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UniProtKB - P14680 (YAK1_YEAST)
Protein
Dual specificity protein kinase YAK1
Gene
YAK1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Negative regulator of the cell cycle acting downstream of the cAMP-dependent protein kinase. Part of a glucose-sensing system involved in growth control in response to glucose availability. Phosphorylates POP2.
1 PublicationCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 398 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 496 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 375 – 383 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein kinase activity Source: SGD
- protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
- protein serine/threonine kinase activity Source: SGD
- protein serine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: SGD
GO - Biological processi
- peptidyl-serine phosphorylation Source: GO_Central
- peptidyl-threonine phosphorylation Source: GO_Central
- positive regulation of cell-substrate adhesion Source: CACAO
- positive regulation of response to extracellular stimulus Source: CACAO
- positive regulation of transcription, DNA-templated Source: CACAO
- positive regulation of transcription by RNA polymerase II Source: SGD
- positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation Source: SGD
- positive regulation of transcription from RNA polymerase II promoter in response to heat stress Source: SGD
- protein kinase A signaling Source: SGD
- protein phosphorylation Source: SGD
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.12.1, 984 |
Reactomei | R-SCE-3899300, SUMOylation of transcription cofactors |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:YAK1 Ordered Locus Names:YJL141C ORF Names:J0652 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003677, YAK1 |
VEuPathDBi | FungiDB:YJL141C |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086828 | 1 – 807 | Dual specificity protein kinase YAK1Add BLAST | 807 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 38 | PhosphoserineCombined sources | 1 | |
Modified residuei | 115 | PhosphoserineCombined sources | 1 | |
Modified residuei | 118 | PhosphoserineCombined sources | 1 | |
Modified residuei | 127 | PhosphoserineCombined sources | 1 | |
Modified residuei | 206 | PhosphoserineCombined sources | 1 | |
Modified residuei | 240 | PhosphoserineCombined sources | 1 | |
Modified residuei | 245 | PhosphoserineCombined sources | 1 | |
Modified residuei | 247 | PhosphoserineCombined sources | 1 | |
Modified residuei | 288 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 295 | PhosphoserineCombined sources | 1 | |
Modified residuei | 530 | PhosphotyrosineCombined sources1 Publication | 1 |
Post-translational modificationi
Phosphorylated; highly.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P14680 |
PaxDbi | P14680 |
PRIDEi | P14680 |
PTM databases
iPTMneti | P14680 |
Interactioni
Binary interactionsi
P14680
With | #Exp. | IntAct |
---|---|---|
HRT1 [Q08273] | 3 | EBI-20777,EBI-31686 |
Protein-protein interaction databases
BioGRIDi | 33616, 180 interactors |
DIPi | DIP-1374N |
ELMi | P14680 |
IntActi | P14680, 48 interactors |
MINTi | P14680 |
STRINGi | 4932.YJL141C |
Miscellaneous databases
RNActi | P14680, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 369 – 704 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 336 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 84 | DisorderedSequence analysisAdd BLAST | 84 | |
Regioni | 124 – 180 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 214 – 254 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 714 – 758 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 38 | Polar residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 48 – 84 | Polar residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 145 – 180 | Polar residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 214 – 234 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 734 – 758 | Polar residuesSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0667, Eukaryota |
GeneTreei | ENSGT00940000164472 |
HOGENOMi | CLU_000288_88_4_1 |
InParanoidi | P14680 |
OMAi | TRTVYTY |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
P14680-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSSNNNDSS SSNSNMNNSL SPTLVTHSDA SMGSGRASPD NSHMGRGIWN
60 70 80 90 100
PSYVNQGSQR SPQQQHQNHH QQQQQQQQQQ QQNSQFCFVN PWNEEKVTNS
110 120 130 140 150
QQNLVYPPQY DDLNSNESLD AYRRRKSSLV VPPARAPAPN PFQYDSYPAY
160 170 180 190 200
TSSNTSLAGN SSGQYPSGYQ QQQQQVYQQG AIHPSQFGSR FVPSLYDRQD
210 220 230 240 250
FQRRQSLAAT NYSSNFSSLN SNTNQGTNSI PVMSPYRRLS AYPPSTSPPL
260 270 280 290 300
QPPFKQLRRD EVQGQKLSIP QMQLCNSKND LQPVLNATPK FRRASLNSKT
310 320 330 340 350
ISPLVSVTKS LITTYSLCSP EFTYQTSKNP KRVLTKPSEG KCNNGFDNIN
360 370 380 390 400
SDYILYVNDV LGVEQNRKYL VLDILGQGTF GQVVKCQNLL TKEILAVKVV
410 420 430 440 450
KSRTEYLTQS ITEAKILELL NQKIDPTNKH HFLRMYDSFV HKNHLCLVFE
460 470 480 490 500
LLSNNLYELL KQNKFHGLSI QLIRTFTTQI LDSLCVLKES KLIHCDLKPE
510 520 530 540 550
NILLCAPDKP ELKIIDFGSS CEEARTVYTY IQSRFYRAPE IILGIPYSTS
560 570 580 590 600
IDMWSLGCIV AELFLGIPIF PGASEYNQLT RIIDTLGYPP SWMIDMGKNS
610 620 630 640 650
GKFMKKLAPE ESSSSTQKHR MKTIEEFCRE YNIVEKPSKQ YFKWRKLPDI
660 670 680 690 700
IRNYRYPKSI QNSQELIDQE MQNRECLIHF LGGVLNLNPL ERWTPQQAML
710 720 730 740 750
HPFITKQEFT GEWFPPGSSL PGPSEKHDDA KGQQSEYGSA NDSSNNAGHN
760 770 780 790 800
YVYNPSSATG GADSVDIGAI SKRKENTSGD ISNNFAVTHS VQEGPTSAFN
KLHIVEE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X16056 Genomic DNA Translation: CAA34192.1 X87371 Genomic DNA Translation: CAA60814.1 Z49417 Genomic DNA Translation: CAA89437.1 BK006943 Genomic DNA Translation: DAA08659.1 |
PIRi | A32582 |
RefSeqi | NP_012394.1, NM_001181574.1 |
Genome annotation databases
EnsemblFungii | YJL141C_mRNA; YJL141C; YJL141C |
GeneIDi | 853300 |
KEGGi | sce:YJL141C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X16056 Genomic DNA Translation: CAA34192.1 X87371 Genomic DNA Translation: CAA60814.1 Z49417 Genomic DNA Translation: CAA89437.1 BK006943 Genomic DNA Translation: DAA08659.1 |
PIRi | A32582 |
RefSeqi | NP_012394.1, NM_001181574.1 |
3D structure databases
SMRi | P14680 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 33616, 180 interactors |
DIPi | DIP-1374N |
ELMi | P14680 |
IntActi | P14680, 48 interactors |
MINTi | P14680 |
STRINGi | 4932.YJL141C |
PTM databases
iPTMneti | P14680 |
Proteomic databases
MaxQBi | P14680 |
PaxDbi | P14680 |
PRIDEi | P14680 |
Genome annotation databases
EnsemblFungii | YJL141C_mRNA; YJL141C; YJL141C |
GeneIDi | 853300 |
KEGGi | sce:YJL141C |
Organism-specific databases
SGDi | S000003677, YAK1 |
VEuPathDBi | FungiDB:YJL141C |
Phylogenomic databases
eggNOGi | KOG0667, Eukaryota |
GeneTreei | ENSGT00940000164472 |
HOGENOMi | CLU_000288_88_4_1 |
InParanoidi | P14680 |
OMAi | TRTVYTY |
Enzyme and pathway databases
BRENDAi | 2.7.12.1, 984 |
Reactomei | R-SCE-3899300, SUMOylation of transcription cofactors |
Miscellaneous databases
PROi | PR:P14680 |
RNActi | P14680, protein |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YAK1_YEAST | |
Accessioni | P14680Primary (citable) accession number: P14680 Secondary accession number(s): D6VW43 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 198 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome X
Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names - SIMILARITY comments
Index of protein domains and families