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Protein

Lamin-B2

Gene

LMNB2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.

Miscellaneous

The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Lamin-B2
Gene namesi
Name:LMNB2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000638222 – 597Lamin-B2Add BLAST596
PropeptideiPRO_0000403472598 – 600Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei597Cysteine methyl esterBy similarity1
Lipidationi597S-farnesyl cysteineBy similarity1

Post-translational modificationi

B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP14732
PRIDEiP14732

PTM databases

iPTMnetiP14732

Interactioni

Protein-protein interaction databases

BioGridi676482, 1 interactor
IntActiP14732, 1 interactor
STRINGi9031.ENSGALP00000034565

Structurei

3D structure databases

ProteinModelPortaliP14732
SMRiP14732
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 381IF rodPROSITE-ProRule annotationAdd BLAST357
Domaini445 – 562LTDPROSITE-ProRule annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 27HeadAdd BLAST26
Regioni28 – 64Coil 1AAdd BLAST37
Regioni75 – 212Coil 1BAdd BLAST138
Regioni237 – 379Coil 2Add BLAST143
Regioni380 – 600TailAdd BLAST221

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi414 – 419Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi398 – 406Poly-Ser9
Compositional biasi435 – 444Poly-Ser10
Compositional biasi568 – 582Asp/Glu-rich (highly acidic; could be involved in chromatin binding)Add BLAST15

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0977 Eukaryota
ENOG410Y2H6 LUCA
HOGENOMiHOG000007711
HOVERGENiHBG013015
InParanoidiP14732
KOiK07611
PhylomeDBiP14732

Family and domain databases

Gene3Di2.60.40.1260, 1 hit
InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR001322 Lamin_tail_dom
IPR036415 Lamin_tail_dom_sf
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF00932 LTD, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
SUPFAMiSSF74853 SSF74853, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
PS51841 LTD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14732-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTPIRGTP GGTPLSPTRI SRLQEKEELR QLNDRLAVYI DRVRALELEN
60 70 80 90 100
DRLLVKISEK EEVTTREVSG IKNLYESELA DARRVLDETA KERARLQIEI
110 120 130 140 150
GKLRAELEEF NKSYKKKDAD LSVAQGRIKD LEVLFHRSEA ELNTVLNEKR
160 170 180 190 200
SLEAEVADLR AQLAKAEDGH AVAKKQLEKE TLMRVDLENR CQSLQEDLDF
210 220 230 240 250
RKNVFEEEIR ETRKRHEHRL VEVDTSRQQE YENKMAQALE DLRNQHDEQV
260 270 280 290 300
KLYKMELEQT YQAKLENAIL ASDQNDKAAG AAREELKEAR MRIESLSHQL
310 320 330 340 350
SGLQKQASAT EDRIRELKET MAGERDKFRK MLDAKEREMT EMRDQMQLQL
360 370 380 390 400
TEYQELLDVK LALDMEISAY RKLLEGEEER LKLSPSPSSR VTVSRATSSS
410 420 430 440 450
SSSSTSLVRS SRGKRRRIEA EELSGSGTSG IGTGSISGSS SSSSFQMSQQ
460 470 480 490 500
ASATGSISIE EIDLEGKYVQ LKNNSEKDQS LGNWRLKRQI GDGEEIAYKF
510 520 530 540 550
TPKYVLRAGQ TVTIWGADAG VSHSPPSVLV WKNQGSWGTG GNIRTYLVNS
560 570 580 590 600
DGEEVAVRTV TKSVVVRENE EEEDEADFGE EDLFNQQGDP RTTSRGCLVM
Length:600
Mass (Da):67,941
Last modified:April 1, 1990 - v1
Checksum:i670E2985202211C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16880 mRNA Translation: CAA34763.1
PIRiS05519
RefSeqiNP_990616.1, NM_205285.1
UniGeneiGga.16090

Genome annotation databases

GeneIDi396222
KEGGigga:396222

Similar proteinsi

Entry informationi

Entry nameiLMNB2_CHICK
AccessioniPrimary (citable) accession number: P14732
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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