK, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS01241, LINK_1, 1 hit PS50963, LINK_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MDKFWWRAAW GLCLVQLSLA QIDLNITCRF EGIYHVEKNG RYSISRTEAA
60 70 80 90 100
DLCKAFNSTL PTMAQMEKAL SIGFETCRYG FIEGHVVIPR IHPNSICAAN
110 120 130 140 150
NTGVYILTSN TSQYDTYCFN ASAPPGEDCT SVTDLPNAFD GPITITIVNR
160 170 180 190 200
DGTRYVKKGE YRTNPEDINP SSPTDDDVSS GSSSERSSTL GGYIFYNHFS
210 220 230 240 250
TSPPIPDEDG PWITDSTDRT PATRDQGAFD PSGGSHTTHG SESAGHSHGS
260 270 280 290 300
REGGANTTSG PLRTPQIPEW LIILASLLAL ALILAVCIAV NSRRRCGQKK
310 320 330 340 350
KLVINNGNGA VEDRKSSGLN GEASKSQEMV HLVNKESSET PDQFMTADET
360
RNLQNVDMKI GV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 67 | E → V AA sequence (PubMed:2471974).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22452 mRNA Translation: AAA35385.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22452 mRNA Translation: AAA35385.1 |
3D structure databases
SMRi | P14745 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR001231, CD44_antigen IPR043210, CD44_antigen-like IPR016187, CTDL_fold IPR000538, Link_dom |
PANTHERi | PTHR10225, PTHR10225, 2 hits PTHR10225:SF6, PTHR10225:SF6, 2 hits |
Pfami | View protein in Pfam PF00193, Xlink, 1 hit |
PRINTSi | PR00658, CD44 PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00445, LINK, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS01241, LINK_1, 1 hit PS50963, LINK_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CD44_PAPHA | |
Accessioni | P14745Primary (citable) accession number: P14745 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | September 29, 2021 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |