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Protein

Interleukin-1 receptor-like 1

Gene

Il1rl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP (PubMed:18450470, PubMed:17675517). Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 (By similarity). Possibly involved in helper T-cell function.By similarity2 Publications
Isoform B: Inhibits IL-33 signaling.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-1257604 PIP3 activates AKT signaling
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-9014843 Interleukin-33 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-like 1
Alternative name(s):
Interleukin-33 receptor alpha chain1 Publication
Lymphocyte antigen 84
Protein ST2
Protein T1
Gene namesi
Name:Il1rl1
Synonyms:Ly84, St2, Ste2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98427 Il1rl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 332ExtracellularSequence analysisAdd BLAST306
Transmembranei333 – 355HelicalSequence analysisAdd BLAST23
Topological domaini356 – 567CytoplasmicSequence analysisAdd BLAST212

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001544327 – 567Interleukin-1 receptor-like 1Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 93PROSITE-ProRule annotation
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi117 ↔ 157PROSITE-ProRule annotation
Disulfide bondi139 ↔ 187PROSITE-ProRule annotation
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi240 ↔ 308PROSITE-ProRule annotation
Disulfide bondi243 ↔ 287PROSITE-ProRule annotation
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP14719
MaxQBiP14719
PaxDbiP14719
PRIDEiP14719

PTM databases

iPTMnetiP14719
PhosphoSitePlusiP14719

Expressioni

Tissue specificityi

Predominantly expressed in hematopoietic tissues, and in macrophage, erythroid, epithelial and fibroblast cell lines. Isoform A is expressed in brain astrocytes and microglia. Isoform B is expressed in brain endothelial cells.2 Publications

Developmental stagei

Expressed first in the fetal liver and then in lung and hematopoietic tissues.

Gene expression databases

BgeeiENSMUSG00000026069 Expressed in 56 organ(s), highest expression level in fibroblast
CleanExiMM_IL1RL1
ExpressionAtlasiP14719 baseline and differential
GenevisibleiP14719 MM

Interactioni

Subunit structurei

Interacts with MYD88, IRAK1, IRAK4, and TRAF6 (By similarity). Bound to its ligand IL-33, interacts with IL1RAP to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (bound to KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88.By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201248, 2 interactors
DIPiDIP-34958N
IntActiP14719, 4 interactors
STRINGi10090.ENSMUSP00000054914

Structurei

Secondary structure

1567
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP14719
SMRiP14719
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 109Ig-like C2-type 1Add BLAST83
Domaini120 – 203Ig-like C2-type 2Add BLAST84
Domaini217 – 324Ig-like C2-type 3Add BLAST108
Domaini375 – 538TIRPROSITE-ProRule annotationAdd BLAST164

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni204 – 216Flexible linkerBy similarityAdd BLAST13

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPTT Eukaryota
ENOG4110Z8K LUCA
GeneTreeiENSGT00760000119071
HOGENOMiHOG000113054
HOVERGENiHBG098401
InParanoidiP14719
KOiK05171
OMAiVQGTIKW
OrthoDBiEOG091G0GXW
PhylomeDBiP14719
TreeFamiTF325519

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR015621 IL-1_rcpt_fam
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF01582 TIR, 1 hit
PRINTSiPR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS50104 TIR, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: P14719-1) [UniParc]FASTAAdd to basket
Also known as: Membrane-bound, ST2L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIDRQRMGLW ALAILTLPMY LTVTEGSKSS WGLENEALIV RCPQRGRSTY
60 70 80 90 100
PVEWYYSDTN ESIPTQKRNR IFVSRDRLKF LPARVEDSGI YACVIRSPNL
110 120 130 140 150
NKTGYLNVTI HKKPPSCNIP DYLMYSTVRG SDKNFKITCP TIDLYNWTAP
160 170 180 190 200
VQWFKNCKAL QEPRFRAHRS YLFIDNVTHD DEGDYTCQFT HAENGTNYIV
210 220 230 240 250
TATRSFTVEE KGFSMFPVIT NPPYNHTMEV EIGKPASIAC SACFGKGSHF
260 270 280 290 300
LADVLWQINK TVVGNFGEAR IQEEEGRNES SSNDMDCLTS VLRITGVTEK
310 320 330 340 350
DLSLEYDCLA LNLHGMIRHT IRLRRKQPID HRSIYYIVAG CSLLLMFINV
360 370 380 390 400
LVIVLKVFWI EVALFWRDIV TPYKTRNDGK LYDAYIIYPR VFRGSAAGTH
410 420 430 440 450
SVEYFVHHTL PDVLENKCGY KLCIYGRDLL PGQDAATVVE SSIQNSRRQV
460 470 480 490 500
FVLAPHMMHS KEFAYEQEIA LHSALIQNNS KVILIEMEPL GEASRLQVGD
510 520 530 540 550
LQDSLQHLVK IQGTIKWRED HVADKQSLSS KFWKHVRYQM PVPERASKTA
560
SVAAPLSGKA CLDLKHF
Length:567
Mass (Da):64,801
Last modified:December 6, 2002 - v2
Checksum:i9228CE227D95B0BC
GO
Isoform B (identifier: P14719-2) [UniParc]FASTAAdd to basket
Also known as: Soluble, ST2

The sequence of this isoform differs from the canonical sequence as follows:
     329-337: IDHRSIYYI → SKECPSHIA
     338-567: Missing.

Show »
Length:337
Mass (Da):38,502
Checksum:i7574372722486926
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UYU3G3UYU3_MOUSE
Interleukin-1 receptor-like 1
Il1rl1
65Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti192A → V in strain: C3H/He. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002668329 – 337IDHRSIYYI → SKECPSHIA in isoform B. 2 Publications9
Alternative sequenceiVSP_002669338 – 567Missing in isoform B. 2 PublicationsAdd BLAST230

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07519 mRNA Translation: CAA68812.1
X60184 Genomic DNA Translation: CAA42742.1
M24843 mRNA Translation: AAA40160.1
D13695 mRNA Translation: BAA02854.1
CCDSiCCDS35548.1 [P14719-1]
CCDS56626.1 [P14719-2]
PIRiS29498
RefSeqiNP_001020773.1, NM_001025602.3 [P14719-1]
NP_001281100.1, NM_001294171.1 [P14719-2]
NP_034873.2, NM_010743.3 [P14719-2]
XP_006495804.1, XM_006495741.1 [P14719-1]
XP_006495807.1, XM_006495744.2 [P14719-1]
XP_017174571.1, XM_017319082.1 [P14719-1]
UniGeneiMm.289824

Genome annotation databases

EnsembliENSMUST00000053043; ENSMUSP00000054914; ENSMUSG00000026069 [P14719-1]
ENSMUST00000097772; ENSMUSP00000095379; ENSMUSG00000026069 [P14719-1]
ENSMUST00000173514; ENSMUSP00000133784; ENSMUSG00000026069 [P14719-2]
ENSMUST00000174335; ENSMUSP00000134351; ENSMUSG00000026069 [P14719-2]
GeneIDi17082
KEGGimmu:17082
UCSCiuc007aub.3 mouse [P14719-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07519 mRNA Translation: CAA68812.1
X60184 Genomic DNA Translation: CAA42742.1
M24843 mRNA Translation: AAA40160.1
D13695 mRNA Translation: BAA02854.1
CCDSiCCDS35548.1 [P14719-1]
CCDS56626.1 [P14719-2]
PIRiS29498
RefSeqiNP_001020773.1, NM_001025602.3 [P14719-1]
NP_001281100.1, NM_001294171.1 [P14719-2]
NP_034873.2, NM_010743.3 [P14719-2]
XP_006495804.1, XM_006495741.1 [P14719-1]
XP_006495807.1, XM_006495744.2 [P14719-1]
XP_017174571.1, XM_017319082.1 [P14719-1]
UniGeneiMm.289824

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VI4X-ray2.79B/E26-326[»]
ProteinModelPortaliP14719
SMRiP14719
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201248, 2 interactors
DIPiDIP-34958N
IntActiP14719, 4 interactors
STRINGi10090.ENSMUSP00000054914

PTM databases

iPTMnetiP14719
PhosphoSitePlusiP14719

Proteomic databases

EPDiP14719
MaxQBiP14719
PaxDbiP14719
PRIDEiP14719

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053043; ENSMUSP00000054914; ENSMUSG00000026069 [P14719-1]
ENSMUST00000097772; ENSMUSP00000095379; ENSMUSG00000026069 [P14719-1]
ENSMUST00000173514; ENSMUSP00000133784; ENSMUSG00000026069 [P14719-2]
ENSMUST00000174335; ENSMUSP00000134351; ENSMUSG00000026069 [P14719-2]
GeneIDi17082
KEGGimmu:17082
UCSCiuc007aub.3 mouse [P14719-1]

Organism-specific databases

CTDi9173
MGIiMGI:98427 Il1rl1

Phylogenomic databases

eggNOGiENOG410IPTT Eukaryota
ENOG4110Z8K LUCA
GeneTreeiENSGT00760000119071
HOGENOMiHOG000113054
HOVERGENiHBG098401
InParanoidiP14719
KOiK05171
OMAiVQGTIKW
OrthoDBiEOG091G0GXW
PhylomeDBiP14719
TreeFamiTF325519

Enzyme and pathway databases

ReactomeiR-MMU-1257604 PIP3 activates AKT signaling
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-9014843 Interleukin-33 signaling

Miscellaneous databases

PROiPR:P14719
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026069 Expressed in 56 organ(s), highest expression level in fibroblast
CleanExiMM_IL1RL1
ExpressionAtlasiP14719 baseline and differential
GenevisibleiP14719 MM

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR015621 IL-1_rcpt_fam
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF01582 TIR, 1 hit
PRINTSiPR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS50104 TIR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiILRL1_MOUSE
AccessioniPrimary (citable) accession number: P14719
Secondary accession number(s): Q05208
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: December 6, 2002
Last modified: September 12, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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