Protein fork head

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity, RNA polymerase II-specific Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2."
    Abrams E.W., Mihoulides W.K., Andrew D.J.
    Development 133:3517-3527(2006) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: InterPro
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: FlyBaseInferred from direct assayⁱ
  • "Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2."
    Abrams E.W., Mihoulides W.K., Andrew D.J.
    Development 133:3517-3527(2006) [PubMed] [Europe PMC] [Abstract]
  • "Ecdysone regulation of the Drosophila Sgs-4 gene is mediated by the synergistic action of ecdysone receptor and SEBP 3."
    Lehmann M., Korge G.
    EMBO J 14:716-726(1995) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• anatomical structure morphogenesis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• determination of adult lifespan Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity."
    Bolukbasi E., Khericha M., Regan J.C., Ivanov D.K., Adcott J., Dyson M.C., Nespital T., Thornton J.M., Alic N., Partridge L.
    Cell Rep 21:641-653(2017) [PubMed] [Europe PMC] [Abstract]
• DNA endoreduplication Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Genome-wide analysis reveals a major role in cell fate maintenance and an unexpected role in endoreduplication for the Drosophila FoxA gene Fork head."
    Maruyama R., Grevengoed E., Stempniewicz P., Andrew D.J.
    PLoS One 6:e20901-e20901(2011) [PubMed] [Europe PMC] [Abstract]
• ecdysone-mediated induction of salivary gland cell autophagic cell death Source: FlyBaseInferred from direct assayⁱ
  • "Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death."
    Cao C., Liu Y., Lehmann M.
    J Cell Biol 176:843-852(2007) [PubMed] [Europe PMC] [Abstract]
• endoderm formation Source: FlyBase <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "A glimpse into the molecular entrails of endoderm formation."
    Stainier D.Y.
    Genes Dev 16:893-907(2002) [PubMed] [Europe PMC] [Abstract]
• insulin receptor signaling pathway Source: FlyBaseInferred from direct assayⁱ
  • "Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity."
    Bolukbasi E., Khericha M., Regan J.C., Ivanov D.K., Adcott J., Dyson M.C., Nespital T., Thornton J.M., Alic N., Partridge L.
    Cell Rep 21:641-653(2017) [PubMed] [Europe PMC] [Abstract]
• Malpighian tubule morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Genome-wide analysis reveals a major role in cell fate maintenance and an unexpected role in endoreduplication for the Drosophila FoxA gene Fork head."
    Maruyama R., Grevengoed E., Stempniewicz P., Andrew D.J.
    PLoS One 6:e20901-e20901(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Fork head prevents apoptosis and promotes cell shape change during formation of the Drosophila salivary glands."
    Myat M.M., Andrew D.J.
    Development 127:4217-4226(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell growth Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycin."
    Bulow M.H., Aebersold R., Pankratz M.J., Junger M.A.
    PLoS One 5:e15171-e15171(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of multicellular organism growth Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycin."
    Bulow M.H., Aebersold R., Pankratz M.J., Junger M.A.
    PLoS One 5:e15171-e15171(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of programmed cell death Source: FlyBaseInferred from direct assayⁱ
  • "Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death."
    Cao C., Liu Y., Lehmann M.
    J Cell Biol 176:843-852(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: FlyBaseTraceable author statementⁱ
  • "Organ formation in Drosophila: specification and morphogenesis of the salivary gland."
    Bradley P.L., Haberman A.S., Andrew D.J.
    Bioessays 23:901-911(2001) [PubMed] [Europe PMC] [Abstract]
• neuroendocrine cell differentiation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Postmitotic specification of Drosophila insulinergic neurons from pioneer neurons."
    Miguel-Aliaga I., Thor S., Gould A.P.
    PLoS Biol 6:e58-e58(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: FlyBaseInferred from direct assayⁱ
  • "Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2."
    Abrams E.W., Mihoulides W.K., Andrew D.J.
    Development 133:3517-3527(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Genes and biological processes controlled by the Drosophila FOXA orthologue Fork head."
    Liu Y., Lehmann M.
    Insect Mol Biol 17:91-101(2008) [PubMed] [Europe PMC] [Abstract]
• salivary gland development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "CrebA regulates secretory activity in the Drosophila salivary gland and epidermis."
    Abrams E.W., Andrew D.J.
    Development 132:2743-2758(2005) [PubMed] [Europe PMC] [Abstract]
  • "Genome-wide analysis reveals a major role in cell fate maintenance and an unexpected role in endoreduplication for the Drosophila FoxA gene Fork head."
    Maruyama R., Grevengoed E., Stempniewicz P., Andrew D.J.
    PLoS One 6:e20901-e20901(2011) [PubMed] [Europe PMC] [Abstract]
• salivary gland morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Fork head prevents apoptosis and promotes cell shape change during formation of the Drosophila salivary glands."
    Myat M.M., Andrew D.J.
    Development 127:4217-4226(2000) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• protein domain specific binding Source: InterPro

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MQKLYAEPPP SSAPVSMASS GGGGPPSGGG GGGGGGGGGG PPPPSNNNPN 
        60         70         80         90        100
PTSNGGSMSP LARSAYTMNS MGLPVGGMSS VSPQAAATFS SSVLDSAAAV 
       110        120        130        140        150
ASMSASMSAS MSASMNASMN GSMGAAAMNS MGGNCMTPSS MSYASMGSPL 
       160        170        180        190        200
GNMGGCMAMS AASMSAAGLS GTYGAMPPGS REMETGSPNS LGRSRVDKPT 
       210        220        230        240        250
TYRRSYTHAK PPYSYISLIT MAIQNNPTRM LTLSEIYQFI MDLFPFYRQN 
       260        270        280        290        300
QQRWQNSIRH SLSFNDCFVK IPRTPDKPGK GSFWTLHPDS GNMFENGCYL 
       310        320        330        340        350
RRQKRFKDEK KEAIRQLHKS PSHSSLEATS PGKKDHEDSH HMHHHHHSRL 
       360        370        380        390        400
DHHQHHKEAG GASIAGVNVL SAAHSKDAEA LAMLHANAEL CLSQQPQHVP 
       410        420        430        440        450
THHHHQHHQL QQEELSAMMA NRCHPSLITD YHSSMHPLKQ EPSGYTPSSH 
       460        470        480        490        500
PFSINRLLPT ESKADIKMYD MSQYAGYNAL SPLTNSHAAL GQDSYYQSLG 
       510
YHAPAGTTSL                                             

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase