Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alcohol dehydrogenase 3

Gene

ADH3

Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48Zinc 1; catalyticBy similarity1
Metal bindingi50Zinc 1By similarity1
Binding sitei50NADBy similarity1
Binding sitei50SubstrateBy similarity1
Metal bindingi70Zinc 1; catalyticBy similarity1
Binding sitei70SubstrateBy similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi114Zinc 2By similarity1
Metal bindingi178Zinc 1; catalyticBy similarity1
Binding sitei227NADBy similarity1
Binding sitei232NADBy similarity1
Binding sitei273NAD; via carbonyl oxygenBy similarity1
Binding sitei296NAD; via carbonyl oxygenBy similarity1
Binding sitei323NAD; via amide nitrogenBy similarity1
Binding sitei373NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi203 – 208NADBy similarity6
Nucleotide bindingi296 – 298NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 3 (EC:1.1.1.1By similarity)
Gene namesi
Name:ADH3
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
Proteomesi
  • UP000011115 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607141 – 380Alcohol dehydrogenase 3Add BLAST380

Expressioni

Gene expression databases

ExpressionAtlasiP14675 baseline

Interactioni

Subunit structurei

Homodimer (By similarity). Homotetramer.By similarity

Protein-protein interaction databases

STRINGi4113.PGSC0003DMT400079071

Structurei

3D structure databases

ProteinModelPortaliP14675
SMRiP14675
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
InParanoidiP14675
KOiK18857

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P14675-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTTVGQVIR CKAAVAWEAG KPLVMEEVDV APPQKMEVRL KILYTSLCHT
60 70 80 90 100
DVYFWEAKGQ NPVFPRILGH EAAGIVESVG EGVTELAPGD HVLPVFTGEC
110 120 130 140 150
KDCAHCKSEE SNMCSLLRIN TDRGVMINDG QSRFSINGKP IYHFVGTSTF
160 170 180 190 200
SEYTVVHVGC VAKINPLAPL DKVCVLSCGI STGLGATLNV AKPTKGSSVA
210 220 230 240 250
IFGLGAVGLA AAEGARIAGA SRIIGVDLNA SRFEQAKKFG VTEFVNPKDY
260 270 280 290 300
SKPVQEVIAE MTDGGVDRSV ECTGHIDAMI SAFECVHDGW GVAVLVGVPH
310 320 330 340 350
KEAVFKTHPM NFLNERTLKG TFFGNYKPRS DIPSVVEKYM NKELELEKFI
360 370 380
THTLPFAEIN KAFDLMLKGE GLRCIITMED
Length:380
Mass (Da):41,142
Last modified:April 1, 1990 - v1
Checksum:i50E904E471732539
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25152 mRNA Translation: AAA33808.1
PIRiS11853 DEPOA1
RefSeqiNP_001275080.1, NM_001288151.1
UniGeneiStu.586

Genome annotation databases

GeneIDi102577519
KEGGisot:102577519

Similar proteinsi

Entry informationi

Entry nameiADH3_SOLTU
AccessioniPrimary (citable) accession number: P14675
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again