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Entry version 137 (16 Oct 2019)
Sequence version 1 (01 Apr 1990)
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Protein

Fibronectin-binding protein A

Gene

fnbA

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possesses multiple, substituting fibronectin (Fn) binding regions, each capable of conferring adherence to both soluble and immobilized forms of Fn. This confers to S.aureus the ability to invade endothelial cells both in vivo and in vitro, without requiring additional factors, although in a slow and inefficient way through actin rearrangements in host cells. This invasion process is mediated by integrin alpha-5/beta-1. Promotes bacterial attachment to both soluble and immobilized forms of fibrinogen (Fg) by means of a unique binding site localized within the 17 C-terminal residues of the gamma-chain of human Fg. Both plasma proteins (Fn and Fg) function as a bridge between bacterium and host cell. Promotes attachment to immobilized elastin peptides in a dose-dependent and saturable manner. Promotes attachment to both full-length and segments of immobilized human tropoelastin at multiple sites in a dose and pH-dependent manner. Promotes adherence to and aggregation of activated platelets independently of other S.aureus surface molecules. Is a critical mediator implicated in the induction of experimental endocarditis in rats with catheter-induced aortic vegetations, promoting both colonization and persistence of the bacterium into the host.8 Publications

Miscellaneous

Fg-binding activity is not regulated by the divalent cations Ca2+, Mn2+ or Mg2+.
Deletion of the Fg-binding domain of FnbA abrogates the ability to promote cardiac valve infection and persistence in vivo.
The mutagenesis studies described in PubMed:17302800 were done with region A alone and not with the entire protein.
Mutants lacking C-terminal residues from the ligand binding A region bind to Fg with a reduced affinity or are unable to bind to both Fg and elastin, depending on the extension of the deletion present in this region. Individual constructs of regions spanning amino acids from 194-336 or 337-511 were unable to bind fibrinogen or elastin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • fibrinogen binding Source: CAFA
  • fibronectin binding Source: CAFA

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Virulence

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
GCF_000013425:G1I0R-2641-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibronectin-binding protein A
Short name:
FnbpA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fnbA
Ordered Locus Names:SAOUHSC_02803
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStaphylococcus aureus (strain NCTC 8325)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri93061 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008816 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell wall, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi222G → A: No change in elastin or fibrinogen binding. 1 Publication1
Mutagenesisi224R → A: Significant reduction in fibrinogen and elastin binding. 1 Publication1
Mutagenesisi304N → A: Significant reduction in fibrinogen and elastin binding. 1 Publication1
Mutagenesisi306F → A: Significant reduction in fibrinogen and elastin binding. 1 Publication1
Mutagenesisi354T → A: Small reduction in fibrinogen binding and greater reduction in elastin binding; when associated with G-356. 1 Publication1
Mutagenesisi355F → A: No reduction in elastin binding. Significant reduction in fibrinogen binding. 1 Publication1
Mutagenesisi356N → G: Small reduction in fibrinogen binding and greater reduction in elastin binding; when associated with A-354. 1 Publication1
Mutagenesisi357K → A: No reduction in elastin binding. Significant reduction in fibrinogen binding. 1 Publication1
Mutagenesisi415A → G: Significant reduction in fibrinogen and elastin binding; when associated with A-417. 1 Publication1
Mutagenesisi417T → A: Significant reduction in fibrinogen and elastin binding; when associated with G-415. 1 Publication1
Mutagenesisi484 – 511Missing : Abolishes interaction with elastin and fibrinogen. 1 PublicationAdd BLAST28
Mutagenesisi497G → A: Significant reduction in fibrinogen and elastin binding. 1 Publication1
Mutagenesisi498L → A: Significant reduction in fibrinogen and elastin binding. 1 Publication1
Mutagenesisi499 – 511Missing : Abolishes interaction with elastin and fibrinogen. 1 PublicationAdd BLAST13
Mutagenesisi510 – 511Missing : No change in elastin binding. Impairs fibrinogen binding. 1 Publication2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 36Add BLAST36
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000560537 – 985Fibronectin-binding protein AAdd BLAST949
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000005606986 – 1018Removed by sortasePROSITE-ProRule annotation2 PublicationsAdd BLAST33

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei985Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchor

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P14738

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expressed predominantly on cells from early exponential phase of growth. Up-regulated by sigma-B factor during early growth stages but not in later stages, although this positive effect on transcription is most probably indirect. Up-regulated by SarA. Down-regulated by Agr.3 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P0275123EBI-8398157,EBI-1220319From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-46263N

Protein interaction database and analysis system

More...
IntActi
P14738, 1 interactor

Molecular INTeraction database

More...
MINTi
P14738

STRING: functional protein association networks

More...
STRINGi
1280.SAXN108_2750

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11018
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P14738

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P14738

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati545 – 574B-1Add BLAST30
Repeati575 – 604B-2Add BLAST30
Repeati745 – 782D-1Add BLAST38
Repeati783 – 820D-2Add BLAST38
Repeati821 – 859D-3Add BLAST39
Repeati860 – 878D-4; truncatedAdd BLAST19
Repeati879 – 892WR 1Add BLAST14
Repeati893 – 906WR 2Add BLAST14
Repeati907 – 920WR 3Add BLAST14
Repeati921 – 934WR 4Add BLAST14
Repeati935 – 948WR 5Add BLAST14

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni37 – 511Ligand-binding A regionAdd BLAST475
Regioni194 – 511Fibrinogen/elastin/tropoelastin-bindingAdd BLAST318
Regioni512 – 872Fibronectin-bindingAdd BLAST361
Regioni545 – 6042 X approximate tandem repeatsAdd BLAST60
Regioni745 – 8784 X approximate tandem repeats, D-3 repeat has more fibronectin-binding activityAdd BLAST134
Regioni879 – 9485 X tandem repeats, Pro-rich (WR)Add BLAST70

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi7 – 18YSIRK-G/S signaling motifCuratedAdd BLAST12
Motifi982 – 986LPXTG sorting signalPROSITE-ProRule annotation5

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG41078HS Bacteria
ENOG410XV8D LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000280272

KEGG Orthology (KO)

More...
KOi
K13732

Family and domain databases

Database of protein disorder

More...
DisProti
DP00025

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1280, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011266 Adhesin_Fg-bd_dom_2
IPR008966 Adhesion_dom_sf
IPR011252 Fibrogen-bd_dom1
IPR004237 Fibron_repeat-bd
IPR019948 Gram-positive_anchor
IPR019931 LPXTG_anchor
IPR041171 SDR_Ig
IPR005877 YSIRK_signal_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17961 Big_8, 1 hit
PF02986 Fn_bind, 3 hits
PF00746 Gram_pos_anchor, 1 hit
PF10425 SdrG_C_C, 1 hit
PF04650 YSIRK_signal, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49401 SSF49401, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01168 YSIRK_signal, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50847 GRAM_POS_ANCHORING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P14738-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNNLRYGIR KHKLGAASVF LGTMIVVGMG QDKEAAASEQ KTTTVEENGN
60 70 80 90 100
SATDNKTSET QTTATNVNHI EETQSYNATV TEQPSNATQV TTEEAPKAVQ
110 120 130 140 150
APQTAQPANI ETVKEEVVKE EAKPQVKETT QSQDNSGDQR QVDLTPKKAT
160 170 180 190 200
QNQVAETQVE VAQPRTASES KPRVTRSADV AEAKEASNAK VETGTDVTSK
210 220 230 240 250
VTVEIGSIEG HNNTNKVEPH AGQRAVLKYK LKFENGLHQG DYFDFTLSNN
260 270 280 290 300
VNTHGVSTAR KVPEIKNGSV VMATGEVLEG GKIRYTFTND IEDKVDVTAE
310 320 330 340 350
LEINLFIDPK TVQTNGNQTI TSTLNEEQTS KELDVKYKDG IGNYYANLNG
360 370 380 390 400
SIETFNKANN RFSHVAFIKP NNGKTTSVTV TGTLMKGSNQ NGNQPKVRIF
410 420 430 440 450
EYLGNNEDIA KSVYANTTDT SKFKEVTSNM SGNLNLQNNG SYSLNIENLD
460 470 480 490 500
KTYVVHYDGE YLNGTDEVDF RTQMVGHPEQ LYKYYYDRGY TLTWDNGLVL
510 520 530 540 550
YSNKANGNEK NGPIIQNNKF EYKEDTIKET LTGQYDKNLV TTVEEEYDSS
560 570 580 590 600
TLDIDYHTAI DGGGGYVDGY IETIEETDSS AIDIDYHTAV DSEAGHVGGY
610 620 630 640 650
TESSEESNPI DFEESTHENS KHHADVVEYE EDTNPGGGQV TTESNLVEFD
660 670 680 690 700
EESTKGIVTG AVSDHTTVED TKEYTTESNL IELVDELPEE HGQAQGPVEE
710 720 730 740 750
ITKNNHHISH SGLGTENGHG NYDVIEEIEE NSHVDIKSEL GYEGGQNSGN
760 770 780 790 800
QSFEEDTEED KPKYEQGGNI VDIDFDSVPQ IHGQNKGNQS FEEDTEKDKP
810 820 830 840 850
KYEHGGNIID IDFDSVPHIH GFNKHTEIIE EDTNKDKPSY QFGGHNSVDF
860 870 880 890 900
EEDTLPKVSG QNEGQQTIEE DTTPPIVPPT PPTPEVPSEP ETPTPPTPEV
910 920 930 940 950
PSEPETPTPP TPEVPSEPET PTPPTPEVPA EPGKPVPPAK EEPKKPSKPV
960 970 980 990 1000
EQGKVVTPVI EINEKVKAVA PTKKPQSKKS ELPETGGEES TNKGMLFGGL
1010
FSILGLALLR RNKKNHKA
Length:1,018
Mass (Da):111,780
Last modified:April 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58175E0020E81F1F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ABD31806 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J04151 Genomic DNA Translation: AAA26632.1
CP000253 Genomic DNA Translation: ABD31806.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
WP_000794582.1, NZ_LS483365.1
YP_501262.1, NC_007795.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABD31806; ABD31806; SAOUHSC_02803

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3921457

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sao:SAOUHSC_02803

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|93061.5.peg.2536

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04151 Genomic DNA Translation: AAA26632.1
CP000253 Genomic DNA Translation: ABD31806.1 Different initiation.
RefSeqiWP_000794582.1, NZ_LS483365.1
YP_501262.1, NC_007795.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RKYX-ray1.80B/D508-530[»]
2RKZX-ray2.00M/N/O/P/Q/R529-549[»]
2RL0X-ray2.00C/E/G/H/J/L638-655[»]
3CALX-ray1.70B/D655-672[»]
4B5ZX-ray2.20A189-505[»]
4B60X-ray1.83A/B189-505[»]
SMRiP14738
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-46263N
IntActiP14738, 1 interactor
MINTiP14738
STRINGi1280.SAXN108_2750

Proteomic databases

PRIDEiP14738

Genome annotation databases

EnsemblBacteriaiABD31806; ABD31806; SAOUHSC_02803
GeneIDi3921457
KEGGisao:SAOUHSC_02803
PATRICifig|93061.5.peg.2536

Phylogenomic databases

eggNOGiENOG41078HS Bacteria
ENOG410XV8D LUCA
HOGENOMiHOG000280272
KOiK13732

Enzyme and pathway databases

BioCyciGCF_000013425:G1I0R-2641-MONOMER

Miscellaneous databases

EvolutionaryTraceiP14738

Protein Ontology

More...
PROi
PR:P14738

Family and domain databases

DisProtiDP00025
Gene3Di2.60.40.1280, 1 hit
InterProiView protein in InterPro
IPR011266 Adhesin_Fg-bd_dom_2
IPR008966 Adhesion_dom_sf
IPR011252 Fibrogen-bd_dom1
IPR004237 Fibron_repeat-bd
IPR019948 Gram-positive_anchor
IPR019931 LPXTG_anchor
IPR041171 SDR_Ig
IPR005877 YSIRK_signal_dom
PfamiView protein in Pfam
PF17961 Big_8, 1 hit
PF02986 Fn_bind, 3 hits
PF00746 Gram_pos_anchor, 1 hit
PF10425 SdrG_C_C, 1 hit
PF04650 YSIRK_signal, 1 hit
SUPFAMiSSF49401 SSF49401, 2 hits
TIGRFAMsiTIGR01168 YSIRK_signal, 1 hit
PROSITEiView protein in PROSITE
PS50847 GRAM_POS_ANCHORING, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFNBA_STAA8
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14738
Secondary accession number(s): Q2G1T8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 16, 2019
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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