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UniProtKB - P14693 (SAM35_YEAST)
Protein
Sorting assembly machinery 35 kDa subunit
Gene
SAM35
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Essential component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which is required for the sorting of proteins with complicated topology, such as beta-barrel proteins, to the mitochondrial outer membrane after import by the TOM complex.
2 PublicationsMiscellaneous
Present with 1470 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- mitochondrial outer membrane translocase complex assembly Source: SGD
- protein import into mitochondrial matrix Source: ComplexPortal
- protein insertion into mitochondrial outer membrane Source: SGD
Keywordsi
Biological process | Protein transport, Transport |
Protein family/group databases
TCDBi | 1.B.33.3.1, the outer membrane protein insertion porin (bam complex) (ompip) family |
Names & Taxonomyi
Protein namesi | Recommended name: Sorting assembly machinery 35 kDa subunitAlternative name(s): Mitochondrial 38 kDa outer membrane protein TOB complex 38 kDa subunit |
Gene namesi | Name:SAM35 Synonyms:OMP85, TOB38, TOM38 Ordered Locus Names:YHR083W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001125, SAM35 |
VEuPathDBi | FungiDB:YHR083W |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane 2 Publications
Mitochondrion
- mitochondrial outer membrane Source: SGD
- mitochondrion Source: ComplexPortal
- SAM complex Source: SGD
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000202903 | 1 – 329 | Sorting assembly machinery 35 kDa subunitAdd BLAST | 329 |
Proteomic databases
MaxQBi | P14693 |
PaxDbi | P14693 |
PRIDEi | P14693 |
PTM databases
iPTMneti | P14693 |
Interactioni
Subunit structurei
Component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which at least consists of SAM35, SAM37 and SAM50.
3 PublicationsBinary interactionsi
P14693
With | #Exp. | IntAct |
---|---|---|
MDM10 [P18409] | 5 | EBI-24602,EBI-10580 |
SAM37 [P50110] | 7 | EBI-24602,EBI-2347180 |
SAM50 [P53969] | 8 | EBI-24602,EBI-28646 |
Protein-protein interaction databases
BioGRIDi | 36518, 96 interactors |
ComplexPortali | CPX-1744, Mitochondrial sorting and assembly machinery complex |
DIPi | DIP-1879N |
IntActi | P14693, 99 interactors |
MINTi | P14693 |
STRINGi | 4932.YHR083W |
Miscellaneous databases
RNActi | P14693, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P14693 |
SMRi | P14693 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502RXPE, Eukaryota |
HOGENOMi | CLU_073166_0_0_1 |
InParanoidi | P14693 |
OMAi | FVENECK |
Family and domain databases
InterProi | View protein in InterPro IPR021211, SAM35 |
Pfami | View protein in Pfam PF10806, SAM35, 1 hit |
i Sequence
Sequence statusi: Complete.
P14693-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSSFSVPMP VKRIFDTFPL QTYAAQTDKD EAVALEIQRR SYTFTERGGG
60 70 80 90 100
SSELTVEGTY KLGVYNVFLE ANTGAALATD PWCLFVQLAL CQKNGLVLPT
110 120 130 140 150
HSQEQTPSHT CNHEMLVLSR LSNPDEALPI LVEGYKKRII RSTVAISEIM
160 170 180 190 200
RSRILDDAEQ LMYYTLLDTV LYDCWITQII FCASDAQFME LYSCQKLSGS
210 220 230 240 250
IVTPLDVENS LLQKLSAKSL KISLTKRNKF QFRHREIVKS MQGVYHNHHN
260 270 280 290 300
SVNQEQVLNV LFENSKQVLL GLKDMLKSDG QPTYLHLKIA SYILCITNVK
310 320
EPIKLKTFVE NECKELVQFA QDTLKNFVQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U10556 Genomic DNA Translation: AAB68885.1 X16112 Genomic DNA Translation: CAA34245.1 BK006934 Genomic DNA Translation: DAA06778.1 |
PIRi | S46807 |
RefSeqi | NP_011951.1, NM_001179213.1 |
Genome annotation databases
EnsemblFungii | YHR083W_mRNA; YHR083W; YHR083W |
GeneIDi | 856483 |
KEGGi | sce:YHR083W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U10556 Genomic DNA Translation: AAB68885.1 X16112 Genomic DNA Translation: CAA34245.1 BK006934 Genomic DNA Translation: DAA06778.1 |
PIRi | S46807 |
RefSeqi | NP_011951.1, NM_001179213.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7BTW | electron microscopy | 2.90 | B | 1-329 | [»] | |
7BTX | electron microscopy | 2.80 | B | 1-329 | [»] | |
7BTY | electron microscopy | 3.20 | B | 1-329 | [»] | |
7E4H | electron microscopy | 3.01 | B | 1-329 | [»] | |
7E4I | electron microscopy | 3.05 | B | 1-329 | [»] | |
AlphaFoldDBi | P14693 | |||||
SMRi | P14693 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 36518, 96 interactors |
ComplexPortali | CPX-1744, Mitochondrial sorting and assembly machinery complex |
DIPi | DIP-1879N |
IntActi | P14693, 99 interactors |
MINTi | P14693 |
STRINGi | 4932.YHR083W |
Protein family/group databases
TCDBi | 1.B.33.3.1, the outer membrane protein insertion porin (bam complex) (ompip) family |
PTM databases
iPTMneti | P14693 |
Proteomic databases
MaxQBi | P14693 |
PaxDbi | P14693 |
PRIDEi | P14693 |
Genome annotation databases
EnsemblFungii | YHR083W_mRNA; YHR083W; YHR083W |
GeneIDi | 856483 |
KEGGi | sce:YHR083W |
Organism-specific databases
SGDi | S000001125, SAM35 |
VEuPathDBi | FungiDB:YHR083W |
Phylogenomic databases
eggNOGi | ENOG502RXPE, Eukaryota |
HOGENOMi | CLU_073166_0_0_1 |
InParanoidi | P14693 |
OMAi | FVENECK |
Miscellaneous databases
PROi | PR:P14693 |
RNActi | P14693, protein |
Family and domain databases
InterProi | View protein in InterPro IPR021211, SAM35 |
Pfami | View protein in Pfam PF10806, SAM35, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SAM35_YEAST | |
Accessioni | P14693Primary (citable) accession number: P14693 Secondary accession number(s): D3DL34 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | February 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VIII
Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references