Sorting assembly machinery 35 kDa subunit

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• mitochondrial outer membrane translocase complex assembly Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.8

    "Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability."
    Milenkovic D., Kozjak V., Wiedemann N., Lohaus C., Meyer H.E., Guiard B., Pfanner N., Meisinger C.
    J. Biol. Chem. 279:22781-22785(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, IDENTIFICATION IN THE SAM COMPLEX.
  • Ref.5

    "Tob38, a novel essential component in the biogenesis of beta-barrel proteins of mitochondria."
    Waizenegger T., Habib S.J., Lech M., Mokranjac D., Paschen S.A., Hell K., Neupert W., Rapaport D.
    EMBO Rep. 5:704-709(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: IDENTIFICATION IN THE SAM COMPLEX.
  • "Alternative function for the mitochondrial SAM complex in biogenesis of alpha-helical TOM proteins."
    Stojanovski D., Guiard B., Kozjak-Pavlovic V., Pfanner N., Meisinger C.
    J Cell Biol 179:881-893(2007) [PubMed] [Europe PMC] [Abstract]
• protein import into mitochondrial matrix Source: ComplexPortal <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation."
    Qiu J., Wenz L.S., Zerbes R.M., Oeljeklaus S., Bohnert M., Stroud D.A., Wirth C., Ellenrieder L., Thornton N., Kutik S., Wiese S., Schulze-Specking A., Zufall N., Chacinska A., Guiard B., Hunte C., Warscheid B., van der Laan M.

    , Pfanner N., Wiedemann N., Becker T.
    Cell 154:596-608(2013) [PubMed] [Europe PMC] [Abstract]
• protein insertion into mitochondrial outer membrane Source: SGDInferred from mutant phenotypeⁱ
  • Ref.8

    "Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability."
    Milenkovic D., Kozjak V., Wiedemann N., Lohaus C., Meyer H.E., Guiard B., Pfanner N., Meisinger C.
    J. Biol. Chem. 279:22781-22785(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, IDENTIFICATION IN THE SAM COMPLEX.
  • Ref.7

    "Two novel proteins in the mitochondrial outer membrane mediate beta-barrel protein assembly."
    Ishikawa D., Yamamoto H., Tamura Y., Moritoh K., Endo T.
    J. Cell Biol. 166:621-627(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: IDENTIFICATION IN THE SAM COMPLEX, SUBCELLULAR LOCATION.
  • "Alternative function for the mitochondrial SAM complex in biogenesis of alpha-helical TOM proteins."
    Stojanovski D., Guiard B., Kozjak-Pavlovic V., Pfanner N., Meisinger C.
    J Cell Biol 179:881-893(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MVSSFSVPMP VKRIFDTFPL QTYAAQTDKD EAVALEIQRR SYTFTERGGG 
        60         70         80         90        100
SSELTVEGTY KLGVYNVFLE ANTGAALATD PWCLFVQLAL CQKNGLVLPT 
       110        120        130        140        150
HSQEQTPSHT CNHEMLVLSR LSNPDEALPI LVEGYKKRII RSTVAISEIM 
       160        170        180        190        200
RSRILDDAEQ LMYYTLLDTV LYDCWITQII FCASDAQFME LYSCQKLSGS 
       210        220        230        240        250
IVTPLDVENS LLQKLSAKSL KISLTKRNKF QFRHREIVKS MQGVYHNHHN 
       260        270        280        290        300
SVNQEQVLNV LFENSKQVLL GLKDMLKSDG QPTYLHLKIA SYILCITNVK 
       310        320 
EPIKLKTFVE NECKELVQFA QDTLKNFVQ                        

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
2. Yeast chromosome VIII
   Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references