UniProtKB - P14678 (RSMB_HUMAN)
Small nuclear ribonucleoprotein-associated proteins B and B'
SNRPB
Functioni
Miscellaneous
GO - Molecular functioni
- RNA binding Source: BHF-UCL
- telomerase RNA binding Source: BHF-UCL
GO - Biological processi
- histone mRNA metabolic process Source: Reactome
- import into nucleus Source: Reactome
- mRNA splicing, via spliceosome Source: UniProtKB
- protein methylation Source: MGI
- RNA splicing Source: ProtInc
- spliceosomal snRNP assembly Source: UniProtKB
- termination of RNA polymerase II transcription Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
PathwayCommonsi | P14678 |
Reactomei | R-HSA-111367, SLBP independent Processing of Histone Pre-mRNAs R-HSA-191859, snRNP Assembly R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72165, mRNA Splicing - Minor Pathway R-HSA-73856, RNA Polymerase II Transcription Termination R-HSA-77588, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
Names & Taxonomyi
Protein namesi | Recommended name: Small nuclear ribonucleoprotein-associated proteins B and B'Short name: snRNP-B Alternative name(s): Sm protein B/B' Short name: Sm-B/B' Short name: SmB/B' |
Gene namesi | Name:SNRPB Synonyms:COD, SNRPB1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000125835.17 |
HGNCi | HGNC:11153, SNRPB |
MIMi | 182282, gene |
neXtProti | NX_P14678 |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB
Nucleus
- catalytic step 2 spliceosome Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- small nuclear ribonucleoprotein complex Source: ProtInc
- spliceosomal complex Source: ProtInc
- telomerase holoenzyme complex Source: BHF-UCL
- U1 snRNP Source: UniProtKB
- U12-type spliceosomal complex Source: UniProtKB
- U2 snRNP Source: GO_Central
- U2-type catalytic step 2 spliceosome Source: UniProtKB
- U2-type precatalytic spliceosome Source: UniProtKB
- U2-type prespliceosome Source: GO_Central
- U4 snRNP Source: UniProtKB
- U4/U6 x U5 tri-snRNP complex Source: UniProtKB
- U5 snRNP Source: GO_Central
- U7 snRNP Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
- methylosome Source: UniProtKB
- SMN-Sm protein complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Nucleus, SpliceosomePathology & Biotechi
Involvement in diseasei
Cerebrocostomandibular syndrome (CCMS)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073380 | 55 | N → S in CCMS; expression of the protein is reduced. 2 Publications | 1 | |
Natural variantiVAR_073381 | 55 | N → T in CCMS. 1 Publication | 1 | |
Natural variantiVAR_073382 | 56 | S → R in CCMS. 2 Publications | 1 | |
Natural variantiVAR_073383 | 56 | S → W in CCMS. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, Mental retardationOrganism-specific databases
DisGeNETi | 6628 |
MalaCardsi | SNRPB |
MIMi | 117650, phenotype |
OpenTargetsi | ENSG00000125835 |
Orphaneti | 1393, Cerebrocostomandibular syndrome |
PharmGKBi | PA35995 |
Miscellaneous databases
Pharosi | P14678, Tbio |
Polymorphism and mutation databases
BioMutai | SNRPB |
DMDMi | 134037 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125517 | 1 – 240 | Small nuclear ribonucleoprotein-associated proteins B and B'Add BLAST | 240 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 108 | Asymmetric dimethylarginine; alternateCombined sources | 1 | |
Modified residuei | 108 | Dimethylated arginine; in A2780 ovarian carcinoma cell line1 Publication | 1 | |
Modified residuei | 108 | Omega-N-methylarginine; alternateCombined sources | 1 | |
Modified residuei | 112 | Asymmetric dimethylarginine; alternateCombined sources | 1 | |
Modified residuei | 112 | Dimethylated arginine; in A2780 ovarian carcinoma cell line1 Publication | 1 | |
Modified residuei | 112 | Omega-N-methylarginine; alternateCombined sources | 1 | |
Modified residuei | 147 | Omega-N-methylarginine1 Publication | 1 | |
Modified residuei | 172 | Omega-N-methylarginineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
MethylationProteomic databases
EPDi | P14678 |
jPOSTi | P14678 |
MassIVEi | P14678 |
MaxQBi | P14678 |
PaxDbi | P14678 |
PeptideAtlasi | P14678 |
PRIDEi | P14678 |
ProteomicsDBi | 53074 [P14678-1] 53075 [P14678-2] 53076 [P14678-3] |
TopDownProteomicsi | P14678-2 [P14678-2] |
PTM databases
iPTMneti | P14678 |
MetOSitei | P14678 |
PhosphoSitePlusi | P14678 |
SwissPalmi | P14678 |
Expressioni
Gene expression databases
Bgeei | ENSG00000125835, Expressed in bone marrow and 239 other tissues |
ExpressionAtlasi | P14678, baseline and differential |
Genevisiblei | P14678, HS |
Organism-specific databases
HPAi | ENSG00000125835, Low tissue specificity |
Interactioni
Subunit structurei
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:10025403, PubMed:19325628, PubMed:21516107, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (PubMed:10025403, PubMed:19325628, PubMed:21516107, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346).
Component of the U1 snRNP (PubMed:19325628, PubMed:25555158). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C (PubMed:19325628, PubMed:25555158).
Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (PubMed:26912367).
Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF and SNRPG; the complex does not contain SNRPD1 and SNRPD2 (PubMed:11574479, PubMed:12975319).
Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (PubMed:15146077). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly (PubMed:12095920, PubMed:18984161).
Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP (PubMed:18984161).
Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity).
Interacts with TDRD3 and SNUPN (PubMed:12095920, PubMed:15955813).
Interacts with PRMT5; interaction leads to its symmetric arginine dimethylation (By similarity).
Interacts with TDRD6; interaction promotes assiociation with PRMT5 (By similarity).
By similarity16 PublicationsBinary interactionsi
P14678
With | #Exp. | IntAct |
---|---|---|
CD2BP2 [O95400] | 8 | EBI-372458,EBI-768015 |
CLNS1A [P54105] | 3 | EBI-372458,EBI-724693 |
SNRPD3 [P62318] | 4 | EBI-372458,EBI-372789 |
Isoform SM-B' [P14678-1]
With | #Exp. | IntAct |
---|---|---|
SMN2 - isoform SMN-delta7 [Q16637-3] | 3 | EBI-372471,EBI-395447 |
Isoform SM-B [P14678-2]
Protein-protein interaction databases
BioGRIDi | 112512, 233 interactors |
CORUMi | P14678 |
DIPi | DIP-31239N |
IntActi | P14678, 133 interactors |
MINTi | P14678 |
STRINGi | 9606.ENSP00000412566 |
Miscellaneous databases
RNActi | P14678, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P14678 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P14678 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 175 – 181 | 7 | ||
Repeati | 191 – 196 | 6 | ||
Repeati | 216 – 221 | 6 | ||
Repeati | 222 – 228 | 7 | ||
Repeati | 230 – 236 | 7 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 175 – 236 | Repeat-rich regionAdd BLAST | 62 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3168, Eukaryota |
GeneTreei | ENSGT00940000155052 |
HOGENOMi | CLU_076902_1_0_1 |
OMAi | RGMGMMP |
OrthoDBi | 1630470at2759 |
PhylomeDBi | P14678 |
TreeFami | TF314232 |
Family and domain databases
IDEALi | IID00143 |
InterProi | View protein in InterPro IPR001163, LSM_dom_euk/arc IPR010920, LSM_dom_sf IPR017131, snRNP-assoc_SmB/SmN |
Pfami | View protein in Pfam PF01423, LSM, 1 hit |
PIRSFi | PIRSF037187, snRNP_SmB/SmN, 1 hit |
SMARTi | View protein in SMART SM00651, Sm, 1 hit |
SUPFAMi | SSF50182, SSF50182, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK
60 70 80 90 100
IKPKNSKQAE REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA
110 120 130 140 150
AGGPGIGRAA GRGIPAGVPM PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV
160 170 180 190 200
AAAAAAATAS IAGAPTQYPP GRGGPPPPMG RGAPPPGMMG PPPGMRPPMG
210 220 230 240
PPMGIPPGRG TPMGMPPPGM RPPPPGMRGP PPPGMRPPRP
The sequence of this isoform differs from the canonical sequence as follows:
230-240: PPPPGMRPPRP → LL
The sequence of this isoform differs from the canonical sequence as follows:
227-228: MR → GCEAFFDPWPQSMEVAPQRRGLDSSGPRYHRPVCFLCCCSWSLMGLSGFLT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketS4R3P3 | S4R3P3_HUMAN | Small nuclear ribonucleoprotein-ass... | SNRPB | 70 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 172 – 173 | RG → L no nucleotide entry (PubMed:2524838).Curated | 2 | |
Sequence conflicti | 201 | Missing no nucleotide entry (PubMed:2524838).Curated | 1 | |
Sequence conflicti | 217 – 218 | PP → S no nucleotide entry (PubMed:2524838).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073380 | 55 | N → S in CCMS; expression of the protein is reduced. 2 Publications | 1 | |
Natural variantiVAR_073381 | 55 | N → T in CCMS. 1 Publication | 1 | |
Natural variantiVAR_073382 | 56 | S → R in CCMS. 2 Publications | 1 | |
Natural variantiVAR_073383 | 56 | S → W in CCMS. 1 Publication | 1 | |
Natural variantiVAR_052274 | 79 | S → P. Corresponds to variant dbSNP:rs11545672Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012221 | 227 – 228 | MR → GCEAFFDPWPQSMEVAPQRR GLDSSGPRYHRPVCFLCCCS WSLMGLSGFLT in isoform SM-B1. 1 Publication | 2 | |
Alternative sequenceiVSP_005914 | 230 – 240 | PPPPGMRPPRP → LL in isoform SM-B. 3 PublicationsAdd BLAST | 11 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X17567 mRNA Translation: CAB57867.1 X17568 mRNA Translation: CAB57868.1 X15893 mRNA Translation: CAA33902.1 AF134825 , AF134822, AF134823, AF134824 Genomic DNA Translation: AAD54488.1 Sequence problems. AL049650 Genomic DNA Translation: CAB46715.1 CH471133 Genomic DNA Translation: EAX10596.1 CR456969 mRNA Translation: CAG33250.1 AL049650 Genomic DNA Translation: CAB46714.1 M34081 mRNA Translation: AAA36578.1 M34082 mRNA Translation: AAA36579.1 X52979 Genomic DNA Translation: CAA37170.1 X52979 Genomic DNA Translation: CAA37171.1 |
CCDSi | CCDS13026.1 [P14678-1] CCDS13027.1 [P14678-2] |
PIRi | S09377 |
RefSeqi | NP_003082.1, NM_003091.3 [P14678-2] NP_937859.1, NM_198216.1 [P14678-1] |
Genome annotation databases
Ensembli | ENST00000381342; ENSP00000370746; ENSG00000125835 [P14678-2] ENST00000438552; ENSP00000412566; ENSG00000125835 [P14678-1] |
GeneIDi | 6628 |
KEGGi | hsa:6628 |
UCSCi | uc002wfz.2, human [P14678-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X17567 mRNA Translation: CAB57867.1 X17568 mRNA Translation: CAB57868.1 X15893 mRNA Translation: CAA33902.1 AF134825 , AF134822, AF134823, AF134824 Genomic DNA Translation: AAD54488.1 Sequence problems. AL049650 Genomic DNA Translation: CAB46715.1 CH471133 Genomic DNA Translation: EAX10596.1 CR456969 mRNA Translation: CAG33250.1 AL049650 Genomic DNA Translation: CAB46714.1 M34081 mRNA Translation: AAA36578.1 M34082 mRNA Translation: AAA36579.1 X52979 Genomic DNA Translation: CAA37170.1 X52979 Genomic DNA Translation: CAA37171.1 |
CCDSi | CCDS13026.1 [P14678-1] CCDS13027.1 [P14678-2] |
PIRi | S09377 |
RefSeqi | NP_003082.1, NM_003091.3 [P14678-2] NP_937859.1, NM_198216.1 [P14678-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1D3B | X-ray | 2.00 | B/D/F/H/J/L | 1-91 | [»] | |
3CW1 | X-ray | 5.49 | A/H/I/J | 1-174 | [»] | |
3JCR | electron microscopy | 7.00 | O/o | 1-240 | [»] | |
3PGW | X-ray | 4.40 | B/Q | 1-229 | [»] | |
4PJO | X-ray | 3.30 | B/P/b/p | 1-95 | [»] | |
4WZJ | X-ray | 3.60 | AA/AH/AO/BA/BH/BO/CA/CH/CO/DA/DH/DO | 1-95 | [»] | |
5MQF | electron microscopy | 5.90 | f/m | 1-240 | [»] | |
5O9Z | electron microscopy | 4.50 | X/f/m | 1-240 | [»] | |
5XJC | electron microscopy | 3.60 | b/i | 1-229 | [»] | |
5YZG | electron microscopy | 4.10 | b/i | 1-229 | [»] | |
5Z56 | electron microscopy | 5.10 | b/i | 1-229 | [»] | |
5Z57 | electron microscopy | 6.50 | b/i | 1-229 | [»] | |
5Z58 | electron microscopy | 4.90 | b/i | 1-229 | [»] | |
6AH0 | electron microscopy | 5.70 | U/f/i | 1-229 | [»] | |
6FF7 | electron microscopy | 4.50 | f/m | 1-240 | [»] | |
6ICZ | electron microscopy | 3.00 | b/i | 1-229 | [»] | |
6ID0 | electron microscopy | 2.90 | b/i | 1-229 | [»] | |
6ID1 | electron microscopy | 2.86 | b/i | 1-229 | [»] | |
6QDV | electron microscopy | 3.30 | b/k | 6-87 | [»] | |
6QW6 | electron microscopy | 2.92 | 4b/5b | 1-240 | [»] | |
6QX9 | electron microscopy | 3.28 | 1b/2b/4b/5b | 1-240 | [»] | |
6V4X | electron microscopy | 3.20 | B | 1-95 | [»] | |
6Y53 | electron microscopy | 7.10 | m | 1-240 | [»] | |
6Y5Q | electron microscopy | 7.10 | m | 1-240 | [»] | |
SMRi | P14678 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112512, 233 interactors |
CORUMi | P14678 |
DIPi | DIP-31239N |
IntActi | P14678, 133 interactors |
MINTi | P14678 |
STRINGi | 9606.ENSP00000412566 |
PTM databases
iPTMneti | P14678 |
MetOSitei | P14678 |
PhosphoSitePlusi | P14678 |
SwissPalmi | P14678 |
Polymorphism and mutation databases
BioMutai | SNRPB |
DMDMi | 134037 |
Proteomic databases
EPDi | P14678 |
jPOSTi | P14678 |
MassIVEi | P14678 |
MaxQBi | P14678 |
PaxDbi | P14678 |
PeptideAtlasi | P14678 |
PRIDEi | P14678 |
ProteomicsDBi | 53074 [P14678-1] 53075 [P14678-2] 53076 [P14678-3] |
TopDownProteomicsi | P14678-2 [P14678-2] |
Protocols and materials databases
Antibodypediai | 4041, 153 antibodies |
DNASUi | 6628 |
Genome annotation databases
Ensembli | ENST00000381342; ENSP00000370746; ENSG00000125835 [P14678-2] ENST00000438552; ENSP00000412566; ENSG00000125835 [P14678-1] |
GeneIDi | 6628 |
KEGGi | hsa:6628 |
UCSCi | uc002wfz.2, human [P14678-1] |
Organism-specific databases
CTDi | 6628 |
DisGeNETi | 6628 |
EuPathDBi | HostDB:ENSG00000125835.17 |
GeneCardsi | SNRPB |
HGNCi | HGNC:11153, SNRPB |
HPAi | ENSG00000125835, Low tissue specificity |
MalaCardsi | SNRPB |
MIMi | 117650, phenotype 182282, gene |
neXtProti | NX_P14678 |
OpenTargetsi | ENSG00000125835 |
Orphaneti | 1393, Cerebrocostomandibular syndrome |
PharmGKBi | PA35995 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3168, Eukaryota |
GeneTreei | ENSGT00940000155052 |
HOGENOMi | CLU_076902_1_0_1 |
OMAi | RGMGMMP |
OrthoDBi | 1630470at2759 |
PhylomeDBi | P14678 |
TreeFami | TF314232 |
Enzyme and pathway databases
PathwayCommonsi | P14678 |
Reactomei | R-HSA-111367, SLBP independent Processing of Histone Pre-mRNAs R-HSA-191859, snRNP Assembly R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72165, mRNA Splicing - Minor Pathway R-HSA-73856, RNA Polymerase II Transcription Termination R-HSA-77588, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
Miscellaneous databases
BioGRID-ORCSi | 6628, 731 hits in 850 CRISPR screens |
ChiTaRSi | SNRPB, human |
EvolutionaryTracei | P14678 |
GeneWikii | SNRPB |
GenomeRNAii | 6628 |
Pharosi | P14678, Tbio |
PROi | PR:P14678 |
RNActi | P14678, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125835, Expressed in bone marrow and 239 other tissues |
ExpressionAtlasi | P14678, baseline and differential |
Genevisiblei | P14678, HS |
Family and domain databases
IDEALi | IID00143 |
InterProi | View protein in InterPro IPR001163, LSM_dom_euk/arc IPR010920, LSM_dom_sf IPR017131, snRNP-assoc_SmB/SmN |
Pfami | View protein in Pfam PF01423, LSM, 1 hit |
PIRSFi | PIRSF037187, snRNP_SmB/SmN, 1 hit |
SMARTi | View protein in SMART SM00651, Sm, 1 hit |
SUPFAMi | SSF50182, SSF50182, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RSMB_HUMAN | |
Accessioni | P14678Primary (citable) accession number: P14678 Secondary accession number(s): Q15490, Q6IB35, Q9UIS5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | November 1, 1991 | |
Last modified: | December 2, 2020 | |
This is version 227 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations