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Entry version 84 (02 Jun 2021)
Sequence version 1 (01 Apr 1990)
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Protein

Involucrin

Gene

IVL

Organism
Pongo pygmaeus (Bornean orangutan)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processKeratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Involucrin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IVL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo pygmaeus (Bornean orangutan)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9600 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001597421 – 835InvolucrinAdd BLAST835

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Substrate of transglutaminase. Specific glutamines or lysines are cross-linked to keratins, desmoplakin and to inter involucrin molecules.

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Keratinocytes of epidermis and other stratified squamous epithelia.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Directly or indirectly cross-linked to cornifelin (CNFN).

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 133DisorderedSequence analysisAdd BLAST133
Regioni150 – 206DisorderedSequence analysisAdd BLAST57
Regioni221 – 285DisorderedSequence analysisAdd BLAST65
Regioni321 – 342DisorderedSequence analysisAdd BLAST22
Regioni381 – 428DisorderedSequence analysisAdd BLAST48
Regioni446 – 486DisorderedSequence analysisAdd BLAST41
Regioni501 – 548DisorderedSequence analysisAdd BLAST48
Regioni566 – 809DisorderedSequence analysisAdd BLAST244

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 35Polar residuesSequence analysisAdd BLAST35
Compositional biasi55 – 69Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi72 – 87Polar residuesSequence analysisAdd BLAST16
Compositional biasi88 – 133Basic and acidic residuesSequence analysisAdd BLAST46
Compositional biasi150 – 171Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi180 – 194Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi221 – 264Basic and acidic residuesSequence analysisAdd BLAST44
Compositional biasi400 – 424Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi446 – 462Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi520 – 544Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi566 – 582Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi598 – 621Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi625 – 639Polar residuesSequence analysisAdd BLAST15
Compositional biasi640 – 655Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi667 – 689Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi690 – 704Polar residuesSequence analysisAdd BLAST15
Compositional biasi710 – 739Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi754 – 778Basic and acidic residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the involucrin family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002360, Involucrin
IPR019743, Involucrin_CS
IPR019571, Involucrin_N
IPR000354, Involucrin_rpt
IPR032675, LRR_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR36910:SF9, PTHR36910:SF9, 7 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00904, Involucrin, 65 hits
PF10583, Involucrin_N, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00795, INVOLUCRIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P14708-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQQHTLPVT LSPALSQELL KTVPPPVNTQ QEQMKQPTPL PPPCQKVPVE
60 70 80 90 100
LPVEVPSKQE EKHMTAVKGL PEQECEQQQQ EPQEQELQQQ HWEQHEEHQK
110 120 130 140 150
AENPEQQLKQ EKAQRDQQLN EQLEEEKKLL DQRLDQELVK RDEQLGMKKE
160 170 180 190 200
QLLELPEQQE QHLKHLEQQE GQLELPEQQE GQLKHLEQQE GQLKHLEQQE
210 220 230 240 250
GQLEVPEEQV GQLKYLEQQE GQLKHLDQQE GQLKHLDQQE GQLKHLDQQE
260 270 280 290 300
GQLKHLDQQE GQLKHLDQQE GQLELPEQQE GQLKHLEQQE GQLKHLEHEE
310 320 330 340 350
GQLEVPEEQV GQLKYLEQQE GQLKHLDQQE GQLELPEQQE GQLKHLEQQE
360 370 380 390 400
GQLKHLEHQK GQLEVPEEQV GQLKYLEQQE GQLKHLDQQE GQLELPEQQE
410 420 430 440 450
GQLKHLEQQE GQLKHLEHQE GQLEVPEEQV GQLKYLEQQE GQLKHLDQQE
460 470 480 490 500
GQLKHLDQQE KQLELPEQQV GQLKHLEQQE GQLEVPEEQV GQLKYLEQQE
510 520 530 540 550
GQLKHLDQQE GQLELPEQQE GQLKHLEQQE GQLKHLEHQE GQLEVPEEQV
560 570 580 590 600
GQLKYLEQQE GQLKHLDQQE GQLKHLDQQE KQLELPEQQV GQLKHLEQQE
610 620 630 640 650
GQLEHLEGQE GQLEHLEHQE GQLGLPEQQV WQLKQLEKQE GQPKNLEEEE
660 670 680 690 700
GQLKHLVQQE GQLEQQEGQV EHLEEQVGQL KHLEEQEGQL KYLEQQQGQL
710 720 730 740 750
EVPEQQVGQP KHLEQEEKQL ELPEQQEGQL KHLEKQEAQL ELPEQQVGQP
760 770 780 790 800
KHLEQQEKQL EHPEQKDGQL KHLEQQEGQL KNLEQQKGQL EQPVFAPAPG
810 820 830
QVQDIQPALP TKGEVLLPVE QQQQKQEVQW PPKHK
Length:835
Mass (Da):97,977
Last modified:April 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2EE73E73E1EA41D4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M25312 Genomic DNA Translation: AAA36935.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I57441

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25312 Genomic DNA Translation: AAA36935.1
PIRiI57441

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR002360, Involucrin
IPR019743, Involucrin_CS
IPR019571, Involucrin_N
IPR000354, Involucrin_rpt
IPR032675, LRR_dom_sf
PANTHERiPTHR36910:SF9, PTHR36910:SF9, 7 hits
PfamiView protein in Pfam
PF00904, Involucrin, 65 hits
PF10583, Involucrin_N, 1 hit
PROSITEiView protein in PROSITE
PS00795, INVOLUCRIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINVO_PONPY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14708
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 2, 2021
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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