UniProtKB - P14734 (FKH_DROME)
Protein
Protein fork head
Gene
fkh
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Fkh promotes terminal as opposed to segmental development. In the absence of fkh, this developmental switch does not occur. The nuclear localization of the fkh protein suggest that fkh regulates the transcription of other, subordinate, genes.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 209 – 300 | Fork-headPROSITE-ProRule annotationAdd BLAST | 92 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: FlyBase
- protein domain specific binding Source: InterPro
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: FlyBase
- transcription factor binding Source: InterPro
GO - Biological processi
- anatomical structure morphogenesis Source: GO_Central
- cell differentiation Source: GO_Central
- determination of adult lifespan Source: FlyBase
- DNA endoreduplication Source: FlyBase
- ecdysone-mediated induction of salivary gland cell autophagic cell death Source: FlyBase
- endoderm formation Source: FlyBase
- insulin receptor signaling pathway Source: FlyBase
- Malpighian tubule morphogenesis Source: FlyBase
- negative regulation of apoptotic process Source: FlyBase
- negative regulation of cell growth Source: FlyBase
- negative regulation of multicellular organism growth Source: FlyBase
- negative regulation of programmed cell death Source: FlyBase
- negative regulation of transcription by RNA polymerase II Source: FlyBase
- neuroendocrine cell differentiation Source: FlyBase
- positive regulation of transcription by RNA polymerase II Source: FlyBase
- regulation of transcription by RNA polymerase II Source: FlyBase
- salivary gland development Source: FlyBase
- salivary gland morphogenesis Source: FlyBase
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-DME-9018519, Estrogen-dependent gene expression |
SignaLinki | P14734 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein fork head |
Gene namesi | Name:fkh ORF Names:CG10002 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0000659, fkh |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: FlyBase
Other locations
- polytene chromosome Source: FlyBase
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000091896 | 1 – 510 | Protein fork headAdd BLAST | 510 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 187 | Phosphoserine1 Publication | 1 | |
Modified residuei | 190 | Phosphoserine1 Publication | 1 | |
Modified residuei | 320 | Phosphoserine1 Publication | 1 | |
Modified residuei | 322 | Phosphoserine1 Publication | 1 | |
Modified residuei | 330 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P14734 |
PTM databases
iPTMneti | P14734 |
Expressioni
Gene expression databases
Bgeei | FBgn0000659, Expressed in digestive system element and 87 other tissues |
ExpressionAtlasi | P14734, baseline and differential |
Genevisiblei | P14734, DM |
Interactioni
GO - Molecular functioni
- protein domain specific binding Source: InterPro
- transcription factor binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 68259, 24 interactors |
DIPi | DIP-17045N |
IntActi | P14734, 5 interactors |
STRINGi | 7227.FBpp0289487 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 21 – 40 | Gly-richAdd BLAST | 20 | |
Compositional biasi | 340 – 356 | His-richAdd BLAST | 17 |
Phylogenomic databases
eggNOGi | KOG3563, Eukaryota |
GeneTreei | ENSGT00940000155999 |
HOGENOMi | CLU_027910_4_1_1 |
InParanoidi | P14734 |
OMAi | CMSAVGY |
OrthoDBi | 1181467at2759 |
PhylomeDBi | P14734 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR013638, Fork-head_N IPR001766, Fork_head_dom IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF08430, Forkhead_N, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P14734-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQKLYAEPPP SSAPVSMASS GGGGPPSGGG GGGGGGGGGG PPPPSNNNPN
60 70 80 90 100
PTSNGGSMSP LARSAYTMNS MGLPVGGMSS VSPQAAATFS SSVLDSAAAV
110 120 130 140 150
ASMSASMSAS MSASMNASMN GSMGAAAMNS MGGNCMTPSS MSYASMGSPL
160 170 180 190 200
GNMGGCMAMS AASMSAAGLS GTYGAMPPGS REMETGSPNS LGRSRVDKPT
210 220 230 240 250
TYRRSYTHAK PPYSYISLIT MAIQNNPTRM LTLSEIYQFI MDLFPFYRQN
260 270 280 290 300
QQRWQNSIRH SLSFNDCFVK IPRTPDKPGK GSFWTLHPDS GNMFENGCYL
310 320 330 340 350
RRQKRFKDEK KEAIRQLHKS PSHSSLEATS PGKKDHEDSH HMHHHHHSRL
360 370 380 390 400
DHHQHHKEAG GASIAGVNVL SAAHSKDAEA LAMLHANAEL CLSQQPQHVP
410 420 430 440 450
THHHHQHHQL QQEELSAMMA NRCHPSLITD YHSSMHPLKQ EPSGYTPSSH
460 470 480 490 500
PFSINRLLPT ESKADIKMYD MSQYAGYNAL SPLTNSHAAL GQDSYYQSLG
510
YHAPAGTTSL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE1JJ07 | E1JJ07_DROME | FI21540p1 | fkh dFoxA, Dm-FoxA, Dmel\CG10002, Dmfkh, FKH | 510 | Annotation score: | ||
A0A0B4KHC0 | A0A0B4KHC0_DROME | Fork head, isoform C | fkh dFoxA, Dm-FoxA, Dmel\CG10002, Dmfkh, FKH | 692 | Annotation score: | ||
A0A126GV17 | A0A126GV17_DROME | Fork head, isoform E | fkh dFoxA, Dm-FoxA, Dmel\CG10002, Dmfkh, FKH | 518 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03177 Genomic DNA Translation: AAA28535.1 AE014297 Genomic DNA Translation: AAF56798.1 |
PIRi | A32380 |
RefSeqi | NP_001163762.1, NM_001170291.1 NP_001287574.1, NM_001300645.1 NP_524542.1, NM_079818.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0085321; FBpp0084690; FBgn0000659 FBtr0300259; FBpp0289487; FBgn0000659 FBtr0345227; FBpp0311419; FBgn0000659 |
GeneIDi | 43383 |
KEGGi | dme:Dmel_CG10002 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03177 Genomic DNA Translation: AAA28535.1 AE014297 Genomic DNA Translation: AAF56798.1 |
PIRi | A32380 |
RefSeqi | NP_001163762.1, NM_001170291.1 NP_001287574.1, NM_001300645.1 NP_524542.1, NM_079818.3 |
3D structure databases
SMRi | P14734 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 68259, 24 interactors |
DIPi | DIP-17045N |
IntActi | P14734, 5 interactors |
STRINGi | 7227.FBpp0289487 |
PTM databases
iPTMneti | P14734 |
Proteomic databases
PaxDbi | P14734 |
Genome annotation databases
EnsemblMetazoai | FBtr0085321; FBpp0084690; FBgn0000659 FBtr0300259; FBpp0289487; FBgn0000659 FBtr0345227; FBpp0311419; FBgn0000659 |
GeneIDi | 43383 |
KEGGi | dme:Dmel_CG10002 |
Organism-specific databases
CTDi | 43383 |
FlyBasei | FBgn0000659, fkh |
Phylogenomic databases
eggNOGi | KOG3563, Eukaryota |
GeneTreei | ENSGT00940000155999 |
HOGENOMi | CLU_027910_4_1_1 |
InParanoidi | P14734 |
OMAi | CMSAVGY |
OrthoDBi | 1181467at2759 |
PhylomeDBi | P14734 |
Enzyme and pathway databases
Reactomei | R-DME-9018519, Estrogen-dependent gene expression |
SignaLinki | P14734 |
Miscellaneous databases
BioGRID-ORCSi | 43383, 0 hits in 3 CRISPR screens |
GenomeRNAii | 43383 |
PROi | PR:P14734 |
Gene expression databases
Bgeei | FBgn0000659, Expressed in digestive system element and 87 other tissues |
ExpressionAtlasi | P14734, baseline and differential |
Genevisiblei | P14734, DM |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR013638, Fork-head_N IPR001766, Fork_head_dom IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF08430, Forkhead_N, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FKH_DROME | |
Accessioni | P14734Primary (citable) accession number: P14734 Secondary accession number(s): Q9VAV0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | February 10, 2021 | |
This is version 189 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase