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Protein

Homeobox protein Hox-B3

Gene

HOXB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi188 – 247HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
SIGNORiP14651

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B3
Alternative name(s):
Homeobox protein Hox-2.7
Homeobox protein Hox-2G
Gene namesi
Name:HOXB3
Synonyms:HOX2G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000120093.11
HGNCiHGNC:5114 HOXB3
MIMi142966 gene
neXtProtiNX_P14651

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3213
OpenTargetsiENSG00000120093
PharmGKBiPA29390

Polymorphism and mutation databases

BioMutaiHOXB3
DMDMi215274007

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001171 – 431Homeobox protein Hox-B3Add BLAST431

Proteomic databases

PaxDbiP14651
PeptideAtlasiP14651
PRIDEiP14651
ProteomicsDBi53070

PTM databases

iPTMnetiP14651
PhosphoSitePlusiP14651

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

BgeeiENSG00000120093 Expressed in 205 organ(s), highest expression level in endometrium
CleanExiHS_HOXB3
ExpressionAtlasiP14651 baseline and differential
GenevisibleiP14651 HS

Organism-specific databases

HPAiCAB009860

Interactioni

Protein-protein interaction databases

BioGridi109453, 2 interactors
ELMiP14651
STRINGi9606.ENSP00000308252

Structurei

3D structure databases

ProteinModelPortaliP14651
SMRiP14651
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi129 – 134Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi154 – 178Gly-richAdd BLAST25

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000252944
HOVERGENiHBG107984
InParanoidiP14651
KOiK09303
OMAiKCGPGTN
OrthoDBiEOG091G09XD
PhylomeDBiP14651
TreeFamiTF315938

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR025281 DUF4074
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF13293 DUF4074, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P14651-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQKATYYDNA AAALFGGYSS YPGSNGFGFD VPPQPPFQAA THLEGDYQRS
60 70 80 90 100
ACSLQSLGNA APHAKSKELN GSCMRPGLAP EPLSAPPGSP PPSAAPTSAT
110 120 130 140 150
SNSSNGGGPS KSGPPKCGPG TNSTLTKQIF PWMKESRQTS KLKNNSPGTA
160 170 180 190 200
EGCGGGGGGG GGGGSGGSGG GGGGGGGGDK SPPGSAASKR ARTAYTSAQL
210 220 230 240 250
VELEKEFHFN RYLCRPRRVE MANLLNLSER QIKIWFQNRR MKYKKDQKAK
260 270 280 290 300
GLASSSGGPS PAGSPPQPMQ STAGFMNALH SMTPSYESPS PPAFGKAHQN
310 320 330 340 350
AYALPSNYQP PLKGCGAPQK YPPTPAPEYE PHVLQANGGA YGTPTMQGSP
360 370 380 390 400
VYVGGGGYAD PLPPPAGPSL YGLNHLSHHP SGNLDYNGAP PMAPSQHHGP
410 420 430
CEPHPTYTDL SSHHAPPPQG RIQEAPKLTH L
Length:431
Mass (Da):44,340
Last modified:November 25, 2008 - v2
Checksum:i56D39C0C9496E65A
GO
Isoform 2 (identifier: P14651-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Note: No experimental confirmation available.
Show »
Length:358
Mass (Da):36,698
Checksum:i8E6B18948B2AD02E
GO
Isoform 3 (identifier: P14651-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.

Note: No experimental confirmation available.
Show »
Length:299
Mass (Da):30,989
Checksum:i6C0A22D64D10D5FD
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VXG0F8VXG0_HUMAN
Homeobox protein Hox-B3
HOXB3
297Annotation score:
C9J2I3C9J2I3_HUMAN
Homeobox protein Hox-B3
HOXB3
90Annotation score:
F8W1L2F8W1L2_HUMAN
Homeobox protein Hox-B3
HOXB3
119Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100T → A in BAH12984 (PubMed:14702039).Curated1
Sequence conflicti199 – 200QL → HV in AAD10852 (Ref. 2) Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04772982P → T4 PublicationsCorresponds to variant dbSNP:rs2229304Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0568151 – 132Missing in isoform 3. 1 PublicationAdd BLAST132
Alternative sequenceiVSP_0564341 – 73Missing in isoform 2. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16667 mRNA Translation: CAA34657.1
U59298 mRNA Translation: AAD10852.1
AF287967 Genomic DNA Translation: AAG31555.1
AK291182 mRNA Translation: BAF83871.1
AK299226 mRNA Translation: BAH12974.1
AK299265 mRNA Translation: BAH12984.1
AK315102 mRNA Translation: BAG37563.1
AK316245 mRNA Translation: BAH14616.1
AC103702 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94739.1
CH471109 Genomic DNA Translation: EAW94740.1
CH471109 Genomic DNA Translation: EAW94741.1
X16175 Genomic DNA Translation: CAA34297.1
CCDSiCCDS11528.1 [P14651-1]
CCDS82153.1 [P14651-3]
CCDS82154.1 [P14651-2]
PIRiS07543 WJHU2G
RefSeqiNP_001317251.1, NM_001330322.1 [P14651-2]
NP_001317252.1, NM_001330323.1 [P14651-3]
NP_002137.4, NM_002146.4 [P14651-1]
XP_005257334.1, XM_005257277.3 [P14651-1]
XP_006721917.1, XM_006721854.2 [P14651-1]
XP_011523010.1, XM_011524708.2 [P14651-3]
XP_011523012.1, XM_011524710.1 [P14651-1]
XP_011523021.1, XM_011524719.1 [P14651-1]
XP_011523022.1, XM_011524720.2 [P14651-1]
XP_011523028.1, XM_011524726.2 [P14651-2]
UniGeneiHs.654560
Hs.675434
Hs.687723

Genome annotation databases

EnsembliENST00000311626; ENSP00000308252; ENSG00000120093 [P14651-1]
ENST00000460160; ENSP00000418035; ENSG00000120093 [P14651-3]
ENST00000470495; ENSP00000417207; ENSG00000120093 [P14651-1]
ENST00000472863; ENSP00000419676; ENSG00000120093 [P14651-2]
ENST00000476342; ENSP00000418892; ENSG00000120093 [P14651-1]
ENST00000489475; ENSP00000418729; ENSG00000120093 [P14651-2]
ENST00000498678; ENSP00000420595; ENSG00000120093 [P14651-1]
GeneIDi3213
KEGGihsa:3213
UCSCiuc002inn.4 human [P14651-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16667 mRNA Translation: CAA34657.1
U59298 mRNA Translation: AAD10852.1
AF287967 Genomic DNA Translation: AAG31555.1
AK291182 mRNA Translation: BAF83871.1
AK299226 mRNA Translation: BAH12974.1
AK299265 mRNA Translation: BAH12984.1
AK315102 mRNA Translation: BAG37563.1
AK316245 mRNA Translation: BAH14616.1
AC103702 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94739.1
CH471109 Genomic DNA Translation: EAW94740.1
CH471109 Genomic DNA Translation: EAW94741.1
X16175 Genomic DNA Translation: CAA34297.1
CCDSiCCDS11528.1 [P14651-1]
CCDS82153.1 [P14651-3]
CCDS82154.1 [P14651-2]
PIRiS07543 WJHU2G
RefSeqiNP_001317251.1, NM_001330322.1 [P14651-2]
NP_001317252.1, NM_001330323.1 [P14651-3]
NP_002137.4, NM_002146.4 [P14651-1]
XP_005257334.1, XM_005257277.3 [P14651-1]
XP_006721917.1, XM_006721854.2 [P14651-1]
XP_011523010.1, XM_011524708.2 [P14651-3]
XP_011523012.1, XM_011524710.1 [P14651-1]
XP_011523021.1, XM_011524719.1 [P14651-1]
XP_011523022.1, XM_011524720.2 [P14651-1]
XP_011523028.1, XM_011524726.2 [P14651-2]
UniGeneiHs.654560
Hs.675434
Hs.687723

3D structure databases

ProteinModelPortaliP14651
SMRiP14651
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109453, 2 interactors
ELMiP14651
STRINGi9606.ENSP00000308252

PTM databases

iPTMnetiP14651
PhosphoSitePlusiP14651

Polymorphism and mutation databases

BioMutaiHOXB3
DMDMi215274007

Proteomic databases

PaxDbiP14651
PeptideAtlasiP14651
PRIDEiP14651
ProteomicsDBi53070

Protocols and materials databases

DNASUi3213
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311626; ENSP00000308252; ENSG00000120093 [P14651-1]
ENST00000460160; ENSP00000418035; ENSG00000120093 [P14651-3]
ENST00000470495; ENSP00000417207; ENSG00000120093 [P14651-1]
ENST00000472863; ENSP00000419676; ENSG00000120093 [P14651-2]
ENST00000476342; ENSP00000418892; ENSG00000120093 [P14651-1]
ENST00000489475; ENSP00000418729; ENSG00000120093 [P14651-2]
ENST00000498678; ENSP00000420595; ENSG00000120093 [P14651-1]
GeneIDi3213
KEGGihsa:3213
UCSCiuc002inn.4 human [P14651-1]

Organism-specific databases

CTDi3213
DisGeNETi3213
EuPathDBiHostDB:ENSG00000120093.11
GeneCardsiHOXB3
HGNCiHGNC:5114 HOXB3
HPAiCAB009860
MIMi142966 gene
neXtProtiNX_P14651
OpenTargetsiENSG00000120093
PharmGKBiPA29390
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000252944
HOVERGENiHBG107984
InParanoidiP14651
KOiK09303
OMAiKCGPGTN
OrthoDBiEOG091G09XD
PhylomeDBiP14651
TreeFamiTF315938

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
SIGNORiP14651

Miscellaneous databases

ChiTaRSiHOXB3 human
GeneWikiiHOXB3
GenomeRNAii3213
PROiPR:P14651
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120093 Expressed in 205 organ(s), highest expression level in endometrium
CleanExiHS_HOXB3
ExpressionAtlasiP14651 baseline and differential
GenevisibleiP14651 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR025281 DUF4074
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF13293 DUF4074, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXB3_HUMAN
AccessioniPrimary (citable) accession number: P14651
Secondary accession number(s): A8K567
, B7Z5N8, B7Z5P8, B7ZAD0, D3DTV3, O95615, P17484
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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