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Protein

Homeobox protein Hox-B2

Gene

HOXB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi143 – 202HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B2
Alternative name(s):
Homeobox protein Hox-2.8
Homeobox protein Hox-2H
K8
Gene namesi
Name:HOXB2
Synonyms:HOX2H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000173917.10
HGNCiHGNC:5113 HOXB2
MIMi142967 gene
neXtProtiNX_P14652

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3212
OpenTargetsiENSG00000173917
PharmGKBiPA29389

Polymorphism and mutation databases

BioMutaiHOXB2
DMDMi123270

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001141 – 356Homeobox protein Hox-B2Add BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei274PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP14652
PeptideAtlasiP14652
PRIDEiP14652
ProteomicsDBi53071

PTM databases

iPTMnetiP14652
PhosphoSitePlusiP14652

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

BgeeiENSG00000173917
CleanExiHS_HOXB2
GenevisibleiP14652 HS

Organism-specific databases

HPAiHPA047857

Interactioni

Subunit structurei

Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2.

Protein-protein interaction databases

BioGridi109452, 1 interactor
ELMiP14652
IntActiP14652, 9 interactors
STRINGi9606.ENSP00000331741

Structurei

3D structure databases

ProteinModelPortaliP14652
SMRiP14652
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi94 – 99Antp-type hexapeptide6

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000063664
HOVERGENiHBG006088
InParanoidiP14652
KOiK09302
OMAiHEFPWMK
OrthoDBiEOG091G0IJ4
PhylomeDBiP14652
TreeFamiTF317730

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P14652-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFEFEREIG FINSQPSLAE CLTSFPAVLE TFQTSSIKES TLIPPPPPFE
60 70 80 90 100
QTFPSLQPGA STLQRPRSQK RAEDGPALPP PPPPPLPAAP PAPEFPWMKE
110 120 130 140 150
KKSAKKPSQS ATSPSPAASA VPASGVGSPA DGLGLPEAGG GGARRLRTAY
160 170 180 190 200
TNTQLLELEK EFHFNKYLCR PRRVEIAALL DLTERQVKVW FQNRRMKHKR
210 220 230 240 250
QTQHREPPDG EPACPGALED ICDPAEEPAA SPGGPSASRA AWEACCHPPE
260 270 280 290 300
VVPGALSADP RPLAVRLEGA GASSPGCALR GAGGLEPGPL PEDVFSGRQD
310 320 330 340 350
SPFLPDLNFF AADSCLQLSG GLSPSLQGSL DSPVPFSEEE LDFFTSTLCA

IDLQFP
Length:356
Mass (Da):37,914
Last modified:April 1, 1990 - v1
Checksum:iD7ACA0E3D5BEBFB9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136 – 138PEA → RRL in CAA34298 (PubMed:2570724).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16665 mRNA Translation: CAA34655.1
BC074805 mRNA Translation: AAH74805.1
BC074806 mRNA Translation: AAH74806.1
X16176 Genomic DNA Translation: CAA34298.1
X14571 mRNA Translation: CAA32709.1
X78978 Genomic DNA Translation: CAA55581.1
CCDSiCCDS11527.1
PIRiS07542 WJHU2H
RefSeqiNP_002136.1, NM_002145.3
UniGeneiHs.514289

Genome annotation databases

EnsembliENST00000330070; ENSP00000331741; ENSG00000173917
GeneIDi3212
KEGGihsa:3212
UCSCiuc002inm.5 human

Similar proteinsi

Entry informationi

Entry nameiHXB2_HUMAN
AccessioniPrimary (citable) accession number: P14652
Secondary accession number(s): P10913, P17485
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 20, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

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